SEPN · Septerna, Inc.
$40.79
-3.14 (-7.15%)
At close · Aug 20
Market Cap
$1.89B
Shares
46.68M
Price & Indicators
20d MA
50d MA
200d MA
Earnings
Filing
Insider
Congress
Investor day
Close$40.79
Open$43.15
Day$40.24–43.62
52W close$11.09–48.19
Avg vol 30d405K
Short int3.5M · 7.5% float · 14.2d
Short vol47%
Last earningsMar 2, 2026
DataOct 2024–Aug 2026
Filing10-Q · Aug 10
Up next
FQ3-26 quarter ends
~Sep 30, 2026
Est
filed Aug 10, 2026
AI Brief
TL;DR.
Bullish
Bearish
From the call
AI-generated from the earnings call and 8-K · may contain errors · not investment advice
Ask ALVIS about this →Equibles Rating
blended score · not investment adviceOverall
Buy
SellHoldBuy
Technical
Buy
Momentum
Very Strong
Sentiment
Neutral
Fundamentals
Excellent
Quant / Vol
Very High
Market backdrop
VIX 14.9 · calm
Equity put/call 0.52
Technical
price trend
50 / 200-day cross
No cross
Price vs 200-day avg
+42%
above
Price vs 50-day avg
+11%
above
RSI (14)
54
neutral
MACD trend
Positive
52-week position
80%
mid-range
Momentum
relative strength
1-month return
+22%
trailing
6-month return
+41%
trailing
YTD return
+46%
this year
Relative strength
+29%
vs S&P · 6-mo
Sentiment
smart money
Trend (MA cross)
No cross
50d $37 › 200d $29 — 50d above 200d
Institutional flow
Accumulating
+24% holders QoQ · +48 funds added
Insider flow
Distributing
Net -$63.5M over 90 days · 100% sells
Short interest
Rising
7.52% of float · ▲ +4.7% MoM · 14.2 days cover
Volume signal
Normal
Volume near normal
Institution breadth
Multi-yr high
155 holders — near 1-yr high, broad support
Squeeze score
81
high risk · 0–100
Fundamentals
Revenue growth
+4175%
Y/Y
EPS growth
+85%
Y/Y
Free cash flow
$109.7M
Balance sheet
$120.7M
net cash
Quant / Vol
risk profile
Volatility
69%
annualized · 1-yr
Max drawdown
−25%
past year
ATR
6.6%
of price · 14-day
Blended from price, momentum, positioning, fundamentals & volatility · daily-close · not investment advice. Market backdrop is context, not part of the score.
Technicals
trend & momentum for long-term holders Buy
50 / 200-day cross
No cross
Neutral
Price vs 200-day avg
+42%
Bullish
Price vs 50-day avg
+11%
Bullish
RSI (14)
54
Neutral
MACD trend
Positive
Bullish
52-week position
80%
Neutral
Market signals — smart money & positioning
Mixed
Trend (MA cross)
No cross
50d $37 › 200d $29 — 50d above 200d
Institutional flow
Accumulating
+24% holders QoQ · +48 funds added
Insider flow
Distributing
Net -$63.5M over 90 days · 100% sells
Short interest
Rising
7.52% of float · ▲ +4.7% MoM · 14.2 days cover
Volume signal
Normal
Volume near normal
Institution breadth
Multi-yr high
155 holders — near 1-yr high, broad support
Price context
position in its 52-week range
Range low $11
Now $41 · 80%
Range high $48
vs 200-day avg +42%
vs 50-day avg +11%
Illustrative technical + ownership context — a signal mix, not investment advice.
Versus peers
Biotechnology — same industry group| Company | Mkt cap | YTD | Rev growth Y/Y | P/E | Short % shares |
|---|---|---|---|---|---|
|
SEPN
this stock
Septerna, Inc.
|
$1.89B | +46.3% | +4174.5% | — | 7.5% |
|
ONC
BeOne Medicines Ltd.
|
$557.05B | +21.5% | +22179.2% | 856.5 | 0.1% |
|
VRTX
Vertex Pharmaceuticals Inc / Ma
|
$136.93B | +19.2% | +46.2% | 31.5 | 1.6% |
|
REGN
Regeneron Pharmaceuticals, Inc.
|
$86.39B | +7.1% | +20.8% | 20.8 | 3.3% |
|
MRNA
Moderna, Inc.
|
$69.62B | +352.1% | +4.3% | — | 12.5% |
Peers by industry group · P/E from as-reported trailing EPS · short % is of shares outstanding
At a glance
key data from every sectionOwnership
Short & Settlement
Smart Money
Financials
Filings
Earnings & Events
Performance
| 5D | 20D | 120D | MTD | YTD | |
|---|---|---|---|---|---|
| SEPN | -9.6% | +21.9% | +40.6% | +18.4% | +46.3% |
| SPY | -2.0% | +3.3% | +11.2% | +2.1% | +11.8% |
| vs SPY | -7.7% | +18.6% | +29.4% | +16.3% | +34.5% |
Key facts
CIK
1984086
CUSIP
81734D104
13F (30d)
153 filings
151 filers
Visit website
Investor relations