CRNX · Crinetics Pharmaceuticals, Inc.

The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 11, 2025.

The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a sale price of $40.00 per share.

The stock option shall vest and become exercisable on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 100% vesting on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 100% vesting on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 100% vesting on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

The stock option shall vest and become exercisable on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

The stock option shall vest and become exercisable on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 100% vesting on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 100% vesting on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 100% vesting on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 100% vesting on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

The stock option shall vest and become exercisable on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

The stock option shall vest and become exercisable on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

The stock option shall vest and become exercisable on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

The stock option shall vest and become exercisable on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 19, 2025.

The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a volume weighted average sale price of $35.62 per share. The range of sale prices on the transaction date was $35.19 to $36.06. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 19, 2025.

The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a volume weighted average sale price of $36.22 per share. The range of sale prices on the transaction date was $36.19 to $36.29. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

(3) Represents contributions of shares by the Reporting Person's spouse to (a) the Iowa Descendants Trust ("Family Trust 7") and (b) the RSS Dynasty Trust ("Family Trust 8"), each of which is an irrevocable trust with an independent trustee of which the Reporting Person and his family members are beneficiaries. The Reporting Person disclaims beneficial ownership of the shares held by Family Trust 5 and Family Trust 6 except to the extent of his pecuniary interest therein.

(2) Represents contributions of shares by the Reporting Person to (a) the GMS Dynasty Trust ("Family Trust 5") and (b) the JSS Dynasty Trust ("Family Trust 6"), each of which is an irrevocable trust with an independent trustee of which the Reporting Person's spouse and her family members, and the Reporting Person's spouse, respectively, are beneficiaries. The Reporting Person disclaims beneficial ownership of the shares held by Family Trust 5 and Family Trust 6 except to the extent of his pecuniary interest therein.

(1) Represents gifts of shares by the Struthers Family Trust ("Family Trust 1"), of which the Reporting Person is the trustee and the Reporting Person and his spouse are beneficiaries, to (a) the Reporting Person, (b) the Reporting Person's spouse and (c) the Struthers Family Charitable Remainder Trust (the "Charitable Trust"), a charitable remainder trust of which the Reporting Person is the trustee and of which the Reporting Person and his spouse are beneficiaries. The Reporting Person disclaims beneficial ownership of the shares held by the Charitable Trust except to the extent of his pecuniary interest therein.

(3) Represents contributions of shares by the Reporting Person's spouse to (a) the Iowa Descendants Trust ("Family Trust 7") and (b) the RSS Dynasty Trust ("Family Trust 8"), each of which is an irrevocable trust with an independent trustee of which the Reporting Person and his family members are beneficiaries. The Reporting Person disclaims beneficial ownership of the shares held by Family Trust 5 and Family Trust 6 except to the extent of his pecuniary interest therein.

(2) Represents contributions of shares by the Reporting Person to (a) the GMS Dynasty Trust ("Family Trust 5") and (b) the JSS Dynasty Trust ("Family Trust 6"), each of which is an irrevocable trust with an independent trustee of which the Reporting Person's spouse and her family members, and the Reporting Person's spouse, respectively, are beneficiaries. The Reporting Person disclaims beneficial ownership of the shares held by Family Trust 5 and Family Trust 6 except to the extent of his pecuniary interest therein.

(3) Represents contributions of shares by the Reporting Person's spouse to (a) the Iowa Descendants Trust ("Family Trust 7") and (b) the RSS Dynasty Trust ("Family Trust 8"), each of which is an irrevocable trust with an independent trustee of which the Reporting Person and his family members are beneficiaries. The Reporting Person disclaims beneficial ownership of the shares held by Family Trust 5 and Family Trust 6 except to the extent of his pecuniary interest therein.

(2) Represents contributions of shares by the Reporting Person to (a) the GMS Dynasty Trust ("Family Trust 5") and (b) the JSS Dynasty Trust ("Family Trust 6"), each of which is an irrevocable trust with an independent trustee of which the Reporting Person's spouse and her family members, and the Reporting Person's spouse, respectively, are beneficiaries. The Reporting Person disclaims beneficial ownership of the shares held by Family Trust 5 and Family Trust 6 except to the extent of his pecuniary interest therein.

(1) Represents gifts of shares by the Struthers Family Trust ("Family Trust 1"), of which the Reporting Person is the trustee and the Reporting Person and his spouse are beneficiaries, to (a) the Reporting Person, (b) the Reporting Person's spouse and (c) the Struthers Family Charitable Remainder Trust (the "Charitable Trust"), a charitable remainder trust of which the Reporting Person is the trustee and of which the Reporting Person and his spouse are beneficiaries. The Reporting Person disclaims beneficial ownership of the shares held by the Charitable Trust except to the extent of his pecuniary interest therein.

(3) Represents contributions of shares by the Reporting Person's spouse to (a) the Iowa Descendants Trust ("Family Trust 7") and (b) the RSS Dynasty Trust ("Family Trust 8"), each of which is an irrevocable trust with an independent trustee of which the Reporting Person and his family members are beneficiaries. The Reporting Person disclaims beneficial ownership of the shares held by Family Trust 5 and Family Trust 6 except to the extent of his pecuniary interest therein.

(1) Represents gifts of shares by the Struthers Family Trust ("Family Trust 1"), of which the Reporting Person is the trustee and the Reporting Person and his spouse are beneficiaries, to (a) the Reporting Person, (b) the Reporting Person's spouse and (c) the Struthers Family Charitable Remainder Trust (the "Charitable Trust"), a charitable remainder trust of which the Reporting Person is the trustee and of which the Reporting Person and his spouse are beneficiaries. The Reporting Person disclaims beneficial ownership of the shares held by the Charitable Trust except to the extent of his pecuniary interest therein.

(1) Represents gifts of shares by the Struthers Family Trust ("Family Trust 1"), of which the Reporting Person is the trustee and the Reporting Person and his spouse are beneficiaries, to (a) the Reporting Person, (b) the Reporting Person's spouse and (c) the Struthers Family Charitable Remainder Trust (the "Charitable Trust"), a charitable remainder trust of which the Reporting Person is the trustee and of which the Reporting Person and his spouse are beneficiaries. The Reporting Person disclaims beneficial ownership of the shares held by the Charitable Trust except to the extent of his pecuniary interest therein.

(1) Represents gifts of shares by the Struthers Family Trust ("Family Trust 1"), of which the Reporting Person is the trustee and the Reporting Person and his spouse are beneficiaries, to (a) the Reporting Person, (b) the Reporting Person's spouse and (c) the Struthers Family Charitable Remainder Trust (the "Charitable Trust"), a charitable remainder trust of which the Reporting Person is the trustee and of which the Reporting Person and his spouse are beneficiaries. The Reporting Person disclaims beneficial ownership of the shares held by the Charitable Trust except to the extent of his pecuniary interest therein.

(1) Represents gifts of shares by the Struthers Family Trust ("Family Trust 1"), of which the Reporting Person is the trustee and the Reporting Person and his spouse are beneficiaries, to (a) the Reporting Person, (b) the Reporting Person's spouse and (c) the Struthers Family Charitable Remainder Trust (the "Charitable Trust"), a charitable remainder trust of which the Reporting Person is the trustee and of which the Reporting Person and his spouse are beneficiaries. The Reporting Person disclaims beneficial ownership of the shares held by the Charitable Trust except to the extent of his pecuniary interest therein.

(2) Represents contributions of shares by the Reporting Person to (a) the GMS Dynasty Trust ("Family Trust 5") and (b) the JSS Dynasty Trust ("Family Trust 6"), each of which is an irrevocable trust with an independent trustee of which the Reporting Person's spouse and her family members, and the Reporting Person's spouse, respectively, are beneficiaries. The Reporting Person disclaims beneficial ownership of the shares held by Family Trust 5 and Family Trust 6 except to the extent of his pecuniary interest therein.

The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 12, 2025.

The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a volume weighted average sale price of $40.10 per share. The range of sale prices on the transaction date was $40.00 to $40.34. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

25% of the shares subject to the option vested on August 30, 2022, and the remaining number of shares subject to the option vested monthly thereafter in thirty-six equal installments.

1/48th of the shares subject to the option vested monthly measured from the vesting commencement date of February 28, 2022.

The option is exercisable as follows: 1/48th of the shares subject to the option vest monthly measured from the vesting commencement date of March 1, 2023, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

Represents the number of shares of common stock sold by the Issuer to cover the Reporting Person's tax withholding obligation upon the vesting of Restricted Stock Units granted on February 28, 2022, March 1, 2023, and March 4, 2024. The disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person.

The common stock was sold in open market transactions on the transaction date, with a volume weighted average sales price of $37.11 per share. The range of sales prices on the transaction date was $36.42 to $37.38 per share. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

Represents the number of shares of common stock sold by the Issuer to cover the Reporting Person's tax withholding obligation upon the vesting of Restricted Stock Units granted on February 28, 2022, March 1, 2023, and March 4, 2024. The disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person.

The common stock was sold in open market transactions on the transaction date, with a volume weighted average sales price of $37.77 per share. The range of sales prices on the transaction date was $37.42 to $38.23 per share. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

Represents the number of shares of common stock sold by the Issuer to cover the Reporting Person's tax withholding obligation upon the vesting of Restricted Stock Units granted on February 28, 2022, March 1, 2023, March 4, 2024, and February 20, 2025. The disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person.

The common stock was sold in open market transactions on the transaction date, with a volume weighted average sales price of $37.77 per share. The range of sales prices on the transaction date was $37.42 to $38.23 per share. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

Represents the number of shares of common stock sold by the Issuer to cover the Reporting Person's tax withholding obligation upon the vesting of Restricted Stock Units granted on February 28, 2022, March 1, 2023, March 4, 2024, and February 20, 2025. The disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person.

The common stock was sold in open market transactions on the transaction date, with a volume weighted average sales price of $37.11 per share. The range of sales prices on the transaction date was $36.42 to $37.38 per share. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

Represents the number of shares of common stock sold by the Issuer to cover the Reporting Person's tax withholding obligation upon the vesting of Restricted Stock Units granted on February 28, 2022, March 1, 2023, March 4, 2024, and February 20, 2025. The disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person.

The common stock was sold in open market transactions on the transaction date, with a volume weighted average sales price of $37.11 per share. The range of sales prices on the transaction date was $36.42 to $37.38 per share. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

Represents the number of shares of common stock sold by the Issuer to cover the Reporting Person's tax withholding obligation upon the vesting of Restricted Stock Units granted on February 28, 2022, March 1, 2023, March 4, 2024, and February 20, 2025. The disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person.

The common stock was sold in open market transactions on the transaction date, with a volume weighted average sales price of $37.77 per share. The range of sales prices on the transaction date was $37.42 to $38.23 per share. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 11, 2025.

The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a volume weighted average sales price of $36.77 per share. The range of sales prices on the transaction date was $36.69 to $36.89 per share. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 11, 2025.

The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a volume weighted average sales price of $36.08 per share. The range of sales prices on the transaction date was $35.65 to $36.53 per share. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 19, 2025.

The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a sale price of $39.67 per share.

Represents the number of shares of common stock sold by the Issuer to cover the Reporting Person's tax withholding obligation upon the vesting of Restricted Stock Units granted on March 10, 2025. The disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person.

The common stock was sold in open market transactions on the transaction date, with a volume weighted average sales price of $39.67 per share. The range of sales prices on the transaction date was $39.67 to $39.74 per share. Detailed information on the exact number of shares can be obtained from the issuer upon request.

The stock option shall vest and become exercisable in a series of forty-eight (48) successive equal monthly installments measured from the vesting commencement date of February 23, 2026.

The stock option shall vest and become exercisable in a series of forty-eight (48) successive equal monthly installments measured from the vesting commencement date of February 23, 2026.