TWO SIGMA INVESTMENTS, LP

Position in FLNA — Filana Therapeutics, Inc.

CIK 1179392 NEW YORK, NY

Position in FLNA

as of Mar 31, 2026 · filed May 15, 2026 Compact

Position Value

$3,361,095

+$2,089,142 QoQ

Shares Held

1,988,814

+209.6% QoQ

Ownership

4.12%

of shares outstanding

% of Portfolio

0.00%

of 13F equity value

Holder Rank

—

not a current holder

Holding Since

Mar 2020

9 quarters on record

Voting authority Sole 98% Shared 0% None 2%

Healthcare · as of Mar 31, 2026

TWO SIGMA INVESTMENTS, LP holds $5,513,200,662 across 316 Biotechnology names. FLNA ranks #126 (0.1% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	ALNY	Alnylam Pharmaceuticals, Inc.	1,992,577	$659,283,951
2	REGN	Regeneron Pharmaceuticals, Inc.	812,236	$627,566,023
3	MRNA	Moderna, Inc.	9,086,404	$461,589,323
4	IONS	Ionis Pharmaceuticals Inc	5,857,629	$439,849,361
5	BBIO	BridgeBio Pharma, Inc.	3,120,631	$231,738,058
6	VRTX	Vertex Pharmaceuticals Inc / Ma	378,146	$168,857,314
7	RVMD	Revolution Medicines, Inc.	1,558,807	$151,593,980
8	VKTX	Viking Therapeutics, Inc.	4,432,142	$144,221,900

9 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-03-31	$3,361,095	1,988,814	+209.6%	Shares	Sole	2026-05-15
2025-12-31	$1,271,953	642,401	+13.7%	Shares	Sole	2026-02-17
2025-09-30	$1,644,144	564,998	+7.3%	Shares	Sole	2025-11-14
2025-06-30	$952,992	526,515	+21.7%	Shares	Sole	2025-08-14
2025-03-31	$648,871	432,581	-23.0%	Shares	Sole	2025-05-15
2024-12-31	$1,326,513	562,082	+679.1%	Shares	Sole	2025-02-14
2024-09-30	$2,123,256	72,146	+284.7%	Shares	Sole	2024-11-14
2024-06-30	$231,599	18,753	-15.8%	Shares	Sole	2024-08-14
2020-03-31	$91,525	22,269	—	Shares	Sole	2020-05-15
No filing history on record for this holder in this stock.