TWO SIGMA INVESTMENTS, LP

Position in URGN — UroGen Pharma Ltd.

CIK 1179392 NEW YORK, NY

Position in URGN

as of Mar 31, 2026 · filed May 15, 2026 Compact

Position Value

$3,198,659

-$2,450,549 QoQ

Shares Held

177,901

-26.2% QoQ

Ownership

0.365%

of shares outstanding

% of Portfolio

0.00%

of 13F equity value

Holder Rank

—

not a current holder

Holding Since

Mar 2021

13 quarters on record

Voting authority Sole 100% Shared 0% None 0%

Healthcare · as of Mar 31, 2026

TWO SIGMA INVESTMENTS, LP holds $5,513,200,662 across 316 Biotechnology names. URGN ranks #129 (0.1% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	ALNY	Alnylam Pharmaceuticals, Inc.	1,992,577	$659,283,951
2	REGN	Regeneron Pharmaceuticals, Inc.	812,236	$627,566,023
3	MRNA	Moderna, Inc.	9,086,404	$461,589,323
4	IONS	Ionis Pharmaceuticals Inc	5,857,629	$439,849,361
5	BBIO	BridgeBio Pharma, Inc.	3,120,631	$231,738,058
6	VRTX	Vertex Pharmaceuticals Inc / Ma	378,146	$168,857,314
7	RVMD	Revolution Medicines, Inc.	1,558,807	$151,593,980
8	VKTX	Viking Therapeutics, Inc.	4,432,142	$144,221,900

13 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-03-31	$3,198,659	177,901	-26.2%	Shares	Sole	2026-05-15
2025-12-31	$5,649,208	241,213	-37.5%	Shares	Sole	2026-02-17
2025-09-30	$7,704,749	386,203	+103.9%	Shares	Sole	2025-11-14
2025-06-30	$2,594,944	189,412	+995.6%	Shares	Sole	2025-08-14
2025-03-31	$191,205	17,288	-69.6%	Shares	Sole	2025-05-15
2024-12-31	$605,931	56,895	-34.6%	Shares	Sole	2025-02-14
2024-09-30	$1,105,331	87,034	-13.3%	Shares	Sole	2024-11-14
2024-06-30	$1,685,081	100,422	+24.8%	Shares	Sole	2024-08-14
2024-03-31	$1,207,455	80,497	-38.4%	Shares	Sole	2024-05-15
2023-12-31	$1,961,325	130,755	+8.8%	Shares	Sole	2024-02-14
2023-09-30	$1,684,198	120,214	+506.7%	Shares	Sole	2023-11-14
2023-06-30	$205,085	19,815	+0.1%	Shares	Sole	2023-08-14
2021-03-31	$385,704	19,800	—	Shares	Sole	2021-05-17
No filing history on record for this holder in this stock.