RVMD · Revolution Medicines, Inc.

Transaction made pursuant to a 10b5-1 trading plan adopted by Sushil Patel on March 30, 2026.

The transaction was executed in multiple trades in prices ranging from $185.37 to $186.35, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

Includes 1,191 restricted stock units.

Transaction made pursuant to a 10b5-1 trading plan adopted by Sushil Patel on March 30, 2026.

The transaction was executed in multiple trades in prices ranging from $190.44 to $190.74, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

Includes 1,191 restricted stock units.

Transaction made pursuant to a 10b5-1 trading plan adopted by Sushil Patel on March 30, 2026.

The transaction was executed in multiple trades in prices ranging from $191.47 to $192.40, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

Includes 1,191 restricted stock units.

Transaction made pursuant to a 10b5-1 trading plan adopted by Sushil Patel on March 30, 2026.

Includes 1,191 restricted stock units.

Transaction made pursuant to a 10b5-1 trading plan adopted by Sushil Patel on March 30, 2026.

Includes 1,191 restricted stock units.

Transaction made pursuant to a 10b5-1 trading plan adopted by Sushil Patel on March 30, 2026.

The transaction was executed in multiple trades in prices ranging from $192.55 to $192.64, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

Includes 1,191 restricted stock units.

Transaction made pursuant to a 10b5-1 trading plan adopted by Sushil Patel on March 30, 2026.

The transaction was executed in multiple trades in prices ranging from $182.93 to $183.54, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

Includes 1,191 restricted stock units.

Transaction made pursuant to a 10b5-1 trading plan adopted by Sushil Patel on March 30, 2026.

The transaction was executed in multiple trades in prices ranging from $187.46to $188.27, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

Includes 1,191 restricted stock units.

Transaction made pursuant to a 10b5-1 trading plan adopted by Sushil Patel on March 30, 2026.

The transaction was executed in multiple trades in prices ranging from $186.38 to $187.35, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

Includes 1,191 restricted stock units.

Transaction made pursuant to a 10b5-1 trading plan adopted by Sushil Patel on March 30, 2026.

Fully vested.

Transaction made pursuant to a 10b5-1 trading plan adopted by Sushil Patel on March 30, 2026.

The transaction was executed in multiple trades in prices ranging from $184.08 to $184.98, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

Includes 1,191 restricted stock units.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 24, 2026.

This transaction was executed in multiple trades at prices ranging from $166.76 to $167.75. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

Includes 51,388 restricted stock units.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 24, 2026.

This transaction was executed in multiple trades at prices ranging from $167.77 to $168.75. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

Includes 51,388 restricted stock units.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 24, 2026.

This transaction was executed in multiple trades at prices ranging from $168.78 to $169.74. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

Includes 51,388 restricted stock units.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 24, 2026.

This transaction was executed in multiple trades at prices ranging from $169.81 to $170.60. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

Includes 51,388 restricted stock units.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 24, 2026.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 24, 2026.

Includes 51,388 restricted stock units.

Includes 1,191 restricted stock units.

Includes 4,080 restricted stock units.

Includes 1,191 restricted stock units.

Shares subject to the Option shall vest in full on the earlier of (i) the first anniversary of June 18, 2026 or (ii) immediately prior to the Annual Meeting following the date of grant subject to the Reporting Person remaining a Service Provider (as defined in the 2020 Plan) through the vesting date.

Includes 1,191 restricted stock units.

Shares subject to the Option shall vest in full on the earlier of (i) the first anniversary of June 18, 2026 or (ii) immediately prior to the Annual Meeting following the date of grant subject to the Reporting Person remaining a Service Provider (as defined in the 2020 Plan) through the vesting date.

Shares subject to the Option shall vest in full on the earlier of (i) the first anniversary of June 18, 2026 or (ii) immediately prior to the Annual Meeting following the date of grant subject to the Reporting Person remaining a Service Provider (as defined in the 2020 Plan) through the vesting date.

Shares subject to the Option shall vest in full on the earlier of (i) the first anniversary of June 18, 2026 or (ii) immediately prior to the Annual Meeting following the date of grant subject to the Reporting Person remaining a Service Provider (as defined in the 2020 Plan) through the vesting date.

Includes 6,083 restricted stock units.

Shares subject to the Option shall vest in full on the earlier of (i) the first anniversary of June 18, 2026 or (ii) immediately prior to the Annual Meeting following the date of grant subject to the Reporting Person remaining a Service Provider (as defined in the 2020 Plan) through the vesting date.

Includes 1,191 restricted stock units.

Shares subject to the Option shall vest in full on the earlier of (i) the first anniversary of June 18, 2026 or (ii) immediately prior to the Annual Meeting following the date of grant subject to the Reporting Person remaining a Service Provider (as defined in the 2020 Plan) through the vesting date.

Includes 1,191 Restricted Stock Units.

Shares subject to the Option shall vest in full on the earlier of (i) the first anniversary of June 18, 2026 or (ii) immediately prior to the Annual Meeting following the date of grant subject to the Reporting Person remaining a Service Provider (as defined in the 2020 Plan) through the vesting date.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 12, 2026.

This transaction was executed in multiple trades in prices ranging from $160.00 to $160.48, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

Includes 66,201 RSUs.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 12, 2026.

One forty-eighth (1/48th) of the shares initially subject to the option will vest on each monthly anniversary measured from March 1, 2025 (the "Vesting Commencement Date"), so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 12, 2026.

Includes 66,201 RSUs.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 12, 2026.

One forty-eighth (1/48th) of the shares initially subject to the option will vest on each monthly anniversary measured from March 1, 2023 (the "Vesting Commencement Date"), so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 12, 2026.

One forty-eighth (1/48th) of the shares initially subject to the option will vest on each monthly anniversary measured from March 1, 2024 (the "Vesting Commencement Date"), so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 12, 2026.

Includes 66,201 RSUs.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 12, 2026.

Includes 66,201 RSUs.

Transaction made pursuant to a Rule 10b5-1 instruction letter adopted on May 31, 2023 to satisfy the Reporting Person's tax withholding obligation upon the vesting of restricted stock units ("RSUs") after July 15, 2023.

This transaction was executed in multiple trades at prices ranging from $156.1105 to $156.8251. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

Includes 51,388 RSUs.

Includes 479 shares acquired under the Issuer's Employee Stock Purchase Plan on May 31, 2026.

Pursuant to an automatic sell-to-cover, the shares were sold following the vesting of the restricted stock units solely to cover applicable withholding taxes.

This transaction was executed in multiple trades at prices ranging from $156.1105 to $156.8250. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

Includes 43,700 Restricted Stock Units.

Includes 190 shares acquired under the Issuer's Employee Stock Purchase Plan on May 31, 2026.

Transaction made pursuant to a Rule 10b5-1 instruction letter adopted on May 31, 2023 to satisfy the Reporting Person's tax withholding obligation upon the vesting of restricted stock units ("RSUs") after July 15, 2023.

This transaction was executed in multiple trades at prices ranging from $156.1105 to $156.8250. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

Includes 76,251 RSUs.

Includes 653 shares acquired under the Issuer's Employee Stock Purchase Plan on May 31, 2026.

Transaction made pursuant to a Rule 10b5-1 instruction letter adopted on May 31, 2023 to satisfy the Reporting Person's tax withholding obligation upon the vesting of restricted stock units ("RSUs") after July 15, 2023.

This transaction was executed in multiple trades at prices ranging from $156.1105 to $156.8250. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

Includes 182,938 restricted stock units.

Includes 652 shares acquired under the Issuer's Employee Stock Purchase Plan on May 31, 2026.

Transaction made pursuant to a Rule 10b5-1 instruction letter adopted on May 31, 2023 to satisfy the Reporting Person's tax withholding obligation upon the vesting of restricted stock units ("RSUs") after July 15, 2023.

This transaction was executed in multiple trades at prices ranging from $156.1105 to $156.8251. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

Includes 43,514 RSUs.

Includes 160 shares acquired under the Issuer's Employee Stock Purchase Plan on May 31, 2026.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 12, 2026.

One forty-eighth (1/48th) of the shares initially subject to the option will vest on each monthly anniversary measured from March 1, 2025 (the "Vesting Commencement Date"), so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 12, 2026.

This transaction was executed in multiple trades in prices ranging from $160.00 to $160.3550, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

Includes 73,050 restricted stock units ("RSUs").

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 12, 2026.

Includes 73,050 restricted stock units ("RSUs").

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 12, 2026.

Includes 73,050 restricted stock units ("RSUs").

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 12, 2026.

One forty-eighth (1/48th) of the shares initially subject to the option will vest on each monthly anniversary measured from March 1, 2024 (the "Vesting Commencement Date"), so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 12, 2026.

Includes 73,050 restricted stock units.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 12, 2026.

This transaction was executed in multiple trades in prices ranging from $145.88 to $146.16, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

Includes 73,050 restricted stock units.