RVMD · Revolution Medicines, Inc. · Insider Trading

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on August 12, 2026.

The transaction was executed in multiple trades at prices ranging from $186.99 to $187.62, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on August 12, 2026.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on August 12, 2026.

The transaction was executed in multiple trades at prices ranging from $191.44 to $192.43, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on August 12, 2026.

The transaction was executed in multiple trades at prices ranging from $183.59 to $184.56, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on August 12, 2026.

The transaction was executed in multiple trades at prices ranging from $185.96 to $186.68, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on August 12, 2026.

The transaction was executed in multiple trades at prices ranging from $181.51 to $182.50, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on August 12, 2026.

Fully vested.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on August 12, 2026.

Fully vested.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on August 12, 2026.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on August 12, 2026.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on August 12, 2026.

The transaction was executed in multiple trades at prices ranging from $182.56 to $183.51, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on August 12, 2026.

The transaction was executed in multiple trades at prices ranging from $190.43 to $191.34, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

Represents a bona fide gift by the Reporting Person for no consideration to a charitable donor advised fund.

Includes 1,191 restricted stock units.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on August 12, 2026.

The transaction was executed in multiple trades at prices ranging from $180.50 to $181.45, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on August 12, 2026.

The transaction was executed in multiple trades at prices ranging from $192.44 to $193.37, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

Includes 43,650 restricted stock units.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on August 12, 2026.

The transaction was executed in multiple trades at prices ranging from $184.59 to $185.40, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

Transaction made pursuant to a 10b5-1 trading plan adopted by Anthony Mancini on June 11, 2026.

Transaction made pursuant to a 10b5-1 trading plan adopted by Anthony Mancini on June 11, 2026.

Transaction made pursuant to a 10b5-1 trading plan adopted by Anthony Mancini on June 11, 2026.

Twenty-five percent of the total shares subject to the option will vest on the first year anniversary measured from April 1, 2025 (the "Vesting Commencement Date") and one forty-eighth (1/48th) of the shares subject to the option will vest on each monthly anniversary of the Vesting Commencement Date thereafter, so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date.

Transaction made pursuant to a 10b5-1 trading plan adopted by Anthony Mancini on June 11, 2026.

One forty-eighth (1/48th) of the shares initially subject to the option will vest on each monthly anniversary measured from March 1, 2026 (the "Vesting Commencement Date"), so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date.

Transaction made pursuant to a 10b5-1 trading plan adopted by Anthony Mancini on June 11, 2026.

Includes 39,575 restricted stock units.

Transaction made pursuant to a 10b5-1 trading plan adopted by Anthony Mancini on June 11, 2026.

Transaction made pursuant to a 10b5-1 trading plan adopted by Anthony Mancini on June 11, 2026.

Includes 39,575 restricted stock units.

Transaction made pursuant to a 10b5-1 trading plan adopted by Anthony Mancini on June 11, 2026.

Twenty-five percent of the total shares subject to the option will vest on the first year anniversary measured from April 1, 2025 (the "Vesting Commencement Date") and one forty-eighth (1/48th) of the shares subject to the option will vest on each monthly anniversary of the Vesting Commencement Date thereafter, so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on June 30, 2026.

The transaction was executed in multiple trades at prices ranging from $204.43 to $204.83, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

Includes 52,350 restricted stock units.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on June 30, 2026.

The transaction was executed in multiple trades at prices ranging from $203.42 to $204.29, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on June 30, 2026.

Twenty-five percent of the total shares subject to the option will vest on the first year anniversary measured from September 29, 2025 (the "Vesting Commencement Date") and one forty-eighth (1/48th) of the shares subject to the option will vest on each monthly anniversary of the Vesting Commencement Date thereafter, so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on June 30, 2026.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on June 30, 2026.

The transaction was executed in multiple trades at prices ranging from $201.41 to $202.16, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on June 30, 2026.

The transaction was executed in multiple trades at prices ranging from $200.41 to $201.38, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on June 30, 2026.

The transaction was executed in multiple trades at prices ranging from $202.42 to $203.34, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

Transaction made pursuant to a 10b5-1 trading plan adopted by Anthony Mancini on June 11, 2026.

Transaction made pursuant to a 10b5-1 trading plan adopted by Anthony Mancini on June 11, 2026.

Twenty-five percent of the total shares subject to the option will vest on the first year anniversary measured from April 1, 2025 (the "Vesting Commencement Date") and one forty-eighth (1/48th) of the shares subject to the option will vest on each monthly anniversary of the Vesting Commencement Date thereafter, so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on May 22, 2026.

Includes 37,088 restricted stock units.

Transaction made pursuant to a 10b5-1 trading plan adopted by Anthony Mancini on June 11, 2026.

Includes 39,575 restricted stock units.

Transaction made pursuant to a 10b5-1 trading plan adopted by Anthony Mancini on June 11, 2026.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on June 23, 2026.

Includes 1,191 restricted stock units.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on June 23, 2026.

The transaction was executed in multiple trades at prices ranging from $192.01 to $192.99, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on June 23, 2026.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on June 23, 2026.

The transaction was executed in multiple trades at prices ranging from $191.65 to $191.99, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on June 23, 2026.

The transaction was executed in multiple trades at prices ranging from $193.00 to $193.81, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on June 23, 2026.

Fully vested.

Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on June 23, 2026.

The transaction was executed in multiple trades at prices ranging from $194.04 to $194.96, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

Transaction made pursuant to a 10b5-1 trading plan adopted by Anthony Mancini on June 11, 2026.

Transaction made pursuant to a Rule 10b5-1 instruction letter adopted on June 15, 2026 to satisfy the Reporting Person's tax withholding obligation upon the vesting of restricted stock units.

Includes 39,575 restricted stock units.

Transaction made pursuant to a Rule 10b5-1 instruction letter adopted on May 31, 2023 to satisfy the Reporting Person's tax withholding obligation upon the vesting of restricted stock units.

Includes 56,713 restricted stock units.

Transaction made pursuant to a Rule 10b5-1 instruction letter adopted on May 31, 2023 to satisfy the Reporting Person's tax withholding obligation upon the vesting of restricted stock units.

Includes 65,613 restricted stock units.

Transaction made pursuant to a Rule 10b5-1 instruction letter adopted on May 31, 2023 to satisfy the Reporting Person's tax withholding obligation upon the vesting of restricted stock units.

Transaction made pursuant to a Rule 10b5-1 instruction letter adopted on June 13, 2026 to satisfy the Reporting Person's tax withholding obligation upon the vesting of restricted stock units.

Includes 52,350 restricted stock units.

Transaction made pursuant to a Rule 10b5-1 instruction letter adopted on May 31, 2023 to satisfy the Reporting Person's tax withholding obligation upon the vesting of restricted stock units.

The transaction was executed in multiple trades at prices ranging from $195.00 to $195.03, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.