SXTP · 60 Degrees Pharmaceuticals, Inc.

The reported transaction reflects an open-market purchase by the reporting person on September 12, 2025.

Reflects a 1-for-5 reverse stock split effective February 24, 2025. As a result, the reporting person's direct beneficial ownership was adjusted from 108,974 shares to 21,795 shares, and indirect beneficial ownership was adjusted from 55,596 shares to 11,119 shares. Fractional shares resulting from the split were rounded up to the nearest whole share.

Reflects a 1-for-5 reverse stock split effective February 24, 2025, resulting in the reporting person's beneficial ownership being adjusted from 54,078 shares to 10,816 shares. Fractional shares were rounded up to the nearest whole share

Reflects a 1-for-5 reverse stock split effective February 24, 2025, resulting in the reporting person's beneficial ownership being adjusted from 54,078 shares to 10,816 shares. Fractional shares were rounded up to the nearest whole share

This Form 4 is being filed late due to an inadvertent administrative error.

The number of shares has been adjusted to reflect the 1-for-5 reverse stock split effected by the Issuer on February 24, 2025.

Adjusted to reflect the Issuer's 1:12 reverse stock split on August 12, 2024.

The stock options were fully vested as of January 2, 2025, the grant date.

The stock options were fully vested as of January 2, 2025, the grant date.

Adjusted for the Issuer's 12-for-1 reverse stock split effected on August 12, 2024.

Adjusted for the Issuer's 12-for-1 reverse stock split effected on August 12, 2024.

Adjusted for the Issuer's 12-for-1 reverse stock split effected on August 12, 2024.

The options were granted pursuant to the 60 Degrees Pharmaceuticals, Inc. 2022 Equity Incentive Plan. The options shall vest and become exercisable in five equal tranches on the last date of each fiscal year, with the first vesting date being December 31, 2024. The options have a maximum term of 10 years from the date of grant.

This Form 4 is being filed late due to an inadvertent administrative error.

All information has been retroactively adjusted to reflect the 1-for-5 reverse stock split effected by the Issuer on February 24, 2025.

Adjusted for the Issuer's 1-for-12 reverse stock split effected on August 12, 2024.

Geoffrey Dow was granted a total of 85,000 restricted stock units on November 21, 2023 that were fully vested as of the grant date. Each RSU represents the right to receive, at settlement, one share of common stock.

17,000 shares underlying the RSUs were settled as of May 16, 2024. After the settlement of the shares of common stock that were underlying the 17,000 RSUs, Geoffrey Dow did not own any RSUs.

4,000 shares underlying the RSUs were settled as of May 16, 2024. After the settlement of the shares of common stock that were underlying the 4,000 RSUs, Charles Allen did not own any RSUs.

This transaction represents the settlement of restricted stock units in shares of common stock on May 16, 2024.

15,000 shares underlying the RSUs were settled on May 16, 2024 (the "5/24 Shares"). Tyrone Miller owned 161,928 shares of common stock immediately prior to the issuance of the 5/24 Shares. As of May 16, 2024, Tyrone Miller owned a total of 176,928 shares of common stock.

4,000 shares underlying the RSUs were settled as of May 16, 2024. After the settlement of the shares of common stock that were underlying the 4,000 RSUs, Stephen Toovey did not own any RSUs.

This transaction represents the settlement of restricted stock units in shares of common stock on May 16, 2024.

A total of 8,000 restricted stock units ("RSUs") were initially granted to Ms. Xu on July 11, 2023, of which were subsequently modified to 4,000 RSUs and fully vested as of December 31, 2023. Each RSU represents the right to receive, at settlement, one share of common stock.

This transaction represents the settlement of restricted stock units in shares of common stock on May 16, 2024.

This transaction represents the settlement of restricted stock units in shares of common stock on May 16, 2024.

4,000 shares underlying the RSUs were settled as of May 16, 2024. After the settlement of the shares of common stock that were underlying the 4,000 RSUs, Paul Field did not own any RSUs.

Tyrone Miller was granted a total of 75,000 restricted stock units on November 21, 2023 that were fully vested as of the grant date. Each RSU represents the right to receive, at settlement, one share of common stock.

15,000 shares underlying the RSUs were settled as of May 16, 2024. After the settlement of the shares of common stock that were underlying the 15,000 RSUs, Tyrone Miller did not own any RSUs.

17,000 shares underlying the RSUs were settled on May 16, 2024 (the "5/24 Shares"). Geoffrey Dow owned 78,482 shares of common stock and through the Dow Trust owned 667,143 shares of common stock immediately prior to the issuance of the 5/24 Shares. As of May 16, 2024, Geoffrey Dow owned a total of 762,625 shares of common stock, consisting of (i) 95,482 shares of common stock held in the name of Geoffrey Dow and (ii) 667,143 shares of common stock held by the Dow Trust.

Geoffrey Dow was granted a total of 85,000 restricted stock units ("RSUs") on November 21, 2023 that were fully vested as of the grant date. 68,000 shares underlying the RSUs were settled on April 12, 2024 (the "4/24 Shares"). Geoffrey Dow owned 10,482 shares of common stock and through the Geoffrey S. Dow Revocable Trust (the "Dow Trust"), as trustee and having control over the voting and disposition of the shares of common stock held by the Dow Trust, owned 667,143 shares of common stock immediately prior to the issuance of the 4/24 Shares. As of April 12, 2024, Geoffrey Dow owned a total of 745,625 shares of common stock, consisting of (i) 78,482 shares of common stock held in the name of Geoffrey Dow and (ii) 667,143 shares of common stock held by the Dow Trust.

Geoffrey Dow was granted a total of 85,000 restricted stock units ("RSUs") on November 21, 2023 that were fully vested as of the grant date. 68,000 shares underlying the RSUs were settled on April 12, 2024 (the "4/24 Shares"). Geoffrey Dow owned 10,482 shares of common stock and through the Geoffrey S. Dow Revocable Trust (the "Dow Trust"), as trustee and having control over the voting and disposition of the shares of common stock held by the Dow Trust, owned 667,143 shares of common stock immediately prior to the issuance of the 4/24 Shares. As of April 12, 2024, Geoffrey Dow owned a total of 745,625 shares of common stock, consisting of (i) 78,482 shares of common stock held in the name of Geoffrey Dow and (ii) 667,143 shares of common stock held by the Dow Trust.

Tyrone Miller was granted a total of 75,000 restricted stock units on November 21, 2023 that were fully vested as of the grant date. Each RSU represents the right to receive, at settlement, one share of common stock.

60,000 shares underlying the RSUs were settled on April 12, 2024. After the settlement of the shares of common stock that were underlying the 60,000 RSUs, Tyrone Miller owned a total of 15,000 RSUs.

Tyrone Miller was granted a total of 75,000 restricted stock units ("RSUs") on November 21, 2023 that were fully vested as of the grant date. 60,000 shares underlying the RSUs were settled on April 12, 2024 (the "4/24 Shares"). Tyrone Miller owned 101,928 shares of common stock immediately prior to the issuance of the 4/24 Shares. As of April 12, 2024, Tyrone Miller owned a total of 161,928 shares of common stock.

Geoffrey Dow was granted a total of 85,000 restricted stock units on November 21, 2023 that were fully vested as of the grant date. Each RSU represents the right to receive, at settlement, one share of common stock.

68,000 shares underlying the RSUs were settled on April 12, 2024. After the settlement of the shares of common stock that were underlying the 68,000 RSUs, Geoffrey Dow owned a total of 17,000 RSUs.

Ms. Xu was granted restricted stock units ("RSUs"), which represent a contingent right to receive one share of Common Stock for each RSU. A total of 8,000 RSUs were granted to Ms. Xu on July 11, 2023 and vest in equal quarterly installments for a period of 12 months. As of the date of this filing, a total of 6,000 RSUs have vested.

Includes 667,143 shares of common stock held by the Geoffrey S. Dow Revocable Trust, of which Geoffrey Dow is the trustee and has voting and dispositive control.