HighVista Strategies LLC

CIK

1335325

Location

BOSTON, MA

Portfolio Value

Small $359,474,418

Diversification

Diversified

Filing Date

Global Rank

#2,819 / 8,232 ▲ 75

Top Industry

Biotechnology 68.3%

3Y Alpha vs SPY

+3.1%

Period ended 2 months ago

Filed May 15, 2026 · 30d

25 quarters · since Mar 2020

Clone Performance

Jun 2023–Jun 2026 · vs SPY

Hypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.

Cloned portfolio

+90.1%

SPY

+76.3%

Annualised alpha

+3.1%

Max drawdown

−29.2%

Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.

Portfolio Concentration

154 positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025

Top Position

8.5%

+2.3 pts

Top 5

18.5%

−0.1 pts

Top 10

27.4%

−1.5 pts

HHI

168

Diversified+5

Portfolio Trend

25 quarters · across all stocks

Sector Breakdown

As of Mar 31, 2026

Sector	% Portfolio	Value	Positions
Healthcare	67.4%	$242,385,867	83
Technology	9.1%	$32,616,951	21
Unclassified	8.5%	$30,607,040	1
Industrials	5.5%	$19,810,669	17
Consumer Cyclical	2.9%	$10,478,055	9
Financial Services	2.3%	$8,419,688	8
Utilities	1.7%	$6,148,792	5
Basic Materials	0.9%	$3,064,480	3
Communication Services	0.6%	$2,210,915	3
Consumer Defensive	0.4%	$1,383,251	2
Real Estate	0.3%	$1,184,735	1
Energy	0.3%	$1,163,975	1

Last Quarter's Activity

Export CSV

Mar 31, 2026 vs Dec 31, 2025

Added To

Positions the filer increased

25 positions

Ticker	Company	Δ Shares	Shares	Value
PALI	Palisade Bio, Inc.	+719,295	2,019,326	$3,533,820
DYN	Dyne Therapeutics, Inc.	+123,286	182,929	$3,316,502
AMLX	Amylyx Pharmaceuticals, Inc.	+113,273	352,085	$4,893,981
OCUL	Ocular Therapeutix, Inc	+97,506	441,573	$3,740,123
TYRA	Tyra Biosciences, Inc.	+96,218	131,304	$5,028,943
CTMX	CytomX Therapeutics, Inc.	+94,116	288,057	$1,353,867
ALKS	Alkermes plc.	+46,788	73,189	$2,587,963
ABVX	Abivax S.A.	+41,069	113,254	$12,610,832
CORZ	Core Scientific, Inc./tx	+39,900	103,412	$1,547,043
CLDX	Celldex Therapeutics, Inc.	+37,592	89,397	$2,835,672
U	Unity Software Inc.	+34,100	62,763	$1,377,020
LBRX	Lb Pharmaceuticals Inc	+33,488	173,595	$4,280,852
SLNO	Soleno Therapeutics Inc	+30,158	165,227	$5,531,799
IMCR	Immunocore Holdings plc	+25,699	58,697	$1,769,714
CPNG	Coupang, Inc.	+21,244	46,036	$869,159
BBD	Bank Bradesco	+18,000	208,264	$760,163
HPE	Hewlett Packard Enterprise Co	+13,800	89,981	$2,142,447
NOK	Nokia Corp	+11,300	70,824	$569,424
PCVX	Vaxcyte, Inc.	+10,598	124,647	$7,243,237
KBR	Kbr, Inc.	+9,400	39,406	$1,452,505
AXSM	Axsome Therapeutics, Inc.	+9,306	20,437	$3,454,261
NVDA	Nvidia Corp	+8,200	22,420	$3,910,048
JANX	Janux Therapeutics, Inc.	+7,940	49,383	$686,423
AMZN	Amazon Com Inc	+5,000	22,397	$4,664,623
XEL	Xcel Energy Inc	+4,500	12,558	$997,607
No positions match the current search.

Trimmed

Positions the filer reduced

25 positions

Ticker	Company	Δ Shares	Shares	Value
VRDN	Viridian Therapeutics, Inc.DE	−238,243	134,229	$2,625,519
BBOT	BridgeBio Oncology Therapeutics, Inc.	−151,076	78,187	$699,773
COGT	Cogent Biosciences, Inc.	−139,616	197,051	$7,584,492
CMPS	COMPASS Pathways plc	−134,573	364,360	$2,014,910
OLMA	Olema Pharmaceuticals, Inc.	−123,888	117,601	$1,753,430
RLAY	Relay Therapeutics, Inc.	−123,198	421,881	$4,197,715
EWTX	Edgewise Therapeutics, Inc.	−79,206	91,931	$2,895,826
MLYS	Mineralys Therapeutics, Inc.	−77,766	46,778	$1,267,216
MAZE	Maze Therapeutics, Inc.	−70,503	99,850	$2,980,522
GPCR	Structure Therapeutics Inc.	−69,092	123,909	$5,972,413
XOMA	XOMA Royalty Corp	−66,103	46,814	$1,468,555
PHVS	Pharvaris N.V.	−64,504	97,866	$2,764,714
TERN	Terns Pharmaceuticals, Inc.	−61,155	114,307	$6,026,265
LQDA	Liquidia Corp	−56,259	99,744	$3,764,338
CYTK	Cytokinetics Inc	−55,921	58,643	$3,865,160
APGE	Apogee Therapeutics, Inc.	−53,468	35,761	$3,010,003
STOK	Stoke Therapeutics, Inc.	−52,922	62,617	$2,038,809
TRVI	Trevi Therapeutics, Inc.	−52,634	53,525	$638,553
RVMD	Revolution Medicines, Inc.	−50,931	69,309	$6,740,300
RXO	RXO, Inc.	−47,900	43,038	$629,215
SYRE	Spyre Therapeutics, Inc.	−41,942	146,264	$7,377,556
PTGX	Protagonist Therapeutics, Inc	−39,693	33,852	$3,568,000
CNTA	Centessa Pharmaceuticals plc	−38,526	5,964	$236,890
AVTX	Avalo Therapeutics, Inc.	−37,009	58,622	$875,226
QXO	QXO, Inc.	−32,400	26,320	$511,134
No positions match the current search.

New Positions

Positions the filer opened this quarter

25 positions

Ticker	Company	Shares	Value
ORKA	Oruka Therapeutics, Inc.	78,911	$3,870,584
MLTX	MoonLake Immunotherapeutics	193,955	$3,615,321
DFTX	Definium Therapeutics, Inc.	185,856	$3,512,678
NRIX	Nurix Therapeutics, Inc.	226,546	$3,511,463
IVA	Inventiva S.A.	615,666	$3,416,946
ERAS	Erasca, Inc.	181,069	$2,929,696
XENE	Xenon Pharmaceuticals Inc.	49,050	$2,852,257
VERA	Vera Therapeutics, Inc.	69,241	$2,785,565
ALMS	Alumis Inc.	112,929	$2,487,825
EYPT	EyePoint, Inc.	183,037	$2,359,346
TNGX	Tango Therapeutics, Inc.	104,193	$2,179,717
ASMB	Assembly Biosciences, Inc.	74,735	$2,073,896
JAZZ	Jazz Pharmaceuticals plc	10,838	$2,048,923
NATL	NCR Atleos Corp	40,100	$1,747,558
ON	On Semiconductor Corp	28,000	$1,733,760
KOD	Kodiak Sciences Inc.	43,569	$1,660,850
AVTR	Avantor, Inc.	186,500	$1,462,160
MIRM	Mirum Pharmaceuticals, Inc.	15,563	$1,437,709
SVRA	Savara Inc	250,999	$1,370,454
KNX	Knight-Swift Transportation Holdings Inc.	22,900	$1,318,582
MU	Micron Technology Inc	3,800	$1,283,792
BLTE	Belite Bio, Inc	8,033	$1,280,781
JHX	James Hardie Industries plc	65,598	$1,242,426
KRC	Kilroy Realty Corp	41,997	$1,184,735
STX	Seagate Technology Holdings plc	2,900	$1,136,104
No positions match the current search.

Sold Out

Positions the filer fully exited

22 positions

Ticker	Company	Shares	Value
ACLX	Arcellx, Inc.	75,002	$4,890,130
AGIO	Agios Pharmaceuticals, Inc.	147,662	$4,019,359
APLS	Apellis Pharmaceuticals, Inc.	150,776	$3,787,493
SEPN	Septerna, Inc.	78,682	$2,193,654
APP	AppLovin Corp	2,482	$1,672,421
UNF	Unifirst Corp	7,727	$1,490,538
CMPX	Compass Therapeutics, Inc.	245,532	$1,318,506
TMO	Thermo Fisher Scientific Inc.	2,269	$1,314,772
OFIX	Orthofix Medical Inc.	85,049	$1,289,342
ACHC	Acadia Healthcare Company, Inc.	81,630	$1,158,329
SCHW	Schwab Charles Corp	10,601	$1,059,145
SNDK	Sandisk Corp	4,378	$1,039,249
AFRM	Affirm Holdings, Inc.	13,086	$973,990
VST	Vistra Corp.	5,673	$915,225
BVN	Buenaventura Mining Co Inc	29,649	$825,131
ALC	Alcon Inc	10,440	$822,776
FOUR	Shift4 Payments, Inc.	12,982	$817,476
GTLB	Gitlab Inc.	19,305	$724,516
RBLX	Roblox Corp	8,431	$683,163
CNX	CNX Resources Corp	17,624	$648,034
ALV	Autoliv Inc	5,243	$622,344
DBVT	DBV Technologies S.A.	15,877	$304,362
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

154 positions · $359,474,418 total · as of Mar 31, 2026

All sectors Basic Materials Communication Services Consumer Cyclical Consumer Defensive Energy Financial Services Healthcare Industrials Real Estate Technology Utilities

Showing 1–50 of 154 positions by value · page 1 of 4

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
CNTA	Centessa Pharmaceuticals plc Healthcare	Reduced	5,964	-38,526	$236,890	−78.7%	0.07%
TCOM	Trip.com Group Ltd Consumer Cyclical	Reduced	5,484	-5,162	$273,048	−64.3%	0.08%
BZ	Kanzhun Ltd Communication Services	Added	21,298	+700	$285,180	−32.1%	0.08%
KYMR	Kymera Therapeutics, Inc. Healthcare	Reduced	3,785	-3,050	$315,252	−40.7%	0.09%
MBX	MBX Biosciences, Inc. Healthcare	NEW	11,472	NEW	$342,439	NEW	0.10%
JD	JD.com, Inc. Consumer Cyclical	Reduced	13,463	-4,000	$398,100	−20.6%	0.11%
KRYS	Krystal Biotech, Inc. Healthcare	NEW	1,824	NEW	$471,175	NEW	0.13%
URGN	UroGen Pharma Ltd. Healthcare	Reduced	26,510	-1,495	$476,649	−27.3%	0.13%
QXO	QXO, Inc. Industrials	Reduced	26,320	-32,400	$511,134	−54.9%	0.14%
NOK	Nokia Corp Technology	Added	70,824	+11,300	$569,424	+47.9%	0.16%
SE	Sea Ltd Consumer Cyclical	Held	7,450	0	$616,934	−35.1%	0.17%
RXO	RXO, Inc. Industrials	Reduced	43,038	-47,900	$629,215	−45.3%	0.18%
PFSI	PennyMac Financial Services, Inc. Financial Services	Reduced	7,306	-500	$638,544	−38.0%	0.18%
TRVI	Trevi Therapeutics, Inc. Healthcare	Reduced	53,525	-52,634	$638,553	−52.0%	0.18%
XNCR	Xencor Inc Healthcare	NEW	53,045	NEW	$639,722	NEW	0.18%
YMM	Full Truck Alliance Co. Ltd. Technology	Reduced	77,191	-10,400	$640,685	−31.8%	0.18%
NAMS	NewAmsterdam Pharma Co N.V. Healthcare	Reduced	20,067	-15,519	$642,344	−48.5%	0.18%
HDB	Hdfc Bank Ltd Financial Services	Added	26,127	+4,000	$650,039	−19.6%	0.18%
RLX	RLX Technology Inc. Consumer Defensive	NEW	311,700	NEW	$685,740	NEW	0.19%
JANX	Janux Therapeutics, Inc. Healthcare	Added	49,383	+7,940	$686,423	+20.0%	0.19%
EDU	New Oriental Education & Technology Group Inc. Consumer Defensive	Reduced	12,317	-500	$697,511	−1.1%	0.19%
BBOT	BridgeBio Oncology Therapeutics, Inc. Healthcare	Reduced	78,187	-151,076	$699,773	−75.6%	0.19%
PDD	PDD Holdings Inc. Consumer Cyclical	NEW	6,900	NEW	$705,042	NEW	0.20%
NU	Nu Holdings Ltd. Financial Services	Reduced	49,570	-13,000	$712,320	−32.0%	0.20%
IBN	Icici Bank Ltd Financial Services	Added	27,884	+1,600	$722,195	−7.8%	0.20%
PVLA	Palvella Therapeutics, Inc. Healthcare	NEW	5,903	NEW	$735,808	NEW	0.20%
MELI	Mercadolibre Inc Consumer Cyclical	Reduced	435	-30	$752,123	−19.7%	0.21%
CAAP	Corporacion America Airports S.A. Industrials	Reduced	29,745	-7,400	$752,251	−22.1%	0.21%
BBD	Bank Bradesco Financial Services	Added	208,264	+18,000	$760,163	+20.0%	0.21%
P	Everpure, Inc. Technology	Reduced	14,009	-3,400	$827,091	−29.1%	0.23%
ZYME	Zymeworks Inc. Healthcare	NEW	34,085	NEW	$853,488	NEW	0.24%
CLF	Cleveland-Cliffs Inc. Basic Materials	Reduced	102,474	-16,100	$865,905	−45.0%	0.24%
CPNG	Coupang, Inc. Consumer Cyclical	Added	46,036	+21,244	$869,159	+48.6%	0.24%
AVTX	Avalo Therapeutics, Inc. Healthcare	Reduced	58,622	-37,009	$875,226	−49.6%	0.24%
UNP	Union Pacific Corp Industrials	Reduced	3,658	-4,400	$887,503	−52.4%	0.25%
MMM	3M Co Industrials	Added	6,150	+2,200	$893,164	+41.2%	0.25%
UTHR	UNITED THERAPEUTICS Corp Healthcare	Reduced	1,514	-816	$897,771	−20.9%	0.25%
RDDT	Reddit, Inc. Communication Services	Added	6,900	+1,600	$929,085	−23.7%	0.26%
AMRZ	Amrize Ltd Basic Materials	Reduced	17,068	-16,400	$956,149	−47.2%	0.27%
TLN	Talen Energy Corp Utilities	Reduced	3,118	-370	$995,359	−23.9%	0.28%
META	Meta Platforms, Inc. Communication Services	Reduced	1,742	-820	$996,650	−41.1%	0.28%
XEL	Xcel Energy Inc Utilities	Added	12,558	+4,500	$997,607	+67.6%	0.28%
DASH	DoorDash, Inc. Consumer Cyclical	NEW	6,710	NEW	$1,007,506	NEW	0.28%
NEE	Nextera Energy Inc Utilities	Reduced	11,085	-8,200	$1,029,574	−33.5%	0.29%
AGX	Argan Inc Industrials	Held	1,896	0	$1,032,656	+73.8%	0.29%
NKTR	Nektar Therapeutics Healthcare	Added	14,555	+2,806	$1,047,232	+110.8%	0.29%
GEV	GE Vernova Inc. Industrials	Reduced	1,218	-550	$1,063,192	−8.0%	0.30%
PTC	Ptc Inc. Technology	Added	7,474	+1,100	$1,064,970	−4.1%	0.30%
WDAY	Workday, Inc. Technology	Added	8,286	+1,800	$1,076,517	−22.7%	0.30%
TVTX	Travere Therapeutics, Inc. Healthcare	NEW	36,325	NEW	$1,079,215	NEW	0.30%