Allostery Investments LP
Filing Date
Global Rank
#7,759
/ 7,991
▼ 1543
Top Industry
Biotechnology
76.9%
3Y Alpha vs SPY
+137.3%
Period ended 12 months ago
Filed Aug 14, 2025 · 10mo
3 quarters · since Dec 2024
Clone Performance
Feb 2025–Jun 2026 · vs SPYHypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.
Cloned portfolio
+245.7%
SPY
+23.4%
Annualised alpha
+137.3%
Max drawdown
−25.1%
Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.
Portfolio Concentration
15 positions · as of Jun 30, 2025 · Δ vs Mar 31, 2025Top Position
22.4%
+10.0 pts
Top 5
66.9%
+18.6 pts
Top 10
90.9%
+14.9 pts
HHI
1,158
Diversified+480
Portfolio Trend
3 quarters · across all stocks
Sector Breakdown
As of Jun 30, 2025| Sector | % Portfolio | Value |
|---|---|---|
| Healthcare | 100.0% | $5,713,898 |
Last Quarter's Activity
Export CSVAdded To
Positions the filer increasedNo qualifying positions this quarter.
Trimmed
Positions the filer reduced
11 positions
| Ticker | Company | Δ Shares | Shares | Value | Open |
|---|---|---|---|---|---|
| ABVX | Abivax S.A. | −932,304 | 167,350 | $1,280,227 | |
| KALV | KalVista Pharmaceuticals, Inc. | −418,302 | 40,000 | $452,200 | |
| EOLS | Evolus, Inc. | −352,754 | 60,000 | $552,600 | |
| CNTA | Centessa Pharmaceuticals plc | −330,024 | 52,500 | $689,850 | |
| AMLX | Amylyx Pharmaceuticals, Inc. | −145,980 | 120,119 | $769,962 | |
| APGE | Apogee Therapeutics, Inc. | −104,000 | 6,000 | $260,580 | |
| AVTX | Avalo Therapeutics, Inc. | −98,141 | 9,000 | $44,910 | |
| BBIO | BridgeBio Pharma, Inc. | −76,000 | 4,000 | $172,720 | |
| CYTK | Cytokinetics Inc | −65,000 | 5,000 | $165,200 | |
| ACLX | Arcellx, Inc. | −43,000 | 1,000 | $65,850 | |
| LEGN | Legend Biotech Corp | −750 | 4,000 | $141,960 | |
| No positions match the current search. | |||||
New Positions
Positions the filer opened this quarter
4 positions
Sold Out
Positions the filer fully exited
21 positions
| Ticker | Company | Shares | Value | Open |
|---|---|---|---|---|
| ALKS | Alkermes plc. | 115,000 | $3,797,300 | |
| ZURA | Zura Bio Ltd | 2,329,384 | $3,004,905 | |
| BEAM | Beam Therapeutics Inc. | 92,754 | $1,811,485 | |
| SLNO | Soleno Therapeutics Inc | 20,000 | $1,429,000 | |
| PCVX | Vaxcyte, Inc. | 32,000 | $1,208,320 | |
| IONS | Ionis Pharmaceuticals Inc | 35,000 | $1,055,950 | |
| XENE | Xenon Pharmaceuticals Inc. | 30,000 | $1,006,500 | |
| INSM | INSMED Inc | 10,000 | $762,900 | |
| TARS | Tarsus Pharmaceuticals, Inc. | 13,600 | $698,632 | |
| GOSS | Gossamer Bio, Inc. | 613,028 | $674,330 | |
| PLRX | Pliant Therapeutics, Inc. | 441,686 | $596,276 | |
| CNTX | Context Therapeutics Inc. | 950,166 | $581,501 | |
| ELDN | Eledon Pharmaceuticals, Inc. | 100,000 | $339,000 | |
| CLYM | Climb Bio, Inc. | 244,988 | $298,885 | |
| ORKA | Oruka Therapeutics, Inc. | 20,000 | $205,200 | |
| MDGL | Madrigal Pharmaceuticals, Inc. | 600 | $198,738 | |
| VIR | Vir Biotechnology, Inc. | 22,202 | $143,868 | |
| WVE | Wave Life Sciences Ltd. | 17,500 | $141,400 | |
| ARQT | Arcutis Biotherapeutics, Inc. | 7,500 | $117,300 | |
| EWTX | Edgewise Therapeutics, Inc. | 3,000 | $66,000 | |
| LXEO | Lexeo Therapeutics, Inc. | 5,054 | $17,537 | |
| No positions match the current search. | ||||
15 positions ·
$5,713,898 total
· as of Jun 30, 2025
| Ticker | Company | Type | Shares | Value (USD) | % of Portfolio | History |
|---|---|---|---|---|---|---|
| ABVX |
Abivax S.A.
Healthcare
|
Reduced | 167,350 | $1,280,227 | 22.41% | |
| AMLX |
Amylyx Pharmaceuticals, Inc.
Healthcare
|
Reduced | 120,119 | $769,962 | 13.48% | |
| CNTA |
Centessa Pharmaceuticals plc
Healthcare
|
Reduced | 52,500 | $689,850 | 12.07% | |
| EOLS |
Evolus, Inc.
Healthcare
|
Reduced | 60,000 | $552,600 | 9.67% | |
| RZLT |
Rezolute, Inc.
Healthcare
|
NEW | 119,294 | $532,051 | 9.31% | |
| KALV |
KalVista Pharmaceuticals, Inc.
Healthcare
|
Reduced | 40,000 | $452,200 | 7.91% | |
| FULC |
Fulcrum Therapeutics, Inc.
Healthcare
|
NEW | 40,353 | $277,628 | 4.86% | |
| APGE |
Apogee Therapeutics, Inc.
Healthcare
|
Reduced | 6,000 | $260,580 | 4.56% | |
| TNGX |
Tango Therapeutics, Inc.
Healthcare
|
NEW | 40,000 | $204,800 | 3.58% | |
| BBIO |
BridgeBio Pharma, Inc.
Healthcare
|
Reduced | 4,000 | $172,720 | 3.02% | |
| CYTK |
Cytokinetics Inc
Healthcare
|
Reduced | 5,000 | $165,200 | 2.89% | |
| LEGN |
Legend Biotech Corp
Healthcare
|
Reduced | 4,000 | $141,960 | 2.48% | |
| NKTR |
Nektar Therapeutics
Healthcare
|
NEW | 4,000 | $103,360 | 1.81% | |
| ACLX |
Arcellx, Inc.
Healthcare
|
Reduced | 1,000 | $65,850 | 1.15% | |
| AVTX |
Avalo Therapeutics, Inc.
Healthcare
|
Reduced | 9,000 | $44,910 | 0.79% |