8-K

ALEXANDRIA REAL ESTATE EQUITIES, INC. (ARE)

8-K 2022-01-31 For: 2022-01-31
View Original
Added on April 01, 2026

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): January 31, 2022

ALEXANDRIA REAL ESTATE EQUITIES, INC.

(Exact name of registrant as specified in its charter)

Maryland 1-12993 95-4502084
(State or other jurisdiction of<br>incorporation) (Commission File Number) (I.R.S. Employer Identification No.)

26 North Euclid Avenue, Pasadena, California 91101

(Address of principal executive offices) (Zip code)

Registrant’s telephone number, including area code: (626) 578-0777

N/A

(Former name or former address, if changed since last report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐            Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐            Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐           Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐            Pre-commencement communications pursuant to Rule 13e-4 (c) under the Exchange Act (17 CFR 240.13e-4 (c))

Securities registered pursuant to Section 12(b) of the Exchange Act:

Title of each class Trading Symbol(s) Name of each exchange on which registered
Common Stock, $.01 par value per share ARE New York Stock Exchange

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Item 2.02.  Results of Operations and Financial Condition.

On January 31, 2022, Alexandria Real Estate Equities, Inc. (the “Company”) issued a press release entitled “Alexandria Real Estate Equities, Inc. Reports Fourth Quarter and Year Ended December 31, 2021 Financial and Operating Results.”  The press release referred to certain supplemental information that is available on the Company’s website at www.are.com.  A copy of the press release and supplemental information are attached hereto as Exhibit 99.1.

The information contained in this Item 2.02, including the exhibit referenced herein, is being furnished and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section.  Such information shall not be incorporated by reference into any filing under the Securities Act of 1933, as amended (the “Securities Act”), or the Exchange Act, whether made before or after the date hereof, regardless of any general incorporation language in such filing.

Item 9.01.  Financial Statements and Exhibits.

(d)  Exhibits.

99.1     Alexandria Real Estate Equities, Inc.’s Earnings Press Release and Supplemental Information for the Fourth Quarter and Year Ended December 31, 2021

104 Cover Page Interactive Data File (embedded within the Inline XBRL document)

Forward-Looking Statements

This current report on Form 8-K contains forward-looking statements within the meaning of Section 27A of the Securities Act, and Section 21E of the Exchange Act.  These statements include words such as “forecast,” “guidance,” “projects,” “estimates,” “anticipates,” “goals,” “believes,” “expects,” “intends,” “may,” “plans,” “seeks,” “should,” or “will,” or the negative of these words or similar words.  Forward-looking statements involve certain risks and uncertainties, and actual results may differ materially from those discussed in each such statement.  A number of important factors could cause actual results to differ materially from those included within or contemplated by the forward-looking statements, including, but not limited to, the factors described in the Company’s filings with the Securities and Exchange Commission, including the Company’s most recent annual report on Form 10-K and any subsequent quarterly reports on Form 10-Q.  The Company does not undertake any responsibility to update any of these factors or to announce publicly any revisions to any of the forward-looking statements contained in this or any other document, whether as a result of new information, future events, or otherwise.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

ALEXANDRIA REAL ESTATE EQUITIES, INC.
January 31, 2022 By: /s/ Joel S. Marcus
Joel S. Marcus
Executive Chairman
By: /s/ Stephen A. Richardson
Stephen A. Richardson
Co-Chief Executive Officer
By: /s/ Peter M. Moglia
Peter M. Moglia
Co-Chief Executive Officer and <br>Co-Chief Investment Officer
By: /s/ Dean A. Shigenaga
Dean A. Shigenaga
President and Chief Financial Officer

Document

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(1)Represents total equity capitalization for publicly traded U.S. REITs, from Bloomberg Professional Services as of December 31, 2021. Alexandria’s total equity capitalization is calculated using shares outstanding and the closing stock price as of December 31, 2021.

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As of December 31, 2021.

(1)We also expect other projects to commence construction in 2022.

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(1)Liquidity as of December 31, 2021, including our outstanding forward equity sales agreements entered into in January 2022. Refer to “Key credit metrics” of our Supplemental Information for additional details.

(2)As of December 31, 2021.

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(1)Represents credit rating levels from Moody’s Investors Service and S&P Global Ratings for publicly traded U.S. REITs, from Bloomberg Professional Services as of December 31, 2021.

(2)As of the date of this report.

(3)As of December 31, 2021. Refer to “Annual rental revenue” and “Investment-grade or publicly traded large cap tenants” in the “Definitions and reconciliations” of our Supplemental Information for additional details.

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(1)Source: Barron’s, “The 10 Most Sustainable REITs, According to Calvert,” February 19, 2021.

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Table of Contents
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December 31, 2021 EARNINGS PRESS RELEASE Page Page
--- --- --- ---
Fourth Quarter and Year Ended December 31, 2021Financial and Operating Results 1 Earnings Call Information and About the Company 9
Acquisitions 4 Consolidated Statements of Operations 10
Dispositions and Sales of Partial Interest 6 Consolidated Balance Sheets 11
Guidance 8 Funds From Operations and Funds From Operations per Share 12
SUPPLEMENTAL INFORMATION Page Page
Company Profile 15 External Growth / Investments in Real Estate
Investor Information 16 Investments in Real Estate 34
Financial and Asset Base Highlights 17 New Class A Development and Redevelopment Properties:
High-Quality, Diverse, and Innovative Tenants 19 Recent Deliveries 36
Class A Properties in AAA Locations 20 Current Projects 39
Occupancy 21 Summary of Pipeline 44
Internal Growth Construction Spending 48
Key Operating Metrics 22 Joint Venture Financial Information 49
Same Property Performance 23 Balance Sheet Management
Leasing Activity 24 Investments 51
Contractual Lease Expirations 25 Key Credit Metrics 52
Top 20 Tenants 26 Summary of Debt 53
Summary of Properties and Occupancy 27 Definitions and Reconciliations
Property Listing 28 Definitions and Reconciliations 56

This document includes “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Please refer to page 9 of this Earnings Press Release and our Supplemental Information for further information.

This document is not an offer to sell or a solicitation to buy securities of Alexandria Real Estate Equities, Inc. Any offers to sell or solicitations to buy our securities shall be made only by means of a prospectus approved for that purpose. Unless otherwise indicated, the “Company,” “Alexandria,” “ARE,” “we,” “us,” and “our” refer to Alexandria Real Estate Equities, Inc. and our consolidated subsidiaries.

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Alexandria Real Estate Equities, Inc., at the Vanguard of the Life Science Industry,

Providing High-Quality Office/Laboratory Space to Meet Historic-High Demand, Reports:

4Q21 and 2021 Net Income per Share – Diluted of $0.47 and $3.82, respectively;

4Q21 and 2021 FFO per Share – Diluted, As Adjusted, of $1.97 and $7.76, respectively

PASADENA, Calif. – January 31, 2022 – Alexandria Real Estate Equities, Inc. (NYSE:ARE) announced financial and operating results for the fourth quarter and year ended December 31, 2021.

Key highlights
Operating results 4Q21 4Q20 2021 2020
Total revenues:
In millions $ 576.9 $ 463.7 $ 2,114.2 $ 1,885.6
Growth 24.4 % 12.1 %
Net income attributable to Alexandria’s common stockholders – diluted
In millions $ 72.8 $ 435.9 $ 563.4 $ 760.8
Per share $ 0.47 $ 3.26 $ 3.82 $ 6.01
Funds from operations attributable to Alexandria’s common stockholders – diluted, as adjusted
In millions $ 303.6 $ 246.6 $ 1,144.9 $ 923.8
Per share $ 1.97 $ 1.84 $ 7.76 $ 7.30

Historic leasing volume and rental rate growth

•Historic demand for our high-quality office/laboratory space has translated into record leasing volume and rental rate growth in 2021 for our overall portfolio and our value-creation pipeline.

4Q21 Previous Quarterly Record 2021 Previous Annual Record
Total leasing activity – RSF 4,094,174 (1) 1,933,838 9,516,301 (1) 5,062,722
Leasing of development and redevelopment space – RSF 1,795,633 (1) 1,063,951 3,867,383 (1) 2,258,262
Lease renewals and re-leasing of space:
RSF (included in total leasing activity above) 1,947,727 (1) 1,472,713 4,614,040 (1) 2,562,178
Rental rate increases 35.9% 37.9% (1) 37.6%
Rental rate increases (cash basis) 22.9% 22.6% (1) 18.3%
(1)Represents the highest leasing volume and rental rate growth in Company history.

Continued strong net operating income and internal growth

•Net operating income (cash basis) of $1.4 billion for 4Q21 annualized, up $279.9 million, or 24.2%, compared to 4Q20 annualized.

•95% of our leases contain contractual annual rent escalations approximating 3%.

•Same property net operating income growth:

•5.0% and 7.5% (cash basis) for 4Q21 over 4Q20.

•4.2% and 7.1% (cash basis) for 2021 over 2020.

A REIT industry-leading high-quality tenant roster with high-quality revenues and cash flows, strong margins, and operational excellence; growth of 100 bps in occupancy over 4Q20(1)

Percentage of total annual rental revenue in effect from investment-grade or publicly traded large cap tenants 51 %
Occupancy of operating properties in North America 94.0 %
Occupancy of operating properties in North America (excluding vacancy at recently acquired properties) 98.7 % (1)
Operating margin 70 %
Adjusted EBITDA margin 71 %
Weighted-average remaining lease term:
All tenants 7.5 years
Top 20 tenants 10.9 years

(1)Excludes 1.8 million RSF, or 4.7%, of vacancy at recently acquired properties representing lease-up opportunities that are expected to provide incremental annual rental revenues. Excluding recently acquired vacancies, occupancy was 98.7% as of December 31, 2021, up 100 bps from 97.7% as of December 31, 2020. Refer to “Occupancy” in our Supplemental Information.

Historic high demand drives visibility for future growth aggregating $610 million of incremental annual rental revenue from 7.4 million RSF of value-creation projects that are 83% leased/negotiating

Our highly leased value-creation pipeline of current and near-term projects that are under construction or that will commence construction in the next six quarters is expected to generate greater than $610 million of incremental annual rental revenues, primarily commencing from 1Q22 through 4Q24.

•7.4 million RSF of our value-creation projects are either under construction or expected to commence construction in the next six quarters.

•83% leased/negotiating.

Strong and flexible balance sheet with significant liquidity

•Investment-grade credit ratings ranked in the top 10% among all publicly traded U.S. REITs as of December 31, 2021.

•Net debt and preferred stock to Adjusted EBITDA of 5.2x and fixed-charge coverage ratio of 5.3x for 4Q21 annualized, representing the best ratios in the past 10 years.

•Total debt and preferred stock to gross assets of 26% as of December 31, 2021.

•$5.4 billion liquidity as of December 31, 2021, including our outstanding forward equity sales agreements entered into in January 2022.

| Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 | 1 | | --- | --- || Fourth Quarter and Year Ended December 31, 2021 Financial and Operating Results (continued) | | --- | | December 31, 2021 |

Strategic value harvesting and asset recycling

During 4Q21, we completed $2.0 billion in dispositions and partial interest sales at an average capitalization rate (cash basis) of 4.2%.

Continued dividend strategy to share growth in cash flows with stockholders

Common stock dividend declared for 4Q21 of $1.15 per common share, aggregating $4.48 per common share for the year ended December 31, 2021, up 24 cents, or 6%, over the year ended December 31, 2020. Our FFO payout ratio of 60% for the three months ended December 31, 2021 allows us to continue to share growth in cash flows from operating activities with our stockholders while also retaining a significant portion for reinvestment.

Key items included in operating results

Key items included in net income attributable to Alexandria’s common stockholders:
4Q21 4Q20 4Q21 4Q20 2021 2020 2021 2020
(In millions, except per share amounts) Amount Per Share – Diluted Amount Per Share – Diluted
Unrealized (losses) gains on non-real estate investments $ (139.7) $ 233.5 $ (0.91) $ 1.75 $ 43.6 $ 374.0 $ 0.30 $ 2.96
Significant realized gains on non-real estate investments 110.1 0.75
Gain on sales of real estate 124.2 (1) 152.5 0.80 1.14 126.6 154.1 0.86 1.22
Impairment of real estate (25.2) (0.19) (52.7) (55.7) (0.35) (0.44)
Impairment of non-real estate investments (24.5) (0.19)
Loss on early extinguishment of debt (7.9) (0.06) (67.3) (60.7) (0.46) (0.48)
Termination fee 86.2 0.68
Acceleration of stock compensation expense due to executive officer resignation (4.5) (0.04)
Total $ (15.5) $ 352.9 $ (0.11) $ 2.64 $ 160.3 $ 468.9 $ 1.10 $ 3.71
(1)Refer to “Funds from operations and funds from operations per share” of this Earnings Press Release for additional details.

External growth and investment in real estate

Alexandria at the vanguard of innovation for over 850 tenants, with a focus on accommodating current tenant needs and providing a path for their future growth

•During 4Q21, we completed acquisitions in our key life science cluster submarkets aggregating 4.1 million SF, comprising 3.9 million RSF of future development opportunities and 191,879 RSF of operating space, for an aggregate purchase price of $1.5 billion, including our previously announced acquisition of One Rogers Street in our Cambridge submarket for a purchase price of $849.4 million. These acquisitions are primarily focused on future development or redevelopment opportunities to expand our mega campuses and accommodate the future growth of our tenants.

Delivery and commencement of value-creation projects

•During 4Q21, we placed into service development and redevelopment projects aggregating 600,768 RSF that are 100% leased across multiple submarkets.

•Annual net operating income (cash basis) is expected to increase by $39 million upon the burn-off of initial free rent from recently delivered projects.

•During 4Q21, we commenced construction on four value-creation projects aggregating 1.1 million RSF, including a 403,892 RSF recently acquired redevelopment project at One Rogers Street, which expands our Alexandria Center® at Kendall Square mega campus in Cambridge. We pre-leased the entire building by executing leases aggregating 403,892 RSF prior to the closing of the acquisition in December 2021.

•In January 2022, we completed the acquisition of 202,997 SF additional development entitlements, for an aggregate of 507,997 SF, at our 421 Park Drive future development site in our Alexandria Center® for Life Science – Fenway mega campus in our Fenway submarket.

Value-creation pipeline of new Class A development and redevelopment projects as a percentage of gross assets 4Q21
Under construction projects 82% leased/negotiating 9%
Pre-leased/negotiating near-term projects 89% leased/negotiating 2%
Income-producing/potential cash flows/covered land play(1) 6%
Land 2%

(1)Includes projects that have existing buildings that are generating or can generate operating cash flows. Also includes development rights associated with existing operating campuses.

Balance sheet management

Credit rating outlook improvement

In October 2021, S&P Global Ratings upgraded our corporate issuer credit rating outlook to BBB+/Positive from BBB+/Stable as a result of our consistently strong operating performance and long-term positive fundamentals.

Key metrics as of December 31, 2021

•$44.0 billion of total market capitalization.

•$35.2 billion of total equity capitalization; represents top 10% in total equity capitalization among all publicly traded U.S. REITs as of December 31, 2021.

•No debt maturities prior to 2024.

•12.1 years weighted-average remaining term of debt as of December 31, 2021.

4Q21 Goal
Quarter Trailing 4Q22
Annualized 12 Months Annualized
Net debt and preferred stock to Adjusted EBITDA 5.2x (1) 5.6x Less than or equal to 5.1x
Fixed-charge coverage ratio 5.3x (1) 5.0x Greater than or equal to 5.1x

(1)Net debt and preferred stock to adjusted EBITDA and fixed-charge coverage represent the best ratios in the past 10 years.

| Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 | 2 | | --- | --- || Fourth Quarter and Year Ended December 31, 2021 Financial and Operating Results (continued) | | --- | | December 31, 2021 |

Key capital events

•In December 2021, we entered into a new ATM common stock offering program, which allows us to sell up to an aggregate of $1.0 billion of our common stock. As of January 31, 2022, the full amount remains available for future sales of our common stock.

•In December 2021, we settled the outstanding forward equity sales agreements by issuing 4.6 million shares of common stock and received net proceeds of $770.6 million.

•In January 2022, we entered into new forward equity sales agreements aggregating $1.7 billion to sell 8.1 million shares of our common stock (including the exercise of underwriters’ option) at a public offering price of $210.00 per share, before underwriting discounts and commissions.

Investments

•As of December 31, 2021, our investments aggregated $1.9 billion, including unrealized gains of $797.7 million.

•Investment income of $259.5 million for the year ended December 31, 2021 included $215.8 million in realized gains and $43.6 million in unrealized gains.

Industry and ESG leadership: catalyzing and leading the way for positive change to benefit human health and society

•In January 2022, Alexandria Venture Investments, our strategic venture capital platform, was recognized by Silicon Valley Bank in its “Healthcare Investments and Exits: 2022 Annual Report” as the #1 most active corporate investor in biopharma by new deal volume (2020-2021) for the fifth consecutive year. Alexandria’s venture activity provides us with, among other things, mission-critical data and knowledge on key industry innovations and trends.

•In December 2021, Alexandria established a new social responsibility pillar to address America’s growing mental health crisis, with a focus on helping children cope with the loss of a parent or family member to suicide. By partnering with Camp Kita, a tuition-free summer camp for 8- to 17-year-olds who are impacted by the loss of a family member to suicide, we have enabled the non-profit to have long-term access to 28 acres in Acton, Maine that will serve as the camp’s future home. The dedicated space will allow Camp Kita to expand its programming, advance its mission, and support the mental health of a community of young survivors.

•As a testament to Alexandria’s operational excellence and exceptional team, in November 2021, we were recognized at the 2021 BOMA Boston TOBY (The Outstanding Building of the Year) & Industry Awards for the Laboratory Building of the Year (100 Binney Street) and the Corporate Facility of the Year (200 Technology Square). Five members from our Greater Boston team were also honored for their individual achievements. The TOBY & Industry Awards recognize excellence in property management, building operations, and service in the commercial real estate industry.

•In November 2021, Alexandria’s executive chairman and founder, Joel S. Marcus, joined the National Medal of Honor Museum Foundation at the Dallas Cowboys’ “Salute to Service” game to support the future National Medal of Honor Museum in Arlington, Texas and its mission to inspire visitors with the stories of our country’s Medal of Honor recipients for generations to come. Mr. Marcus has served on the foundation’s board of directors since 2019.

•In October 2021, OneFifteen, an innovative, data-driven non-profit evidence-based healthcare ecosystem dedicated to the full and sustained recovery of people living with addiction, celebrated its second anniversary. Since seeing its first patients in October 2019 at its pioneering campus in Dayton, Ohio, which was designed and developed by Alexandria, OneFifteen has treated over 4,000 patients and conducted over 11,500 telehealth visits.

•In October 2021, STEAM:Coders honored Alexandria with the Corporate Vanguard Award, recognizing our longstanding commitment to the non-profit’s mission to inspire underrepresented and underserved students and their families through science, technology, engineering, art, and math (STEAM) education in preparation for academic and career opportunities.

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Acquisitions
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December 31, 2021
(Dollars in thousands) Property Submarket/Market Date of<br>Purchase Number of Properties Operating<br>Occupancy Square Footage Purchase Price
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Acquisitions With Development/Redevelopment Opportunities(1)
Future Development Active Development/Redevelopment Operating With Future Development/ Redevelopment Operating(2) Operating Total(3)
Completed in YTD 3Q21 76 93% 7,946,121 1,434,803 2,823,087 2,801,041 238,948 14,272,878 $ 3,941,902
Completed in 4Q21:
One Rogers Street Cambridge/Inner Suburbs/<br><br>Greater Boston 12/30/21 1 100 (4) TBD 403,892 4,367 408,259 849,422
1178 El Camino Real South San Francisco/San Francisco Bay Area 11/5/21 N/A 620,000 620,000 128,000
3420 and 3440 Hillview Avenue Greater Stanford/San Francisco Bay Area 10/5/21 2 75 185,228 185,228 203,800
888 Bransten Road Greater Stanford/San Francisco Bay Area 11/4/21 N/A 210,830 210,830 55,000
Other Various Various 8 75 1,888,874 144,113 489,466 187,512 2,709,965 291,030
11 75 2,719,704 548,005 674,694 (5) 4,367 (5) 187,512 (5) 4,134,282 1,527,252
2021 acquisitions 87 91% 10,665,825 1,982,808 3,497,781 2,805,408 426,460 18,407,160 $ 5,469,154

(1)We expect to provide total estimated costs and related yields for development and redevelopment projects in the future, subsequent to the commencement of construction. Refer to “New Class A development and redevelopment properties: current projects” in our Supplemental Information for additional details on active development and redevelopment projects.

(2)Represents the operating component of our value-creation acquisitions that is not expected to undergo development or redevelopment.

(3)Represents total square footage upon completion of development or redevelopment of a new Class A property. Square footage presented includes RSF of buildings currently in operations with future development or redevelopment opportunities. We intend to demolish and develop or to redevelop the existing properties upon expiration of the existing in-place leases. Refer to “Definitions and reconciliations” in our Supplemental Information for additional details on value-creation square feet currently included in rental properties.

(4)We pre-leased the entire building by executing leases aggregating 403,892 RSF prior to closing of the acquisition in December 2021.

(5)We expect the acquisitions completed during the three months ended December 31, 2021 to generate initial annual net operating income of $14.8 million for the twelve months following acquisition. These acquisitions included 11 operating properties with a weighted-average acquisition date of October 19, 2021 (weighted by initial annual net operating income).

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Acquisitions (continued)
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December 31, 2021
(Dollars in thousands)
Property Submarket/Market Date of<br>Purchase Number of Properties Operating<br>Occupancy Square Footage
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Acquisitions With Development/Redevelopment Opportunities(1)
Future Development Active Development/Redevelopment Operating With Future Development/ Redevelopment Operating(2) Operating Total(3)
Completed in January 2022:
421 Park Drive(4) Fenway/Greater Boston 1/13/22 N/A 202,997 (4) 202,997 $ 81,119
225 and 235 Presidential Way Route 128/Greater Boston 1/28/22 2 100% 440,130 440,130 124,673
3301, 3303, 3305, and 3307 Hillview Avenue Greater Stanford/<br><br>San Francisco Bay Area 1/6/22 4 100 292,013 292,013 446,000
Costa Verde by Alexandria University Town Center/<br><br>San Diego 1/11/22 1 100 537,000 8,730 545,730 125,000
Alexandria Center® for Life Science – Durham Research Triangle/Research Triangle 1/11/22 N/A 1,175,000 1,175,000 99,428
104 and 108/110/112/114 TW Alexander Drive, 2752 East NC Highway 54, and 10 South Triangle Drive(5) Research Triangle/Research Triangle 1/6/22 4 88 750,000 69,484 819,484 80,000
Other Various Various 7 92 228,250 428,097 381,760 1,038,107 263,620
18 96% 2,893,247 1,238,454 381,760 4,513,461 1,219,840
Pending acquisitions:
Mercer Mega Block Lake Union/Seattle February 2022 N/A 800,000 800,000 143,500
Intersection Campus Texas February 2022 9 81% 998,304 998,304 402,000
545,500
Other targeted acquisitions(6) 1,234,660
2022 acquisitions (midpoint) $ 3,000,000
2022 guidance range 2,500,000 – 3,500,000

All values are in US Dollars.

(1)We expect to provide total estimated costs and related yields for development and redevelopment projects in the future, subsequent to the commencement of construction.

(2)Represents the operating component of our value-creation acquisitions that is not expected to undergo development or redevelopment.

(3)Represents total square footage upon completion of development or redevelopment of a new Class A property. Square footage presented includes RSF of buildings currently in operation with future development or redevelopment opportunities. We intend to demolish and develop or to redevelop the existing properties upon expiration of the existing in-place leases. Refer to “Definitions and reconciliations” in our Supplemental Information for additional details on value-creation square feet currently included in rental properties.

(4)Represents the incremental purchase price related to the achievement of additional entitlement rights of 202,997 SF at our Alexandria Center® for Life Science – Fenway mega campus.

(5)Represents the acquisition of fee simple interests in the land underlying our recently acquired 108/110/112/114 TW Alexander Drive buildings, which were previously subject to ground leases.

(6)Includes a land parcel aggregating 680,000 RSF of future development opportunity at 1150 El Camino Real in our South San Francisco submarket. The property is a transit-oriented opportunity with a BART station located on premises that will combine with other contiguous land that was recently acquired, including 1122 and 1178 El Camino Real, to create a new mega campus consisting of 2.0 million RSF of future development opportunities.

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Dispositions and Sales of Partial Interest
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December 31, 2021
(Dollars in thousands) Capitalization Rate<br>(Cash Basis) Sales Price per RSF Gain or Consideration in Excess of Book Value
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Property Submarket/Market Date of Sale Interest Sold RSF Capitalization Rate Sales Price(1)
Completed in YTD 3Q21 1,011,263 $ 663,283 $ 201,490
Completed in 4Q21:
50 and 60 Binney Street Cambridge/Inner Suburbs/<br><br>Greater Boston 12/15/21 66 % 532,395 4.3 % 3.9 % 782,259 $ 2,226 457,529 (3)
409 and 499 Illinois Street Mission Bay/San Francisco Bay Area 10/5/21 35 % (2) 455,069 5.0 % 4.2 % 274,681 $ 1,366 113,756 (3)
1500 Owens Street Mission Bay/San Francisco Bay Area 25.1 % (2) 158,267
455 Mission Bay Boulevard South Mission Bay/San Francisco Bay Area 12/16/21 75 % 228,140 4.1 % 3.8 % 381,355 $ 1,295 221,868 (3)
1700 Owens Street Mission Bay/San Francisco Bay Area 164,513
Menlo Gateway Greater Stanford/San Francisco Bay Area 12/21/21 (4) 772,983 5.4 % 5.1 % 397,851 (5) $ 1,430 101,050 (6)
2301 5th Avenue Lake Union/Seattle 12/22/21 100 % 197,135 6.3 % 4.9 % 118,707 $ 602 23,175 (6)
Other Various Various 100 % 79,007 N/A N/A 12,000 N/A
2,587,509 1,966,853 917,378
2021 dispositions and sales of partial interest 3,598,772 $ 2,630,136 (7) $ 1,118,868 (8)

(1)For sales of partial interests; represents the contractual sales price for the percentage interest of the property sold by us.

(2)We recapitalized these consolidated real estate joint ventures and sold: (i) a 35% interest in 409 and 499 Illinois Street and (ii) a 25.1% interest in 1500 Owens Street, resulting in an acquisition by the investor of a 75% ownership interest in each joint venture, including the interest held by our previous joint venture partners.

(3)For each partial interest sale, we retained control over the newly formed real estate joint venture and therefore continued to consolidate this property. We accounted for the difference between the consideration received and the book value of the interest sold as an equity transaction, with no gain or loss recognized in earnings.

(4)We sold our 49.0% interest in Menlo Gateway, which represents our entire equity interest in the unconsolidated real estate joint venture.

(5)Represents a sales price of $541.5 million less our share of the debt held by the unconsolidated real estate joint venture assumed by the buyer aggregating $143.6 million.

(6)We sold our entire interest in this property and recognized the related gain in earnings, classified within gain (loss) on sales of real estate in our consolidated statements of operations.

(7)Represents the highest total volume of dispositions in Company history, at a weighted-average capitalization rate (cash basis) of 4.1%.

(8)We achieved a weighted-average value-creation margin of 75% on our completed dispositions and sales of partial interest.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 6
Dispositions and Sales of Partial Interest (continued)
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December 31, 2021
(Dollars in thousands) Property Market Date of Sale Interest Sold RSF Sales Price
--- --- --- --- --- --- --- --- --- --- ---
Partial interest sale Greater Boston 1Q22 TBD TBD $ 650,000 $ 750,000
Other real estate dispositions and partial interest sales 1Q22 TBD TBD 50,000 150,000
Other targeted real estate dispositions and partial interest sales 600,000 1,200,000
2022 guidance range $ 1,300,000 $ 2,100,000 Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 7
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Guidance
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December 31, 2021
(Dollars in millions, except per share amounts)

The following guidance is based on our current view of existing market conditions and assumptions for the year ending December 31, 2022. There can be no assurance that actual amounts will not be materially higher or lower than these expectations. Also, refer to our discussion of “forward-looking statements” on page 9 of this Earnings Press Release for additional details.

Projected 2022 Earnings per Share and Funds From Operations per Share Attributable to Alexandria’s Common Stockholders – Diluted
Earnings per share(1) 2.65 to 2.85
Depreciation and amortization of real estate assets
Allocation to unvested restricted stock awards
Funds from operations per share(2) 8.26 to 8.46
Midpoint 8.36

All values are in US Dollars.

Key Assumptions Low High
Occupancy percentage in North America as of December 31, 2022 95.2% 95.8%
Lease renewals and re-leasing of space:
Rental rate increases 30.0% 35.0%
Rental rate increases (cash basis) 18.0% 23.0%
Same property performance:
Net operating income increase 5.5% 7.5%
Net operating income increase (cash basis) 6.5% 8.5%
Straight-line rent revenue $ 150 $ 160
General and administrative expenses $ 168 $ 176
Capitalization of interest $ 269 $ 279
Interest expense $ 90 $ 100
Key Credit Metrics 2022 Guidance
--- ---
Net debt and preferred stock to Adjusted EBITDA – 4Q22 annualized Less than or equal to 5.1x
Fixed-charge coverage ratio – 4Q22 annualized Greater than or equal to 5.1x Key Sources and Uses of Capital Range Midpoint Certain<br>Completed Items
--- --- --- --- --- --- --- --- ---
Sources of capital:
Net cash provided by operating activities after dividends $ 275 $ 325 $ 300
Incremental debt 1,375 1,025 1,200
Real estate dispositions and partial interest sales (refer to page 7) 1,300 2,100 1,700
Common equity 2,250 3,250 2,750 $ 1,691
Total sources of capital $ 5,200 $ 6,700 $ 5,950
Uses of capital:
Construction (refer to page 48) $ 2,700 $ 3,200 $ 2,950
Acquisitions (refer to page 5) 2,500 3,500 3,000 $ 1,220
Total uses of capital $ 5,200 $ 6,700 $ 5,950
Incremental debt (included above):
Issuance of unsecured senior notes payable $ 1,200 $ 1,700 $ 1,450
Unsecured senior line of credit, commercial paper, and other 175 (675) (250)
Incremental debt $ 1,375 $ 1,025 $ 1,200

(1)Excludes unrealized gains or losses after December 31, 2021 that are required to be recognized in earnings and are excluded from funds from operations per share, as adjusted.

(2)Refer to “Funds from operations and funds from operations, as adjusted, attributable to Alexandria’s common stockholders” in the “Definitions and reconciliations” of our Supplemental Information for additional details.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 8
Earnings Call Information and About the Company
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December 31, 2021

We will host a conference call on Tuesday, February 1, 2022, at 3:00 p.m. Eastern Time (“ET”)/noon Pacific Time (“PT”), which is open to the general public, to discuss our financial and operating results for the fourth quarter and year ended December 31, 2021. To participate in this conference call, dial (833) 366-1125 or (412) 902-6738 shortly before 3:00 p.m. ET/noon PT and ask the operator to join the call for Alexandria Real Estate Equities, Inc. The audio webcast can be accessed at www.are.com in the “For Investors” section. A replay of the call will be available for a limited time from 5:00 p.m. ET/2:00 p.m. PT on Tuesday, February 1, 2022. The replay number is (877) 344-7529 or (412) 317-0088, and the access code is 10161869.

Additionally, a copy of this Earnings Press Release and Supplemental Information for the fourth quarter and year ended December 31, 2021, is available in the “For Investors” section of our website at www.are.com or by following this link: http://www.are.com/fs/2021q4.pdf.

For any questions, please contact Joel S. Marcus, executive chairman and founder; Stephen A. Richardson, co-chief executive officer; Peter M. Moglia, co-chief executive officer and co-chief investment officer; Dean A. Shigenaga, president and chief financial officer; Paula Schwartz, managing director of Rx Communications Group, at (917) 322-2216; or Sara M. Kabakoff, vice president – communications, at (626) 578-0777.

About the Company

Alexandria Real Estate Equities, Inc. (NYSE:ARE), an S&P 500® urban office real estate investment trust (“REIT”), is the first, longest-tenured, and pioneering owner, operator, and developer uniquely focused on collaborative life science, agtech, and technology campuses in AAA innovation cluster locations, with a total market capitalization of $44.0 billion as of December 31, 2021, and an asset base in North America of 67.0 million square feet (“SF”). The asset base in North America includes 38.8 million RSF of operating properties and 4.8 million RSF of Class A properties undergoing construction, 8.7 million RSF of near-term and intermediate-term development and redevelopment projects, and 14.7 million SF of future development projects. Founded in 1994, Alexandria pioneered this niche and has since established a significant market presence in key locations, including Greater Boston, the San Francisco Bay Area, New York City, San Diego, Seattle, Maryland, and Research Triangle. Alexandria has a longstanding and proven track record of developing Class A properties clustered in urban life science, agtech, and technology campuses that provide our innovative tenants with highly dynamic and collaborative environments that enhance their ability to successfully recruit and retain world-class talent and inspire productivity, efficiency, creativity, and success. Alexandria also provides strategic capital to transformative life science, agtech, and technology companies through our venture capital platform. We believe our unique business model and diligent underwriting ensure a high-quality and diverse tenant base that results in higher occupancy levels, longer lease terms, higher rental income, higher returns, and greater long-term asset value. For additional information on Alexandria, please visit www.are.com.

***********

This document includes “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Such forward-looking statements include, without limitation, statements regarding our 2022 earnings per share attributable to Alexandria’s common stockholders – diluted, 2022 funds from operations per share attributable to Alexandria’s common stockholders – diluted, net operating income, and our projected sources and uses of capital. You can identify the forward-looking statements by their use of forward-looking words, such as “forecast,” “guidance,” “goals,” “projects,” “estimates,” “anticipates,” “believes,” “expects,” “intends,” “may,” “plans,” “seeks,” “should,” “targets,” or “will,” or the negative of those words or similar words. These forward-looking statements are based on our current expectations, beliefs, projections, future plans and strategies, anticipated events or trends, and similar expressions concerning matters that are not historical facts, as well as a number of assumptions concerning future events. There can be no assurance that actual results will not be materially higher or lower than these expectations. These statements are subject to risks, uncertainties, assumptions, and other important factors that could cause actual results to differ materially from the results discussed in the forward-looking statements. Factors that might cause such a difference include, without limitation, our failure to obtain capital (debt, construction financing, and/or equity) or refinance debt maturities, lower than expected yields, increased interest rates and operating costs, adverse economic or real estate developments in our markets, our failure to successfully place into service and lease any properties undergoing development or redevelopment and our existing space held for future development or redevelopment (including new properties acquired for that purpose), our failure to successfully operate or lease acquired properties, decreased rental rates, increased vacancy rates or failure to renew or replace expiring leases, defaults on or non-renewal of leases by tenants, adverse general and local economic conditions, an unfavorable capital market environment, decreased leasing activity or lease renewals, failure to obtain LEED and other healthy building certifications and efficiencies, and other risks and uncertainties detailed in our filings with the Securities and Exchange Commission (“SEC”). Accordingly, you are cautioned not to place undue reliance on such forward-looking statements. All forward-looking statements are made as of the date of this Earnings Press Release and Supplemental Information, and unless otherwise stated, we assume no obligation to update this information and expressly disclaim any obligation to update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise. For more discussion relating to risks and uncertainties that could cause actual results to differ materially from those anticipated in our forward-looking statements, and risks to our business in general, please refer to our SEC filings, including our most recent annual report on Form 10-K and any subsequent quarterly reports on Form 10-Q.

Alexandria®, Lighthouse Design® logo, Building the Future of Life-Changing Innovation™, That’s What’s in Our DNA®, Labspace®, Alexandria Center®, Alexandria Technology Square®, Alexandria Technology Center®, and Alexandria Innovation Center® are copyrights and trademarks of Alexandria Real Estate Equities, Inc. All other company names, trademarks, and logos referenced herein are the property of their respective owners.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 9
Consolidated Statements of Operations
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December 31, 2021
(Dollars in thousands, except per share amounts) Three Months Ended Year Ended
--- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
12/31/21 9/30/21 6/30/21 3/31/21 12/31/20 12/31/21 12/31/20
Revenues:
Income from rentals $ 574,656 $ 546,527 $ 508,371 $ 478,695 $ 461,335 $ 2,108,249 $ 1,878,208
Other income 2,267 1,232 1,248 1,154 2,385 5,901 7,429
Total revenues 576,923 547,759 509,619 479,849 463,720 2,114,150 1,885,637
Expenses:
Rental operations 175,717 165,995 143,955 137,888 136,767 623,555 530,224
General and administrative 41,654 37,931 37,880 33,996 32,690 151,461 133,341
Interest 34,862 35,678 35,158 36,467 37,538 142,165 171,609
Depreciation and amortization 239,254 210,842 190,052 180,913 177,750 821,061 698,104
Impairment of real estate 42,620 4,926 5,129 25,177 52,675 48,078
Loss on early extinguishment of debt 67,253 7,898 67,253 60,668
Total expenses 491,487 493,066 411,971 461,646 417,820 1,858,170 1,642,024
Equity in earnings of unconsolidated real estate joint ventures 3,018 3,091 2,609 3,537 3,593 12,255 8,148
Investment (loss) income (112,884) 67,084 304,263 1,014 255,137 259,477 421,321
Gain (loss) on sales of real estate 124,226 (1) (435) 2,779 152,503 126,570 (1) 154,089
Net income 99,796 124,433 404,520 25,533 457,133 654,282 827,171
Net income attributable to noncontrolling interests (24,901) (21,286) (19,436) (17,412) (15,649) (83,035) (56,212)
Net income attributable to Alexandria Real Estate Equities, Inc.’s stockholders 74,895 103,147 385,084 8,121 441,484 571,247 770,959
Net income attributable to unvested restricted stock awards (2,098) (1,883) (4,521) (2,014) (5,561) (7,848) (10,168)
Net income attributable to Alexandria Real Estate Equities, Inc.’s common stockholders $ 72,797 $ 101,264 $ 380,563 $ 6,107 $ 435,923 $ 563,399 $ 760,791
Net income per share attributable to Alexandria Real Estate Equities, Inc.’s common stockholders:
Basic $ 0.47 $ 0.67 $ 2.61 $ 0.04 $ 3.26 $ 3.83 $ 6.03
Diluted $ 0.47 $ 0.67 $ 2.61 $ 0.04 $ 3.26 $ 3.82 $ 6.01
Weighted-average shares of common stock outstanding:
Basic 153,464 150,854 145,825 137,319 133,688 146,921 126,106
Diluted 154,307 151,561 146,058 137,688 133,827 147,460 126,490
Dividends declared per share of common stock $ 1.15 $ 1.12 $ 1.12 $ 1.09 $ 1.09 $ 4.48 $ 4.24

(1)Refer to “Funds from operations and funds from operations per share” of this Earnings Press Release for additional details.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 10
Consolidated Balance Sheets
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December 31, 2021
(In thousands)
12/31/21 9/30/21 6/30/21 3/31/21 12/31/20
--- --- --- --- --- --- --- --- --- --- ---
Assets
Investments in real estate $ 24,980,669 $ 23,071,514 $ 21,692,385 $ 20,253,418 $ 18,092,372
Investments in unconsolidated real estate joint ventures 38,483 321,737 323,622 325,928 332,349
Cash and cash equivalents 361,348 325,872 323,876 492,184 568,532
Restricted cash 53,879 42,182 33,697 42,219 29,173
Tenant receivables 7,379 7,749 6,710 7,556 7,333
Deferred rent 839,335 816,219 781,600 751,967 722,751
Deferred leasing costs 402,898 329,952 321,005 294,328 272,673
Investments 1,876,564 2,046,878 1,999,283 1,641,811 1,611,114
Other assets 1,658,818 1,596,615 1,536,672 1,424,935 1,191,581
Total assets $ 30,219,373 $ 28,558,718 $ 27,018,850 $ 25,234,346 $ 22,827,878
Liabilities, Noncontrolling Interests, and Equity
Secured notes payable $ 205,198 $ 198,758 $ 227,984 $ 229,406 $ 230,925
Unsecured senior notes payable 8,316,678 8,314,851 8,313,025 8,311,512 7,232,370
Unsecured senior line of credit and commercial paper 269,990 749,978 299,990 99,991
Accounts payable, accrued expenses, and other liabilities 2,210,410 2,149,450 1,825,387 1,750,687 1,669,832
Dividends payable 183,847 173,560 170,647 160,779 150,982
Total liabilities 11,186,123 11,586,597 10,837,033 10,452,384 9,384,100
Commitments and contingencies
Redeemable noncontrolling interests 9,612 11,681 11,567 11,454 11,342
Alexandria Real Estate Equities, Inc.’s stockholders’ equity:
Common stock 1,580 1,532 1,507 1,457 1,367
Additional paid-in capital 16,195,256 14,727,735 14,194,023 12,994,748 11,730,970
Accumulated other comprehensive loss (7,294) (6,029) (4,508) (5,799) (6,625)
Alexandria Real Estate Equities, Inc.’s stockholders’ equity 16,189,542 14,723,238 14,191,022 12,990,406 11,725,712
Noncontrolling interests 2,834,096 2,237,202 1,979,228 1,780,102 1,706,724
Total equity 19,023,638 16,960,440 16,170,250 14,770,508 13,432,436
Total liabilities, noncontrolling interests, and equity $ 30,219,373 $ 28,558,718 $ 27,018,850 $ 25,234,346 $ 22,827,878
Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 11
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Funds From Operations and Funds From Operations per Share
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December 31, 2021
(In thousands)

The following table presents a reconciliation of net income (loss) attributable to Alexandria’s common stockholders, the most directly comparable financial measure presented in accordance with U.S. generally accepted accounting principles (“GAAP”), including our share of amounts from consolidated and unconsolidated real estate joint ventures, to funds from operations attributable to Alexandria’s common stockholders – diluted, and funds from operations attributable to Alexandria’s common stockholders – diluted, as adjusted, for the periods below:

Three Months Ended Year Ended
12/31/21 9/30/21 6/30/21 3/31/21 12/31/20 12/31/21 12/31/20
Net income attributable to Alexandria’s common stockholders $ 72,797 $ 101,264 $ 380,563 $ 6,107 $ 435,923 $ 563,399 $ 760,791
Depreciation and amortization of real estate assets 234,979 205,436 186,498 177,720 173,392 804,633 684,682
Noncontrolling share of depreciation and amortization from consolidated real estate JVs (21,265) (17,871) (16,301) (15,443) (15,032) (70,880) (61,933)
Our share of depreciation and amortization from unconsolidated real estate JVs 3,058 3,465 4,135 3,076 2,976 13,734 11,413
(Gain) loss on sales of real estate (124,226) (1) 435 (2,779) (152,503) (126,570) (1) (154,089)
Impairment of real estate – rental properties 18,602 1,754 5,129 25,177 25,485 40,501
Allocation to unvested restricted stock awards (1,472) (2,191) (201) (420) (6,315) (7,018)
Funds from operations attributable to Alexandria’s common stockholders – diluted(2) 165,343 309,859 554,458 173,609 469,513 1,203,486 1,274,347
Unrealized losses (gains) on non-real estate investments 139,716 14,432 (244,031) 46,251 (233,538) (43,632) (374,033)
Significant realized gains on non-real estate investments (52,427) (34,773) (22,919) (110,119)
Impairment of non-real estate investments 24,482
Impairment of real estate 24,018 3,172 27,190 15,221
Loss on early extinguishment of debt 67,253 7,898 67,253 60,668
Termination fee (86,179)
Acceleration of stock compensation expense due to executive officer resignation 4,499
Allocation to unvested restricted stock awards (1,432) 149 3,428 (1,208) 2,774 710 4,790
Funds from operations attributable to Alexandria’s common stockholders – diluted, as adjusted $ 303,627 $ 296,031 $ 282,254 $ 262,986 $ 246,647 $ 1,144,888 $ 923,795

(1)Includes $101.1 million related to the sale of our entire 49.0% interest in the unconsolidated real estate joint venture at Menlo Gateway.

(2)Calculated in accordance with standards established by the Nareit Board of Governors.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 12
Funds From Operations and Funds From Operations per Share (continued)
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December 31, 2021
(In thousands, except per share amounts)

The following table presents a reconciliation of net income (loss) per share attributable to Alexandria’s common stockholders, the most directly comparable financial measure presented in accordance with GAAP, including our share of amounts from consolidated and unconsolidated real estate joint ventures, to funds from operations per share attributable to Alexandria’s common stockholders – diluted, and funds from operations per share attributable to Alexandria’s common stockholders – diluted, as adjusted, for the periods below. Per share amounts may not add due to rounding.

Three Months Ended Year Ended
12/31/21 9/30/21 6/30/21 3/31/21 12/31/20 12/31/21 12/31/20
Net income per share attributable to Alexandria’s common stockholders – diluted $ 0.47 $ 0.67 $ 2.61 $ 0.04 $ 3.26 $ 3.82 $ 6.01
Depreciation and amortization of real estate assets 1.40 1.26 1.19 1.20 1.21 5.07 5.01
(Gain) loss on sales of real estate (0.80) (0.02) (1.14) (0.86) (1.22)
Impairment of real estate – rental properties 0.12 0.01 0.04 0.19 0.17 0.32
Allocation to unvested restricted stock awards (0.01) (0.01) (0.01) (0.04) (0.05)
Funds from operations per share attributable to Alexandria’s common stockholders – diluted 1.07 2.04 3.80 1.26 3.51 8.16 10.07
Unrealized losses (gains) on non-real estate investments 0.91 0.10 (1.67) 0.34 (1.75) (0.30) (2.96)
Significant realized gains on non-real estate investments (0.35) (0.24) (0.17) (0.75)
Impairment of non-real estate investments 0.19
Impairment of real estate 0.16 0.02 0.18 0.12
Loss on early extinguishment of debt 0.49 0.06 0.46 0.48
Termination fee (0.68)
Acceleration of stock compensation expense due to executive officer resignation 0.04
Allocation to unvested restricted stock awards (0.01) 0.02 (0.01) 0.02 0.01 0.04
Funds from operations per share attributable to Alexandria’s common stockholders – diluted, as adjusted $ 1.97 $ 1.95 $ 1.93 $ 1.91 $ 1.84 $ 7.76 $ 7.30
Weighted-average shares of common stock outstanding – diluted 154,307 151,561 146,058 137,688 133,827 147,460 126,490
Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 13
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SUPPLEMENTAL

INFORMATION

Company Profile
December 31, 2021

Alexandria Real Estate Equities, Inc. (NYSE:ARE), an S&P 500® urban office REIT, is the first, longest-tenured, and pioneering owner, operator, and developer uniquely focused on collaborative life science, agtech, and technology campuses in AAA innovation cluster locations, with a total market capitalization of $44.0 billion as of December 31, 2021, and an asset base in North America of 67.0 million SF. The asset base in North America includes 38.8 million RSF of operating properties and 4.8 million RSF of Class A properties undergoing construction, 8.7 million RSF of near-term and intermediate-term development and redevelopment projects, and 14.7 million SF of future development projects. Founded in 1994, Alexandria pioneered this niche and has since established a significant market presence in key locations, including Greater Boston, the San Francisco Bay Area, New York City, San Diego, Seattle, Maryland, and Research Triangle. Alexandria has a longstanding and proven track record of developing Class A properties clustered in urban life science, agtech, and technology campuses that provide our innovative tenants with highly dynamic and collaborative environments that enhance their ability to successfully recruit and retain world-class talent and inspire productivity, efficiency, creativity, and success. Alexandria also provides strategic capital to transformative life science, agtech, and technology companies through our venture capital platform. We believe our unique business model and diligent underwriting ensure a high-quality and diverse tenant base that results in higher occupancy levels, longer lease terms, higher rental income, higher returns, and greater long-term asset value. For additional information on Alexandria, please visit www.are.com.

Tenant base

Alexandria is known for our high-quality and diverse tenant base, with 51% of our total annual rental revenue generated from tenants that are investment-grade rated or publicly traded large cap companies. The quality, diversity, breadth, and depth of our significant relationships with our tenants provide Alexandria with high-quality and stable cash flows. Alexandria’s underwriting team and long-term industry relationships positively distinguish us from all other publicly traded REITs and real estate companies.

Executive and senior management team

Alexandria’s executive and senior management team has unique experience and expertise in creating, owning, and operating highly dynamic and collaborative campuses in key urban life science, agtech, and technology cluster locations that inspire innovation. From the development of high-quality, sustainable real estate, to the ongoing cultivation of collaborative environments with unique amenities and events, the Alexandria team has a first-in-class reputation of excellence in our niche. Alexandria’s highly experienced management team also includes regional market directors with leading reputations and longstanding relationships within the life science, agtech, and technology communities in their respective innovation clusters. We believe that our expertise, experience, reputation, and key relationships in the real estate, life science, agtech, and technology sectors provide Alexandria significant competitive advantages in attracting new business opportunities.

Alexandria’s executive and senior management team consists of 53 individuals, averaging 25 years of real estate experience, including 12 years with Alexandria. Our executive management team alone averages 18 years of experience with Alexandria.

EXECUTIVE MANAGEMENT TEAM
Joel S. Marcus Stephen A. Richardson
Executive Chairman & Founder Co-Chief Executive Officer
Dean A. Shigenaga Peter M. Moglia
President & Chief Financial Officer Co-Chief Executive Officer & <br>Co-Chief Investment Officer
Daniel J. Ryan Lawrence J. Diamond
Co-Chief Investment Officer & Regional Market Director – San Diego Co-Chief Operating Officer & Regional Market Director – Maryland
Vincent R. Ciruzzi John H. Cunningham
Chief Development Officer Executive Vice President – Regional Market Director – New York City
Hunter L. Kass Jackie B. Clem
Executive Vice President – Regional Market Director – Greater Boston General Counsel & Secretary
Joseph Hakman Terezia C. Nemeth
Co-Chief Operating Officer & <br>Chief Strategic Transactions Officer Executive Vice President – Regional Market Director – San Francisco <br>Bay Area
Marc E. Binda Andres R. Gavinet
Executive Vice President – <br>Finance & Treasurer Chief Accounting Officer
Gary D. Dean
Executive Vice President – <br>Real Estate Legal Affairs
Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 15
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Investor Information
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December 31, 2021 Corporate Headquarters New York Stock Exchange Trading Symbol Information Requests
--- --- --- ---
26 North Euclid Avenue Common stock: ARE Phone: (626) 578-0777
Pasadena, California 91101 Email: corporateinformation@are.com
Website: www.are.com Equity Research Coverage
--- Alexandria is currently covered by the following research analysts. This list may be incomplete and is subject to change as firms initiate or discontinue coverage of our company. Please note that any opinions, estimates, or forecasts regarding our historical or predicted performance made by these analysts are theirs alone and do not represent opinions, estimates, or forecasts of Alexandria or our management. Alexandria does not by our reference or distribution of the information below imply our endorsement of or concurrence with any opinions, estimates, or forecasts of these analysts. Interested persons may obtain copies of analysts’ reports on their own as we do not distribute these reports. Several of these firms may, from time to time, own our stock and/or hold other long or short positions in our stock and may provide compensated services to us.
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Bank of America Merrill Lynch Citigroup Global Markets Inc. JMP Securities RBC Capital Markets
--- --- --- ---
Jamie Feldman Michael Bilerman / Emmanuel Korchman Aaron Hecht Michael Carroll / Jason Idoine
(646) 855-5808 (212) 816-1383 / (212) 816-1382 (415) 835-3963 (440) 715-2649 / (440) 715-2651
Berenberg Capital Markets Evercore ISI J.P. Morgan Securities LLC Robert W. Baird & Co. Incorporated
Connor Siversky / Nate Crossett Sheila McGrath / Wendy Ma Anthony Paolone / Ray Zhong David Rodgers / Nicholas Thillman
(646) 949-9037 / (646) 949-9030 (212) 497-0882 / (212) 497-0870 (212) 622-6682 / (212) 622-5411 (216) 737-7341 / (414) 298-5053
BTIG, LLC Green Street Mizuho Securities USA LLC SMBC Nikko Securities America, Inc.
Tom Catherwood / John Nickodemus Daniel Ismail / Dylan Burzinski Vikram Malhotra / Lydia Jiang Richard Anderson / Jay Kornreich
(212) 738-6140 / (212) 738-6050 (949) 640-8780 / (949) 640-8780 (212) 282-3827 / (212) 209-9379 (646) 521-2351 / (646) 424-3202
CFRA
Kenneth Leon
(646) 517-2552
Fixed Income Coverage Rating Agencies
Barclays Capital Inc. Stifel Financial Corp. Moody’s Investors Service S&P Global Ratings
Srinjoy Banerjee / Devon Zhou Thierry Perrein (212) 553-0376 Fernanda Hernandez / Michael Souers
(212) 526-3521 / (212) 526-6961 (646) 376-5303 (212) 438-1347 / (212) 438-2508
J.P. Morgan Securities LLC
Mark Streeter / Ian Snyder
(212) 834-5086 / (212) 834-3798 Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 16
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Financial and Asset Base Highlights
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December 31, 2021
(Dollars in thousands, except per share amounts)
Three Months Ended (unless stated otherwise)
--- --- --- --- --- ---
12/31/21 9/30/21 6/30/21 3/31/21 12/31/20
Selected financial data from consolidated financial statements and related information
Rental revenues
Tenant recoveries
General and administrative expenses
General and administrative expenses as a percentage of net operating income –<br><br>trailing 12 months 10.2% 10.1% 9.8% 9.8% 9.8%
Operating margin 70% 70% 72% 71% 71%
Adjusted EBITDA margin 71% 71% 73% 73% 72%
Adjusted EBITDA – quarter annualized
Adjusted EBITDA – trailing 12 months
Net debt at end of period
Net debt and preferred stock to Adjusted EBITDA – quarter annualized 5.2x 5.8x 5.8x 5.8x 5.3x
Net debt and preferred stock to Adjusted EBITDA – trailing 12 months 5.6x 6.2x 6.2x 6.1x 5.5x
Total debt and preferred stock at end of period
Gross assets at end of period
Total debt and preferred stock to gross assets at end of period 26% 29% 29% 30% 29%
Fixed-charge coverage ratio – quarter annualized 5.3x 5.1x 4.9x 4.7x 4.6x
Fixed-charge coverage ratio – trailing 12 months 5.0x 4.8x 4.6x 4.4x 4.4x
Unencumbered net operating income as a percentage of total net operating income 97% 97% 97% 97% 97%
Closing stock price at end of period
Common shares outstanding (in thousands) at end of period 158,044 153,284 150,708 145,656 136,690
Total equity capitalization at end of period
Total market capitalization at end of period
Dividend per share – quarter/annualized 1.15/4.60 1.12/4.48 1.12/4.48 1.09/4.36 1.09/4.36
Dividend payout ratio for the quarter 60% 58% 60% 60% 60%
Dividend yield – annualized 2.1% 2.3% 2.5% 2.7% 2.4%
Amounts related to operating leases:
Operating lease liabilities at end of period
Rent expense
Capitalized interest
Weighted-average interest rate for capitalization of interest during the period 3.22% 3.30% 3.47% 3.44% 3.66%

All values are in US Dollars.

| Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 | 17 | | --- | --- || Financial and Asset Base Highlights (continued) | | --- | | December 31, 2021 | | (Dollars in thousands, except annual rental revenue per occupied RSF amounts) || | Three Months Ended (unless stated otherwise) | | | | | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | | 12/31/21 | | | 9/30/21 | | 6/30/21 | | 3/31/21 | | 12/31/20 | | | Amounts included in funds from operations and non-revenue-enhancing capital expenditures | | | | | | | | | | | | | Straight-line rent revenue | $ | 25,942 | | $ | 33,918 | $ | 27,903 | $ | 27,382 | $ | 23,890 | | Amortization of acquired below-market leases | $ | 15,737 | | $ | 13,664 | $ | 13,267 | $ | 12,112 | $ | 13,514 | | Straight-line rent expense on ground leases | $ | 301 | | $ | 58 | $ | 248 | $ | 290 | $ | 348 | | Stock compensation expense | $ | 14,253 | | $ | 9,728 | $ | 12,242 | $ | 12,446 | $ | 11,394 | | Amortization of loan fees | $ | 2,911 | | $ | 2,854 | $ | 2,859 | $ | 2,817 | $ | 2,905 | | Amortization of debt premiums | $ | 502 | | $ | 498 | $ | 465 | $ | 576 | $ | 869 | | Non-revenue-enhancing capital expenditures: | | | | | | | | | | | | | Building improvements | $ | 4,027 | | $ | 3,901 | $ | 3,669 | $ | 3,760 | $ | 3,466 | | Tenant improvements and leasing commissions | $ | 109,516 | (1) | $ | 16,409 | $ | 47,439 | $ | 16,035 | $ | 31,235 | | Operating statistics and related information (at end of period) | | | | | | | | | | | | | Number of properties – North America | 414 | | | 407 | | 381 | | 360 | | 338 | | | RSF – North America (including development and redevelopment projects under construction) | 43,670,737 | | | 43,044,195 | | 40,076,883 | | 37,916,882 | | 35,163,572 | | | Total square feet – North America | 66,970,705 | | | 63,858,780 | | 58,108,390 | | 52,591,039 | | 49,712,701 | | | Annual rental revenue per occupied RSF – North America | $ | 48.65 | (2) | $ | 47.73 | $ | 48.65 | $ | 49.58 | $ | 49.08 | | Occupancy of operating properties – North America | 94.0% | | | 94.4% | | 94.3% | | 94.5% | | 94.6% | | | Occupancy of operating properties – North America (excluding vacancy at recently acquired properties) | 98.7% | | (3) | 98.5% | | 98.1% | | 98.0% | | 97.7% | | | Occupancy of operating and redevelopment properties – North America | 88.5% | | | 89.6% | | 90.1% | | 89.2% | | 90.0% | | | Weighted-average remaining lease term (in years) | 7.5 | | | 7.4 | | 7.5 | | 7.6 | | 7.6 | | | Total leasing activity – RSF | 4,094,174 | | | 1,810,630 | | 1,933,838 | | 1,677,659 | | 1,369,599 | | | Lease renewals and re-leasing of space – change in average new rental rates over expiring rates: | | | | | | | | | | | | | Rental rate increases | 35.9% | | | 35.3% | | 42.4% | | 36.2% | | 29.8% | | | Rental rate increases (cash basis) | 22.9% | | | 19.3% | | 25.4% | | 17.4% | | 10.7% | | | RSF (included in total leasing activity above) | 1,947,727 | | | 671,775 | | 1,472,713 | | 521,825 | | 699,916 | | | Same property – percentage change over comparable quarter from prior year: | | | | | | | | | | | | | Net operating income increase | 5.0% | | | 3.0% | | 3.7% | | 4.4% | | 2.7% | | | Net operating income increase (cash basis) | 7.5% | | | 7.1% | | 7.8% | | 6.1% | | 5.0% | |

(1)Refer to “Leasing activity” in this Supplemental Information for additional details.

(2)The decrease in weighted-average annual rental revenue per occupied RSF during the quarters ended in 2021 compared to 2020 is related to our properties acquired during 2021 with 5.9 million RSF occupied primarily under in-place leases with weighted-average annual rental revenue per occupied RSF of $31.50. Excluding 2021 acquisitions, weighted average annual rental revenue per occupied RSF was $51.99, up $2.91 or 5.9% from $49.08 in effect as of December 31, 2020.

(3)Refer to “Occupancy” in this Supplemental Information for additional details.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 18
High-Quality, Diverse, and Innovative Tenants
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December 31, 2021

Long-Duration Cash Flows From High-Quality, Diverse, and

Innovative Tenants

Investment-Grade or<br>Publicly Traded Large Cap Tenants Industry Mix of 850+ Tenants
51%
of ARE’s Total Annual Rental Revenue(1)
Long-Duration Lease Terms
7.5 Years
Weighted-Average Remaining Term(2)
Percentage of ARE’s Annual Rental Revenue(1)

(1)Represents annual rental revenue in effect as of December 31, 2021.

(2)Based on aggregate annual rental revenue in effect as of December 31, 2021. Refer to “Annual rental revenue” in the “Definitions and reconciliations” of this Supplemental Information for additional details about our methodology on annual rental revenue from unconsolidated real estate joint ventures.

(3)Represents annual rental revenue currently generated from office space that is targeted for a future change in use. The weighted-average remaining term of these leases is 3.8 years.

(4)Our other tenants, aggregating 5.0% of our annual rental revenue, comprise 4.0% of annual rental revenue from technology, professional services, finance, telecommunications, and construction/real estate companies and only 1.0% from retail-related tenants.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 19
Class A Properties in AAA Locations
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December 31, 2021

High-Quality Cash Flows From High-Quality Tenants and

Class A Properties in AAA Locations

Industry-Leading<br>Tenant Roster AAA Locations
88%
of ARE’s Top 20 Tenants’
Annual Rental Revenue(1)
Is From Investment-Grade
or Publicly Traded Large Cap Tenants
Percentage of ARE’s Annual Rental Revenue(1)

(1)Represents annual rental revenue in effect as of December 31, 2021.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 20
Occupancy
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December 31, 2021 Solid Historical Occupancy(1) Occupancy Across Key Locations(2)
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96%
Over 10 Years

(1)Represents average occupancy of operating properties in North America as of each December 31 for the last 10 years.

(2)As of December 31, 2021.

(3)Excludes 1.8 million RSF, or 4.7%, of vacancy at recently acquired properties (noted below) representing lease-up opportunities that are expected to generate incremental annual rental revenues. This vacancy also includes 20% of various spaces, spread across multiple recently acquired properties, that are expected to be converted to laboratory/office space in the future. Approximately 48% of the vacant 1.8 million RSF is currently leased/negotiating, with occupancy expected primarily over the next two quarters. Excluding recently acquired vacancies, occupancy of operating properties in North America was 98.7% as of December 31, 2021, up 100 bps from 97.7% as of December 31, 2020. The following table provides vacancy detail for our recent acquisitions:

As of December 31, 2021 Percentage of Vacancy Leased/Negotiating
Vacant Occupancy Impact
Property Market/Submarket RSF Region Consolidated
601, 611, and 651 Gateway Boulevard San Francisco Bay Area/South San Francisco 318,119 4.0 % 0.8 % 44 %
Alexandria Center® for Life Science – Durham Research Triangle/Research Triangle 150,337 4.5 % 0.4 99
275 Grove Street Greater Boston/Route 128 134,889 1.3 % 0.3 48
SD Tech by Alexandria San Diego/Sorrento Mesa 93,494 1.2 % 0.2 8
Other Greater Boston/Other 94,849 0.9 % 0.2 94
Alexandria Center® for Life Science – Fenway Greater Boston/Fenway 81,831 0.8 % 0.2 32
Other acquisitions Various 937,043 N/A 2.6 42
1,810,562 4.7 % 48 % Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 21
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Key Operating Metrics
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December 31, 2021 Historical Same Property<br>Net Operating Income Growth Favorable Lease Structure(1)
--- --- --- --- --- ---
q421sampropav2a.jpg Strategic Lease Structure by Owner and Operator of Collaborative <br>Life Science, Agtech, and Technology Campuses
Increasing cash flows
Percentage of leases containing<br><br>annual rent escalations 95%
Stable cash flows
Percentage of triple<br><br>net leases 91% (2)
Lower capex burden
Percentage of leases providing for the<br><br>recapture of capital expenditures 94%
Historical Rental Rate Growth: <br>Renewed/Re-Leased Space Margins(3)
Operating Adjusted EBITDA
70% 71%

(1)Percentages calculated based on RSF as of December 31, 2021.

(2)Decline to 91% from 94% as of December 31, 2020 is primarily related to non-triple net leases in place at operating properties with future development or redevelopment opportunities acquired during the year ended December 31, 2021. We expect to transition these properties to our triple net lease structure in conjunction with our future development or redevelopment activities.

(3)Represents percentages for the three months ended December 31, 2021.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 22
Same Property Performance
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December 31, 2021
(Dollars in thousands) December 31, 2021 December 31, 2021
--- --- --- --- --- ---
Same Property Financial Data Three Months Ended Year Ended Same Property Statistical Data Three Months Ended Year Ended
Percentage change over comparable period from prior year: Number of same properties 275 247
Net operating income increase 5.0% 4.2% Rentable square feet 27,398,046 23,490,412
Net operating income increase (cash basis) 7.5% 7.1% Occupancy – current-period average 94.9% 96.6%
Operating margin 71% 72% Occupancy – same-period prior-year average 94.7% 96.3%
Three Months Ended December 31, Year Ended December 31,
--- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
2021 2020 Change % Change 2021 2020 Change % Change
Income from rentals:
Same properties $ 342,992 $ 324,436 5.7 % $ 1,220,160 $ 1,171,595 4.1 %
Non-same properties 92,645 29,514 63,131 213.9 398,432 300,245 98,187 32.7
Rental revenues 435,637 353,950 81,687 23.1 1,618,592 1,471,840 146,752 10.0
Same properties 115,697 101,394 14,303 14.1 406,162 370,895 35,267 9.5
Non-same properties 23,322 5,991 17,331 289.3 83,495 35,473 48,022 135.4
Tenant recoveries 139,019 107,385 31,634 29.5 489,657 406,368 83,289 20.5
Income from rentals 574,656 461,335 113,321 24.6 2,108,249 1,878,208 230,041 12.2
Same properties 93 131 (38) (29.0) 475 366 109 29.8
Non-same properties 2,174 2,254 (80) (3.5) 5,426 7,063 (1,637) (23.2)
Other income 2,267 2,385 (118) (4.9) 5,901 7,429 (1,528) (20.6)
Same properties 458,782 425,961 32,821 7.7 1,626,797 1,542,856 83,941 5.4
Non-same properties 118,141 37,759 80,382 212.9 487,353 342,781 144,572 42.2
Total revenues 576,923 463,720 113,203 24.4 2,114,150 1,885,637 228,513 12.1
Same properties 134,401 117,069 17,332 14.8 456,705 420,264 36,441 8.7
Non-same properties 41,316 19,698 21,618 109.7 166,850 109,960 56,890 51.7
Rental operations 175,717 136,767 38,950 28.5 623,555 530,224 93,331 17.6
Same properties 324,381 308,892 15,489 5.0 1,170,092 1,122,592 47,500 4.2
Non-same properties 76,825 18,061 58,764 325.4 320,503 232,821 87,682 37.7
Net operating income $ 401,206 $ 326,953 22.7 % $ 1,490,595 $ 1,355,413 10.0 %
Net operating income – same properties $ 324,381 $ 308,892 5.0 % $ 1,170,092 $ 1,122,592 4.2 %
Straight-line rent revenue (16,332) (21,396) 5,064 (23.7) (60,157) (82,681) 22,524 (27.2)
Amortization of acquired below-market leases (7,632) (8,142) 510 (6.3) (12,357) (15,348) 2,991 (19.5)
Net operating income – same properties (cash basis) $ 300,417 $ 279,354 7.5 % $ 1,097,578 $ 1,024,563 7.1 %

All values are in US Dollars.

Refer to “Same property comparisons” in the “Definitions and reconciliations” of this Supplemental Information for a reconciliation of same properties to total properties. “Definitions and reconciliations” also contains definitions of “Tenant recoveries” and “Net operating income” and their respective reconciliations from the most directly comparable financial measures presented in accordance with GAAP.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 23
Leasing Activity
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December 31, 2021
(Dollars per RSF)
Three Months Ended Year Ended Year Ended
--- --- --- --- --- --- --- --- --- --- ---
December 31, 2021 December 31, 2021 December 31, 2020
Including <br>Straight-Line Rent Cash Basis Cash Basis Including <br>Straight-Line Rent
Leasing activity:
Renewed/re-leased space(1)
Rental rate changes 35.9% 22.9% 37.9% 22.6% 37.6% 18.3%
New rates 61.09 56.29 59.00 55.60 49.51 $46.53
Expiring rates 44.95 45.79 42.80 45.36 35.99 $39.32
RSF 1,947,727 4,614,040 2,556,833
Tenant improvements/leasing commissions 55.76 41.05 35.08
Weighted-average lease term 7.3 years 6.3 years 6.0 years
Developed/redeveloped/previously vacant space leased(5)
New rates 85.69 75.52 78.52 69.42 56.67 $53.61
RSF 2,146,447 4,902,261 1,802,013
Weighted-average lease term 12.2 years 11.2 years 9.0 years
Leasing activity summary (totals):
New rates 73.99 66.37 69.05 62.72 52.47 $49.46
RSF 4,094,174 9,516,301 4,358,846
Weighted-average lease term 9.8 years 8.8 years 7.3 years
Lease expirations(1)
Expiring rates 43.38 44.63 41.53 43.70 36.03 $39.01
RSF 2,427,571 5,747,192 3,560,188

All values are in US Dollars.

Leasing activity includes 100% of results for each property in which we have an investment in North America.

(1)Excludes month-to-month leases aggregating 110,180 RSF and 96,383 RSF as of December 31, 2021 and 2020, respectively.

(2)Represents the highest annual rental rate growth in Company history.

(3)Represents the highest quarterly and annual leasing volumes in Company history.

(4)Includes tenant improvements and leasing commissions averaging $78.91 per RSF related to long-term lease extensions aggregating 938,004 RSF with two tenants in Greater Boston. The weighted-average lease term of these extensions was 8.0 years, with a weighted-average increase of 50% in net effective rents from the existing leases. Excluding these leases, new tenant improvements and leasing commissions for renewed/re-leased space was $34.27 and $31.39 per RSF during the three months and year ended December 31, 2021, respectively.

(5)Refer to “New Class A development and redevelopment properties: summary of pipeline” of this Supplemental Information for additional information on total project costs.

(6)During the year ended December 31, 2021, we granted tenant concessions/free rent averaging 2.4 months with respect to the 9,516,301 RSF leased. Approximately 54% of the leases executed during the year ended December 31, 2021 did not include concessions for free rent.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 24
Contractual Lease Expirations
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December 31, 2021 Year RSF Percentage of<br>Occupied RSF Annual Rental Revenue (per RSF)(1) Percentage of Total<br>Annual Rental Revenue
--- --- --- --- --- --- --- --- --- --- --- --- --- ---
2022 (2) 2,793,222 7.7 % $ 40.58 6.5 %
2023 3,827,027 10.5 % $ 40.73 8.9 %
2024 3,166,324 8.7 % $ 43.36 7.9 %
2025 2,978,305 8.2 % $ 50.41 8.6 %
2026 2,267,304 6.2 % $ 47.63 6.2 %
2027 2,135,473 5.9 % $ 45.41 5.6 %
2028 3,322,877 9.1 % $ 52.67 10.0 %
2029 2,089,274 5.7 % $ 56.45 6.8 %
2030 2,186,023 6.0 % $ 57.85 7.2 %
2031 2,617,681 7.2 % $ 59.61 8.9 %
Thereafter 9,000,095 24.8 % $ 45.39 23.4 %
Market 2022 Contractual Lease Expirations (in RSF) Annual Rental Revenue<br><br>(per RSF)(1) 2023 Contractual Lease Expirations (in RSF) Annual Rental Revenue<br><br>(per RSF)(1)
--- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Leased Negotiating/<br>Anticipating Targeted for<br><br>Development/<br><br>Redevelopment(3) Remaining<br><br>Expiring<br><br>Leases(4) Total(2) Leased Negotiating/<br>Anticipating Targeted for<br>Development/<br>Redevelopment Remaining<br>Expiring Leases Total
Greater Boston 112,267 188,384 295,070 595,721 $ 56.30 66,361 14,857 312,845 751,245 1,145,308 $ 49.57
San Francisco Bay Area 57,726 60,906 490,127 90,111 698,870 49.09 431,620 (6) 431,620 66.57
New York City 14,891 6,918 5,085 26,894 N/A 52,724 52,724 N/A
San Diego 123,522 52,652 305,034 (5) 155,646 636,854 35.85 269,053 269,048 744,404 1,282,505 34.12
Seattle 26,177 51,255 123,760 201,192 25.94 84,782 227,636 312,418 21.95
Maryland 70,933 88,187 159,120 21.08 144,051 207,761 351,812 26.19
Research Triangle 40,884 62,490 106,172 209,546 23.24 219,521 219,521 31.18
Canada 26,426 2,197 28,623 20.18 13,224 13,224 30.65
Non-cluster/other markets 65,188 70,700 100,514 236,402 21.84 17,895 17,895 68.01
Total 446,649 400,225 979,606 966,742 2,793,222 $ 40.58 66,361 441,185 666,675 2,652,806 3,827,027 $ 40.73
Percentage of expiring leases 16 % 14 % 35 % 35 % 100 % 2 % 12 % 17 % 69 % 100 %

(1)Represents amounts in effect as of December 31, 2021.

(2)Excludes month-to-month leases aggregating 110,180 RSF as of December 31, 2021.

(3)Represents RSF targeted for development or redevelopment upon expiration of existing in-place leases primarily related to recently acquired properties with an average contractual lease expiration date, weighted by annual rental revenue, of May 2, 2022. Refer to “Investments in real estate” in the “Definitions and reconciliations” of this Supplemental Information for additional details on value-creation square feet currently included in rental properties.

(4)The largest remaining contractual expiration is 113,555 RSF in our Cambridge/Inner Suburbs submarket.

(5)Includes 139,135 RSF at 11255 and 11355 North Torrey Pines Road in our Torrey Pines submarket which we plan to develop into two buildings totaling 309,094 RSF that are fully leased.

(6)Includes 76,752 RSF at 3412 Hillview Avenue in our Greater Stanford submarket which is under evaluation to be redeveloped, subject to market conditions.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 25
Top 20 Tenants
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December 31, 2021
(Dollars in thousands, except average market cap amounts)

88% of Top 20 Annual Rental Revenue From Investment-Grade

or Publicly Traded Large Cap Tenants(1)

Tenant Remaining Lease Term(1) (in years) Aggregate <br>RSF Annual Rental Revenue(1) Percentage of Aggregate Annual Rental Revenue(1) Investment-Grade <br>Credit Ratings Average Market Cap(1)<br><br>(in billions)
Moody’s S&P
1 Bristol-Myers Squibb Company 6.7 916,234 $ 53,085 3.0 % A2 A+ $ 140.6
2 Moderna, Inc. 15.1 855,458 52,709 3.0 $ 99.2
3 Eli Lilly and Company 7.5 645,178 40,846 2.3 A2 A+ $ 214.9
4 Sanofi 6.8 589,464 40,808 2.3 A1 AA $ 126.5
5 Takeda Pharmaceutical Company Ltd. 7.6 606,249 39,416 2.3 Baa2 BBB+ $ 51.9
6 Illumina, Inc. 8.6 891,495 36,141 2.1 Baa3 BBB $ 63.4
7 2seventy bio, Inc.(2) 11.7 312,805 33,558 1.9 $ 0.7
8 Novartis AG 6.6 447,820 30,582 1.8 A1 AA- $ 215.8
9 Roche 5.8 561,883 30,149 1.7 Aa3 AA $ 322.0
10 Uber Technologies, Inc. 61.0 (3) 1,009,188 27,488 1.6 $ 91.5
11 Merck & Co., Inc. 10.8 349,429 22,276 1.3 A1 A+ $ 196.1
12 Maxar Technologies 3.7 (4) 478,000 21,803 1.2 $ 2.4
13 Massachusetts Institute of Technology 7.0 257,626 21,165 1.2 Aaa AAA $
14 United States Government 13.2 918,516 20,697 1.2 Aaa AA+ $
15 The Children's Hospital Corporation 14.8 269,816 20,066 1.1 Aa2 AA $
16 New York University 9.9 203,500 19,241 1.1 Aa2 AA- $
17 Pfizer Inc. 3.2 416,996 17,799 1.0 A2 A+ $ 235.8
18 SAP 3.2 211,293 17,479 1.0 A2 A $ 169.2
19 FibroGen, Inc. 6.9 234,249 16,896 1.0 $ 2.1
20 Amgen Inc. 2.3 407,369 16,838 1.0 Baa1 A- $ 132.5
Total/weighted-average 10.9 (3) 10,582,568 $ 579,042 33.1 %

(1)Based on aggregate annual rental revenue in effect as of December 31, 2021. Refer to “Annual rental revenue” and “Investment-grade or publicly traded large cap tenants” in the “Definitions and reconciliations” of this Supplemental Information for additional details about our methodology on annual rental revenue from unconsolidated real estate joint ventures and average daily market capitalization.

(2)2seventy bio, Inc. is a publicly-traded, commercial-stage cell therapy company developing a pipeline of engineered T cells to better treat cancer. 2seventy bio, Inc. was formerly the oncology division of bluebird bio, Inc. and spun out from bluebird in November 2021.

(3)Includes (i) ground leases for land at 1455 and 1515 Third Street (two buildings aggregating 422,980 RSF) and (ii) leases at 1655 and 1725 Third Street (two buildings aggregating 586,208 RSF) owned by our unconsolidated real estate joint venture in which we have an ownership interest of 10%. Annual rental revenue is presented using 100% of the annual rental revenue of our consolidated properties and our share of annual rental revenue for our unconsolidated real estate joint ventures. Refer to footnote 1 for additional details. Excluding the ground leases, the weighted-average remaining lease term for our top 20 tenants was 8.4 years as of December 31, 2021.

(4)Represents remaining lease term at two recently acquired properties with future redevelopment and development opportunities. The leases with this tenant were in place when we acquired the properties in 2019.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 26
Summary of Properties and Occupancy
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December 31, 2021
(Dollars in thousands, except per RSF amounts)

Summary of properties

Market RSF Number of Properties Annual Rental Revenue
Operating Development Redevelopment Total % of Total Total % of Total Per RSF
Greater Boston 9,992,631 972,216 1,440,756 12,405,603 28 % 84 $ 621,025 36 % $ 65.30
San Francisco Bay Area 8,041,015 332,821 34,604 8,408,440 19 67 424,836 24 61.09
New York City 1,174,016 96,003 1,270,019 3 5 85,099 5 73.67
San Diego 7,889,614 486,004 121,662 8,497,280 19 103 286,784 16 39.04
Seattle 2,639,312 311,631 213,976 3,164,919 7 44 100,497 6 39.82
Maryland 3,961,376 84,264 157,428 4,203,068 10 52 106,786 6 27.48
Research Triangle 3,308,463 257,644 325,936 3,892,043 9 36 81,706 5 26.10
Canada 552,018 552,018 1 6 10,070 1 23.20
Non-cluster/other markets 1,277,347 1,277,347 4 17 29,777 1 31.05
North America 38,835,792 2,444,580 2,390,365 43,670,737 100 % 414 $ 1,746,580 100 % $ 48.65
4,834,945

Summary of occupancy

Operating Properties Operating and Redevelopment Properties
Market 12/31/21 9/30/21 12/31/20 12/31/21 9/30/21 12/31/20
Greater Boston 95.2 % (1) 94.3 % 98.1 % 83.2 % 86.7 % 94.8 %
San Francisco Bay Area 93.0 (1) 94.5 95.8 92.6 94.0 94.7
New York City 98.4 98.3 97.3 91.0 90.2 87.8
San Diego 93.1 (1) 93.9 93.5 91.7 92.5 92.4
Seattle 95.6 96.2 96.0 88.5 89.2 85.5
Maryland 99.8 99.7 96.1 96.0 91.0 90.6
Research Triangle 94.6 (1) 94.1 89.6 86.1 85.4 72.7
Subtotal 94.9 95.0 95.5 89.1 90.1 90.7
Canada 78.6 82.8 81.8 78.6 82.8 81.8
Non-cluster/other markets 75.1 76.2 52.7 75.1 76.2 52.7
North America 94.0 % (1) 94.4 % 94.6 % 88.5 % 89.6 % 90.0 %

(1)Refer to “Occupancy” of this Supplemental Information for additional details on vacancy at recently acquired properties.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 27
Property Listing
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December 31, 2021
(Dollars in thousands)

Mega Campuses Encompass 63% of Our Operating Property RSF(1)

Market / Submarket / Address RSF Number of Properties Annual Rental Revenue Occupancy Percentage
Operating Operating and Redevelopment
Operating Development Redevelopment Total
Greater Boston
Cambridge/Inner Suburbs
Mega Campus: Alexandria Center® at Kendall Square 2,369,854 403,892 2,773,746 11 $ 182,839 98.9 % 84.5 %
50(2), 60(2), 75/125(2), 100, and 225(2) Binney Street, 161 and 215 First Street, 150 Second Street, 300 Third Street, 11 Hurley Street, and One Rogers Street
Mega Campus: Alexandria Center® at One Kendall Square 814,779 462,100 1,276,879 11 69,341 96.6 96.6
One Kendall Square – Buildings 100, 200, 300, 400, 500, 600/700, 1400, 1800, and 2000, and 325 and 399 Binney Street
Mega Campus: Alexandria Technology Square® 1,181,635 1,181,635 7 114,713 99.8 99.8
100, 200, 300, 400, 500, 600, and 700 Technology Square
Mega Campus: The Arsenal on the Charles 622,098 250,567 872,665 11 30,432 93.8 66.9
311, 321, and 343 Arsenal Street, 300 and 400 North Beacon Street,<br>     1, 2, and 3 Kingsbury Avenue, and 100, 200, and 400 Talcott Avenue
Mega Campus: 480 Arsenal Way and 500 and 550 Arsenal Street 495,127 495,127 3 21,227 98.3 98.3
640 Memorial Drive 225,504 225,504 1 14,431 100.0 100.0
780 and 790 Memorial Drive 99,658 99,658 2 8,786 100.0 100.0
167 Sidney Street and 99 Erie Street 54,549 54,549 2 4,027 100.0 100.0
79/96 13th Street (Charlestown Navy Yard) 25,309 25,309 1 797 100.0 100.0
Cambridge/Inner Suburbs 5,888,513 462,100 654,459 7,005,072 49 446,593 98.2 88.4
Fenway
Mega Campus: Alexandria Center® for Life Science – Fenway 927,499 510,116 1,437,615 2 59,023 91.2 91.2
401 Park Drive and 201 Brookline Avenue(2)
Seaport Innovation District
Mega Campus: 380 and 420 E Street 195,506 195,506 2 4,209 100.0 100.0
5 Necco Street 87,163 87,163 1 5,888 86.6 86.6
Seaport Innovation District 282,669 282,669 3 10,097 95.9 95.9
Route 128
Mega Campus: One Upland Road, 100 Tech Drive, and One Investors Way 706,988 706,988 4 29,189 96.7 96.7
Reservoir Woods 312,845 202,428 515,273 3 15,469 100.0 60.7
40, 50, and 60 Sylvan Road
275 Grove Street 509,702 509,702 1 15,649 73.5 73.5
Alexandria Park at 128 343,882 343,882 8 12,949 100.0 100.0
3 and 6/8 Preston Court, 29, 35, and 44 Hartwell Avenue, 35 and 45/47 Wiggins Avenue, and 60 Westview Street
225, 266, and 275 Second Avenue 316,865 316,865 3 15,479 90.8 90.8
840 Winter Street 30,009 130,000 160,009 1 1,239 95.1 17.8
19 Presidential Way 144,892 144,892 1 5,362 99.8 99.8
100 Beaver Street 82,330 82,330 1 4,941 100.0 100.0
285 Bear Hill Road 26,270 26,270 1 1,167 100.0 100.0
Route 128 2,473,783 332,428 2,806,211 23 $ 101,444 92.3 % 81.4 %
(1)As of December 31, 2021. Mega campuses are cluster campuses that consist of approximately 1 million or more RSF, including operating, active development/redevelopment, and land RSF less operating RSF expected to be demolished. Refer to the “Summary of pipeline” and “Definitions and reconciliations” of this Supplemental Information for additional details.<br><br>(2)We own a partial interest in this property through a real estate joint venture. Refer to “Joint venture financial information” of this Supplemental Information for additional details. Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 28
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December 31, 2021
(Dollars in thousands) Market / Submarket / Address RSF Number of Properties Annual Rental Revenue Occupancy Percentage
--- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Operating Operating and Redevelopment
Operating Development Redevelopment Total
Greater Boston (continued)
Route 495
111 and 130 Forbes Boulevard 155,846 155,846 2 $ 1,826 100.0 % 100.0 %
20 Walkup Drive 91,045 91,045 1 649 100.0 100.0
Route 495 246,891 246,891 3 2,475 100.0 100.0
Other 173,276 453,869 627,145 4 1,393 44.9 12.4
Greater Boston 9,992,631 972,216 1,440,756 12,405,603 84 621,025 95.2 83.2
San Francisco Bay Area
Mission Bay
Mega Campus: Alexandria Center® for Science and Technology –<br><br>Mission Bay(1) 2,015,177 2,015,177 9 97,216 98.7 98.7
1455(2), 1515(2), 1655, and 1725 Third Street, 409 and 499 Illinois Street, 1500 and 1700 Owens Street, and 455 Mission Bay Boulevard South
Mission Bay 2,015,177 2,015,177 9 97,216 98.7 98.7
South San Francisco
Mega Campus: Alexandria Technology Center® – Gateway(1) 1,415,175 230,592 1,645,767 12 56,712 76.5 76.5
600(2), 601, 611, 630(2), 650(2), 651, 681, 685, 701, 751, 901(2), and 951(2)<br><br>Gateway Boulevard
Mega Campus: 213(1), 249, 259, 269, and 279 East Grand Avenue 919,704 919,704 5 48,951 100.0 100.0
Alexandria Center® for Life Science – South San Francisco 443,447 52,311 495,758 3 26,509 84.6 84.6
201 Haskins Way and 400 and 450 East Jamie Court
Mega Campus: 1122 El Camino Real 223,232 223,232 1 3,102 100.0 100.0
500 Forbes Boulevard(1) 155,685 155,685 1 10,680 100.0 100.0
7000 Shoreline Court 139,709 139,709 1 8,632 100.0 100.0
341 and 343 Oyster Point Boulevard 108,208 108,208 2 6,578 100.0 100.0
849/863 Mitten Road/866 Malcolm Road 103,857 103,857 1 4,716 100.0 100.0
South San Francisco 3,509,017 282,903 3,791,920 26 165,880 88.6 88.6
Greater Stanford
Mega Campus: Alexandria Center® for Life Science – San Carlos 689,274 49,918 739,192 9 43,398 95.3 95.3
825, 835, 960, and 1501-1599 Industrial Road
3825 and 3875 Fabian Way 478,000 478,000 2 21,802 100.0 100.0
Alexandria Stanford Life Science District 347,381 34,604 381,985 4 29,597 100.0 90.9
3160, 3165, 3170, and 3181 Porter Drive
3330, 3412, 3420, 3440, 3450, and 3460 Hillview Avenue 368,495 368,495 6 26,779 87.4 87.4
Alexandria PARC 197,498 197,498 4 9,302 78.0 78.0
2100, 2200, 2300, and 2400 Geng Road
2475 and 2625/2627/2631 Hanover Street 116,869 116,869 2 9,972 100.0 100.0
2425 Garcia Avenue/2400/2450 Bayshore Parkway 99,208 99,208 1 $ 4,257 100.0 % 100.0 %
Mega campuses are cluster campuses that consist of approximately 1 million or more RSF, including operating, active development/redevelopment, and land RSF less operating RSF expected to be demolished. Refer to the “Summary of pipeline” and “Definitions and reconciliations” of this Supplemental Information for additional details.<br><br><br><br>(1)We own a partial interest in this property through a real estate joint venture. Refer to “Joint venture financial information” of this Supplemental Information for additional details.<br><br>(2)We own 100% of this property. Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 29
--- --- Property Listing (continued)
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December 31, 2021
(Dollars in thousands) Market / Submarket / Address RSF Number of Properties Annual Rental Revenue Occupancy Percentage
--- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Operating Operating and Redevelopment
Operating Development Redevelopment Total
San Francisco Bay Area (continued)
Greater Stanford (continued)
Shoreway Science Center 82,462 82,462 2 $ 5,220 100.0 % 100.0 %
75 and 125 Shoreway Road
1450 Page Mill Road 77,634 77,634 1 8,009 100.0 100.0
3350 West Bayshore Road 60,000 60,000 1 3,404 83.3 83.3
Greater Stanford 2,516,821 49,918 34,604 2,601,343 32 161,740 94.7 93.5
San Francisco Bay Area 8,041,015 332,821 34,604 8,408,440 67 424,836 93.0 92.6
New York City
New York City
Mega Campus: Alexandria Center® for Life Science – New York City 740,972 740,972 3 67,283 97.5 97.5
430 and 450 East 29th Street
219 East 42nd Street 349,947 349,947 1 14,006 100.0 100.0
Alexandria Center® for Life Science – Long Island City 83,097 96,003 179,100 1 3,810 100.0 46.4
30-02 48th Avenue
New York City 1,174,016 96,003 1,270,019 5 85,099 98.4 91.0
San Diego
Torrey Pines
Mega Campus: One Alexandria Square 987,791 146,456 1,134,247 13 40,730 92.4 92.4
3115 and 3215 Merryfield Row, 3010, 3013, and 3033 Science Park Road, 10931/10933, 10975, 11119, 11255, and 11355 North Torrey Pines Road, 10975, 10995, and 10996 Torreyana Road, and 3545 Cray Court
ARE Torrey Ridge 298,863 298,863 3 15,570 99.3 99.3
10578, 10618, and 10628 Science Center Drive
ARE Nautilus 213,900 213,900 4 12,323 100.0 100.0
3530 and 3550 John Hopkins Court and 3535 and 3565 General Atomics Court
Torrey Pines 1,500,554 146,456 1,647,010 20 68,623 94.9 94.9
University Town Center
Mega Campus: Alexandria Point(1) 1,435,916 1,435,916 8 65,221 96.4 96.4
9880(2), 10210, 10260, 10290, and 10300 Campus Point Drive and 4161, 4224, and 4242 Campus Point Court
Mega Campus: 5200 Illumina Way(1) 792,687 792,687 6 29,978 100.0 100.0
Mega Campus: University District 406,732 406,732 5 17,616 100.0 100.0
9625 Towne Centre Drive(1), 4755, 4757, and 4767 Nexus Center Drive, and 4796 Executive Drive
University Town Center 2,635,335 2,635,335 19 $ 112,815 98.1 % 98.1 %
Mega campuses are cluster campuses that consist of approximately 1 million or more RSF, including operating, active development/redevelopment, and land RSF less operating RSF expected to be demolished. Refer to the “Summary of pipeline” and “Definitions and reconciliations” of this Supplemental Information for additional details.<br><br><br><br>(1)We own a partial interest in this property through a real estate joint venture. Refer to “Joint venture financial information” of this Supplemental Information for additional details.<br><br>(2)We own 100% of this property. Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 30
--- --- Property Listing (continued)
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December 31, 2021
(Dollars in thousands) Market / Submarket / Address RSF Number of Properties Annual Rental Revenue Occupancy Percentage
--- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Operating Operating and Redevelopment
Operating Development Redevelopment Total
San Diego (continued)
Sorrento Mesa
Mega Campus: SD Tech by Alexandria(1) 810,517 195,435 51,621 1,057,573 14 $ 25,338 85.3 % 80.2 %
9605, 9645, 9675, 9685, 9725, 9735, 9808, 9855, and 9868 Scranton Road, 5505 Morehouse Drive(2), and 10055, 10065, 10121(2), and 10151(2) Barnes Canyon Road
Mega Campus: Sequence District by Alexandria 805,223 805,223 7 26,544 92.5 92.5
6260, 6290, 6310, 6340, 6350, 6420, and 6450 Sequence Drive
Pacific Technology Park(1) 632,732 632,732 6 9,088 88.1 88.1
9389, 9393, 9401, 9444, 9455, and 9477 Waples Street
Summers Ridge Science Park 316,531 316,531 4 11,077 100.0 100.0
9965, 9975, 9985, and 9995 Summers Ridge Road
ARE Portola 101,857 101,857 3 3,603 100.0 100.0
6175, 6225, and 6275 Nancy Ridge Drive
7330 and 7360 Carroll Road 84,441 84,441 2 2,643 85.7 85.7
5810/5820 Nancy Ridge Drive 83,354 83,354 1 1,042 40.9 40.9
9877 Waples Street 63,774 63,774 1 2,374 100.0 100.0
5871 Oberlin Drive 33,842 33,842 1 815 50.1 50.1
Sorrento Mesa 2,932,271 195,435 51,621 3,179,327 39 82,524 88.6 87.1
Sorrento Valley
3911, 3931, 3985, 4025, 4031, and 4045 Sorrento Valley Boulevard 151,406 151,406 6 5,401 100.0 100.0
11025, 11035, 11045, 11055, 11065, and 11075 Roselle Street 121,655 121,655 6 3,290 95.0 95.0
Sorrento Valley 273,061 273,061 12 8,691 97.8 97.8
Other 548,393 144,113 70,041 762,547 13 14,131 86.0 76.3
San Diego 7,889,614 486,004 121,662 8,497,280 103 286,784 93.1 91.7
Seattle
Lake Union
Mega Campus: The Eastlake Life Science Campus by Alexandria 937,290 311,631 1,248,921 9 54,997 99.5 99.5
1150, 1165, 1201(1), 1208(1), 1551, and 1616 Eastlake Avenue East, 188 and 199(1) East Blaine Street, and 1600 Fairview Avenue East
Mega Campus: Alexandria Center® for Life Science – South Lake Union
400(1) and 601 Dexter Avenue North 308,791 308,791 2 15,130 100.0 100.0
219 Terry Avenue North 30,705 30,705 1 1,853 100.0 100.0
Lake Union 1,276,786 311,631 1,588,417 12 71,980 99.6 99.6
SoDo
830 4th Avenue South 42,380 42,380 1 1,576 70.5 70.5
Elliott Bay
3000/3018 Western Avenue 47,746 47,746 1 1,839 100.0 100.0
410 West Harrison Street and 410 Elliott Avenue West 36,849 36,849 2 1,395 100.0 100.0
Elliott Bay 84,595 84,595 3 $ 3,234 100.0 % 100.0 %
Mega campuses are cluster campuses that consist of approximately 1 million or more RSF, including operating, active development/redevelopment, and land RSF less operating RSF expected to be demolished. Refer to the “Summary of pipeline” and “Definitions and reconciliations” of this Supplemental Information for additional details.<br><br><br><br>(1)We own a partial interest in this property through a real estate joint venture. Refer to “Joint venture financial information” of this Supplemental Information for additional details.<br><br>(2)We own 100% of this property. Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 31
--- --- Property Listing (continued)
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December 31, 2021
(Dollars in thousands) Market / Submarket / Address RSF Number of Properties Annual Rental Revenue Occupancy Percentage
--- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Operating Operating and Redevelopment
Operating Development Redevelopment Total
Seattle (continued)
Bothell
Mega Campus: Alexandria Center® for Advanced Technologies – Canyon Park 886,467 886,467 20 $ 17,827 90.9 % 90.9 %
22121 and 22125 17th Avenue Southeast, 22021, 22025, 22026, 22030, 22118, and 22122 20th Avenue Southeast, 22333, 22422, 22515, 22522, 22722, and 22745 29th Drive Southeast, 21540 30th Drive Southeast, and 1629, 1631, 1725, 1916, and 1930 220th Street Southeast
Alexandria Center® for Advanced Technologies – Monte Villa Parkway 246,647 213,976 460,623 6 4,817 95.4 51.1
3301, 3303, 3305, 3307, 3555, and 3755 Monte Villa Parkway
Bothell 1,133,114 213,976 1,347,090 26 22,644 91.9 77.3
Other 102,437 102,437 2 1,063 93.7 93.7
Seattle 2,639,312 311,631 213,976 3,164,919 44 100,497 95.6 88.5
Maryland
Rockville
Mega Campus: Alexandria Center® for Life Science – Shady Grove 1,642,741 84,264 76,878 1,803,883 21 42,720 100.0 95.5
9601, 9603, 9605, 9609, 9613, 9615, 9704, 9708, 9712, 9714, 9800, 9804, 9900, 9920, and 9950 Medical Center Drive, 14920 and 15010 Broschart Road, and 9920 Belward Campus Drive
1330 Piccard Drive 131,511 131,511 1 4,021 100.0 100.0
1405 and 1450(1) Research Boulevard 114,849 114,849 2 2,947 100.0 100.0
1500 and 1550 East Gude Drive 91,359 91,359 2 1,844 100.0 100.0
5 Research Place 63,852 63,852 1 2,950 100.0 100.0
5 Research Court 51,520 51,520 1 1,788 100.0 100.0
12301 Parklawn Drive 49,185 49,185 1 1,530 100.0 100.0
Rockville 2,145,017 84,264 76,878 2,306,159 29 57,800 100.0 96.5
Gaithersburg
Alexandria Technology Center® – Gaithersburg I 613,438 613,438 9 17,384 100.0 100.0
9, 25, 35, 45, 50, and 55 West Watkins Mill Road and 910, 930, and 940 Clopper Road
Alexandria Technology Center® – Gaithersburg II 486,324 486,324 7 17,637 100.0 100.0
700, 704, and 708 Quince Orchard Road and 19, 20, 21, and 22 Firstfield Road
20400 Century Boulevard 80,550 80,550 1 N/A
401 Professional Drive 63,154 63,154 1 1,911 100.0 100.0
950 Wind River Lane 50,000 50,000 1 1,004 100.0 100.0
620 Professional Drive 27,950 27,950 1 1,207 100.0 100.0
Gaithersburg 1,240,866 80,550 1,321,416 20 $ 39,143 100.0 % 93.9 %
Mega campuses are cluster campuses that consist of approximately 1 million or more RSF, including operating, active development/redevelopment, and land RSF less operating RSF expected to be demolished. Refer to the “Summary of pipeline” and “Definitions and reconciliations” of this Supplemental Information for additional details.<br><br><br><br>(1)We own a partial interest in this property through a real estate joint venture. Refer to “Joint venture financial information” of this Supplemental Information for additional details. Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 32
--- --- Property Listing (continued)
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December 31, 2021
(Dollars in thousands) Market / Submarket / Address RSF Number of Properties Annual Rental Revenue Occupancy Percentage
--- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Operating Operating and Redevelopment
Operating Development Redevelopment Total
Maryland (continued)
Beltsville
8000/9000/10000 Virginia Manor Road 191,884 191,884 1 $ 2,768 96.7 % 96.7 %
101 West Dickman Street(1) 135,423 135,423 1 948 100.0 100.0
Beltsville 327,307 327,307 2 3,716 98.0 98.0
Northern Virginia
14225 Newbrook Drive 248,186 248,186 1 6,127 100.0 100.0
Maryland 3,961,376 84,264 157,428 4,203,068 52 106,786 99.8 96.0
Research Triangle
Research Triangle
Mega Campus: Alexandria Center® for Life Science – Durham 1,912,211 325,936 2,238,147 16 36,948 92.1 78.7
6, 8, 10, 12, 14, 40, 41, 42, and 65 Moore Drive, 21, 25, 27, 29, and 31<br><br>Parmer Way, 2400 Ellis Road, and 14 TW Alexander Drive
Mega Campus: Alexandria Center® for Advanced Technologies 182,487 184,753 367,240 4 6,089 90.6 90.6
6, 8, 10, and 12 Davis Drive
Alexandria Center® for AgTech 267,509 72,891 340,400 2 11,064 100.0 100.0
5 and 9 Laboratory Drive
Alexandria Technology Center® – Alston 186,870 186,870 3 4,405 96.7 96.7
100, 800, and 801 Capitola Drive
108/110/112/114 TW Alexander Drive 158,417 158,417 1 5,196 97.4 97.4
Alexandria Innovation Center® – Research Triangle 136,729 136,729 3 4,155 100.0 100.0
7010, 7020, and 7030 Kit Creek Road
7 Triangle Drive 96,626 96,626 1 3,156 100.0 100.0
2525 East NC Highway 54 82,996 82,996 1 3,651 100.0 100.0
407 Davis Drive 81,956 81,956 1 1,644 100.0 100.0
601 Keystone Park Drive 77,395 77,395 1 1,375 100.0 100.0
6040 George Watts Hill Drive 61,547 61,547 1 2,148 100.0 100.0
5 Triangle Drive 32,120 32,120 1 1,147 100.0 100.0
6101 Quadrangle Drive 31,600 31,600 1 728 100.0 100.0
Research Triangle 3,308,463 257,644 325,936 3,892,043 36 81,706 94.6 86.1
Canada 552,018 552,018 6 10,070 78.6 78.6
Non-cluster/other markets 1,277,347 1,277,347 17 29,777 75.1 75.1
Total – North America 38,835,792 2,444,580 2,390,365 43,670,737 414 $ 1,746,580 94.0 % 88.5 %

Mega campuses are cluster campuses that consist of approximately 1 million or more RSF, including operating, active development/redevelopment, and land RSF less operating RSF expected to be demolished. Refer to the “Summary of pipeline” and “Definitions and reconciliations” of this Supplemental Information for additional details.

(1)We own a partial interest in this property through a real estate joint venture. Refer to “Joint venture financial information” of this Supplemental Information for additional details.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 33
Investments in Real Estate
---
December 31, 2021

Demand for our value-creation development and redevelopment projects of high-quality office/laboratory space and our continued operational excellence at our world-class, sophisticated laboratory facilities and strong execution by our team has translated into record leasing activity.

Projects Either Under Construction or<br><br>Expected to Commence Construction in the Next Six Quarters
>$610 Million<br><br>Projected Incremental Annual Rental Revenues<br><br>Primarily commencing from 1Q22 through 4Q24
7.4 million RSF(1)
83% Leased/Negotiating

As of December 31, 2021.

(1)Includes 4.8 million RSF under construction and 2.6 million RSF expected to commence construction in the next six quarters.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 34
Investments in Real Estate
---
December 31, 2021
(Dollars in thousands)
Development and Redevelopment
--- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Operating Under Construction Near<br>Term Intermediate<br>Term Future Subtotal Total
Investments in real estate
Book value as of December 31, 2021(1) $ 22,204,468 $ 3,168,442 $ 1,147,726 $ 738,464 $ 1,474,008 $ 6,528,640 $ 28,733,108
Square footage
Operating 38,835,792 38,835,792
New Class A development and redevelopment properties 4,834,945 6,209,111 (2) 3,855,608 17,620,857 32,520,521 32,520,521
Value-creation square feet currently included in rental properties(3) (1,250,525) (122,991) (3,012,092) (4,385,608) (4,385,608)
Total square footage 38,835,792 4,834,945 4,958,586 3,732,617 14,608,765 28,134,913 66,970,705

(1)Balances exclude depreciation and our share of the cost basis associated with our properties held by our unconsolidated real estate joint ventures, which is classified as investments in unconsolidated real estate joint ventures in our consolidated balance sheets. Refer to “Investments in real estate” in the “Definitions and reconciliations” of this Supplemental Information for reconciliation detail of investments in real estate.

(2)Includes 2,565,808 RSF currently 89% leased/negotiating expected to commence construction in the next six quarters. Refer to “New Class A development and redevelopment properties: current projects” for additional details.

(3)Refer to “Investments in real estate” in the “Definitions and reconciliations” of this Supplemental Information for additional details on value-creation square feet currently included in rental properties.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 35
New Class A Development and Redevelopment Properties: Recent Deliveries
---
December 31, 2021 The Arsenal on the Charles 201 Haskins Way 825 and 835 Industrial Road
--- --- ---
Greater Boston/<br>Cambridge/Inner Suburbs San Francisco Bay Area/<br>South San Francisco San Francisco Bay Area/<br>Greater Stanford
137,111 RSF 270,879 RSF 476,211 RSF
100% Occupancy 100% Occupancy 100% Occupancy 3160 Porter Drive 30-02 48th Avenue 5505 Morehouse Drive
--- --- ---
San Francisco Bay Area/<br>Greater Stanford New York City/New York City San Diego/Sorrento Mesa
57,696 RSF 41,848 RSF 28,324 RSF
100% Occupancy 100% Occupancy 100% Occupancy
Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 36
--- --- New Class A Development and Redevelopment Properties: Recent Deliveries (continued)
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December 31, 2021
1165 Eastlake Avenue East 9601 and 9603 Medical Center Drive 9804 Medical Center Drive
--- --- ---
Seattle/Lake Union Maryland/Rockville Maryland/Rockville
100,086 RSF 17,378 RSF 176,832 RSF
100% Occupancy 100% Occupancy 100% Occupancy
700 Quince Orchard Road 2400 Ellis Road, 40 Moore Drive, and<br><br>14 TW Alexander Drive(1) 5 and 9 Laboratory Drive(2) 8 and 10 Davis Drive(3)
--- --- --- ---
Maryland/Gaithersburg Research Triangle/Research Triangle Research Triangle/Research Triangle Research Triangle/Research Triangle
171,239 RSF 326,445 RSF 87,109 RSF 65,247 RSF
100% Occupancy 100% Occupancy 100% Occupancy 100% Occupancy

(1)Image represents 2400 Ellis Road in our Alexandria Center® for Life Science – Durham mega campus.

(2)Image represents 9 Laboratory Drive in our Alexandria Center® for AgTech campus.

(3)Image represents 10 Davis Drive in our Alexandria Center® for Advanced Technologies mega campus.

| Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 | 37 | | --- | --- || New Class A Development and Redevelopment Properties: Recent Deliveries (continued) | | --- | | December 31, 2021 | | (Dollars in thousands) | | Property/Market/Submarket | | | Our Ownership Interest | | RSF Placed in Service | | | | | | | | | | | | | Occupancy Percentage(2) | | Total Project | | | | Unlevered Yields | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | | 4Q21 Delivery Date(1) | | | Prior to 1/1/21 | | 1Q21 | | 2Q21 | | 3Q21 | | | 4Q21 | | Total | | | | Initial Stabilized | | Initial Stabilized (Cash Basis) | | | | | | | | | | | | | | | | | RSF | | | | Investment | | | | Development projects | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | 201 Haskins Way/San Francisco Bay Area/South San Francisco | | 11/1/21 | 100% | | — | | — | | 171,042 | | 55,358 | | | 44,479 | | | 270,879 | | 100% | 323,190 | | $ | 370,000 | | 6.4 | % | | 6.2 | % | | | 825 and 835 Industrial Road/San Francisco Bay Area/Greater Stanford | | 10/22/21 | 100% | | 96,463 | | 99,557 | | 114,157 | | 6,369 | | | 159,665 | | | 476,211 | | 100% | 526,129 | | 630,000 | | | 6.4 | | | 6.1 | | | | 1165 Eastlake Avenue East/Seattle/<br><br>Lake Union | | N/A | 100% | | — | | 100,086 | | — | | — | | | — | | | 100,086 | | 100% | 100,086 | | 138,000 | | | 6.3 | | (3) | 6.4 | | (3) | | 9804 Medical Center Drive/Maryland/Rockville | | N/A | 100% | | — | | 176,832 | | — | | — | | | — | | | 176,832 | | 100% | 176,832 | | 89,300 | | | 8.3 | | | 8.0 | | | | 5 and 9 Laboratory Drive/Research Triangle/Research Triangle | | 11/27/21 | 100% | | — | | — | | — | | 25,812 | | | 61,297 | | | 87,109 | | 100% | 340,400 | | 193,000 | | | 7.1 | | | 7.0 | | | | 8 and 10 Davis Drive/Research Triangle/Research Triangle | | 10/24/21 | 100% | | — | | — | | — | | 20,500 | | | 44,747 | | | 65,247 | | 100% | 250,000 | | 151,000 | | | 7.5 | | | 7.3 | | | | Redevelopment projects | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | The Arsenal on the Charles/Greater Boston/Cambridge/Inner Suburbs | | 12/27/21 | 100% | | — | | — | | — | | 86,546 | | | 50,565 | | | 137,111 | | 100% | 872,665 | | 772,000 | | | 6.2 | | | 5.5 | | | | 3160 Porter Drive/San Francisco Bay Area/Greater Stanford | | 10/15/21 | 100% | | — | | — | | — | | 43,578 | | | 14,118 | | | 57,696 | | 100% | 92,300 | | 107,000 | | | 5.2 | | | 5.0 | | | | 30-02 48th Avenue/New York City/<br><br>New York City | | 12/1/21 | 100% | | 17,716 | | — | | 15,176 | | — | | | 8,956 | | | 41,848 | | 100% | 179,100 | | 224,000 | | | 5.8 | | | 5.8 | | | | 5505 Morehouse Drive/San Diego/<br>    Sorrento Mesa | | 11/19/21 | 100% | | — | | — | | — | | — | | | 28,324 | | | 28,324 | | 100% | 79,945 | | 67,000 | | | 6.9 | | | 7.0 | | | | Other/San Diego | | N/A | 100% | | — | | — | | 128,745 | | — | | | — | | | 128,745 | | 100% | 128,745 | | 47,000 | | | 8.0 | | (4) | 8.0 | | (4) | | 9601 and 9603 Medical Center Drive/Maryland/Rockville | | 12/1/21 | 100% | | — | | — | | — | | — | | | 17,378 | | | 17,378 | | 100% | 94,256 | | 54,000 | | | 8.4 | | | 7.1 | | | | 700 Quince Orchard Road/Maryland/Rockville | | 11/1/21 | 100% | | — | | — | | — | | — | | | 171,239 | | | 171,239 | | 100% | 171,239 | | 79,000 | | | 8.8 | | | 7.4 | | | | 2400 Ellis Road, 40 Moore Drive, and 14 TW Alexander Drive/Research Triangle/Research Triangle | | N/A | 100% | | — | | — | | 326,445 | | — | | | — | | | 326,445 | | 100% | 652,381 | | 245,000 | | | 7.5 | | | 6.7 | | | | Total | | 11/5/21 | | | 114,179 | | 376,475 | | 755,565 | | 238,163 | | | 600,768 | | | 2,085,150 | | | 3,987,268 | | $ | 3,166,300 | | 6.6 | % | | 6.2 | % | |

Refer to “New Class A development and redevelopment properties: current projects” of this Supplemental Information for details on the RSF in service and under construction, if applicable.

(1)Represents the average delivery date for deliveries that occurred during the current quarter, weighted by annual rental revenue.

(2)Relates to total operating RSF placed in service as of the most recent delivery.

(3)Unlevered yields represent aggregate returns for 1165 Eastlake Avenue East, an amenity-rich research headquarters for Adaptive Biotechnologies Corporation, and 1208 Eastlake Avenue East, an adjacent multi-tenant office/laboratory building.

(4)We achieved yields greater than 8.0%.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 38
New Class A Development and Redevelopment Properties: Current Projects
---
December 31, 2021
325 Binney Street One Rogers Street The Arsenal on the Charles 201 Brookline Avenue 40, 50, and 60 Sylvan Road
--- --- --- --- ---
Greater Boston/<br>Cambridge/Inner Suburbs Greater Boston/<br>Cambridge/Inner Suburbs Greater Boston/<br>Cambridge/Inner Suburbs Greater Boston/Fenway Greater Boston/Route 128
462,100 RSF 403,892 RSF 250,567 RSF 510,116 RSF 202,428 RSF
100% Leased 100% Leased 94% Leased/Negotiating 96% Leased/Negotiating 61% Leased/Negotiating
840 Winter Street 201 Haskins Way 751 Gateway Boulevard 825 and 835 Industrial Road 3160 Porter Drive
--- --- --- --- ---
Greater Boston/Route 128 San Francisco Bay Area/<br>South San Francisco San Francisco Bay Area/<br>South San Francisco San Francisco Bay Area/<br>Greater Stanford San Francisco Bay Area/<br>Greater Stanford
130,000 RSF 52,311 RSF 230,592 RSF 49,918 RSF 34,604 RSF
99% Leased/Negotiating 100% Leased 100% Leased 100% Leased 97% Leased/Negotiating
Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 39
--- --- New Class A Development and Redevelopment Properties: Current Projects (continued)
---
December 31, 2021 30-02 48th Avenue 3115 Merryfield Row 10055 Barnes Canyon Road 1150 Eastlake Avenue East 9601 and 9603 Medical Center Drive
--- --- --- --- ---
New York City/New York City San Diego/Torrey Pines San Diego/Sorrento Mesa Seattle/Lake Union Maryland/Rockville
96,003 RSF 146,456 RSF 195,435 RSF 311,631 RSF 76,878 RSF
69% Leased/Negotiating 100% Leased 100% Leased 62% Leased/Negotiating 100% Leased/Negotiating
9950 Medical Center Drive 20400 Century Boulevard 2400 Ellis Road, 40 Moore Drive, and 14 TW Alexander Drive(1) 5 and 9 Laboratory Drive(2) 8 and 10 Davis Drive(3)
--- --- --- --- ---
Maryland/Rockville Maryland/Gaithersburg Research Triangle/Research Triangle Research Triangle/Research Triangle Research Triangle/Research Triangle
84,264 RSF 80,550 RSF 325,936 RSF 72,891 RSF 184,753 RSF
100% Leased 40% Leased/Negotiating 80% Leased/Negotiating 95% Leased/Negotiating 94% Leased/Negotiating

(1)Image represents 14 TW Alexander Drive in our Alexandria Center® for Life Science – Durham mega campus.

(2)Image represents 9 Laboratory Drive in our Alexandria Center® for AgTech campus.

(3)Image represents 10 Davis Drive in our Alexandria Center® for Advanced Technologies mega campus.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 40
New Class A Development and Redevelopment Properties: Current Projects (continued)
---
December 31, 2021 Market<br><br>Property/Submarket Square Footage Percentage Occupancy(1)
--- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Dev/Redev In Service CIP Total Leased Leased/Negotiating Initial Stabilized
Under construction
Greater Boston
325 Binney Street/Cambridge/Inner Suburbs Dev 462,100 462,100 100 % 100 % 2023 2024
One Rogers Street/Cambridge/Inner Suburbs Redev 4,367 403,892 408,259 100 100 2023 2023
The Arsenal on the Charles/Cambridge/Inner Suburbs Redev 622,098 250,567 872,665 83 94 3Q21 2022
201 Brookline Avenue/Fenway Dev 510,116 510,116 88 96 2022 2023
40, 50, and 60 Sylvan Road/Route 128 Redev 312,845 202,428 515,273 61 61 2023 2024
840 Winter Street/Route 128 Redev 30,009 130,000 160,009 18 99 2023 2024
Other Redev 453,869 453,869 2023 TBD
San Francisco Bay Area
201 Haskins Way/South San Francisco Dev 270,879 52,311 323,190 100 100 2Q21 2022
751 Gateway Boulevard/South San Francisco Dev 230,592 230,592 100 100 2023 2023
825 and 835 Industrial Road/Greater Stanford Dev 476,211 49,918 526,129 100 100 4Q20 2022
3160 Porter Drive/Greater Stanford Redev 57,696 34,604 92,300 89 97 3Q21 2022
New York City
30-02 48th Avenue/New York City Redev 83,097 96,003 179,100 60 69 4Q20 2022
San Diego
3115 Merryfield Row/Torrey Pines Dev 146,456 146,456 100 100 2022 2022
10055 Barnes Canyon Road/Sorrento Mesa Dev 195,435 195,435 100 100 2022 2022
5505 Morehouse Drive/Sorrento Mesa Redev 28,324 51,621 79,945 100 100 4Q21 2022
10102 Hoyt Park Drive/Other Dev 144,113 144,113 100 100 2023 2023
10277 Scripps Ranch Boulevard/Other Redev 70,041 70,041 2023 TBD
Seattle
1150 Eastlake Avenue East/Lake Union Dev 311,631 311,631 32 62 2023 TBD
3301, 3555, and 3755 Monte Villa Parkway/Bothell Redev 246,647 213,976 460,623 53 53 2022 2023
Maryland
9601 and 9603 Medical Center Drive/Rockville Redev 17,378 76,878 94,256 51 100 4Q21 2023
9950 Medical Center Drive/Rockville Dev 84,264 84,264 100 100 1H22 2022
20400 Century Boulevard/Gaithersburg Redev 80,550 80,550 40 40 2022 2023
Research Triangle
2400 Ellis Road, 40 Moore Drive, and 14 TW Alexander Drive/Research Triangle Redev 326,445 325,936 652,381 77 80 2Q21 2022
5 and 9 Laboratory Drive/Research Triangle Redev/Dev 267,509 72,891 340,400 93 95 3Q21 2022
8 and 10 Davis Drive/Research Triangle Dev 65,247 184,753 250,000 (2) 83 (2) 94 (2) 3Q21 2022
2,808,752 4,834,945 7,643,697 75 % 82 %
(1)Initial occupancy dates are subject to leasing and/or market conditions. Multi-tenant projects may have occupancy by tenants over a period of time. Stabilized occupancy may vary depending on single tenancy versus multi-tenancy.<br><br>(2)Represents 150,000 RSF that is 90% leased/negotiating at 8 Davis Drive and 100,000 RSF that is 100% leased at 10 Davis Drive. Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 41
--- ---
New Class A Development and Redevelopment Properties: Current Projects (continued)
---
December 31, 2021
Market<br><br>Property/Submarket Square Footage Percentage
--- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Dev/Redev In Service CIP Total Leased Leased/Negotiating
Pre-leased/negotiating near-term projects expected to commence construction in the next six quarters
Greater Boston
99 Coolidge Avenue/Cambridge/Inner Suburbs Dev 275,000 275,000 % 34 %
The Arsenal on the Charles, Phase I/Cambridge/Inner Suburbs Dev 120,454 120,454 84 84
The Arsenal on the Charles, Phase II/Cambridge/Inner Suburbs Dev 100,000 100,000 88
15 Necco Street/Seaport Innovation District Dev 350,000 350,000 97
San Diego
11255 and 11355 North Torrey Pines Road/Torrey Pines Dev 309,094 309,094 100 100
10931 and 10933 North Torrey Pines Road/Torrey Pines Dev 299,158 299,158 100 100
Alexandria Point, Phase II/University Town Center Dev 409,000 409,000 100
Alexandria Point, Phase I/University Town Center Dev 171,102 171,102 100 100
Maryland
9820 Darnestown Road/Rockville Dev 250,000 250,000 100
9810 Darnestown Road/Rockville Dev 192,000 192,000 100 100
9808 Medical Center Drive/Rockville Dev 90,000 90,000 29 29
2,565,808 2,565,808 43 89
2,808,752 7,400,753 10,209,505 67 % 83 % Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 42
--- --- New Class A Development and Redevelopment Properties: Current Projects (continued)
---
December 31, 2021
(Dollars in thousands) Our Ownership Interest Unlevered Yields
--- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Market<br><br>Property/Submarket In Service CIP Cost to Complete Total at<br>Completion Initial Stabilized Initial Stabilized (Cash Basis)
Under construction
Greater Boston
325 Binney Street/Cambridge/Inner Suburbs 100 % $ $ 240,287 $ 540,713 $ 781,000 8.6 % 7.2 %
One Rogers Street/Cambridge/Inner Suburbs 100 % 10,844 847,262 347,894 1,206,000 5.2 % 4.2 %
The Arsenal on the Charles/Cambridge/Inner Suburbs 100 % 500,636 226,128 45,236 772,000 6.2 % 5.5 %
201 Brookline Avenue/Fenway 98.3 % 476,012 257,988 734,000 7.2 % (1) 6.2 % (1)
40, 50, and 60 Sylvan Road/Route 128 100 % 173,595 92,461 TBD
840 Winter Street/Route 128 100 % 14,013 66,142
Other 100 % 115,214
San Francisco Bay Area
201 Haskins Way/South San Francisco 100 % 304,606 49,710 15,684 370,000 6.4 % 6.2 %
751 Gateway Boulevard/South San Francisco 49.9 % 78,007 211,993 290,000 6.5 % 6.3 %
825 and 835 Industrial Road/Greater Stanford 100 % 565,335 46,072 18,593 630,000 6.4 % 6.1 %
3160 Porter Drive/Greater Stanford 100 % 62,893 38,826 5,281 107,000 5.2 % 5.0 %
New York City
30-02 48th Avenue/New York City 100 % 75,062 108,037 40,901 224,000 5.8 % 5.8 %
San Diego
3115 Merryfield Row/Torrey Pines 100 % 124,372 27,628 152,000 6.2 % 6.2 %
10055 Barnes Canyon Road/Sorrento Mesa 50.0 % 88,400 92,600 181,000 7.2 % 6.6 %
5505 Morehouse Drive/Sorrento Mesa 100 % 17,909 37,074 12,017 67,000 6.9 % 7.0 %
10102 Hoyt Park Drive/Other 100 % 42,713 71,287 114,000 7.4 % 6.5 %
10277 Scripps Ranch Boulevard/Other 100 % 25,966 TBD
Seattle
1150 Eastlake Avenue East/Lake Union 100 % 117,929 287,071 405,000 6.4 % 6.2 %
3301, 3555, and 3755 Monte Villa Parkway/Bothell 100 % 55,198 72,233 TBD
Maryland
9601 and 9603 Medical Center Drive/Rockville 100 % 6,124 24,179 23,697 54,000 8.4 % 7.1 %
9950 Medical Center Drive/Rockville 100 % 42,673 16,927 59,600 8.6 % 7.7 %
20400 Century Boulevard/Gaithersburg 100 % 16,217 18,783 35,000 8.5 % 8.6 %
Research Triangle
2400 Ellis Road, 40 Moore Drive, and 14 TW Alexander Drive/Research Triangle 100 % 92,403 77,021 75,576 245,000 7.5 % 6.7 %
5 and 9 Laboratory Drive/Research Triangle 100 % 148,582 39,347 5,071 193,000 7.1 % 7.0 %
8 and 10 Davis Drive/Research Triangle 100 % 30,252 76,160 44,588 151,000 7.5 % 7.3 %
$ 2,057,452 $ 3,168,442 $ 3,070,000 (2)(3) $ 8,290,000 (2)

(1)We expect to achieve initial stabilized yields of 7.2% and 6.2% (cash basis), which represent improvements of 40 bps and 20 bps, from the respective initial stabilized yields disclosed on October 25, 2021. The increase is primarily attributable to higher rental rates.

(2)Amounts rounded to the nearest $10 million.

(3)Based on the expected incremental EBITDA generated upon stabilization of these projects over the period of 2022 to 2024 and our 4Q22 annualized target of net debt and preferred stock to adjusted EBITDA of less than or equal to 5.1x, we expect $1.1 billion of incremental equity funding on a leverage neutral basis to complete our projects under construction aggregating 4.8 million RSF as of December 31, 2021. The balance of the remaining cost to complete is expected to be funded with $2.0 billion of debt. Refer to the key sources and uses of capital within “Guidance” of this Earnings Press Release for additional details. Actual debt and equity capital funding until stabilization of these projects may vary from these estimates.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 43
New Class A Development and Redevelopment Properties: Summary of Pipeline
---
December 31, 2021
(Dollars in thousands)
Market<br><br>Property/Submarket Our Ownership Interest Book Value Square Footage
--- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Development and Redevelopment
Under Construction Near<br>Term Intermediate<br>Term Future Total(1)
Greater Boston
Mega Campus: Alexandria Center® at One Kendall Square/Cambridge/<br><br>Inner Suburbs 100 % $ 240,287 462,100 462,100
325 Binney Street
Mega Campus: Alexandria Center® at Kendall Square/Cambridge/<br><br>Inner Suburbs 100 % 847,262 403,892 403,892
One Rogers Street
Mega Campus: The Arsenal on the Charles/Cambridge/Inner Suburbs 100 % 267,261 250,567 220,454 34,157 505,178
311 Arsenal Street, 300 and 400 North Beacon Street, and 100 and 200 Talcott Avenue
Mega Campus: Alexandria Center® for Life Science – Fenway/Fenway (2) 719,937 510,116 507,997 1,018,113
201 Brookline Avenue and 421 Park Drive
Reservoir Woods/Route 128 100 % 140,723 202,428 312,845 440,000 955,273
40, 50, and 60 Sylvan Road
840 Winter Street/Route 128 100 % 66,142 130,000 130,000
99 Coolidge Avenue/Cambridge/Inner Suburbs 75.0 % 66,124 275,000 275,000
15 Necco Street/Seaport Innovation District 90.0 % 227,051 350,000 350,000
10 Necco Street/Seaport Innovation District 100 % 94,490 175,000 175,000
215 Presidential Way/Route 128 100 % 6,808 112,000 112,000
Mega Campus: Alexandria Technology Square®/Cambridge/Inner Suburbs 100 % 7,881 100,000 100,000
Mega Campus: 480 Arsenal Way and 500 and 550 Arsenal Street/Cambridge/Inner Suburbs 100 % 55,680 775,000 775,000
Mega Campus: 380 and 420 E Street/Seaport Innovation District 100 % 120,865 1,000,000 1,000,000
99 A Street/Seaport Innovation District 100 % 47,139 235,000 235,000
Mega Campus: One Upland Road, 100 Tech Drive, and One Investors Way/Route 128 100 % 22,861 1,100,000 1,100,000
Other value-creation projects 100 % 165,496 453,869 190,992 466,504 1,111,365
$ 3,096,007 2,412,972 1,349,291 794,997 4,150,661 8,707,921
(1)Represents total square footage upon completion of development or redevelopment of a new Class A property. Square footage presented includes RSF of buildings currently in operation at properties that also have inherent future development or redevelopment opportunities. Upon expiration of existing in-place leases, we have the intent to demolish or redevelop the existing property and commence future construction. Refer to “Definitions and reconciliations” of this Supplemental Information for additional details on value-creation square feet currently included in rental properties.<br><br>(2)We have a 98.3% ownership interest in 201 Brookline Avenue aggregating 510,116 RSF, which is currently under construction. We have a 100% ownership interest in the intermediate-term development project at 421 Park Drive aggregating 507,997 SF. Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 44
--- ---
New Class A Development and Redevelopment Properties: Summary of Pipeline (continued)
---
December 31, 2021
(Dollars in thousands)
Market<br><br>Property/Submarket Our Ownership Interest Book Value Square Footage
--- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Development and Redevelopment
Under Construction Near<br>Term Intermediate<br>Term Future Total(1)
San Francisco Bay Area
Mega Campus: Alexandria Technology Center® – Gateway/<br><br>South San Francisco 49.9 % $ 100,575 230,592 300,010 291,000 821,602
651 and 751 Gateway Boulevard
Alexandria Center® for Life Science – South San Francisco/<br><br>South San Francisco 100 % 49,710 52,311 52,311
201 Haskins Way
Mega Campus: Alexandria Center® for Life Science – San Carlos/Greater Stanford 100 % 391,038 49,918 700,000 797,830 1,547,748
825, 835, and 960 Industrial Road, 987 and 1075 Commercial Street, and 888 Bransten Road
3160 Porter Drive/Greater Stanford 100 % 38,826 34,604 34,604
Mega Campus: Alexandria Center® for Science and Technology – Mission Bay/Mission Bay 100 % 53,408 191,000 191,000
1450 Owens Street
3825 and 3875 Fabian Way/Greater Stanford 100 % 250,000 228,000 478,000
901 California Avenue/Greater Stanford 100 % 3,797 56,924 56,924
3450 and 3460 Hillview Avenue/Greater Stanford 100 % 42,340 34,611 76,951
Mega Campus: 88 Bluxome Street/SoMa 100 % 323,680 1,070,925 1,070,925
Mega Campus: 1122 and 1178 El Camino Real/South San Francisco 100 % 235,985 1,320,000 1,320,000
Mega Campus: 213, 249, 259, 269, and 279 East Grand Avenue/<br><br>South San Francisco 30.0 % 6,352 90,000 90,000
2475 Hanover Street/Greater Stanford 100 % 83,980 83,980
Other value-creation projects (2) 54,275 303,407 303,407
1,257,646 367,425 1,911,199 734,611 3,114,217 6,127,452
New York City
Alexandria Center® for Life Science – Long Island City/New York City 100 % 138,631 96,003 135,938 231,941
30-02 48th Avenue and 47-50 30th Street
Mega Campus: Alexandria Center® for Life Science – New York City/<br><br>New York City 100 % 79,961 550,000 (3) 550,000
219 East 42nd Street/New York City 100 % 579,947 579,947
$ 218,592 96,003 135,938 550,000 579,947 1,361,888
(1)Represents total square footage upon completion of development or redevelopment of a new Class A property. Square footage presented includes RSF of buildings currently in operation at properties that also have inherent future development or redevelopment opportunities. Upon expiration of existing in-place leases, we have the intent to demolish or redevelop the existing property and commence future construction. Refer to “Definitions and reconciliations” of this Supplemental Information for additional details on value-creation square feet currently included in rental properties.<br><br>(2)Includes a future development project aggregating 278,407 RSF at Alexandria Center® for Life Science – Millbrae Station, where we have a 40.3% ownership interest.<br><br>(3)Pursuant to an option agreement, we are currently negotiating a long-term ground lease with the City of New York for the future site of a new building approximating 550,000 RSF. Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 45
--- ---
New Class A Development and Redevelopment Properties: Summary of Pipeline (continued)
---
December 31, 2021
(Dollars in thousands)
Market<br><br>Property/Submarket Our Ownership Interest Book Value Square Footage
--- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Development and Redevelopment
Under Construction Near<br>Term Intermediate<br>Term Future Total(1)
San Diego
Mega Campus: One Alexandria Square/Torrey Pines 100 % $ 287,221 146,456 608,252 125,280 879,988
3115 Merryfield Row, 10931, 10933, 11255, and 11355 North Torrey Pines Road, and 10975 and 10995 Torreyana Road
Mega Campus: SD Tech by Alexandria/Sorrento Mesa 50.0 % 215,498 247,056 190,074 160,000 333,845 930,975
9805 Scranton Road, 5505 Morehouse Drive(2), and 10055 and 10075 Barnes Canyon Road
10102 Hoyt Park Drive/Other 100 % 42,713 144,113 144,113
10277 Scripps Ranch Boulevard/Other 100 % 25,966 70,041 70,041
Mega Campus: Alexandria Point/University Town Center 55.0 % 117,757 580,102 324,445 904,547
10260 Campus Point Drive and 4110, 4150, and 4160 Campus Point Court
Mega Campus: Sequence District by Alexandria/Sorrento Mesa 100 % 40,142 200,000 509,000 1,089,915 1,798,915
6260, 6290, 6310, 6340, 6350, and 6450 Sequence Drive
Mega Campus: University District/University Town Center 100 % 68,817 600,000 600,000
9363, 9373, 9393 Towne Centre Drive, and 4555 Executive Drive
9444 Waples Street/Sorrento Mesa 50.0 % 19,062 149,000 149,000
Mega Campus: 5200 Illumina Way/University Town Center 51.0 % 13,524 451,832 451,832
4025, 4031, 4045, and 4075 Sorrento Valley Boulevard/Sorrento Valley 100 % 14,710 247,000 247,000
Other value-creation projects 100 % 14,162 54,000 114,235 168,235
859,572 607,666 1,632,428 1,418,000 2,686,552 6,344,646
Seattle
Mega Campus: The Eastlake Life Science Company by Alexandria/<br><br>Lake Union 100 % 117,929 311,631 311,631
1150 Eastlake Avenue East
Mega Campus: Alexandria Center® for Life Science – South Lake Union/<br><br>Lake Union 100 % 114,210 217,000 188,400 405,400
601 and 701 Dexter Avenue North
Alexandria Center® for Advanced Technologies – Monte Villa Parkway/Bothell 100 % 72,233 213,976 51,255 265,231
3301, 3555, and 3755 Monte Villa Parkway
1010 4th Avenue South/SoDo 100 % 51,395 544,825 544,825
830 4th Avenue South/SoDo 100 % 52,488 52,488
Mega Campus: Alexandria Center® for Advanced Technologies – Canyon Park/Bothell 100 % 12,835 230,000 230,000
21660 20th Avenue Southeast
Other value-creation projects 100 % 77,484 691,000 691,000
$ 446,086 525,607 268,255 1,706,713 2,500,575
(1)Represents total square footage upon completion of development or redevelopment of a new Class A property. Square footage presented includes RSF of buildings currently in operation at properties that also have inherent future development or redevelopment opportunities. Upon expiration of existing in-place leases, we have the intent to demolish or redevelop the existing property and commence future construction. Refer to “Definitions and reconciliations” of this Supplemental Information for additional details on value-creation square feet currently included in rental properties.<br><br>(2)We own 100% of this property. Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 46
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New Class A Development and Redevelopment Properties: Summary of Pipeline (continued)
---
December 31, 2021
(Dollars in thousands)
Market<br><br>Property/Submarket Our Ownership Interest Book Value Square Footage
--- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Development and Redevelopment
Under Construction Near<br>Term Intermediate<br>Term Future Total(1)
Maryland
Mega Campus: Alexandria Center® for Life Science – Shady Grove/Rockville 100 % $ 135,795 161,142 532,000 258,000 38,000 989,142
9601, 9603, and 9950 Medical Center Drive and 9810, 9820, and 9830 Darnestown Road
20400 Century Boulevard/Gaithersburg 100 % 16,217 80,550 80,550
152,012 241,692 532,000 258,000 38,000 1,069,692
Research Triangle
Mega Campus: Alexandria Center® for Life Science – Durham/<br><br>Research Triangle 100 % 120,888 325,936 100,000 885,000 1,310,936
40 and 41 Moore Drive and 14 TW Alexander Drive
Mega Campus: Alexandria Center® for Advanced Technologies/<br><br>Research Triangle 100 % 121,663 184,753 180,000 990,000 1,354,753
4, 8, and 10 Davis Drive
Alexandria Center® for AgTech/Research Triangle 100 % 39,347 72,891 72,891
9 Laboratory Drive
Mega Campus: Alexandria Center® for NextGen Medicines/<br><br>Research Triangle 100 % 96,056 100,000 100,000 855,000 1,055,000
3029 East Cornwallis Road
Other value-creation projects 100 % 4,185 76,262 76,262
382,139 583,580 380,000 100,000 2,806,262 3,869,842
Other value-creation projects 100 % 116,586 2,538,505 2,538,505
Total pipeline as of December 31, 2021 $ 6,528,640 (2) 4,834,945 6,209,111 3,855,608 17,620,857 32,520,521 (1)
Key pending acquisition
Mega Campus: Alexandria Center® for Life Science – South Lake Union/<br><br>Lake Union 800,000 800,000
800 Mercer Street
4,834,945 7,009,111 3,855,608 17,620,857 33,320,521

(1)Total square footage includes 4,385,608 RSF of buildings currently in operation that will be redeveloped or replaced with new development RSF upon commencement of future construction. Refer to “Definitions and reconciliations” of this Supplemental Information for additional details on value-creation square feet currently included in rental properties.

(2)Total book value includes $3.2 billion of projects currently under construction that are 82% leased/negotiating. We also expect to commence construction on pre-leased/negotiating near-term projects aggregating $570.5 million in the next six quarters that are 89% leased/negotiating.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 47
Construction Spending
---
December 31, 2021
(In thousands)
Year Ended
--- --- ---
Construction Spending December 31, 2021
Additions to real estate – consolidated projects $ 2,089,849
Investments in unconsolidated real estate joint ventures 13,666
Contributions from noncontrolling interests (94,285)
Construction spending (cash basis) 2,009,230
Change in accrued construction 149,939
Construction spending $ 2,159,169 Year Ending
--- --- ---
Projected Construction Spending December 31, 2022
Development, redevelopment, and pre-construction projects $ 2,990,000
Contributions from noncontrolling interests (consolidated real estate joint ventures) (220,000)
Revenue-enhancing and repositioning capital expenditures 98,000
Non-revenue-enhancing capital expenditures 82,000
Guidance midpoint $ 2,950,000
Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 48
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Joint Venture Financial Information
---
December 31, 2021 Consolidated Real Estate Joint Ventures
--- --- --- --- --- --- --- --- --- ---
Property Market Submarket Noncontrolling<br><br>Interest Share(1) Operating RSF<br><br>at 100%
50 and 60 Binney Street Greater Boston Cambridge/Inner Suburbs 66.0% 532,395
75/125 Binney Street Greater Boston Cambridge/Inner Suburbs 60.0% 388,270
225 Binney Street Greater Boston Cambridge/Inner Suburbs 70.0% 305,212
99 Coolidge Avenue Greater Boston Cambridge/Inner Suburbs 25.0% (2)
409 and 499 Illinois Street San Francisco Bay Area Mission Bay 75.0% 455,069
1500 Owens Street San Francisco Bay Area Mission Bay 75.0% 158,267
1700 Owens Street San Francisco Bay Area Mission Bay 75.0% 164,513
455 Mission Bay Boulevard South San Francisco Bay Area Mission Bay 75.0% 228,140
Alexandria Technology Center® – Gateway(3) San Francisco Bay Area South San Francisco 50.1% 1,089,852
213 East Grand Avenue San Francisco Bay Area South San Francisco 70.0% 300,930
500 Forbes Boulevard San Francisco Bay Area South San Francisco 90.0% 155,685
Alexandria Center® for Life Science – Millbrae Station San Francisco Bay Area South San Francisco 59.7%
Alexandria Point(4) San Diego University Town Center 45.0% 1,337,916
5200 Illumina Way San Diego University Town Center 49.0% 792,687
9625 Towne Centre Drive San Diego University Town Center 49.9% 163,648
SD Tech by Alexandria(5) San Diego Sorrento Mesa 50.0% 679,801
Pacific Technology Park San Diego Sorrento Mesa 50.0% 632,732
1201 and 1208 Eastlake Avenue East and 199 East Blaine Street Seattle Lake Union 70.0% 321,218
400 Dexter Avenue North Seattle Lake Union 70.0% 290,111
Unconsolidated Real Estate Joint Ventures
Property Market Submarket Our Ownership Share(6) Operating RSF<br><br>at 100%
1655 and 1725 Third Street San Francisco Bay Area Mission Bay 10.0 % 586,208
1401/1413 Research Boulevard Maryland Rockville 65.0 % (7) (8)
1450 Research Boulevard Maryland Rockville 73.2 % (9) 42,679
101 West Dickman Street Maryland Beltsville 57.9 % (9) 135,423

(1)In addition to the consolidated real estate joint ventures listed, various partners hold insignificant noncontrolling interests in three other real estate joint ventures in North America.

(2)We expect to commence vertical construction of 275,000 RSF during 2022.

(3)Includes 601, 611, 651, 681, 685, 701, and 751 Gateway Boulevard in our South San Francisco submarket. Noncontrolling interest share is anticipated to be 49% as we make further contributions into the joint venture over time.

(4)Includes 10210, 10260, 10290, and 10300 Campus Point Drive and 4161, 4224, and 4242 Campus Point Court in our University Town Center submarket.

(5)Includes 9605, 9645, 9675, 9685, 9725, 9735, 9808, 9855, and 9868 Scranton Road and 10055 and 10065 Barnes Canyon Road in our Sorrento Mesa submarket.

(6)In addition to the unconsolidated real estate joint ventures listed, we hold an interest in one other insignificant unconsolidated real estate joint venture in North America.

(7)Represents our ownership interest; our voting interest is limited to 50%.

(8)Represents a joint venture with a distinguished retail real estate developer for an approximate 90,000 RSF retail shopping center.

(9)Represent joint ventures with local real estate operators. Each of these joint ventures operates one office property which are expected to be redeveloped into office/lab. Our investments into 101 West Dickman Street and 1450 Research Boulevard joint ventures were $8.3 million and $4.0 million, respectively. The joint ventures each have a construction loan in place which is expected to fund future redevelopment cost; therefore, we expect minimal equity contributions to be required in the future. Our partners manage the day-to-day activities that most significantly affect the economic performance of each joint venture; therefore, we account for these investments under the equity method of accounting.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 49
Joint Venture Financial Information (continued)
---
December 31, 2021
(Dollars in thousands)
As of December 31, 2021
--- --- --- --- ---
Noncontrolling Interest <br>Share of Consolidated <br>Real Estate JVs Our Share of <br>Unconsolidated Real <br>Estate JVs
Investments in real estate $ 2,580,819 $ 110,432
Cash, cash equivalents, and restricted cash 92,703 4,993
Other assets 290,389 10,168
Secured notes payable (refer to page 54) (1,998) (83,910)
Other liabilities (118,205) (3,200)
Redeemable noncontrolling interests (9,612)
$ 2,834,096 $ 38,483
Noncontrolling Interest Share of <br>Consolidated Real Estate JVs Our Share of Unconsolidated <br>Real Estate JVs
--- --- --- --- --- --- --- --- ---
December 31, 2021 December 31, 2021
Three Months Ended Year Ended Three Months Ended Year Ended
Total revenues $ 64,273 $ 211,807 $ 9,962 $ 43,557
Rental operations (18,278) (58,123) (1,469) (7,079)
45,995 153,684 8,493 36,478
General and administrative (36) (635) (113) (298)
Interest (2,304) (10,191)
Depreciation and amortization (21,265) (70,880) (3,058) (13,734)
Fixed returns allocated to redeemable noncontrolling interests(1) 207 866
$ 24,901 $ 83,035 $ 3,018 $ 12,255
Straight-line rent and below-market lease revenue $ 1,859 $ 5,318 $ 170 $ 3,094
Funds from operations(2) $ 46,166 $ 153,915 $ 6,076 $ 25,989

(1)Represents an allocation of joint venture earnings to redeemable noncontrolling interests primarily in one property in our South San Francisco submarket. These redeemable noncontrolling interests earn a fixed return on their investment rather than participate in the operating results of the property.

(2)Refer to “Funds from operations and funds from operations per share” in our Earnings Press Release and “Funds from operations and funds from operations, as adjusted, attributable to Alexandria’s common stockholders” in the “Definitions and reconciliations” of this Supplemental Information for the definition and reconciliation from the most directly comparable financial measure presented in accordance with GAAP.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 50
Investments
---
December 31, 2021
(Dollars in thousands)

We hold investments in publicly traded companies and privately held entities primarily involved in the life science, agtech, and technology industries. The tables below summarize components of our non-real estate investments and investment income. For additional details, refer to “Investments” in the “Definitions and reconciliations” of this Supplemental Information.

December 31, 2021
Three Months Ended Year Ended Year Ended December 31, 2020
Realized gains $ 26,832 $ 215,845 (1) $ 47,288 (2)
Unrealized (losses) gains (139,716) 43,632 374,033
Investment (loss) income $ (112,884) $ 259,477 $ 421,321
December 31, 2021
--- --- --- --- --- --- --- --- ---
Investments Cost Unrealized<br>Gains Carrying Amount
Publicly traded companies $ 203,290 $ 280,527 (3) $ 483,817
Entities that report NAV 385,692 444,172 829,864
Entities that do not report NAV:
Entities with observable price changes 56,257 72,974 129,231
Entities without observable price changes 362,064 362,064
Investments accounted for under the equity method of accounting N/A N/A 71,588
December 31, 2021 $ 1,007,303 (4) $ 797,673 1,876,564
December 31, 2020 $ 835,438 $ 775,676 $ 1,611,114

(1)Includes six separate significant realized gains aggregating $110.1 million related to the following transactions: (i) the sales of investments in three publicly traded biotechnology companies, (ii) a distribution received from a limited partnership investment, and (iii) the acquisition of two of our privately held non-real estate investments in a biopharmaceutical company and biotechnology company.

(2)Includes impairments of $24.5 million related to investments in privately held entities that do not report NAV.

(3)Includes gross unrealized gains and losses of $310.0 million and $29.5 million, respectively, as of December 31, 2021.

(4)Represents 3.0% of gross assets as of December 31, 2021.

Public/Private<br>Mix (Cost)
Tenant/Non-Tenant<br>Mix (Cost)
Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 51
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Key Credit Metrics
---
December 31, 2021
Liquidity Minimal Outstanding Borrowings and Significant Availability on Unsecured Senior Line of Credit
--- --- ---
(in millions)
5.4B q421lineofcreditv3a.jpg
(in millions)
Availability under our unsecured senior line of credit, net of amounts outstanding under our commercial paper program 2,730
Remaining construction loan commitments
Cash, cash equivalents, and restricted cash
Investments in publicly traded companies
Liquidity as of December 31, 2021
Outstanding forward equity sales agreements(1)
Total 5,435
Net Debt and Preferred Stock to Adjusted EBITDA(2) Fixed-Charge Coverage Ratio(2)

All values are in US Dollars.

(1)Represents expected net proceeds from the future settlement of 8.1 million shares of forward equity sales agreements entered into in January 2022.

(2)Quarter annualized. Refer to “Fixed-charge coverage ratio” and “Net debt and preferred stock to Adjusted EBITDA” in the “Definitions and reconciliations” of this Supplemental Information for additional details.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 52
Summary of Debt
---
December 31, 2021
(in millions)

Weighted-Average Remaining Term of 12.1 Years

(1)Refer to footnote 2 on the next page under “Fixed-rate and variable-rate debt” for additional details.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 53
Summary of Debt (continued)
---
December 31, 2021
(Dollars in thousands)
Fixed-rate and variable-rate debt Fixed-Rate<br>Debt Variable-Rate Debt Total Percentage Weighted-Average
--- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Interest Rate(1) Remaining Term<br>(in years)
Secured notes payable $ 195,196 $ 10,002 $ 205,198 2.3 % 3.40 % 2.2
Unsecured senior notes payable 8,316,678 8,316,678 94.6 3.54 12.6
Unsecured senior line of credit N/A 4.0
Commercial paper program 269,990 269,990 3.1 0.29 (2)
Total/weighted average $ 8,511,874 $ 279,992 $ 8,791,866 100.0 % 3.44 % 12.1 (2)
Percentage of total debt 97 % 3 % 100 %

(1)Represents the weighted-average interest rate as of the end of the applicable period, including expense/income related to the amortization of loan fees, amortization of debt premiums (discounts), and other bank fees.

(2)The commercial paper notes bear interest at short-term fixed rates and can generally be issued with a maturity of 30 days or less and with a maximum maturity of 397 days from the date of issuance. Borrowings under the program are used to fund short-term capital needs and are backed by our unsecured senior line of credit. The commercial paper outstanding as of December 31, 2021, matured on January 18, 2022. In the event we are unable to issue commercial paper notes or refinance outstanding borrowings under terms equal to or more favorable than those under our unsecured senior line of credit, we expect to borrow under the unsecured senior line of credit at L+0.815%. As such, we calculate the weighted-average remaining term of our commercial paper by using the maturity date of our unsecured senior line of credit. Using the maturity date of our outstanding commercial paper, the consolidated weighted-average maturity of our debt is 11.9 years. The commercial paper notes sold during the three months ended December 31, 2021, were issued at a weighted-average yield to maturity of 0.24% and had a weighted-average maturity term of 12 days.

Debt covenants Unsecured Senior Notes Payable Unsecured Senior Line of Credit
Debt Covenant Ratios(1) Requirement December 31, 2021 Requirement December 31, 2021
Total Debt to Total Assets ≤ 60% 28% ≤ 60.0% 26.7%
Secured Debt to Total Assets ≤ 40% 1% ≤ 45.0% 0.6%
Consolidated EBITDA to Interest Expense ≥ 1.5x 11.4x ≥ 1.50x 4.51x
Unencumbered Total Asset Value to Unsecured Debt ≥ 150% 343% N/A N/A
Unsecured Interest Coverage Ratio N/A N/A ≥ 1.75x 9.16x

(1)All covenant ratio titles utilize terms as defined in the respective debt and credit agreements. The calculation of consolidated EBITDA is based on the definitions contained in our loan agreements and is not directly comparable to the computation of EBITDA as described in Exchange Act Release No. 47226.

Unconsolidated real estate joint ventures’ debt At 100%
Unconsolidated Joint Venture Our Share Maturity Date Stated Rate Interest Rate(1) Aggregate Commitment Debt Balance(2)
1401/1413 Research Boulevard 65.0% 12/23/24 2.70% 3.14% $ 28,500 $ 28,124
1655 and 1725 Third Street 10.0% 3/10/25 4.50% 4.57% 600,000 598,657
101 West Dickman Street 57.9% 11/10/26 SOFR + 1.95% (3) 2.81% 26,750 9,947
1450 Research Boulevard 73.2% 12/10/26 SOFR + 1.95% (3) N/A 13,000
$ 668,250 $ 636,728

(1)Includes interest expense and amortization of loan fees.

(2)Represents outstanding principal, net of unamortized deferred financing costs, as of December 31, 2021.

(3)This loan is subject to a fixed SOFR floor rate of 0.75%.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 54
Summary of Debt (continued)
---
December 31, 2021
(Dollars in thousands)
Debt Stated <br>Rate Interest<br><br>Rate(1) Maturity<br><br>Date(2) Principal Payments Remaining for the Periods Ending December 31, Principal Unamortized (Deferred Financing Cost), (Discount)/Premium Total
--- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
2022 2023 2024 2025 2026 Thereafter
Secured notes payable
Greater Boston 4.82 % 3.40 % 2/6/24 $ 3,564 $ 3,742 $ 183,527 $ $ $ $ 190,833 $ 5,696 $ 196,529
Greater Boston(3) SOFR + 2.70 % 3.10 11/19/26 10,002 10,002 (2,011) 7,991
San Francisco Bay Area 6.50 % 6.50 7/1/36 28 30 32 34 36 518 678 678
Secured debt weighted-average interest rate/subtotal 4.74 % 3.40 3,592 3,772 183,559 34 10,038 518 201,513 3,685 205,198
Commercial paper program(4) 0.29 % (4) 0.29 (4) (4) (4) 270,000 (4) 270,000 (10) 269,990
Unsecured senior line of credit L+0.815 % (5) N/A 1/6/26
Unsecured senior notes payable 3.45 % 3.62 4/30/25 600,000 600,000 (2,934) 597,066
Unsecured senior notes payable 4.30 % 4.50 1/15/26 300,000 300,000 (1,987) 298,013
Unsecured senior notes payable – green bond 3.80 % 3.96 4/15/26 350,000 350,000 (2,116) 347,884
Unsecured senior notes payable 3.95 % 4.13 1/15/27 350,000 350,000 (2,570) 347,430
Unsecured senior notes payable 3.95 % 4.07 1/15/28 425,000 425,000 (2,569) 422,431
Unsecured senior notes payable 4.50 % 4.60 7/30/29 300,000 300,000 (1,689) 298,311
Unsecured senior notes payable 2.75 % 2.87 12/15/29 400,000 400,000 (3,284) 396,716
Unsecured senior notes payable 4.70 % 4.81 7/1/30 450,000 450,000 (3,167) 446,833
Unsecured senior notes payable 4.90 % 5.05 12/15/30 700,000 700,000 (7,067) 692,933
Unsecured senior notes payable 3.375 % 3.48 8/15/31 750,000 750,000 (6,264) 743,736
Unsecured senior notes payable – green bond 2.00 % 2.12 5/18/32 900,000 900,000 (9,712) 890,288
Unsecured senior notes payable 1.875 % 1.97 2/1/33 1,000,000 1,000,000 (9,701) 990,299
Unsecured senior notes payable 4.85 % 4.93 4/15/49 300,000 300,000 (3,217) 296,783
Unsecured senior notes payable 4.00 % 3.91 2/1/50 700,000 700,000 10,320 710,320
Unsecured senior notes payable 3.00 % 3.08 5/18/51 850,000 850,000 (12,365) 837,635
Unsecured debt weighted average/subtotal 3.44 600,000 920,000 7,125,000 8,645,000 (58,332) 8,586,668
Weighted-average interest rate/total 3.44 % $ 3,592 $ 3,772 $ 183,559 $ 600,034 $ 930,038 $ 7,125,518 $ 8,846,513 $ (54,647) $ 8,791,866
Balloon payments $ $ $ 183,221 $ 600,000 $ 930,002 $ 7,125,068 $ 8,838,291 $ $ 8,838,291
Principal amortization 3,592 3,772 338 34 36 450 8,222 (54,647) (46,425)
Total debt $ 3,592 $ 3,772 $ 183,559 $ 600,034 $ 930,038 $ 7,125,518 $ 8,846,513 $ (54,647) $ 8,791,866
Fixed-rate debt $ 3,592 $ 3,772 $ 183,559 $ 600,034 $ 650,036 $ 7,125,518 $ 8,566,511 $ (54,637) $ 8,511,874
Variable-rate debt 280,002 280,002 (10) 279,992
Total debt $ 3,592 $ 3,772 $ 183,559 $ 600,034 $ 930,038 $ 7,125,518 $ 8,846,513 $ (54,647) $ 8,791,866
Weighted-average stated rate on maturing debt N/A N/A 4.82% 3.45% 2.93% 3.38%

(1)Represents the weighted-average interest rate as of the end of the applicable period, including amortization of loan fees, amortization of debt premiums (discounts), and other bank fees.

(2)Reflects any extension options that we control.

(3)Relates to our real estate joint venture at 99 Coolidge Avenue, of which we own 75.0%. As of December 31, 2021, this joint venture has a $185.3 million availability under the existing lender commitments. The interest rate shall be reduced from SOFR+2.70% to SOFR+2.10% over time upon the completion of certain leasing, construction, and financial covenant milestones.

(4)Refer to footnote 2 on the prior page under “Fixed-rate and variable-rate debt.”

(5)During the year ended December 31, 2020, we achieved certain sustainability measures, as described in our unsecured senior line of credit agreement, which reduced the borrowing rate by one basis point for a one-year period.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 55
Definitions and Reconciliations
---
December 31, 2021

This section contains additional details for sections throughout this Supplemental Information and the accompanying Earnings Press Release, as well as explanations and reconciliations of certain non-GAAP financial measures and the reasons why we use these supplemental measures of performance and believe they provide useful information to investors. Additional detail can be found in our most recent annual report on Form 10-K and subsequent quarterly reports on Form 10-Q, as well as other documents filed with or furnished to the SEC from time to time.

Adjusted EBITDA and Adjusted EBITDA margin

The following table reconciles net income (loss) and revenues, the most directly comparable financial measures calculated and presented in accordance with GAAP, to Adjusted EBITDA and calculates the Adjusted EBITDA margin:

Three Months Ended
(Dollars in thousands) 12/31/21 9/30/21 6/30/21 3/31/21 12/31/20
Net income $ 99,796 $ 124,433 $ 404,520 $ 25,533 $ 457,133
Interest expense 34,862 35,678 35,158 36,467 37,538
Income taxes 4,156 3,672 2,800 1,426 2,053
Depreciation and amortization 239,254 210,842 190,052 180,913 177,750
Stock compensation expense 14,253 9,728 12,242 12,446 11,394
Loss on early extinguishment of debt 67,253 7,898
(Gain) loss on sales of real estate (124,226) 435 (2,779) (152,503)
Significant realized gains on non-real estate investments (52,427) (34,773) (22,919)
Unrealized losses (gains) on non-real estate investments 139,716 14,432 (244,031) 46,251 (233,538)
Impairment of real estate 42,620 4,926 5,129 25,177
Adjusted EBITDA $ 407,811 $ 389,413 $ 370,894 $ 349,720 $ 332,902
Total revenues $ 576,923 $ 547,759 $ 509,619 $ 479,849 $ 463,720
Adjusted EBITDA margin 71% 71% 73% 73% 72%

We use Adjusted EBITDA as a supplemental performance measure of our operations, for financial and operational decision-making, and as a supplemental means of evaluating period-to-period comparisons on a consistent basis. Adjusted EBITDA is calculated as earnings before interest, taxes, depreciation, and amortization (“EBITDA”), excluding stock compensation expense, gains or losses on early extinguishment of debt, gains or losses on sales of real estate, impairments of real estate, and significant termination fees. Adjusted EBITDA also excludes unrealized gains or losses and significant realized gains or losses and impairments that result from our non-real estate investments. These non-real estate investment amounts are classified in our consolidated statements of operations outside of total revenues.

We believe Adjusted EBITDA provides investors with relevant and useful information as it allows investors to evaluate the operating performance of our business activities without having to account for differences recognized because of investing and financing decisions related to our real estate and non-real estate investments, our capital structure, capital market transactions, and variances resulting from the volatility of market conditions outside of our control. For example, we exclude gains or losses on the early extinguishment of debt to allow investors to measure our performance independent of our indebtedness and capital structure. We believe that adjusting for the effects of impairments and gains or losses on sales of real estate, significant impairments and realized gains or losses on non-real estate investments, and significant termination fees allows investors to evaluate performance from period to period on a consistent basis without having to account for differences recognized because of investing and financing decisions related to our real estate and non-real estate investments or other corporate activities that may not be representative of the operating performance of our properties.

In addition, we believe that excluding charges related to stock compensation and unrealized gains or losses facilitates for investors a comparison of our business activities across periods without the volatility resulting from market forces outside of our control. Adjusted EBITDA has limitations as a measure of our performance. Adjusted EBITDA does not reflect our historical expenditures or future requirements for capital expenditures or contractual commitments. While Adjusted EBITDA is a relevant measure of performance, it does not represent net income (loss) or cash flows from operations calculated and presented in accordance with GAAP, and it should not be considered as an alternative to those indicators in evaluating performance or liquidity.

In order to calculate the Adjusted EBITDA margin, we divide Adjusted EBITDA by total revenue as presented in our consolidated statements of operations. We believe this supplemental performance measure provides investors with additional useful information regarding the profitability of our operating activities.

Annual rental revenue

Annual rental revenue represents the annualized fixed base rental obligations, calculated in accordance with GAAP, for leases in effect as of the end of the period, related to our operating RSF. Annual rental revenue is presented using 100% of the annual rental revenue of our consolidated properties and our share of annual rental revenue for our unconsolidated real estate joint ventures. Annual rental revenue per RSF is computed by dividing annual rental revenue by the sum of 100% of the RSF of our consolidated properties and our share of the RSF of properties held in unconsolidated real estate joint ventures. As of December 31, 2021, approximately 91% of our leases (on an RSF basis) were triple net leases, which require tenants to pay substantially all real estate taxes, insurance, utilities, repairs and maintenance, common area expenses, and other operating expenses (including increases thereto) in addition to base rent. Annual rental revenue excludes these operating expenses recovered from our tenants. Amounts recovered from our tenants related to these operating expenses, along with base rent, are classified in income from rentals in our consolidated statements of operations.

Capitalization Rates

Capitalization rates are calculated based upon net operating income and net operating income (cash basis) annualized for the quarter preceding the date on which the property is sold, or near term prospective net operating income.

| Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 | 56 | | --- | --- || Definitions and Reconciliations (continued) | | --- | | December 31, 2021 |

Cash interest

Cash interest is equal to interest expense calculated in accordance with GAAP plus capitalized interest, less amortization of loan fees and debt premiums (discounts). Refer to the definition of fixed-charge coverage ratio for a reconciliation of interest expense, the most directly comparable financial measure calculated and presented in accordance with GAAP, to cash interest.

Class A properties and AAA locations

Class A properties are properties clustered in AAA locations that provide innovative tenants with highly dynamic and collaborative environments that enhance their ability to successfully recruit and retain world-class talent and inspire productivity, efficiency, creativity, and success. Class A properties generally command higher annual rental rates than other classes of similar properties.

AAA locations are in close proximity to concentrations of specialized skills, knowledge, institutions, and related businesses. Such locations are generally characterized by high barriers to entry for new landlords, high barriers to exit for tenants, and a limited supply of available space.

Development, redevelopment, and pre-construction

A key component of our business model is our disciplined allocation of capital to the development and redevelopment of new Class A properties, and property enhancements identified during the underwriting of certain acquired properties, located in collaborative life science, agtech, and technology campuses in AAA innovation clusters. These projects are generally focused on providing high-quality, generic, and reusable spaces that meet the real estate requirements of, and are reusable by, a wide range of tenants. Upon completion, each value-creation project is expected to generate a significant increase in rental income, net operating income, and cash flows. Our development and redevelopment projects are generally in locations that are highly desirable to high-quality entities, which we believe results in higher occupancy levels, longer lease terms, higher rental income, higher returns, and greater long-term asset value.

Development projects generally consist of the ground-up development of generic and reusable facilities. Redevelopment projects consist of the permanent change in use of office, warehouse, and shell space into office/laboratory, agtech, or tech office space. We generally will not commence new development projects for aboveground construction of new Class A office/laboratory, agtech, and tech office space without first securing significant pre-leasing for such space, except when there is solid market demand for high-quality Class A properties.

Pre-construction activities include entitlements, permitting, design, site work, and other activities preceding commencement of construction of aboveground building improvements. The advancement of pre-construction efforts is focused on reducing the time required to deliver projects to prospective tenants. These critical activities add significant value for future ground-up development and are required for the vertical construction of buildings. Ultimately, these projects will provide high-quality facilities and are expected to generate significant revenue and cash flows.

Development, redevelopment, and pre-construction spending also includes the following costs: (i) certain tenant improvements and renovations that will be reimbursed, (ii) amounts to bring certain acquired properties up to market standard and/or other costs identified during the acquisition process (generally within two years of acquisition), and (iii) permanent conversion of space for highly flexible, move-in-ready office/laboratory space to foster the growth of promising early- and growth-stage life science companies.

Revenue-enhancing and repositioning capital expenditures represent spending to reposition or significantly change the use of a property, including through improvement in the asset quality from Class B to Class A.

Non-revenue-enhancing capital expenditures represent costs required to maintain the current revenues of a stabilized property, including the associated costs for renewed and re-leased space.

Dividend payout ratio (common stock)

Dividend payout ratio (common stock) is the ratio of the absolute dollar amount of dividends on our common stock (shares of common stock outstanding on the respective record dates multiplied by the related dividend per share) to funds from operations attributable to Alexandria’s common stockholders – diluted, as adjusted.

Dividend yield

Dividend yield for the quarter represents the annualized quarter dividend divided by the closing common stock price at the end of the quarter.

Fixed-charge coverage ratio

Fixed-charge coverage ratio is a non-GAAP financial measure representing the ratio of Adjusted EBITDA to fixed charges. We believe this ratio is useful to investors as a supplemental measure of our ability to satisfy fixed financing obligations and preferred stock dividends. Cash interest is equal to interest expense calculated in accordance with GAAP plus capitalized interest, less amortization of loan fees and debt premiums (discounts).

The following table reconciles interest expense, the most directly comparable financial measure calculated and presented in accordance with GAAP, to cash interest and fixed charges:

Three Months Ended
(Dollars in thousands) 12/31/21 9/30/21 6/30/21 3/31/21 12/31/20
Adjusted EBITDA $ 407,811 $ 389,413 $ 370,894 $ 349,720 $ 332,902
Interest expense $ 34,862 $ 35,678 $ 35,158 $ 36,467 $ 37,538
Capitalized interest 44,078 43,185 43,492 39,886 37,589
Amortization of loan fees (2,911) (2,854) (2,859) (2,817) (2,905)
Amortization of debt premiums 502 498 465 576 869
Cash interest and fixed charges $ 76,531 $ 76,507 $ 76,256 $ 74,112 $ 73,091
Fixed-charge coverage ratio:
– quarter annualized 5.3x 5.1x 4.9x 4.7x 4.6x
– trailing 12 months 5.0x 4.8x 4.6x 4.4x 4.4x
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Funds from operations and funds from operations, as adjusted, attributable to Alexandria’s common stockholders

GAAP-basis accounting for real estate assets utilizes historical cost accounting and assumes that real estate values diminish over time. In an effort to overcome the difference between real estate values and historical cost accounting for real estate assets, the Nareit Board of Governors established funds from operations as an improved measurement tool. Since its introduction, funds from operations has become a widely used non-GAAP financial measure among equity REITs. We believe that funds from operations is helpful to investors as an additional measure of the performance of an equity REIT. Moreover, we believe that funds from operations, as adjusted, allows investors to compare our performance to the performance of other real estate companies on a consistent basis, without having to account for differences recognized because of real estate acquisition and disposition decisions, financing decisions, capital structure, capital market transactions, variances resulting from the volatility of market conditions outside of our control, or other corporate activities that may not be representative of the operating performance of our properties.

The 2018 White Paper published by the Nareit Board of Governors (the “Nareit White Paper”) defines funds from operations as net income (computed in accordance with GAAP), excluding gains or losses on sales of real estate, and impairments of real estate, plus depreciation and amortization of operating real estate assets, and after adjustments for our share of consolidated and unconsolidated partnerships and real estate joint ventures. Impairments represent the write-down of assets when fair value over the recoverability period is less than the carrying value due to changes in general market conditions and do not necessarily reflect the operating performance of the properties during the corresponding period.

We compute funds from operations, as adjusted, as funds from operations calculated in accordance with the Nareit White Paper, excluding significant gains, losses, and impairments realized on non-real estate investments, unrealized gains or losses on non-real estate investments, gains or losses on early extinguishment of debt, significant termination fees, acceleration of stock compensation expense due to the resignation of an executive officer, deal costs, the income tax effect related to such items, and the amount of such items that is allocable to our unvested restricted stock awards. Neither funds from operations nor funds from operations, as adjusted, should be considered as alternatives to net income (determined in accordance with GAAP) as indications of financial performance, or to cash flows from operating activities (determined in accordance with GAAP) as measures of liquidity, nor are they indicative of the availability of funds for our cash needs, including our ability to make distributions.

The following table reconciles net income to funds from operations for the share of consolidated real estate joint ventures attributable to noncontrolling interests and our share of unconsolidated real estate joint ventures:

(In thousands) Noncontrolling Interest Share of Consolidated Real Estate JVs Our Share of Unconsolidated <br>Real Estate JVs
December 31, 2021 December 31, 2021
Three Months Ended Year Ended Three Months Ended Year Ended
Net income $ 24,901 $ 83,035 $ 3,018 $ 12,255
Depreciation and amortization 21,265 70,880 3,058 13,734
Funds from operations $ 46,166 $ 153,915 $ 6,076 $ 25,989

Gross assets

Gross assets is calculated as total assets plus accumulated depreciation:

(in thousands) 12/31/21 9/30/21 6/30/21 3/31/21 12/31/20
Total assets $ 30,219,373 $ 28,558,718 $ 27,018,850 $ 25,234,346 $ 22,827,878
Accumulated depreciation 3,771,241 3,614,440 3,461,780 3,319,597 3,182,438
Gross assets $ 33,990,614 $ 32,173,158 $ 30,480,630 $ 28,553,943 $ 26,010,316

Initial stabilized yield (unlevered)

Initial stabilized yield is calculated as the estimated amounts of net operating income at stabilization divided by our investment in the property. Our initial stabilized yield excludes the benefit of leverage. Our cash rents related to our value-creation projects are generally expected to increase over time due to contractual annual rent escalations. Our estimates for initial stabilized yields, initial stabilized yields (cash basis), and total costs at completion represent our initial estimates at the commencement of the project. We expect to update this information upon completion of the project, or sooner if there are significant changes to the expected project yields or costs.

•Initial stabilized yield reflects rental income, including contractual rent escalations and any rent concessions over the term(s) of the lease(s), calculated on a straight-line basis.

•Initial stabilized yield (cash basis) reflects cash rents at the stabilization date after initial rental concessions, if any, have elapsed and our total cash investment in the property.

Investment-grade or publicly traded large cap tenants

Investment-grade or publicly traded large cap tenants represent tenants that are investment-grade rated or publicly traded companies with an average daily market capitalization greater than $10 billion for the twelve months ended December 31, 2021, as reported by Bloomberg Professional Services. Credit ratings from Moody’s Investors Service and S&P Global Ratings reflect credit ratings of the tenant’s parent entity, and there can be no assurance that a tenant’s parent entity will satisfy the tenant’s lease obligation upon such tenant’s default. We monitor the credit quality and related material changes of our tenants. Material changes that cause a tenant’s market capitalization to decrease below $10 billion, which are not immediately reflected in the twelve-month average, may result in their exclusion from this measure.

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Investments

We hold investments in publicly traded companies and privately held entities primarily

involved in the life science, agtech, and technology industries. We recognize, measure, present, and

disclose these investments as follows:

Statements of Operations
Balance Sheet Gains and Losses
Carrying Amount Unrealized Realized
Difference between proceeds received upon disposition and historical cost
Publicly traded companies Fair value Changes in fair value
Privately held entities without readily determinable fair values that:
Report NAV Fair value, using NAV as a practical expedient Changes in NAV, as a practical expedient to fair value
Do not report NAV Cost, adjusted for observable price changes and impairments(1) Observable price changes(1) Impairments to reduce costs to fair value, which result in an adjusted cost basis and the differences between proceeds received upon disposition and adjusted or historical cost
Equity method investments Contributions, adjusted for our share of the investee’s earnings or losses, less distributions received, reduced by other-than-temporary impairments Our share of unrealized gains or losses reported by the investee Our share of realized gains or losses reported by the investee, and other-than-temporary impairments

(1)An observable price is a price observed in an orderly transaction for an identical or similar investment of the same issuer. Observable price changes result from, among other things, equity transactions for the same issuer with similar rights and obligations executed during the reporting period, including subsequent equity offerings or other reported equity transactions related to the same issuer.

Investments in real estate

The following table reconciles our investments in real estate as of December 31, 2021:

(In thousands) Investments in <br>Real Estate
Gross investments in real estate $ 28,733,108
Less: accumulated depreciation (3,766,758)
Net investments in real estate – North America 24,966,350
Net investments in real estate – Asia 14,319
Investments in real estate $ 24,980,669

The square footage presented in the table below includes RSF of buildings in operation as of December 31, 2021, primarily representing lease expirations at recently acquired properties that also have inherent future development or redevelopment opportunities, for which we have the intent to demolish or redevelop the existing property upon expiration of the existing in-place leases and commencement of future construction:

Dev/<br>Redev RSF of Lease Expirations Targeted for<br>Development and Redevelopment
Property/Submarket 2022 2023 Thereafter Total
Near-term projects:
40 Sylvan Road/Route 128 Redev 312,845 312,845
651 Gateway Boulevard/South San Francisco Redev 197,787 102,223 (1) 300,010
3825 Fabian Way/Greater Stanford Redev 250,000 250,000
3450 Hillview Avenue/Greater Stanford Redev 42,340 42,340
11255 and 11355 North Torrey Pines Road/<br>   Torrey Pines Dev 139,135 139,135
10931 and 10933 North Torrey Pines Road/<br>   Torrey Pines Dev 92,450 92,450
3301 Monte Villa Parkway/Bothell Redev 51,255 51,255
41 Moore Drive/Research Triangle Redev 62,490 62,490
835,457 312,845 102,223 1,250,525
Intermediate-term projects:
3460 Hillview Avenue/Greater Stanford Redev 34,611 34,611
9444 Waples Street/Sorrento Mesa Dev 30,855 57,525 (1) 88,380
30,855 92,136 122,991
Future projects:
550 Arsenal Street/Cambridge/Inner Suburbs Dev 260,867 260,867
380 and 420 E Street/Seaport Innovation District Dev 195,506 195,506
Other/Greater Boston Redev 167,549 (1) 167,549
1122 El Camino Real/South San Francisco Dev 223,232 223,232
3875 Fabian Way/Greater Stanford Redev 228,000 228,000
960 Industrial Road/Greater Stanford Dev 110,000 110,000
2475 Hanover Street/Greater Stanford Redev 83,980 83,980
219 East 42nd Street/New York City Dev 349,947 349,947
10975 and 10995 Torreyana Road/Torrey Pines Dev 84,829 84,829
4161 Campus Point Court/University Town Center Dev 159,884 159,884
10260 Campus Point Drive/University Town Center Dev 109,164 109,164
Sequence District by Alexandria/Sorrento Mesa Dev/Redev 689,938 689,938
4025, 4031, and 4045 Sorrento Valley Boulevard/Sorrento Valley Dev 42,594 42,594
601 Dexter Avenue North/Lake Union Dev 18,680 18,680
830 4th Avenue South/SoDo Dev 42,380 42,380
Other/Seattle Dev 84,782 17,655 (1) 102,437
Other TBD 70,700 72,405 (1) 143,105
113,294 353,830 2,544,968 3,012,092
979,606 666,675 2,739,327 4,385,608

(1)Includes vacant square footage as of December 31, 2021.

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Joint venture financial information

We present components of balance sheet and operating results information related to our real estate joint ventures, which are not presented, or intended to be presented, in accordance with GAAP. We present the proportionate share of certain financial line items as follows: (i) for each real estate joint venture that we consolidate in our financial statements, which are controlled by us through contractual rights or majority voting rights, but of which we own less than 100%, we apply the noncontrolling interest economic ownership percentage to each financial item to arrive at the amount of such cumulative noncontrolling interest share of each component presented; and (ii) for each real estate joint venture that we do not control and do not consolidate, and are instead controlled jointly or by our joint venture partners through contractual rights or majority voting rights, we apply our economic ownership percentage to each financial item to arrive at our proportionate share of each component presented.

The components of balance sheet and operating results information related to our real estate joint ventures do not represent our legal claim to those items. For each entity that we do not wholly own, the joint venture agreement generally determines what equity holders can receive upon capital events, such as sales or refinancing, or in the event of a liquidation. Equity holders are normally entitled to their respective legal ownership of any residual cash from a joint venture only after all liabilities, priority distributions, and claims have been repaid or satisfied.

We believe this information can help investors estimate the balance sheet and operating results information related to our partially owned entities. Presenting this information provides a perspective not immediately available from consolidated financial statements and one that can supplement an understanding of the joint venture assets, liabilities, revenues, and expenses included in our consolidated results.

The components of balance sheet and operating results information related to our real estate joint ventures are limited as an analytical tool as the overall economic ownership interest does not represent our legal claim to each of our joint ventures’ assets, liabilities, or results of operations. In addition, joint venture financial information may include financial information related to the unconsolidated real estate joint ventures that we do not control. We believe that in order to facilitate for investors a clear understanding of our operating results and our total assets and liabilities, joint venture financial information should be examined in conjunction with our consolidated statements of operations and balance sheets. Joint venture financial information should not be considered an alternative to our consolidated financial statements, which are presented and prepared in accordance with GAAP.

Key items included in net income attributable to Alexandria’s common stockholders

We present a tabular comparison of items, whether gain or loss, that may facilitate a high-level understanding of our results and provide context for the disclosures included in this Supplemental Information, our most recent annual report on Form 10-K, and our subsequent quarterly reports on Form 10-Q. We believe such tabular presentation promotes a better understanding for investors of the corporate-level decisions made and activities performed that significantly affect comparison of our operating results from period to period. We also believe this tabular presentation will supplement for investors an understanding of our disclosures and real estate operating results. Gains or losses on sales of real estate and impairments of held for sale assets are related to corporate-level decisions to dispose of real estate. Gains or losses on early extinguishment of debt are related to corporate-level financing decisions focused on our capital structure strategy. Significant realized and unrealized gains or losses on non-real estate investments and impairments of real estate and non-real estate investments are not related to the operating performance of our real estate assets as they result from strategic, corporate-level non-real estate investment decisions and external market conditions. Impairments of non-real estate investments are not related to the operating performance of our real estate as they represent the write-down of non-real estate investments when their fair values decrease below their respective

carrying values due to changes in general market or other conditions outside of our control. Significant items, whether a gain or loss, included in the tabular disclosure for current periods are described in further detail in this Supplemental Information and accompanying Earnings Press Release.

Mega campus

Mega campuses are cluster campuses that consist of approximately 1 million or more RSF, including operating, active development/redevelopment, and land RSF less operating RSF expected to be demolished. The following table reconciles our operating RSF as of December 31, 2021:

Operating RSF
Mega campus 24,599,149
Non-mega campus 14,236,643
Total 38,835,792
Mega campus RSF as a percentage of total operating property RSF 63 %

Net cash provided by operating activities after dividends

Net cash provided by operating activities after dividends includes the deduction for distributions to noncontrolling interests. For purposes of this calculation, changes in operating assets and liabilities are excluded as they represent timing differences.

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Net debt and preferred stock to Adjusted EBITDA

Net debt and preferred stock to Adjusted EBITDA is a non-GAAP financial measure that we believe is useful to investors as a supplemental measure of evaluating our balance sheet leverage. Net debt and preferred stock is equal to the sum of total consolidated debt less cash, cash equivalents, and restricted cash, plus preferred stock outstanding as of the end of the period. Refer to the definition of Adjusted EBITDA and Adjusted EBITDA margin for further information on the calculation of Adjusted EBITDA.

The following table reconciles debt to net debt and preferred stock and computes the ratio to Adjusted EBITDA:

(Dollars in thousands) 12/31/21 9/30/21 6/30/21 3/31/21 12/31/20
Secured notes payable $ 205,198 $ 198,758 $ 227,984 $ 229,406 $ 230,925
Unsecured senior notes payable 8,316,678 8,314,851 8,313,025 8,311,512 7,232,370
Unsecured senior line of credit and commercial paper 269,990 749,978 299,990 99,991
Unamortized deferred financing costs 65,476 65,112 66,913 68,293 56,312
Cash and cash equivalents (361,348) (325,872) (323,876) (492,184) (568,532)
Restricted cash (53,879) (42,182) (33,697) (42,219) (29,173)
Preferred stock
Net debt and preferred stock $ 8,442,115 $ 8,960,645 $ 8,550,339 $ 8,074,808 $ 7,021,893
Adjusted EBITDA:
– quarter annualized $ 1,631,244 $ 1,557,652 $ 1,483,576 $ 1,398,880 $ 1,331,608
– trailing 12 months $ 1,517,838 $ 1,442,929 $ 1,371,586 $ 1,314,153 $ 1,274,187
Net debt and preferred stock to Adjusted EBITDA:
– quarter annualized 5.2 x 5.8 x 5.8 x 5.8 x 5.3 x
– trailing 12 months 5.6 x 6.2 x 6.2 x 6.1 x 5.5 x

Net operating income, net operating income (cash basis), and operating margin

The following table reconciles net income to net operating income and to net operating income (cash basis):

Three Months Ended Year Ended
(Dollars in thousands) 12/31/21 12/31/20 12/31/21 12/31/20
Net income $ 99,796 $ 457,133 $ 654,282 $ 827,171
Equity in earnings of unconsolidated real estate joint ventures (3,018) (3,593) (12,255) (8,148)
General and administrative expenses 41,654 32,690 151,461 133,341
Interest expense 34,862 37,538 142,165 171,609
Depreciation and amortization 239,254 177,750 821,061 698,104
Impairment of real estate 25,177 52,675 48,078
Loss on early extinguishment of debt 7,898 67,253 60,668
Gain on sales of real estate (124,226) (152,503) (126,570) (154,089)
Investment loss (income) 112,884 (255,137) (259,477) (421,321)
Net operating income 401,206 326,953 1,490,595 1,355,413
Straight-line rent revenue (25,942) (23,890) (115,145) (96,676)
Amortization of acquired below-market leases (15,737) (13,514) (54,780) (57,244)
Net operating income (cash basis) $ 359,527 $ 289,549 $ 1,320,670 $ 1,201,493
Net operating income (cash basis) – annualized $ 1,438,108 $ 1,158,196 $ 1,320,670 $ 1,201,493
Net operating income (from above) $ 401,206 $ 326,953 $ 1,490,595 $ 1,355,413
Total revenues $ 576,923 $ 463,720 $ 2,114,150 $ 1,885,637
Operating margin 70% 71% 71% 72%

Net operating income is a non-GAAP financial measure calculated as net income, the most directly comparable financial measure calculated and presented in accordance with GAAP, excluding equity in the earnings of our unconsolidated real estate joint ventures, general and administrative expenses, interest expense, depreciation and amortization, impairments of real estate, gains or losses on early extinguishment of debt, gains or losses on sales of real estate, and investment income or loss. We believe net operating income provides useful information to investors regarding our financial condition and results of operations because it primarily reflects those income and expense items that are incurred at the property level. Therefore, we believe net operating income is a useful measure for investors to evaluate the operating performance of our consolidated real estate assets. Net operating income on a cash basis is net operating income adjusted to exclude the effect of straight-line rent and amortization of acquired above- and below-market lease revenue adjustments required by GAAP. We believe that net operating income on a cash basis is helpful to investors as an additional measure of operating performance because it eliminates straight-line rent revenue and the amortization of acquired above- and below-market leases.

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Furthermore, we believe net operating income is useful to investors as a performance measure of our consolidated properties because, when compared across periods, net operating income reflects trends in occupancy rates, rental rates, and operating costs, which provide a perspective not immediately apparent from net income or loss. Net operating income can be used to measure the initial stabilized yields of our properties by calculating net operating income generated by a property divided by our investment in the property. Net operating income excludes certain components from net income in order to provide results that are more closely related to the results of operations of our properties. For example, interest expense is not necessarily linked to the operating performance of a real estate asset and is often incurred at the corporate level rather than at the property level. In addition, depreciation and amortization, because of historical cost accounting and useful life estimates, may distort comparability of operating performance at the property level. Impairments of real estate have been excluded in deriving net operating income because we do not consider impairments of real estate to be property-level operating expenses. Impairments of real estate relate to changes in the values of our assets and do not reflect the current operating performance with respect to related revenues or expenses. Our impairments of real estate represent the write-down in the value of the assets to the estimated fair value less cost to sell. These impairments result from investing decisions or a deterioration in market conditions. We also exclude realized and unrealized investment gain or loss, which results from investment decisions that occur at the corporate level related to non-real estate investments in publicly traded companies and certain privately held entities. Therefore, we do not consider these activities to be an indication of operating performance of our real estate assets at the property level. Our calculation of net operating income also excludes charges incurred from changes in certain financing decisions, such as losses on early extinguishment of debt, as these charges often relate to corporate strategy. Property operating expenses included in determining net operating income primarily consist of costs that are related to our operating properties, such as utilities, repairs, and maintenance; rental expense related to ground leases; contracted services, such as janitorial, engineering, and landscaping; property taxes and insurance; and property-level salaries. General and administrative expenses consist primarily of accounting and corporate compensation, corporate insurance, professional fees, office rent, and office supplies that are incurred as part of corporate office management. We calculate operating margin as net operating income divided by total revenues.

We believe that in order to facilitate for investors a clear understanding of our operating results, net operating income should be examined in conjunction with net income or loss as presented in our consolidated statements of operations. Net operating income should not be considered as an alternative to net income or loss as an indication of our performance, nor as an alternative to cash flows as a measure of our liquidity or our ability to make distributions.

Operating statistics

We present certain operating statistics related to our properties, including number of properties, RSF, occupancy percentage, leasing activity, and contractual lease expirations as of the end of the period. We believe these measures are useful to investors because they facilitate an understanding of certain trends for our properties. We compute the number of properties, RSF, occupancy percentage, leasing activity, and contractual lease expirations at 100% for all properties in which we have an investment, including properties owned by our consolidated and unconsolidated real estate joint ventures. For operating metrics based on annual rental revenue, refer to our discussion of annual rental revenue herein.

Same property comparisons

As a result of changes within our total property portfolio during the comparative periods presented, including changes from assets acquired or sold, properties placed into development or redevelopment, and development or redevelopment properties recently placed into service, the consolidated total income from rentals, as well as rental operating expenses in our operating results, can show significant changes from period to period. In order to supplement an evaluation of our results of operations over a given quarterly or annual period, we analyze the operating performance for all consolidated properties that were fully operating for the entirety of the comparative periods presented, referred to as same properties. We separately present quarterly and year-to-date same property results to align with the interim financial information required by the SEC in our management’s discussion and analysis of our financial condition and results of operations. These same properties are analyzed separately from properties acquired subsequent to the first day in the earliest comparable quarterly or year-to-date period presented, properties that underwent development or redevelopment at any time during the comparative periods, unconsolidated real estate joint ventures, properties classified as held for sale, and corporate entities (legal entities performing general and administrative functions), which are excluded from same property results. Additionally, termination fees, if any, are excluded from the results of same properties.

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The following table reconciles the number of same properties to total properties for the year ended December 31, 2021:

Development – under construction Properties Acquisitions after January 1, 2020 Properties
9950 Medical Center Drive 1 3181 Porter Drive 1
825 and 835 Industrial Road 2 275 Grove Street 1
3115 Merryfield Row 1 601, 611, and 651 Gateway Boulevard 3
201 Haskins Way 1 3330, 3412, 3420, 3440, 3450, and 3460 Hillview Avenue 6
5 and 9 Laboratory Drive 2
8 and 10 Davis Drive 2 9605, 9609, 9613, and 9615 Medical Center Drive 4
201 Brookline Avenue 1
10055 Barnes Canyon Road 1 9808 and 9868 Scranton Road 2
751 Gateway Boulevard 1 Alexandria Center® for Life Science – Durham
325 Binney Street 1 13
1150 Eastlake Avenue East 1 One Upland Road 1
10102 Hoyt Park Drive 1 830 4th Avenue South 1
15 11255 and 11355 North Torrey Pines Road 2
Development – placed into
service after January 1, 2020 Properties Sequence District by Alexandria 7
9804 Medical Center Drive 1 380 and 420 E Street 2
1165 Eastlake Avenue East 1 Alexandria Center® for Life Science – Fenway 1
2
Redevelopment – under construction Properties 550 Arsenal Street 1
5505 Morehouse Drive 1 1501-1599 Industrial Road 6
30-02 48th Avenue 1 One Investors Way 2
3160 Porter Drive 1 2475 Hanover Street 1
The Arsenal on the Charles 11 10975 and 10995 Torreyana Road 2
2400 Ellis Road, 40 Moore Drive, and 14 TW Alexander Drive 3 Pacific Technology Park 6
1122 El Camino Real 1
840 Winter Street 1 12 Davis Drive 1
20400 Century Boulevard 1 7360 Carroll Road 1
10277 Scripps Ranch Boulevard 1 3303, 3305, and 3307 Monte Villa Parkway 3
9601 and 9603 Medical Center Drive 2
One Rogers Street 1 Other 44
40, 50, and 60 Sylvan Road 3 112
3301, 3555, and 3755 Monte Villa Parkway 3 Unconsolidated real estate JVs 4
Properties held for sale
Other 2
31 Total properties excluded from same properties 167
Redevelopment – placed into
service after January 1, 2020 Properties Same properties 247
9877 Waples Street 1 Total properties in North America as of December 31, 2021 414
700 Quince Orchard Road 1
Other 1
3

Stabilized occupancy date

The stabilized occupancy date represents the estimated date on which the project is expected to reach occupancy of 95% or greater.

Tenant recoveries

Tenant recoveries represent revenues comprising reimbursement of real estate taxes, insurance, utilities, repairs and maintenance, common area expenses, and other operating expenses and earned in the period during which the applicable expenses are incurred and the tenant’s obligation to reimburse us arises.

We classify rental revenues and tenant recoveries generated through the leasing of real estate assets within revenue in income from rentals in our consolidated statements of operations. We provide investors with a separate presentation of rental revenues and tenant recoveries in “Same Property Performance” of this Supplemental Information because we believe it promotes investors’ understanding of our operating results. We believe that the presentation of tenant recoveries is useful to investors as a supplemental measure of our ability to recover operating expenses under our triple net leases, including recoveries of utilities, repairs and maintenance, insurance, property taxes, common area expenses, and other operating expenses, and of our ability to mitigate the effect to net income for any significant variability to components of our operating expenses.

The following table reconciles income from rentals to tenant recoveries:

Three Months Ended Year Ended
(In thousands) 12/31/21 9/30/21 6/30/21 3/31/21 12/31/20 12/31/21 12/31/20
Income from rentals $ 574,656 $ 546,527 $ 508,371 $ 478,695 $ 461,335 $ 2,108,249 $ 1,878,208
Rental revenues (435,637) (415,918) (396,804) (370,233) (353,950) (1,618,592) (1,471,840)
Tenant recoveries $ 139,019 $ 130,609 $ 111,567 $ 108,462 $ 107,385 $ 489,657 $ 406,368

Total equity capitalization

Total equity capitalization is equal to the outstanding shares of common stock multiplied by the closing price on the last trading day at the end of each period presented.

Total market capitalization

Total market capitalization is equal to the sum of total equity capitalization and total debt.

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Unencumbered net operating income as a percentage of total net operating income

Unencumbered net operating income as a percentage of total net operating income is a non-GAAP financial measure that we believe is useful to investors as a performance measure of the results of operations of our unencumbered real estate assets as it reflects those income and expense items that are incurred at the unencumbered property level. Unencumbered net operating income is derived from assets classified in continuing operations, which are not subject to any mortgage, deed of trust, lien, or other security interest, as of the period for which income is presented.

The following table summarizes unencumbered net operating income as a percentage of total net operating income:

Three Months Ended
(Dollars in thousands) 12/31/21 9/30/21 6/30/21 3/31/21 12/31/20
Unencumbered net operating income $ 390,017 $ 371,026 $ 353,104 $ 330,160 $ 315,586
Encumbered net operating income 11,189 10,738 12,560 11,801 11,367
Total net operating income $ 401,206 $ 381,764 $ 365,664 $ 341,961 $ 326,953
Unencumbered net operating income as a percentage of total net operating income 97% 97% 97% 97% 97%

Weighted-average interest rate for capitalization of interest

The weighted-average interest rate required for calculating capitalization of interest pursuant to GAAP represents a weighted-average rate based on the rates applicable to borrowings outstanding during the period, including expense/income related to interest rate hedge agreements, amortization of loan fees, amortization of debt premiums (discounts), and other bank fees. A separate calculation is performed to determine our weighted-average interest rate for capitalization for each month. The rate will vary each month due to changes in variable interest rates, outstanding debt balances, the proportion of variable-rate debt to fixed-rate debt, the amount and terms of interest rate hedge agreements, and the amount of loan fee and premium (discount) amortization.

Weighted-average shares of common stock outstanding – diluted

From time to time, we enter into capital market transactions, including forward equity sales agreements (“Forward Agreements”), to fund acquisitions, to fund construction of our highly leased development and redevelopment projects, and for general working capital purposes. We are required to consider the potential dilutive effect of our forward equity sales agreements under the treasury stock method while the forward equity sales agreements are outstanding. As of December 31, 2021, we had no Forward Agreements outstanding.

The weighted-average shares of common stock outstanding used in calculating EPS – diluted, FFO per share – diluted, and FFO per share – diluted, as adjusted, during each period are calculated as follows:

Three Months Ended Year Ended
(In thousands) 12/31/21 9/30/21 6/30/21 3/31/21 12/31/20 12/31/21 12/31/20
Weighted-average of common stock outstanding – basic 153,464 150,854 145,825 137,319 133,688 146,921 126,106
Forward Agreements 843 707 233 369 139 539 384
Weighted-average of common stock outstanding – diluted 154,307 151,561 146,058 137,688 133,827 147,460 126,490
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