PTCT · Ptc Therapeutics, Inc.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by Section Six Partners, L.P., of which the Reporting Person is a general partner and limited partner, on May 14, 2026.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $72.11 to $72.25 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

Represents shares of common stock held by Section Six Partners, L.P. The Reporting Person is a general and limited partner of Section Six Partners, L.P. The Reporting Person disclaims beneficial ownership of the shares of common stock held by Section Six Partners, L.P. except to the extent of his pecuniary interest therein.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by Section Six Partners, L.P., of which the Reporting Person is a general partner and limited partner, on May 14, 2026.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $70.94 to $71.92 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

Represents shares of common stock held by Section Six Partners, L.P. The Reporting Person is a general and limited partner of Section Six Partners, L.P. The Reporting Person disclaims beneficial ownership of the shares of common stock held by Section Six Partners, L.P. except to the extent of his pecuniary interest therein.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by Section Six Partners, L.P., of which the Reporting Person is a general partner and limited partner, on May 14, 2026.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $72.02 to $73.01 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

Represents shares of common stock held by Section Six Partners, L.P. The Reporting Person is a general and limited partner of Section Six Partners, L.P. The Reporting Person disclaims beneficial ownership of the shares of common stock held by Section Six Partners, L.P. except to the extent of his pecuniary interest therein.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by Section Six Partners, L.P., of which the Reporting Person is a general partner and limited partner, on May 14, 2026.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $73.02 to $73.40 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

Represents shares of common stock held by Section Six Partners, L.P. The Reporting Person is a general and limited partner of Section Six Partners, L.P. The Reporting Person disclaims beneficial ownership of the shares of common stock held by Section Six Partners, L.P. except to the extent of his pecuniary interest therein.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by Section Six Partners, L.P., of which the Reporting Person is a general partner and limited partner, on May 14, 2026

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $72.60 to $73.48 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

Represents shares of common stock held by Section Six Partners, L.P. The Reporting Person is a general and limited partner of Section Six Partners, L.P. The Reporting Person disclaims beneficial ownership of the shares of common stock held by Section Six Partners, L.P. except to the extent of his pecuniary interest therein.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by Section Six Partners, L.P., of which the Reporting Person is a general partner and limited partner, on May 14, 2026

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $70.50 to $71.49 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

Represents shares of common stock held by Section Six Partners, L.P. The Reporting Person is a general and limited partner of Section Six Partners, L.P. The Reporting Person disclaims beneficial ownership of the shares of common stock held by Section Six Partners, L.P. except to the extent of his pecuniary interest therein.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by Section Six Partners, L.P., of which the Reporting Person is a general partner and limited partner, on May 14, 2026

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $71.50 to $72.46 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

Represents shares of common stock held by Section Six Partners, L.P. The Reporting Person is a general and limited partner of Section Six Partners, L.P. The Reporting Person disclaims beneficial ownership of the shares of common stock held by Section Six Partners, L.P. except to the extent of his pecuniary interest therein.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by Section Six Partners, L.P., of which the Reporting Person is a general partner and limited partner, on May 14, 2026

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $72.33 to $73.32 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

Represents shares of common stock held by Section Six Partners, L.P. The Reporting Person is a general and limited partner of Section Six Partners, L.P. The Reporting Person disclaims beneficial ownership of the shares of common stock held by Section Six Partners, L.P. except to the extent of his pecuniary interest therein.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by Section Six Partners, L.P., of which the Reporting Person is a general partner and limited partner, on May 14, 2026

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $73.33 to $74.02 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

Represents shares of common stock held by Section Six Partners, L.P. The Reporting Person is a general and limited partner of Section Six Partners, L.P. The Reporting Person disclaims beneficial ownership of the shares of common stock held by Section Six Partners, L.P. except to the extent of his pecuniary interest therein.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 10, 2025.

This option was granted on February 15, 2024, and vests over four years, with 25% of the shares underlying the option vesting on February 15, 2025, and an additional 6.25% of the original number of shares underlying the option vesting at the end of each successive three-month period thereafter, beginning on May 15, 2025.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 10, 2025.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 10, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $71.72 to $72.67 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 10, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $72.73 to $73.02 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of the 25,000 RSUs from an August 1, 2025 grant of 75,000 RSUs.

Includes 162 shares of common stock acquired under the Issuer's employee stock purchase plan for the period ended June 30, 2026.

This option was granted on July 28, 2026 and vests over six equal monthly installments, commencing on August 2, 2026.

This option was granted on July 28, 2026 and vests over 36 equal monthly installments, commencing on August 28, 2026.

Restricted stock units granted on July 28, 2026, with the shares underlying such restricted stock units vesting on January 2, 2027.

Restricted stock units granted on July 28, 2026, with the shares underlying such restricted stock units vesting in three equal annual installments, commencing on July 28, 2027.

Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 6,500 RSUs from a July 13, 2023 grant of 26,000 RSUs

Includes 162 shares of common stock acquired under the Issuer's employee stock purchase plan for the period ended June 30, 2026.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $90.00 to $90.70 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

Currently exercisable.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This option was granted on January 3, 2025, and vests over four years, with 25% of the shares underlying the option vesting on January 3, 2026, and an additional 6.25% of the original number of shares underlying the option vesting at the end of each successive three-month period thereafter, beginning on April 3, 2026.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

Currently exercisable.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $88.29 to $89.28 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This option was granted on January 5, 2023, and vests over four years, with 25% of the shares underlying the option vesting on January 5, 2024, and an additional 6.25% of the original number of shares underlying the option vesting at the end of each successive three-month period thereafter, beginning on April 5, 2024.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $87.00 to $87.81 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $89.29 to $89.75 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $86.03 to $86.74 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 10, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $82.76 to $83.68 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 10, 2025.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 10, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $85.18 to $86.17 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 10, 2025.

This option was granted on January 5, 2023 and vests over four years, with 25% of the shares underlying the option vesting on January 5, 2024, and an additional 6.25% of the original number of shares underlying the option vesting at the end of each successive three-month period thereafter, beginning on April 5, 2024.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 10, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $85.18 to $86.17 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $85.00 to $85.98 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 10, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $83.98 to $84.94 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 10, 2025.

This option was granted on January 3, 2025, and vests over four years, with 25% of the shares underlying the option vesting on January 3, 2026, and an additional 6.25% of the original number of shares underlying the option vesting at the end of each successive three-month period thereafter, beginning on April 3, 2026.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 10, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $83.98 to $84.94 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 10, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $86.18 to $86.73 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $85.00 to $85.95 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $87.00 to $87.07 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 10, 2025.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This option was granted on January 5, 2023, and vests over four years, with 25% of the shares underlying the option vesting on January 5, 2024, and an additional 6.25% of the original number of shares underlying the option vesting at the end of each successive three-month period thereafter, beginning on April 5, 2024.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

Includes 162 shares of common stock acquired under the Issuer's employee stock purchase plan for the period ended June 30, 2026.