PTCT

Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 6,500 RSUs from a July 13, 2023 grant of 26,000 RSUs

Includes 162 shares of common stock acquired under the Issuer's employee stock purchase plan for the period ended June 30, 2026.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $90.00 to $90.70 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

Currently exercisable.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This option was granted on January 3, 2025, and vests over four years, with 25% of the shares underlying the option vesting on January 3, 2026, and an additional 6.25% of the original number of shares underlying the option vesting at the end of each successive three-month period thereafter, beginning on April 3, 2026.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

Currently exercisable.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $88.29 to $89.28 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This option was granted on January 5, 2023, and vests over four years, with 25% of the shares underlying the option vesting on January 5, 2024, and an additional 6.25% of the original number of shares underlying the option vesting at the end of each successive three-month period thereafter, beginning on April 5, 2024.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $87.00 to $87.81 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $89.29 to $89.75 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $86.03 to $86.74 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 10, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $82.76 to $83.68 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 10, 2025.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 10, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $85.18 to $86.17 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 10, 2025.

This option was granted on January 5, 2023 and vests over four years, with 25% of the shares underlying the option vesting on January 5, 2024, and an additional 6.25% of the original number of shares underlying the option vesting at the end of each successive three-month period thereafter, beginning on April 5, 2024.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 10, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $85.18 to $86.17 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $85.00 to $85.98 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 10, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $83.98 to $84.94 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 10, 2025.

This option was granted on January 3, 2025, and vests over four years, with 25% of the shares underlying the option vesting on January 3, 2026, and an additional 6.25% of the original number of shares underlying the option vesting at the end of each successive three-month period thereafter, beginning on April 3, 2026.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 10, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $83.98 to $84.94 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 10, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $86.18 to $86.73 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $85.00 to $85.95 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $87.00 to $87.07 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 10, 2025.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This option was granted on January 5, 2023, and vests over four years, with 25% of the shares underlying the option vesting on January 5, 2024, and an additional 6.25% of the original number of shares underlying the option vesting at the end of each successive three-month period thereafter, beginning on April 5, 2024.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

Includes 162 shares of common stock acquired under the Issuer's employee stock purchase plan for the period ended June 30, 2026.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $86.02 to $86.73 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 10, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $86.18 to $86.73 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 10, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $82.76 to $83.68 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

Currently exercisable.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

Currently exercisable.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $85.07 to $85.30 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $85.00 to $85.75 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

Currently exercisable.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

Currently exercisable.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $85.00 to $85.84 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

Currently exercisable.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $86.02 to $86.97 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 11, 2025.

This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $85.00 to $85.98 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.