IONS · Ionis Pharmaceuticals Inc

Track IONS — free

$52.29 -5.84 (-10.05%) At close · Sep 4

Russell 1000 member Rebalance outlook locked

Market Cap

$9.65B

166.18M

Options Chain

Underlying $52.29 · today Options Calculator

Positioning

Sep 18, 2026 · 13 days to expiry · 60 contracts · mixed daily-bar sessions · Mar 20, 2026–Sep 4, 2026; 14 unknown

Put / call OI

0.53

Call-heavy positioning

Open interest

21,050

as of Sep 2, 2026

Volume

—

dated and unknown daily-bar sessions

Max pain

$60.00

$7.71 above spot

ATM implied vol

88.9%

market's expected move

Open interest by strike · near the money

Calls Puts

32.5

37.5

42.5

47.5

52.5

57.5

62.5

67.5

72.5

77.5

82.5

87.5

92.5

100

105

110

115

Chain

Click any strike for greeks, breakeven and the calculator

Expiry

Sep 18 13d Oct 16 41d Nov 20 76d Dec 18 104d Jan 15 132d Apr 16 223d Dec 17 468d Jan 21 503d

Calls								Puts
OI	Vol	IV	Δ	Bid	Ask	Last	Strike	Last	Bid	Ask	Δ	IV	Vol	OI
—	—	—	—	$23.80	$27.70	—		—	$0.00	$0.25	—	—	—	—
Call · $32.5 In the money Daily-bar session Unknown Quote as of 2026-09-04 19:59:29.708 UTC Last — Breakeven — Implied vol — Delta — Gamma — Theta — Vega — Open interest — OI effective date — Model this call Put · $32.5 Daily-bar session Unknown Quote as of 2026-09-04 13:30:03.621 UTC Last — Breakeven — Implied vol — Delta — Gamma — Theta — Vega — Open interest — OI effective date — Model this put
—	—	—	—	$21.10	$25.20	—		$0.40	$0.00	$2.15	—	—	1	1
Call · $35 In the money Daily-bar session Unknown Quote as of 2026-09-04 19:59:42.520 UTC Last — Breakeven — Implied vol — Delta — Gamma — Theta — Vega — Open interest — OI effective date — Model this call Put · $35 Daily-bar session Jul 17, 2026 Quote as of 2026-09-04 19:59:53.405 UTC Last $0.40 Breakeven $34.60 Implied vol — Delta — Gamma — Theta — Vega — Open interest 1 OI effective date Sep 2, 2026 Model this put
—	—	—	—	$18.60	$22.70	—		$0.85	$0.00	$2.15	—	—	1	1
Call · $37.5 In the money Daily-bar session Unknown Quote as of 2026-09-04 19:59:56.773 UTC Last — Breakeven — Implied vol — Delta — Gamma — Theta — Vega — Open interest — OI effective date — Model this call Put · $37.5 Daily-bar session Mar 20, 2026 Quote as of 2026-09-04 19:59:34.227 UTC Last $0.85 Breakeven $36.65 Implied vol — Delta — Gamma — Theta — Vega — Open interest 1 OI effective date Sep 2, 2026 Model this put
—	—	—	—	$16.10	$20.20	—		$0.40	$0.00	$0.50	—	—	1	—
Call · $40 In the money Daily-bar session Unknown Quote as of 2026-09-04 19:59:53.404 UTC Last — Breakeven — Implied vol — Delta — Gamma — Theta — Vega — Open interest — OI effective date — Model this call Put · $40 Daily-bar session May 6, 2026 Quote as of 2026-09-04 19:59:55.365 UTC Last $0.40 Breakeven $39.60 Implied vol — Delta — Gamma — Theta — Vega — Open interest — OI effective date — Model this put
—	—	—	—	$14.40	$17.80	—		$0.45	$0.00	$2.15	—	—	1	1k
Call · $42.5 In the money Daily-bar session Unknown Quote as of 2026-09-04 19:59:39.206 UTC Last — Breakeven — Implied vol — Delta — Gamma — Theta — Vega — Open interest — OI effective date — Model this call Put · $42.5 Daily-bar session Aug 7, 2026 Quote as of 2026-09-04 19:59:39.764 UTC Last $0.45 Breakeven $42.05 Implied vol — Delta — Gamma — Theta — Vega — Open interest 1k OI effective date Sep 2, 2026 Model this put
—	—	242.4%	0.711	$11.20	$15.30	—		$0.05	$0.00	$2.20	—	—	10	33
Call · $45 In the money Daily-bar session Unknown Quote as of 2026-09-04 19:59:57.097 UTC Last — Breakeven — Implied vol 242.4% Delta 0.711 ≈71% ITM Gamma 0.014 Theta -0.305 Vega 0.035 Open interest — OI effective date — Model this call Put · $45 Daily-bar session Aug 26, 2026 Quote as of 2026-09-04 19:59:39.764 UTC Last $0.05 Breakeven $44.95 Implied vol — Delta — Gamma — Theta — Vega — Open interest 33 OI effective date Sep 2, 2026 Model this put
—	—	212%	0.671	$8.80	$12.90	—		$0.62	$0.00	$0.95	—	—	1	130
Call · $47.5 In the money Daily-bar session Unknown Quote as of 2026-09-04 19:59:57.469 UTC Last — Breakeven — Implied vol 212% Delta 0.671 ≈67% ITM Gamma 0.017 Theta -0.283 Vega 0.037 Open interest — OI effective date — Model this call Put · $47.5 Daily-bar session Aug 13, 2026 Quote as of 2026-09-04 19:59:43.272 UTC Last $0.62 Breakeven $46.88 Implied vol — Delta — Gamma — Theta — Vega — Open interest 130 OI effective date Sep 2, 2026 Model this put
15	5	171.2%	0.62	$6.60	$9.50	$13.20		$0.47	$0.00	$1.00	—	—	1	794
Call · $50 In the money Daily-bar session Aug 27, 2026 Quote as of 2026-09-04 19:59:45.314 UTC Last $13.20 Breakeven $63.20 Implied vol 171.2% Delta 0.62 ≈62% ITM Gamma 0.022 Theta -0.241 Vega 0.039 Open interest 15 OI effective date Sep 2, 2026 Model this call Put · $50 Daily-bar session Sep 4, 2026 Quote as of 2026-09-04 19:59:55.693 UTC Last $0.47 Breakeven $49.53 Implied vol — Delta — Gamma — Theta — Vega — Open interest 794 OI effective date Sep 2, 2026 Model this put
Underlying $52.29
267	40	160%	0.559	$5.00	$7.90	$6.50		$0.91	$0.05	$1.55	-0.523	17.8%	2	309
Call · $52.5 Daily-bar session Sep 4, 2026 Quote as of 2026-09-04 19:59:59.927 UTC Last $6.50 Breakeven $59.00 Implied vol 160% Delta 0.559 ≈56% ITM Gamma 0.024 Theta -0.233 Vega 0.04 Open interest 267 OI effective date Sep 2, 2026 Model this call Put · $52.5 In the money Daily-bar session Sep 3, 2026 Quote as of 2026-09-04 19:59:39.818 UTC Last $0.91 Breakeven $51.59 Implied vol 17.8% Delta -0.523 ≈52% ITM Gamma 0.218 Theta -0.023 Vega 0.041 Open interest 309 OI effective date Sep 2, 2026 Model this put
689	6	150.5%	0.492	$4.00	$6.10	$5.00		$1.38	$0.80	$1.75	—	—	5	1.3k
Call · $55 Daily-bar session Sep 4, 2026 Quote as of 2026-09-04 19:59:59.946 UTC Last $5.00 Breakeven $60.00 Implied vol 150.5% Delta 0.492 ≈49% ITM Gamma 0.026 Theta -0.222 Vega 0.041 Open interest 689 OI effective date Sep 2, 2026 Model this call Put · $55 In the money Daily-bar session Sep 4, 2026 Quote as of 2026-09-04 19:59:59.927 UTC Last $1.38 Breakeven $53.62 Implied vol — Delta — Gamma — Theta — Vega — Open interest 1.3k OI effective date Sep 2, 2026 Model this put
857	22	122.1%	0.393	$2.30	$3.80	$3.25		$2.35	$1.45	$3.50	—	—	112	171
Call · $57.5 Daily-bar session Sep 4, 2026 Quote as of 2026-09-04 19:59:59.927 UTC Last $3.25 Breakeven $60.75 Implied vol 122.1% Delta 0.393 ≈39% ITM Gamma 0.031 Theta -0.174 Vega 0.039 Open interest 857 OI effective date Sep 2, 2026 Model this call Put · $57.5 In the money Daily-bar session Sep 4, 2026 Quote as of 2026-09-04 19:59:59.927 UTC Last $2.35 Breakeven $55.15 Implied vol — Delta — Gamma — Theta — Vega — Open interest 171 OI effective date Sep 2, 2026 Model this put
868	402	105.1%	0.288	$1.10	$2.40	$2.05		$3.40	$3.80	$4.60	—	—	345	2.5k
Call · $60 Daily-bar session Sep 4, 2026 Quote as of 2026-09-04 19:59:59.927 UTC Last $2.05 Breakeven $62.05 Implied vol 105.1% Delta 0.288 ≈29% ITM Gamma 0.032 Theta -0.133 Vega 0.035 Open interest 868 OI effective date Sep 2, 2026 Model this call Put · $60 In the money Daily-bar session Sep 4, 2026 Quote as of 2026-09-04 19:59:59.927 UTC Last $3.40 Breakeven $56.60 Implied vol — Delta — Gamma — Theta — Vega — Open interest 2.5k OI effective date Sep 2, 2026 Model this put
1.5k	10	102.1%	0.216	$0.95	$1.40	$1.35		$5.50	$4.20	$6.60	—	—	3	525
Call · $62.5 Daily-bar session Sep 4, 2026 Quote as of 2026-09-04 19:59:46.316 UTC Last $1.35 Breakeven $63.85 Implied vol 102.1% Delta 0.216 ≈22% ITM Gamma 0.028 Theta -0.11 Vega 0.03 Open interest 1.5k OI effective date Sep 2, 2026 Model this call Put · $62.5 In the money Daily-bar session Sep 4, 2026 Quote as of 2026-09-04 19:59:59.946 UTC Last $5.50 Breakeven $57.00 Implied vol — Delta — Gamma — Theta — Vega — Open interest 525 OI effective date Sep 2, 2026 Model this put
3.1k	18	89.1%	0.125	$0.05	$1.00	$0.85		$3.30	$6.30	$8.50	—	—	2	136
Call · $65 Daily-bar session Sep 4, 2026 Quote as of 2026-09-04 19:59:49.567 UTC Last $0.85 Breakeven $65.85 Implied vol 89.1% Delta 0.125 ≈12% ITM Gamma 0.023 Theta -0.068 Vega 0.021 Open interest 3.1k OI effective date Sep 2, 2026 Model this call Put · $65 In the money Daily-bar session Aug 27, 2026 Quote as of 2026-09-04 19:59:57.405 UTC Last $3.30 Breakeven $61.70 Implied vol — Delta — Gamma — Theta — Vega — Open interest 136 OI effective date Sep 2, 2026 Model this put
921	10	—	—	$0.00	$1.10	$0.59		$5.60	$7.80	$11.10	—	—	42	65
Call · $67.5 Daily-bar session Sep 4, 2026 Quote as of 2026-09-04 19:59:59.924 UTC Last $0.59 Breakeven $68.09 Implied vol — Delta — Gamma — Theta — Vega — Open interest 921 OI effective date Sep 2, 2026 Model this call Put · $67.5 In the money Daily-bar session Aug 25, 2026 Quote as of 2026-09-04 19:59:39.764 UTC Last $5.60 Breakeven $61.90 Implied vol — Delta — Gamma — Theta — Vega — Open interest 65 OI effective date Sep 2, 2026 Model this put
1.8k	5	99.4%	0.082	$0.20	$0.50	$0.35		$7.59	$10.20	$14.20	—	—	2	10
Call · $70 Daily-bar session Sep 4, 2026 Quote as of 2026-09-04 19:59:59.927 UTC Last $0.35 Breakeven $70.35 Implied vol 99.4% Delta 0.082 ≈8% ITM Gamma 0.015 Theta -0.055 Vega 0.015 Open interest 1.8k OI effective date Sep 2, 2026 Model this call Put · $70 In the money Daily-bar session Aug 25, 2026 Quote as of 2026-09-04 19:59:06.983 UTC Last $7.59 Breakeven $62.41 Implied vol — Delta — Gamma — Theta — Vega — Open interest 10 OI effective date Sep 2, 2026 Model this put
29	2	—	—	$0.00	$2.15	$0.25		$2.65	$12.60	$16.60	—	—	27	54
Call · $72.5 Daily-bar session Sep 4, 2026 Quote as of 2026-09-04 19:59:59.927 UTC Last $0.25 Breakeven $72.75 Implied vol — Delta — Gamma — Theta — Vega — Open interest 29 OI effective date Sep 2, 2026 Model this call Put · $72.5 In the money Daily-bar session Jul 8, 2026 Quote as of 2026-09-04 19:59:01.576 UTC Last $2.65 Breakeven $69.85 Implied vol — Delta — Gamma — Theta — Vega — Open interest 54 OI effective date Sep 2, 2026 Model this put
1.3k	1k	—	—	$0.00	$0.40	$0.65		$22.50	$15.00	$18.10	—	—	1k	—
Call · $75 Daily-bar session Aug 26, 2026 Quote as of 2026-09-04 17:14:52.912 UTC Last $0.65 Breakeven $75.65 Implied vol — Delta — Gamma — Theta — Vega — Open interest 1.3k OI effective date Sep 2, 2026 Model this call Put · $75 In the money Daily-bar session Jul 22, 2026 Quote as of 2026-09-04 19:59:53.405 UTC Last $22.50 Breakeven $52.50 Implied vol — Delta — Gamma — Theta — Vega — Open interest — OI effective date — Model this put
79	10	—	—	$0.05	$2.20	$0.27		$25.65	$17.50	$21.50	—	—	180	—
Call · $77.5 Daily-bar session Aug 24, 2026 Quote as of 2026-09-04 19:59:39.764 UTC Last $0.27 Breakeven $77.77 Implied vol — Delta — Gamma — Theta — Vega — Open interest 79 OI effective date Sep 2, 2026 Model this call Put · $77.5 In the money Daily-bar session Jul 31, 2026 Quote as of 2026-09-04 19:57:33.038 UTC Last $25.65 Breakeven $51.85 Implied vol — Delta — Gamma — Theta — Vega — Open interest — OI effective date — Model this put
191	8	—	—	$0.05	$0.50	$0.10		$28.43	$19.90	$23.30	—	—	220	227
Call · $80 Daily-bar session Sep 2, 2026 Quote as of 2026-09-04 19:55:07.058 UTC Last $0.10 Breakeven $80.10 Implied vol — Delta — Gamma — Theta — Vega — Open interest 191 OI effective date Sep 2, 2026 Model this call Put · $80 In the money Daily-bar session Jul 31, 2026 Quote as of 2026-09-04 19:58:52.815 UTC Last $28.43 Breakeven $51.57 Implied vol — Delta — Gamma — Theta — Vega — Open interest 227 OI effective date Sep 2, 2026 Model this put
133	6	—	—	$0.00	$2.20	$0.73		$30.71	$22.40	$25.80	—	—	140	—
Call · $82.5 Daily-bar session Sep 3, 2026 Quote as of 2026-09-04 19:59:39.764 UTC Last $0.73 Breakeven $83.23 Implied vol — Delta — Gamma — Theta — Vega — Open interest 133 OI effective date Sep 2, 2026 Model this call Put · $82.5 In the money Daily-bar session Jul 31, 2026 Quote as of 2026-09-04 19:55:56.885 UTC Last $30.71 Breakeven $51.79 Implied vol — Delta — Gamma — Theta — Vega — Open interest — OI effective date — Model this put
734	2	—	—	$0.00	$0.60	$0.20		$28.83	$24.90	$29.00	—	—	200	—
Call · $85 Daily-bar session Aug 25, 2026 Quote as of 2026-09-04 19:59:55.365 UTC Last $0.20 Breakeven $85.20 Implied vol — Delta — Gamma — Theta — Vega — Open interest 734 OI effective date Sep 2, 2026 Model this call Put · $85 In the money Daily-bar session Jul 23, 2026 Quote as of 2026-09-04 19:58:10.137 UTC Last $28.83 Breakeven $56.17 Implied vol — Delta — Gamma — Theta — Vega — Open interest — OI effective date — Model this put
241	1	—	—	$0.00	$2.15	$0.05		$9.20	$27.40	$31.40	—	—	2	—
Call · $87.5 Daily-bar session Aug 7, 2026 Quote as of 2026-09-04 19:59:39.764 UTC Last $0.05 Breakeven $87.55 Implied vol — Delta — Gamma — Theta — Vega — Open interest 241 OI effective date Sep 2, 2026 Model this call Put · $87.5 In the money Daily-bar session Jul 6, 2026 Quote as of 2026-09-04 19:59:44.243 UTC Last $9.20 Breakeven $78.30 Implied vol — Delta — Gamma — Theta — Vega — Open interest — OI effective date — Model this put
884	2k	—	—	$0.00	$0.95	$0.05		—	$29.90	$34.00	—	—	—	—
Call · $90 Daily-bar session Jul 20, 2026 Quote as of 2026-09-04 19:59:55.365 UTC Last $0.05 Breakeven $90.05 Implied vol — Delta — Gamma — Theta — Vega — Open interest 884 OI effective date Sep 2, 2026 Model this call Put · $90 In the money Daily-bar session Unknown Quote as of 2026-09-04 19:59:56.756 UTC Last — Breakeven — Implied vol — Delta — Gamma — Theta — Vega — Open interest — OI effective date — Model this put
2	2	—	—	$0.00	$2.15	$4.10		—	$32.40	$36.30	—	—	—	—
Call · $92.5 Daily-bar session Jul 8, 2026 Quote as of 2026-09-04 19:59:56.914 UTC Last $4.10 Breakeven $96.60 Implied vol — Delta — Gamma — Theta — Vega — Open interest 2 OI effective date Sep 2, 2026 Model this call Put · $92.5 In the money Daily-bar session Unknown Quote as of 2026-09-04 19:55:08.612 UTC Last — Breakeven — Implied vol — Delta — Gamma — Theta — Vega — Open interest — OI effective date — Model this put
102	9	—	—	$0.00	$1.55	$2.85		—	$34.90	$39.00	—	—	—	—
Call · $95 Daily-bar session Jul 6, 2026 Quote as of 2026-09-04 19:59:55.365 UTC Last $2.85 Breakeven $97.85 Implied vol — Delta — Gamma — Theta — Vega — Open interest 102 OI effective date Sep 2, 2026 Model this call Put · $95 In the money Daily-bar session Unknown Quote as of 2026-09-04 19:58:44.652 UTC Last — Breakeven — Implied vol — Delta — Gamma — Theta — Vega — Open interest — OI effective date — Model this put
55	5	—	—	$0.00	$0.95	$0.05		—	$39.90	$44.00	—	—	—	—
Call · $100 Daily-bar session Jul 10, 2026 Quote as of 2026-09-04 19:59:55.365 UTC Last $0.05 Breakeven $100.05 Implied vol — Delta — Gamma — Theta — Vega — Open interest 55 OI effective date Sep 2, 2026 Model this call Put · $100 In the money Daily-bar session Unknown Quote as of 2026-09-04 19:59:56.805 UTC Last — Breakeven — Implied vol — Delta — Gamma — Theta — Vega — Open interest — OI effective date — Model this put
2	1	—	—	$0.00	$1.35	$0.34		$24.90	$44.90	$49.00	—	—	2	—
Call · $105 Daily-bar session Jul 9, 2026 Quote as of 2026-09-04 19:59:55.365 UTC Last $0.34 Breakeven $105.34 Implied vol — Delta — Gamma — Theta — Vega — Open interest 2 OI effective date Sep 2, 2026 Model this call Put · $105 In the money Daily-bar session Jul 2, 2026 Quote as of 2026-09-04 19:59:56.707 UTC Last $24.90 Breakeven $80.10 Implied vol — Delta — Gamma — Theta — Vega — Open interest — OI effective date — Model this put
1	8	—	—	$0.00	$2.15	$2.33		—	$49.90	$54.00	—	—	—	—
Call · $110 Daily-bar session Jun 30, 2026 Quote as of 2026-09-04 19:59:39.786 UTC Last $2.33 Breakeven $112.33 Implied vol — Delta — Gamma — Theta — Vega — Open interest 1 OI effective date Sep 2, 2026 Model this call Put · $110 In the money Daily-bar session Unknown Quote as of 2026-09-04 19:59:03.802 UTC Last — Breakeven — Implied vol — Delta — Gamma — Theta — Vega — Open interest — OI effective date — Model this put
1	1	—	—	$0.00	$0.95	$0.74		—	$54.90	$59.00	—	—	—	—
Call · $115 Daily-bar session Aug 25, 2026 Quote as of 2026-09-04 19:59:55.365 UTC Last $0.74 Breakeven $115.74 Implied vol — Delta — Gamma — Theta — Vega — Open interest 1 OI effective date Sep 2, 2026 Model this call Put · $115 In the money Daily-bar session Unknown Quote as of 2026-09-04 19:59:56.909 UTC Last — Breakeven — Implied vol — Delta — Gamma — Theta — Vega — Open interest — OI effective date — Model this put

About this data

Each contract's last price, day range and volume belong to the daily-bar session shown in its details; unknown means the source omitted that timestamp. Open interest has its own effective date shown separately; implied volatility and greeks are model values computed when fetched. This chain has mixed daily-bar sessions · Mar 20, 2026–Sep 4, 2026; 14 unknown. Positioning totals are shown only when every returned open-interest value has the same known effective date. Bid and ask are real-time consolidated OPRA readings.

In-the-money strikes are tinted, deepening toward the money, and the bar beside each open-interest figure scales to the heaviest strike shown. The 21 strikes around the money are shown by default — switch to "All 30" for the wings. Max pain is the listed strike where the most open interest would expire worthless — a positioning reference, not a forecast.

Key facts CIK 874015 CUSIP 462222100 13F (30d) 370 filings 356 filers Visit website Investor relations