TWO SIGMA INVESTMENTS, LP

Position in ACIU — AC Immune SA

CIK 1179392 NEW YORK, NY

Position in ACIU

as of Mar 31, 2026 · filed May 15, 2026 Compact

Position Value

$107,500

-$168,455 QoQ

Shares Held

39,091

-55.5% QoQ

Ownership

0.038%

of shares outstanding

% of Portfolio

0.00%

of 13F equity value

Holder Rank

—

not a current holder

Holding Since

Jun 2021

10 quarters on record

Voting authority Sole 100.ToString("F0")% Shared 0.ToString("F0")% None 0.ToString("F0")%

Healthcare · as of Mar 31, 2026

TWO SIGMA INVESTMENTS, LP holds $5,506,832,621 across 316 Biotechnology names. ACIU ranks #282 (0.0% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	ALNY	Alnylam Pharmaceuticals, Inc.	1,992,577	$659,283,951
2	REGN	Regeneron Pharmaceuticals, Inc.	812,236	$627,566,023
3	MRNA	Moderna, Inc.	9,086,404	$461,589,323
4	IONS	Ionis Pharmaceuticals Inc	5,857,629	$439,849,361
5	BBIO	BridgeBio Pharma, Inc.	3,120,631	$231,738,058
6	VRTX	Vertex Pharmaceuticals Inc / Ma	378,146	$168,857,314
7	RVMD	Revolution Medicines, Inc.	1,558,807	$151,593,980
8	VKTX	Viking Therapeutics, Inc.	4,432,142	$144,221,900

10 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-03-31	$107,500	39,091	-55.5%	Shares	Sole	2026-05-15
2025-12-31	$275,955	87,884	+423.9%	Shares	Sole	2026-02-17
2025-09-30	$48,479	16,775	-45.3%	Shares	Sole	2025-11-14
2025-06-30	$62,300	30,690	-24.8%	Shares	Sole	2025-08-14
2024-12-31	$110,208	40,818	-28.8%	Shares	Sole	2025-02-14
2024-09-30	$216,673	57,321	-42.3%	Shares	Sole	2024-11-14
2024-06-30	$396,378	99,343	+550.2%	Shares	Sole	2024-08-14
2023-06-30	$45,149	15,279	-76.1%	Shares	Sole	2023-08-14
2021-09-30	$429,782	64,051	-67.7%	Shares	Sole	2021-11-15
2021-06-30	$1,572,471	198,294	—	Shares	Sole	2021-08-16
No filing history on record for this holder in this stock.