TWO SIGMA INVESTMENTS, LP
Position in ARWR — Arrowhead Pharmaceuticals, Inc.
CIK 1179392
NEW YORK, NY
Position in ARWR
as of Jun 30, 2026
· filed Aug 14, 2026
Position Value
$47,325,439
+$45,080,779 QoQ
Shares Held
580,609
+1521.8% QoQ
Ownership
0.411%
of shares outstanding
% of Portfolio
0.04%
of 13F equity value
Holder Rank
#37
of 497 holders
Holding Since
Mar 2020
19 quarters on record
Voting authority
Sole 100%
Shared 0%
None 0%
Common Shares in ARWR Over Time
Shares Held
Position Value (USD)
Derivatives in ARWR
reported options exposure · as of Mar 31, 2026CallValue
$363,660
CallShares
5,800
PutValue
$257,070
PutShares
4,100
Notional value of option positions as reported on Form 13F. Calls and puts are disclosed separately and do not net against the common-share stake above.
Position in Biotechnology
Healthcare · as of Jun 30, 2026TWO SIGMA INVESTMENTS, LP holds $7,273,657,992 across 342 Biotechnology names. ARWR ranks #38 (0.7% of the industry book) .
| # | Ticker | Company | Shares | Value (USD) | Open |
|---|---|---|---|---|---|
| 1 | ALNY |
Alnylam Pharmaceuticals, Inc.
|
1,875,937 | $564,713,315 | |
| 2 | MRNA |
Moderna, Inc.
|
7,193,530 | $503,762,905 | |
| 3 | IONS |
Ionis Pharmaceuticals Inc
|
6,252,342 | $495,748,197 | |
| 4 | REGN |
Regeneron Pharmaceuticals, Inc.
|
656,124 | $409,119,558 | |
| 5 | BBIO |
BridgeBio Pharma, Inc.
|
4,722,185 | $351,708,338 | |
| 6 | EXEL |
Exelixis, Inc.
|
4,209,861 | $229,058,537 | |
| 7 | INCY |
Incyte Corp
|
2,003,559 | $227,123,448 | |
| 8 | ARGX |
Argenx SE
|
185,638 | $172,229,367 |
All Filings in ARWR
Export CSV
21 filing rows on record
| Report Date | Value (USD) | Shares | Type | Discretion | Filed | |
|---|---|---|---|---|---|---|
| 2026-06-30 | $47,325,439 | 580,609 | Shares | Sole | 2026-08-14 | |
| 2026-03-31 | $257,070 | 4,100 | Put | Sole | 2026-05-15 | |
| 2026-03-31 | $363,660 | 5,800 | Call | Sole | 2026-05-15 | |
| 2026-03-31 | $2,244,660 | 35,800 | Shares | Sole | 2026-05-15 | |
| 2025-06-30 | $2,107,767 | 133,403 | Shares | Sole | 2025-08-14 | |
| 2025-03-31 | $10,640,116 | 835,174 | Shares | Sole | 2025-05-15 | |
| 2024-12-31 | $14,934,212 | 794,373 | Shares | Sole | 2025-02-14 | |
| 2024-09-30 | $4,034,984 | 208,311 | Shares | Sole | 2024-11-14 | |
| 2024-06-30 | $4,894,254 | 188,313 | Shares | Sole | 2024-08-14 | |
| 2024-03-31 | $952,437 | 33,302 | Shares | Sole | 2024-05-15 | |
| 2023-12-31 | $792,601 | 25,902 | Shares | Sole | 2024-02-14 | |
| 2023-09-30 | $7,199,386 | 267,934 | Shares | Sole | 2023-11-14 | |
| 2023-06-30 | $11,091,686 | 311,040 | Shares | Sole | 2023-08-14 | |
| 2023-03-31 | $2,293,620 | 90,300 | Shares | Sole | 2023-05-15 | |
| 2022-12-31 | $565,609 | 13,945 | Shares | Sole | 2023-02-14 | |
| 2022-06-30 | $1,510,016 | 42,886 | Shares | Sole | 2022-08-15 | |
| 2022-03-31 | $304,867 | 6,629 | Shares | Sole | 2022-05-16 | |
| 2021-06-30 | $6,145,244 | 74,200 | Shares | Sole | 2021-08-16 | |
| 2021-03-31 | $3,438,969 | 51,862 | Shares | Sole | 2021-05-17 | |
| 2020-06-30 | $1,372,880 | 31,787 | Shares | Sole | 2020-08-14 | |
| 2020-03-31 | $16,468,034 | 572,403 | Shares | Sole | 2020-05-15 | |
| No filing history on record for this holder in this stock. | ||||||