TWO SIGMA INVESTMENTS, LP

Position in AVTX — Avalo Therapeutics, Inc.

CIK 1179392 NEW YORK, NY

Position in AVTX

as of Jun 30, 2026 · filed Aug 14, 2026 Compact

Position Value

$1,239,897

+$278,032 QoQ

Shares Held

67,094

+4.1% QoQ

Ownership

0.125%

of shares outstanding

% of Portfolio

0.00%

of 13F equity value

Holder Rank

#73

of 126 holders

Holding Since

Jun 2020

13 quarters on record

Voting authority Sole 100% Shared 0% None 0%

Healthcare · as of Jun 30, 2026

TWO SIGMA INVESTMENTS, LP holds $7,273,657,992 across 342 Biotechnology names. AVTX ranks #193 (0.0% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	ALNY	Alnylam Pharmaceuticals, Inc.	1,875,937	$564,713,315
2	MRNA	Moderna, Inc.	7,193,530	$503,762,905
3	IONS	Ionis Pharmaceuticals Inc	6,252,342	$495,748,197
4	REGN	Regeneron Pharmaceuticals, Inc.	656,124	$409,119,558
5	BBIO	BridgeBio Pharma, Inc.	4,722,185	$351,708,338
6	EXEL	Exelixis, Inc.	4,209,861	$229,058,537
7	INCY	Incyte Corp	2,003,559	$227,123,448
8	ARGX	Argenx SE	185,638	$172,229,367

13 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-06-30	$1,239,897	67,094	+4.1%	Shares	Sole	2026-08-14
2026-03-31	$961,865	64,425	-56.5%	Shares	Sole	2026-05-15
2025-12-31	$2,691,983	148,237	+201.0%	Shares	Sole	2026-02-17
2025-09-30	$625,865	49,242	+282.0%	Shares	Sole	2025-11-14
2025-06-30	$64,316	12,889	-81.8%	Shares	Sole	2025-08-14
2022-03-31	$51,259	70,703	-76.1%	Shares	Sole	2022-05-16
2021-12-31	$503,160	295,977	-59.6%	Shares	Sole	2022-02-14
2021-09-30	$1,597,789	732,931	—	Shares	Sole	2021-11-15
2021-06-30 CERC	—	1,133,618	+66.8%	Shares	Sole	2021-08-16
2021-03-31 CERC	—	679,785	+43.4%	Shares	Sole	2021-05-17
2020-12-31 CERC	—	474,022	-19.8%	Shares	Sole	2021-02-16
2020-09-30 CERC	—	591,210	+128.7%	Shares	Sole	2020-11-16
2020-06-30 CERC	—	258,536	—	Shares	Sole	2020-08-14
No filing history on record for this holder in this stock.