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8-K

Perspective Therapeutics, Inc. (CATX)

8-K 2025-09-02 For: 2025-09-02
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UNITED STATESSECURITIES AND EXCHANGE COMMISSIONWASHINGTON, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): September 2, 2025

Perspective Therapeutics, Inc.

(Exact name of Registrant as Specified in Its Charter)

Delaware 001-33407 41-1458152
(State or Other Jurisdiction<br>of Incorporation) (Commission File Number) (IRS Employer<br>Identification No.)
c/o Perspective Therapeutics, Inc.<br><br>2401 Elliott Avenue<br><br>Suite 320
Seattle, Washington 98121
(Address of Principal Executive Offices) (Zip Code)
Registrant’s Telephone Number, Including Area Code: (206) 676-0900
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(Former Name or Former Address, if Changed Since Last Report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

Title of each class Trading<br>Symbol(s) Name of each exchange on which registered
Common Stock, $0.001 par value CATX NYSE American LLC

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Item 8.01 Other Events.

On September 2, 2025, Perspective Therapeutics, Inc. updated its corporate presentation. A copy of the presentation is filed as Exhibit 99.1 to this Current Report on Form 8-K and is incorporated by reference into this Item 8.01.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits

Exhibit No. Description
99.1 Corporate Presentation.
104 Cover Page Interactive Data File (embedded within the Inline XBRL document).

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

PERSPECTIVE THERAPEUTICS, INC.
Date: September 2, 2025 By: /s/ Juan Graham
Juan Graham<br>Chief Financial Officer

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Corporate Presentation

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Developing the Next Generation of Targeted Therapies

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Higher Potency Payloads with Cancer-Specific Targeting

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Radiopharmaceutical Therapy Poised to Revolutionize Oncology Treatment Perspective’s pipeline and platform has the potential to significantly expand the breadth of tumors addressed by RPT

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Perspective’s Innovative Platform

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Perspective’s Radiopharmaceutical Platform Optimized for a Broader Therapeutic Window

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Perspective’s Proprietary Chelator Has Been Optimized for Lead-Based RPTs

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Proposed Mechanism of Action for 212Pb

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Rationale for Synergy with Immune Checkpoint Inhibitors

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Supply Chain and Manufacturing Infrastructure

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On-Demand Order Fulfillment at Regional Sites to Deliver Finished Products

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Neuroendocrine Tumors: VMT-⍺-NET

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Trial Design: [212Pb]VMT-⍺-NET Phase 1/2a For Neuroendocrine Tumors

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Anti-Tumor Activity

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[212Pb]VMT-α-NET Was Well Tolerated

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Mild and Generally Transient Blood Creatinine Increase

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Patient (103-105) with Confirmed PR After [212Pb]VMT-α-NET

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Melanoma Program: VMT01/02

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Trial Design: [212Pb]VMT01 Phase 1/2a For Metastatic Melanoma

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Treatment Emergent Adverse Events (all grades, occurring in ≥ 2 patients)

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PSV359 is Active Against FAP-α Expression on Tumor and on Stroma

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Trial Design: [212Pb]PSV359 Phase 1/2a Trial

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General Corporate Information

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Abbreviations

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APPENDIX

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NETs Trials

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Refractory Metastatic Melanoma Trials

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Daily Production at Regional Sites Ensures Supply of Ready-to-Administer Product

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Perspective’s Pre-Targeting Platform