TWO SIGMA INVESTMENTS, LP

Position in CGEM — Cullinan Therapeutics, Inc.

CIK 1179392 NEW YORK, NY

Position in CGEM

as of Jun 30, 2026 · filed Aug 14, 2026 Compact

Position Value

$4,963,700

-$2,454,587 QoQ

Shares Held

272,581

-47.8% QoQ

Ownership

0.424%

of shares outstanding

% of Portfolio

0.00%

of 13F equity value

Holder Rank

#38

of 183 holders

Holding Since

Dec 2021

13 quarters on record

Voting authority Sole 98% Shared 0% None 2%

Healthcare · as of Jun 30, 2026

TWO SIGMA INVESTMENTS, LP holds $7,283,390,440 across 343 Biotechnology names. CGEM ranks #118 (0.1% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	ALNY	Alnylam Pharmaceuticals, Inc.	1,875,937	$564,713,315
2	MRNA	Moderna, Inc.	7,193,530	$503,762,905
3	IONS	Ionis Pharmaceuticals Inc	6,252,342	$495,748,197
4	REGN	Regeneron Pharmaceuticals, Inc.	656,124	$409,119,558
5	BBIO	BridgeBio Pharma, Inc.	4,722,185	$351,708,338
6	EXEL	Exelixis, Inc.	4,209,861	$229,058,537
7	INCY	Incyte Corp	2,003,559	$227,123,448
8	ARGX	Argenx SE	185,638	$172,229,367

13 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-06-30	$4,963,700	272,581	-47.8%	Shares	Sole	2026-08-14
2026-03-31	$7,418,287	522,047	+10.9%	Shares	Sole	2026-05-15
2025-12-31	$4,869,944	470,526	+688.5%	Shares	Sole	2026-02-17
2025-09-30	$353,854	59,672	+303.3%	Shares	Sole	2025-11-14
2025-03-31	$112,005	14,796	-64.9%	Shares	Sole	2025-05-15
2024-12-31	$514,056	42,205	+83.9%	Shares	Sole	2025-02-14
2024-09-30	$384,082	22,944	-60.0%	Shares	Sole	2024-11-14
2024-06-30	$1,000,375	57,361	+13.9%	Shares	Sole	2024-08-14
2023-12-31	$512,984	50,342	+284.3%	Shares	Sole	2024-02-14
2022-09-30	$167,942	13,100	-5.1%	Shares	Sole	2022-11-14
2022-06-30	$176,916	13,800	+4.4%	Shares	Sole	2022-08-15
2022-03-31	$138,340	13,213	-18.1%	Shares	Sole	2022-05-16
2021-12-31	$248,824	16,126	—	Shares	Sole	2022-02-14
No filing history on record for this holder in this stock.