CYRX · Cryoport, Inc. · Insider Trading

The transactions reported in this Form 4 occurred automatically pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 11, 2026. The Rule 10b5-1 trading plan was terminated on August 11, 2026.

The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $14.66 to $15.16, inclusive. The reporting person undertakes to provide to Cryoport, Inc., any security holder of Cryoport, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $14.33 to $14.615, inclusive.

1/12 of options vested on the 23rd of each month for twelve months beginning July 23, 2017.

The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $15.20 to $15.26, inclusive.

1/12 of options vested on the 23rd of each month for twelve months beginning July 23, 2017.

The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $15.40 to $15.48, inclusive. The reporting person undertakes to provide to Cryoport, Inc., any security holder of Cryoport, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

1/12th of the options vest on the 5th of the month for twelve months beginning July 5, 2026.

1/12th of the options vest on the 5th of the month for twelve months beginning July 5, 2026.

Reflects grant of restricted stock rights that vest in full on June 5, 2027, and upon vesting automatically convert to shares of common stock on a one-for-one basis.

Reflects grant of restricted stock rights that vest in full on June 5, 2027, and upon vesting automatically convert to shares of common stock on a one-for-one basis.

Reflects grant of restricted stock rights that vest in full on June 5, 2027, and upon vesting automatically convert to shares of common stock on a one-for-one basis.

Reflects grant of restricted stock rights that vest in full on June 5, 2027, and upon vesting automatically convert to shares of common stock on a one-for-one basis.

1/12th of the options vest on the 5th of the month for twelve months beginning July 5, 2026.

1/12th of the options vest on the 5th of the month for twelve months beginning July 5, 2026.

The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.05 to $16.70, inclusive. The reporting person undertakes to provide to Cryoport, Inc., any security holder of Cryoport, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

1/48 of options vested on the 6th of each month for forty-eight months beginning May 6, 2016.

1/48 of options vested on the 6th of each month for forty-eight months beginning May 6, 2016.

Shares required to be sold in accordance with the Issuer's policies, in payment of taxes due upon the vesting of restricted stock rights.

Shares required to be sold in accordance with the Issuer's policies, in payment of taxes due upon the vesting of restricted stock rights.

1/48 of options vested on the 6th of each month for forty-eight months beginning May 6, 2016.

Shares required to be sold in accordance with the Issuer's policies, in payment of taxes due upon the vesting of restricted stock rights.

Shares required to be sold in accordance with the Issuer's policies, in payment of taxes due upon the vesting of restricted stock rights.

Shares required to be sold in accordance with the Issuer's policies, in payment of taxes due upon the vesting of restricted stock rights.

Shares required to be sold in accordance with the Issuer's policies, in payment of taxes due upon the vesting of restricted stock rights.

Shares required to be sold in accordance with the Issuer's policies, in payment of taxes due upon the vesting of restricted stock rights.

Represents restricted stock rights, which are a contingent right to receive one share of CYRX common stock, that vest in four equal annual installments beginning March 14, 2027.

1/48 of options vest on the 14th of each month for forty-eight months beginning April 14, 2026.

1/48 of options vest on the 14th of each month for forty-eight months beginning April 14, 2026.

Represents restricted stock rights, which are a contingent right to receive one share of CYRX common stock, that vest in four equal annual installments beginning March 14, 2027.

1/48 of options vest on the 14th of each month for forty-eight months beginning April 14, 2026.

1/48 of options vest on the 14th of each month for forty-eight months beginning April 14, 2026.

Represents restricted stock rights, which are a contingent right to receive one share of CYRX common stock, that vest in four equal annual installments beginning March 14, 2027.

1/48 of options vested on the 6th of each month for forty-eight months beginning May 6, 2016.

The proceeds of the sale of Common Stock were used to pay the exercise price and withholding taxes due upon exercise of the Stock Option reported in this Form 4.

The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $7.725 to $7.83, inclusive.

The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $9.93 to $10.0696, inclusive.

The proceeds of the sale of Common Stock were used to pay the exercise price and withholding taxes due upon exercise of the Stock Option reported in this Form 4.

1/48 of the options vested on the 25th of each month for forty-eight months beginning on 9/25/2015.

The proceeds of the sale of Common Stock were used to pay the exercise price and withholding taxes due upon exercise of the Stock Option reported in this Form 4.

The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $9.50 to $9.8609, inclusive.

1/48 of the options vested on the 20th of each month for forty-eight months beginning on August 19, 2015.

The proceeds of the sale of Common Stock were used to pay the exercise price due upon the exercise of the Stock Option reported in this Form 4.

The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $8.60 to $8.75, inclusive.

This transaction involved a cash exercise of a stock option without a subsequent sale of the underlying shares of common stock.

This transaction involved a cash exercise of a stock option without a subsequent sale of the underlying shares of common stock.

1/48 of the options vested on the 19th of each month for forty-eight months beginning on 8/19/2015.