ECL · Ecolab Inc. · Debt

There is hereby established a series of Securities designated the “4.600% Notes due 2029” (the “2029 Notes”), a series of Securities designated the “4.800% Notes due 2031” (the “2031 Notes”), a series of Securities designated the “5.150% Notes due 2033” (the “2033 Notes”), a series of Securities designated the “5.350% Notes due 2036” (the “2036 Notes” and, together with the 2029 Notes, the 2031 Notes and the 2033 Notes, the “Notes”). The Notes shall be unsecured and unsubordinated obligations of the Company. The initial maximum aggregate principal amount of the 2029 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,200,000,000, except for 2029 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2029 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2031 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $900,000,000, except for 2031 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2031 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2033 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,500,000,000, except for 2033 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2033 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2036 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,400,000,000, except for 2036 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2036 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. Notwithstanding the foregoing, the Company may from time to time, without giving notice to or seeking the consent of the Holders of the Notes of any series, issue debt securities having the same terms (except for the issue date, and, in some cases, the public offering price and the first Interest Payment Date) and ranking equally and ratably with the Notes of a series created hereunder (the “Additional Notes”). The Notes of the applicable series and the Additional Notes shall together constitute one series for purposes of the Existing Indenture and this Fifteenth Supplemental Indenture, including, without limitation, waivers, amendments, redemptions and offers to purchase, provided they are fungible for U.S. federal income tax purposes and that no Event of Default with respect to the Notes of the applicable series shall have occurred or be continuing.

Issuer evidence: This FIFTEENTH SUPPLEMENTAL INDENTURE (this “Fifteenth Supplemental Indenture”) dated as of May 29, 2026, is between ECOLAB INC., a Delaware corporation (the “Company”), and COMPUTERSHARE TRUST COMPANY, N.A., as successor to Wells Fargo Bank, National Association (the “Trustee”).

Supporting evidence: (a) The 2029 Notes shall mature, and the principal of the 2029 Notes shall be due and payable in U.S. Dollars to the Holders thereof, together with all accrued and unpaid interest thereon, on June 15, 2029 (the Stated Maturity of principal of the 2029 Notes). The 2031 Notes shall mature, and the principal of the 2031 Notes shall be due and payable in U.S. Dollars to the Holders thereof, together with all accrued and unpaid interest thereon, on June 15, 2031 (the Stated Maturity of principal of the 2031 Notes). The 2033 Notes shall mature, and the principal of the 2033 Notes shall be due and payable in U.S. Dollars to the Holders thereof, together with all accrued and unpaid interest thereon, on June 15, 2033 (the Stated Maturity of principal of the 2033 Notes). The 2036 Notes shall mature, and the principal of the 2036 Notes shall be due and payable in U.S. Dollars to the Holders thereof, together with all accrued and unpaid interest thereon, on June 15, 2036 (the Stated Maturity of principal of the 2036 Notes).

Supporting evidence: (b) The 2029 Notes shall bear interest at the rate of 4.600% per annum, the 2031 Notes shall bear interest at the rate of 4.800% per annum, the 2033 Notes shall bear interest at the rate of 5.150% per annum and the 2036 Notes shall bear interest at the rate of 5.350% per annum, in each case from and including May 29, 2026 or from the most recent applicable Interest Payment Date on which interest has been paid or provided for, until the principal thereof becomes due and payable, and on any overdue principal and premium, if any, and (to the extent that payment of such interest is enforceable under applicable law) on any overdue installment of interest at the same rate per annum. Interest shall be calculated on the basis of a 360-day year comprised of twelve 30-day months. Interest on the Notes shall be payable semi-annually in arrears in U.S. Dollars on June 15 and December 15 of each year, beginning December 15, 2026 to the Person in whose name a Note (or predecessor Note) is registered (which shall initially be the Depositary) at the close of business on June 1 or December 1, as the case may be, immediately preceding each applicable Interest Payment Date.

Supporting evidence: There is hereby established a series of Securities designated the “4.600% Notes due 2029” (the “2029 Notes”), a series of Securities designated the “4.800% Notes due 2031” (the “2031 Notes”), a series of Securities designated the “5.150% Notes due 2033” (the “2033 Notes”), a series of Securities designated the “5.350% Notes due 2036” (the “2036 Notes” and, together with the 2029 Notes, the 2031 Notes and the 2033 Notes, the “Notes”). The Notes shall be unsecured and unsubordinated obligations of the Company. The initial maximum aggregate principal amount of the 2029 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,200,000,000, except for 2029 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2029 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2031 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $900,000,000, except for 2031 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2031 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2033 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,500,000,000, except for 2033 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2033 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2036 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,400,000,000, except for 2036 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2036 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. Notwithstanding the foregoing, the Company may from time to time, without giving notice to or seeking the consent of the Holders of the Notes of any series, issue debt securities having the same terms (except for the issue date, and, in some cases, the public offering price and the first Interest Payment Date) and ranking equally and ratably with the Notes of a series created hereunder (the “Additional Notes”). The Notes of the applicable series and the Additional Notes shall together constitute one series for purposes of the Existing Indenture and this Fifteenth Supplemental Indenture, including, without limitation, waivers, amendments, redemptions and offers to purchase, provided they are fungible for U.S. federal income tax purposes and that no Event of Default with respect to the Notes of the applicable series shall have occurred or be continuing.

Supporting evidence: There is hereby established a series of Securities designated the “4.600% Notes due 2029” (the “2029 Notes”), a series of Securities designated the “4.800% Notes due 2031” (the “2031 Notes”), a series of Securities designated the “5.150% Notes due 2033” (the “2033 Notes”), a series of Securities designated the “5.350% Notes due 2036” (the “2036 Notes” and, together with the 2029 Notes, the 2031 Notes and the 2033 Notes, the “Notes”). The Notes shall be unsecured and unsubordinated obligations of the Company. The initial maximum aggregate principal amount of the 2029 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,200,000,000, except for 2029 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2029 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2031 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $900,000,000, except for 2031 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2031 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2033 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,500,000,000, except for 2033 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2033 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2036 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,400,000,000, except for 2036 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2036 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. Notwithstanding the foregoing, the Company may from time to time, without giving notice to or seeking the consent of the Holders of the Notes of any series, issue debt securities having the same terms (except for the issue date, and, in some cases, the public offering price and the first Interest Payment Date) and ranking equally and ratably with the Notes of a series created hereunder (the “Additional Notes”). The Notes of the applicable series and the Additional Notes shall together constitute one series for purposes of the Existing Indenture and this Fifteenth Supplemental Indenture, including, without limitation, waivers, amendments, redemptions and offers to purchase, provided they are fungible for U.S. federal income tax purposes and that no Event of Default with respect to the Notes of the applicable series shall have occurred or be continuing.

There is hereby established a series of Securities designated the “4.600% Notes due 2029” (the “2029 Notes”), a series of Securities designated the “4.800% Notes due 2031” (the “2031 Notes”), a series of Securities designated the “5.150% Notes due 2033” (the “2033 Notes”), a series of Securities designated the “5.350% Notes due 2036” (the “2036 Notes” and, together with the 2029 Notes, the 2031 Notes and the 2033 Notes, the “Notes”). The Notes shall be unsecured and unsubordinated obligations of the Company. The initial maximum aggregate principal amount of the 2029 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,200,000,000, except for 2029 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2029 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2031 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $900,000,000, except for 2031 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2031 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2033 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,500,000,000, except for 2033 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2033 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2036 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,400,000,000, except for 2036 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2036 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. Notwithstanding the foregoing, the Company may from time to time, without giving notice to or seeking the consent of the Holders of the Notes of any series, issue debt securities having the same terms (except for the issue date, and, in some cases, the public offering price and the first Interest Payment Date) and ranking equally and ratably with the Notes of a series created hereunder (the “Additional Notes”). The Notes of the applicable series and the Additional Notes shall together constitute one series for purposes of the Existing Indenture and this Fifteenth Supplemental Indenture, including, without limitation, waivers, amendments, redemptions and offers to purchase, provided they are fungible for U.S. federal income tax purposes and that no Event of Default with respect to the Notes of the applicable series shall have occurred or be continuing.

Issuer evidence: This FIFTEENTH SUPPLEMENTAL INDENTURE (this “Fifteenth Supplemental Indenture”) dated as of May 29, 2026, is between ECOLAB INC., a Delaware corporation (the “Company”), and COMPUTERSHARE TRUST COMPANY, N.A., as successor to Wells Fargo Bank, National Association (the “Trustee”).

Supporting evidence: (a) The 2029 Notes shall mature, and the principal of the 2029 Notes shall be due and payable in U.S. Dollars to the Holders thereof, together with all accrued and unpaid interest thereon, on June 15, 2029 (the Stated Maturity of principal of the 2029 Notes). The 2031 Notes shall mature, and the principal of the 2031 Notes shall be due and payable in U.S. Dollars to the Holders thereof, together with all accrued and unpaid interest thereon, on June 15, 2031 (the Stated Maturity of principal of the 2031 Notes). The 2033 Notes shall mature, and the principal of the 2033 Notes shall be due and payable in U.S. Dollars to the Holders thereof, together with all accrued and unpaid interest thereon, on June 15, 2033 (the Stated Maturity of principal of the 2033 Notes). The 2036 Notes shall mature, and the principal of the 2036 Notes shall be due and payable in U.S. Dollars to the Holders thereof, together with all accrued and unpaid interest thereon, on June 15, 2036 (the Stated Maturity of principal of the 2036 Notes).

Supporting evidence: (b) The 2029 Notes shall bear interest at the rate of 4.600% per annum, the 2031 Notes shall bear interest at the rate of 4.800% per annum, the 2033 Notes shall bear interest at the rate of 5.150% per annum and the 2036 Notes shall bear interest at the rate of 5.350% per annum, in each case from and including May 29, 2026 or from the most recent applicable Interest Payment Date on which interest has been paid or provided for, until the principal thereof becomes due and payable, and on any overdue principal and premium, if any, and (to the extent that payment of such interest is enforceable under applicable law) on any overdue installment of interest at the same rate per annum. Interest shall be calculated on the basis of a 360-day year comprised of twelve 30-day months. Interest on the Notes shall be payable semi-annually in arrears in U.S. Dollars on June 15 and December 15 of each year, beginning December 15, 2026 to the Person in whose name a Note (or predecessor Note) is registered (which shall initially be the Depositary) at the close of business on June 1 or December 1, as the case may be, immediately preceding each applicable Interest Payment Date.

Supporting evidence: There is hereby established a series of Securities designated the “4.600% Notes due 2029” (the “2029 Notes”), a series of Securities designated the “4.800% Notes due 2031” (the “2031 Notes”), a series of Securities designated the “5.150% Notes due 2033” (the “2033 Notes”), a series of Securities designated the “5.350% Notes due 2036” (the “2036 Notes” and, together with the 2029 Notes, the 2031 Notes and the 2033 Notes, the “Notes”). The Notes shall be unsecured and unsubordinated obligations of the Company. The initial maximum aggregate principal amount of the 2029 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,200,000,000, except for 2029 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2029 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2031 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $900,000,000, except for 2031 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2031 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2033 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,500,000,000, except for 2033 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2033 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2036 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,400,000,000, except for 2036 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2036 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. Notwithstanding the foregoing, the Company may from time to time, without giving notice to or seeking the consent of the Holders of the Notes of any series, issue debt securities having the same terms (except for the issue date, and, in some cases, the public offering price and the first Interest Payment Date) and ranking equally and ratably with the Notes of a series created hereunder (the “Additional Notes”). The Notes of the applicable series and the Additional Notes shall together constitute one series for purposes of the Existing Indenture and this Fifteenth Supplemental Indenture, including, without limitation, waivers, amendments, redemptions and offers to purchase, provided they are fungible for U.S. federal income tax purposes and that no Event of Default with respect to the Notes of the applicable series shall have occurred or be continuing.

Supporting evidence: There is hereby established a series of Securities designated the “4.600% Notes due 2029” (the “2029 Notes”), a series of Securities designated the “4.800% Notes due 2031” (the “2031 Notes”), a series of Securities designated the “5.150% Notes due 2033” (the “2033 Notes”), a series of Securities designated the “5.350% Notes due 2036” (the “2036 Notes” and, together with the 2029 Notes, the 2031 Notes and the 2033 Notes, the “Notes”). The Notes shall be unsecured and unsubordinated obligations of the Company. The initial maximum aggregate principal amount of the 2029 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,200,000,000, except for 2029 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2029 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2031 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $900,000,000, except for 2031 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2031 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2033 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,500,000,000, except for 2033 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2033 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2036 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,400,000,000, except for 2036 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2036 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. Notwithstanding the foregoing, the Company may from time to time, without giving notice to or seeking the consent of the Holders of the Notes of any series, issue debt securities having the same terms (except for the issue date, and, in some cases, the public offering price and the first Interest Payment Date) and ranking equally and ratably with the Notes of a series created hereunder (the “Additional Notes”). The Notes of the applicable series and the Additional Notes shall together constitute one series for purposes of the Existing Indenture and this Fifteenth Supplemental Indenture, including, without limitation, waivers, amendments, redemptions and offers to purchase, provided they are fungible for U.S. federal income tax purposes and that no Event of Default with respect to the Notes of the applicable series shall have occurred or be continuing.

There is hereby established a series of Securities designated the “4.600% Notes due 2029” (the “2029 Notes”), a series of Securities designated the “4.800% Notes due 2031” (the “2031 Notes”), a series of Securities designated the “5.150% Notes due 2033” (the “2033 Notes”), a series of Securities designated the “5.350% Notes due 2036” (the “2036 Notes” and, together with the 2029 Notes, the 2031 Notes and the 2033 Notes, the “Notes”). The Notes shall be unsecured and unsubordinated obligations of the Company. The initial maximum aggregate principal amount of the 2029 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,200,000,000, except for 2029 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2029 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2031 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $900,000,000, except for 2031 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2031 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2033 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,500,000,000, except for 2033 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2033 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2036 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,400,000,000, except for 2036 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2036 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. Notwithstanding the foregoing, the Company may from time to time, without giving notice to or seeking the consent of the Holders of the Notes of any series, issue debt securities having the same terms (except for the issue date, and, in some cases, the public offering price and the first Interest Payment Date) and ranking equally and ratably with the Notes of a series created hereunder (the “Additional Notes”). The Notes of the applicable series and the Additional Notes shall together constitute one series for purposes of the Existing Indenture and this Fifteenth Supplemental Indenture, including, without limitation, waivers, amendments, redemptions and offers to purchase, provided they are fungible for U.S. federal income tax purposes and that no Event of Default with respect to the Notes of the applicable series shall have occurred or be continuing.

Issuer evidence: This FIFTEENTH SUPPLEMENTAL INDENTURE (this “Fifteenth Supplemental Indenture”) dated as of May 29, 2026, is between ECOLAB INC., a Delaware corporation (the “Company”), and COMPUTERSHARE TRUST COMPANY, N.A., as successor to Wells Fargo Bank, National Association (the “Trustee”).

Supporting evidence: (a) The 2029 Notes shall mature, and the principal of the 2029 Notes shall be due and payable in U.S. Dollars to the Holders thereof, together with all accrued and unpaid interest thereon, on June 15, 2029 (the Stated Maturity of principal of the 2029 Notes). The 2031 Notes shall mature, and the principal of the 2031 Notes shall be due and payable in U.S. Dollars to the Holders thereof, together with all accrued and unpaid interest thereon, on June 15, 2031 (the Stated Maturity of principal of the 2031 Notes). The 2033 Notes shall mature, and the principal of the 2033 Notes shall be due and payable in U.S. Dollars to the Holders thereof, together with all accrued and unpaid interest thereon, on June 15, 2033 (the Stated Maturity of principal of the 2033 Notes). The 2036 Notes shall mature, and the principal of the 2036 Notes shall be due and payable in U.S. Dollars to the Holders thereof, together with all accrued and unpaid interest thereon, on June 15, 2036 (the Stated Maturity of principal of the 2036 Notes).

Supporting evidence: (b) The 2029 Notes shall bear interest at the rate of 4.600% per annum, the 2031 Notes shall bear interest at the rate of 4.800% per annum, the 2033 Notes shall bear interest at the rate of 5.150% per annum and the 2036 Notes shall bear interest at the rate of 5.350% per annum, in each case from and including May 29, 2026 or from the most recent applicable Interest Payment Date on which interest has been paid or provided for, until the principal thereof becomes due and payable, and on any overdue principal and premium, if any, and (to the extent that payment of such interest is enforceable under applicable law) on any overdue installment of interest at the same rate per annum. Interest shall be calculated on the basis of a 360-day year comprised of twelve 30-day months. Interest on the Notes shall be payable semi-annually in arrears in U.S. Dollars on June 15 and December 15 of each year, beginning December 15, 2026 to the Person in whose name a Note (or predecessor Note) is registered (which shall initially be the Depositary) at the close of business on June 1 or December 1, as the case may be, immediately preceding each applicable Interest Payment Date.

Supporting evidence: There is hereby established a series of Securities designated the “4.600% Notes due 2029” (the “2029 Notes”), a series of Securities designated the “4.800% Notes due 2031” (the “2031 Notes”), a series of Securities designated the “5.150% Notes due 2033” (the “2033 Notes”), a series of Securities designated the “5.350% Notes due 2036” (the “2036 Notes” and, together with the 2029 Notes, the 2031 Notes and the 2033 Notes, the “Notes”). The Notes shall be unsecured and unsubordinated obligations of the Company. The initial maximum aggregate principal amount of the 2029 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,200,000,000, except for 2029 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2029 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2031 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $900,000,000, except for 2031 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2031 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2033 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,500,000,000, except for 2033 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2033 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2036 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,400,000,000, except for 2036 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2036 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. Notwithstanding the foregoing, the Company may from time to time, without giving notice to or seeking the consent of the Holders of the Notes of any series, issue debt securities having the same terms (except for the issue date, and, in some cases, the public offering price and the first Interest Payment Date) and ranking equally and ratably with the Notes of a series created hereunder (the “Additional Notes”). The Notes of the applicable series and the Additional Notes shall together constitute one series for purposes of the Existing Indenture and this Fifteenth Supplemental Indenture, including, without limitation, waivers, amendments, redemptions and offers to purchase, provided they are fungible for U.S. federal income tax purposes and that no Event of Default with respect to the Notes of the applicable series shall have occurred or be continuing.

Supporting evidence: There is hereby established a series of Securities designated the “4.600% Notes due 2029” (the “2029 Notes”), a series of Securities designated the “4.800% Notes due 2031” (the “2031 Notes”), a series of Securities designated the “5.150% Notes due 2033” (the “2033 Notes”), a series of Securities designated the “5.350% Notes due 2036” (the “2036 Notes” and, together with the 2029 Notes, the 2031 Notes and the 2033 Notes, the “Notes”). The Notes shall be unsecured and unsubordinated obligations of the Company. The initial maximum aggregate principal amount of the 2029 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,200,000,000, except for 2029 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2029 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2031 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $900,000,000, except for 2031 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2031 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2033 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,500,000,000, except for 2033 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2033 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2036 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,400,000,000, except for 2036 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2036 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. Notwithstanding the foregoing, the Company may from time to time, without giving notice to or seeking the consent of the Holders of the Notes of any series, issue debt securities having the same terms (except for the issue date, and, in some cases, the public offering price and the first Interest Payment Date) and ranking equally and ratably with the Notes of a series created hereunder (the “Additional Notes”). The Notes of the applicable series and the Additional Notes shall together constitute one series for purposes of the Existing Indenture and this Fifteenth Supplemental Indenture, including, without limitation, waivers, amendments, redemptions and offers to purchase, provided they are fungible for U.S. federal income tax purposes and that no Event of Default with respect to the Notes of the applicable series shall have occurred or be continuing.

There is hereby established a series of Securities designated the “4.600% Notes due 2029” (the “2029 Notes”), a series of Securities designated the “4.800% Notes due 2031” (the “2031 Notes”), a series of Securities designated the “5.150% Notes due 2033” (the “2033 Notes”), a series of Securities designated the “5.350% Notes due 2036” (the “2036 Notes” and, together with the 2029 Notes, the 2031 Notes and the 2033 Notes, the “Notes”). The Notes shall be unsecured and unsubordinated obligations of the Company. The initial maximum aggregate principal amount of the 2029 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,200,000,000, except for 2029 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2029 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2031 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $900,000,000, except for 2031 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2031 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2033 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,500,000,000, except for 2033 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2033 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2036 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,400,000,000, except for 2036 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2036 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. Notwithstanding the foregoing, the Company may from time to time, without giving notice to or seeking the consent of the Holders of the Notes of any series, issue debt securities having the same terms (except for the issue date, and, in some cases, the public offering price and the first Interest Payment Date) and ranking equally and ratably with the Notes of a series created hereunder (the “Additional Notes”). The Notes of the applicable series and the Additional Notes shall together constitute one series for purposes of the Existing Indenture and this Fifteenth Supplemental Indenture, including, without limitation, waivers, amendments, redemptions and offers to purchase, provided they are fungible for U.S. federal income tax purposes and that no Event of Default with respect to the Notes of the applicable series shall have occurred or be continuing.

Issuer evidence: This FIFTEENTH SUPPLEMENTAL INDENTURE (this “Fifteenth Supplemental Indenture”) dated as of May 29, 2026, is between ECOLAB INC., a Delaware corporation (the “Company”), and COMPUTERSHARE TRUST COMPANY, N.A., as successor to Wells Fargo Bank, National Association (the “Trustee”).

Supporting evidence: (a) The 2029 Notes shall mature, and the principal of the 2029 Notes shall be due and payable in U.S. Dollars to the Holders thereof, together with all accrued and unpaid interest thereon, on June 15, 2029 (the Stated Maturity of principal of the 2029 Notes). The 2031 Notes shall mature, and the principal of the 2031 Notes shall be due and payable in U.S. Dollars to the Holders thereof, together with all accrued and unpaid interest thereon, on June 15, 2031 (the Stated Maturity of principal of the 2031 Notes). The 2033 Notes shall mature, and the principal of the 2033 Notes shall be due and payable in U.S. Dollars to the Holders thereof, together with all accrued and unpaid interest thereon, on June 15, 2033 (the Stated Maturity of principal of the 2033 Notes). The 2036 Notes shall mature, and the principal of the 2036 Notes shall be due and payable in U.S. Dollars to the Holders thereof, together with all accrued and unpaid interest thereon, on June 15, 2036 (the Stated Maturity of principal of the 2036 Notes).

Supporting evidence: (b) The 2029 Notes shall bear interest at the rate of 4.600% per annum, the 2031 Notes shall bear interest at the rate of 4.800% per annum, the 2033 Notes shall bear interest at the rate of 5.150% per annum and the 2036 Notes shall bear interest at the rate of 5.350% per annum, in each case from and including May 29, 2026 or from the most recent applicable Interest Payment Date on which interest has been paid or provided for, until the principal thereof becomes due and payable, and on any overdue principal and premium, if any, and (to the extent that payment of such interest is enforceable under applicable law) on any overdue installment of interest at the same rate per annum. Interest shall be calculated on the basis of a 360-day year comprised of twelve 30-day months. Interest on the Notes shall be payable semi-annually in arrears in U.S. Dollars on June 15 and December 15 of each year, beginning December 15, 2026 to the Person in whose name a Note (or predecessor Note) is registered (which shall initially be the Depositary) at the close of business on June 1 or December 1, as the case may be, immediately preceding each applicable Interest Payment Date.

Supporting evidence: There is hereby established a series of Securities designated the “4.600% Notes due 2029” (the “2029 Notes”), a series of Securities designated the “4.800% Notes due 2031” (the “2031 Notes”), a series of Securities designated the “5.150% Notes due 2033” (the “2033 Notes”), a series of Securities designated the “5.350% Notes due 2036” (the “2036 Notes” and, together with the 2029 Notes, the 2031 Notes and the 2033 Notes, the “Notes”). The Notes shall be unsecured and unsubordinated obligations of the Company. The initial maximum aggregate principal amount of the 2029 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,200,000,000, except for 2029 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2029 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2031 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $900,000,000, except for 2031 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2031 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2033 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,500,000,000, except for 2033 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2033 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2036 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,400,000,000, except for 2036 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2036 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. Notwithstanding the foregoing, the Company may from time to time, without giving notice to or seeking the consent of the Holders of the Notes of any series, issue debt securities having the same terms (except for the issue date, and, in some cases, the public offering price and the first Interest Payment Date) and ranking equally and ratably with the Notes of a series created hereunder (the “Additional Notes”). The Notes of the applicable series and the Additional Notes shall together constitute one series for purposes of the Existing Indenture and this Fifteenth Supplemental Indenture, including, without limitation, waivers, amendments, redemptions and offers to purchase, provided they are fungible for U.S. federal income tax purposes and that no Event of Default with respect to the Notes of the applicable series shall have occurred or be continuing.

Supporting evidence: There is hereby established a series of Securities designated the “4.600% Notes due 2029” (the “2029 Notes”), a series of Securities designated the “4.800% Notes due 2031” (the “2031 Notes”), a series of Securities designated the “5.150% Notes due 2033” (the “2033 Notes”), a series of Securities designated the “5.350% Notes due 2036” (the “2036 Notes” and, together with the 2029 Notes, the 2031 Notes and the 2033 Notes, the “Notes”). The Notes shall be unsecured and unsubordinated obligations of the Company. The initial maximum aggregate principal amount of the 2029 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,200,000,000, except for 2029 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2029 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2031 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $900,000,000, except for 2031 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2031 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2033 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,500,000,000, except for 2033 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2033 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. The initial maximum aggregate principal amount of the 2036 Notes that may be authenticated and delivered under this Fifteenth Supplemental Indenture shall not exceed $1,400,000,000, except for 2036 Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, 2036 Notes pursuant to Sections 3.04, 3.06, 3.07 and 4.06 of the Existing Indenture. Notwithstanding the foregoing, the Company may from time to time, without giving notice to or seeking the consent of the Holders of the Notes of any series, issue debt securities having the same terms (except for the issue date, and, in some cases, the public offering price and the first Interest Payment Date) and ranking equally and ratably with the Notes of a series created hereunder (the “Additional Notes”). The Notes of the applicable series and the Additional Notes shall together constitute one series for purposes of the Existing Indenture and this Fifteenth Supplemental Indenture, including, without limitation, waivers, amendments, redemptions and offers to purchase, provided they are fungible for U.S. federal income tax purposes and that no Event of Default with respect to the Notes of the applicable series shall have occurred or be continuing.