TWO SIGMA INVESTMENTS, LP

Position in GLUE — Monte Rosa Therapeutics, Inc.

CIK 1179392 NEW YORK, NY

Position in GLUE

as of Jun 30, 2026 · filed Aug 14, 2026 Compact

Position Value

$3,410,336

+$3,092,851 QoQ

Shares Held

140,923

+630.2% QoQ

Ownership

0.165%

of shares outstanding

% of Portfolio

0.00%

of 13F equity value

Holder Rank

#65

of 193 holders

Holding Since

Mar 2023

10 quarters on record

Voting authority Sole 99% Shared 0% None 1%

Healthcare · as of Jun 30, 2026

TWO SIGMA INVESTMENTS, LP holds $7,273,657,992 across 342 Biotechnology names. GLUE ranks #132 (0.0% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	ALNY	Alnylam Pharmaceuticals, Inc.	1,875,937	$564,713,315
2	MRNA	Moderna, Inc.	7,193,530	$503,762,905
3	IONS	Ionis Pharmaceuticals Inc	6,252,342	$495,748,197
4	REGN	Regeneron Pharmaceuticals, Inc.	656,124	$409,119,558
5	BBIO	BridgeBio Pharma, Inc.	4,722,185	$351,708,338
6	EXEL	Exelixis, Inc.	4,209,861	$229,058,537
7	INCY	Incyte Corp	2,003,559	$227,123,448
8	ARGX	Argenx SE	185,638	$172,229,367

10 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-06-30	$3,410,336	140,923	+630.2%	Shares	Sole	2026-08-14
2026-03-31	$317,485	19,300	+37.9%	Shares	Sole	2026-05-15
2025-12-31	$219,520	14,000	-91.3%	Shares	Sole	2026-02-17
2025-09-30	$1,196,574	161,481	-32.7%	Shares	Sole	2025-11-14
2025-06-30	$1,082,115	239,937	+7.5%	Shares	Sole	2025-08-14
2025-03-31	$1,035,323	223,130	-20.0%	Shares	Sole	2025-05-15
2024-12-31	$1,934,767	278,785	+1965.1%	Shares	Sole	2025-02-14
2024-09-30	$71,550	13,500	-79.8%	Shares	Sole	2024-11-14
2023-09-30	$319,732	66,750	+560.9%	Shares	Sole	2023-11-14
2023-03-31	$78,679	10,100	—	Shares	Sole	2023-05-15
No filing history on record for this holder in this stock.