TWO SIGMA INVESTMENTS, LP

Position in HOWL — Werewolf Therapeutics, Inc.

CIK 1179392 NEW YORK, NY

Position in HOWL

as of Jun 30, 2026 · filed Aug 14, 2026 Compact

Position Value

$9,828

-$29,845 QoQ

Shares Held

27,300

+35.6% QoQ

Ownership

0.056%

of shares outstanding

% of Portfolio

0.00%

of 13F equity value

Holder Rank

#24

of 45 holders

Holding Since

Dec 2021

14 quarters on record

Voting authority Sole 92% Shared 0% None 8%

Healthcare · as of Jun 30, 2026

TWO SIGMA INVESTMENTS, LP holds $7,273,657,992 across 342 Biotechnology names. HOWL ranks #336 (0.0% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	ALNY	Alnylam Pharmaceuticals, Inc.	1,875,937	$564,713,315
2	MRNA	Moderna, Inc.	7,193,530	$503,762,905
3	IONS	Ionis Pharmaceuticals Inc	6,252,342	$495,748,197
4	REGN	Regeneron Pharmaceuticals, Inc.	656,124	$409,119,558
5	BBIO	BridgeBio Pharma, Inc.	4,722,185	$351,708,338
6	EXEL	Exelixis, Inc.	4,209,861	$229,058,537
7	INCY	Incyte Corp	2,003,559	$227,123,448
8	ARGX	Argenx SE	185,638	$172,229,367

14 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-06-30	$9,828	27,300	+35.6%	Shares	Sole	2026-08-14
2025-09-30	$39,673	20,139	-55.7%	Shares	Sole	2025-11-14
2025-06-30	$49,509	45,422	-21.9%	Shares	Sole	2025-08-14
2025-03-31	$56,504	58,132	-37.8%	Shares	Sole	2025-05-15
2024-12-31	$138,291	93,440	-48.3%	Shares	Sole	2025-02-14
2024-09-30	$382,888	180,608	-17.7%	Shares	Sole	2024-11-14
2024-06-30	$535,253	219,366	+18.5%	Shares	Sole	2024-08-14
2024-03-31	$1,199,182	185,059	+26.1%	Shares	Sole	2024-05-15
2023-12-31	$566,400	146,736	+787.3%	Shares	Sole	2024-02-14
2023-06-30	$50,437	16,537	-36.0%	Shares	Sole	2023-08-14
2023-03-31	$67,176	25,837	-5.0%	Shares	Sole	2023-05-15
2022-12-31	$55,729	27,185	+79.1%	Shares	Sole	2023-02-14
2022-03-31	$66,792	15,180	-31.1%	Shares	Sole	2022-05-16
2021-12-31	$262,424	22,034	—	Shares	Sole	2022-02-14
No filing history on record for this holder in this stock.