TWO SIGMA INVESTMENTS, LP

Position in JBIO — Jade Biosciences, Inc.

CIK 1179392 NEW YORK, NY

Position in JBIO

as of Jun 30, 2026 · filed Aug 14, 2026 Compact

Position Value

$1,007,921

+$751,495 QoQ

Shares Held

45,361

+148.5% QoQ

Ownership

0.071%

of shares outstanding

% of Portfolio

0.00%

of 13F equity value

Holder Rank

#77

of 153 holders

Holding Since

Dec 2022

14 quarters on record

Voting authority Sole 100% Shared 0% None 0%

Healthcare · as of Jun 30, 2026

TWO SIGMA INVESTMENTS, LP holds $7,273,657,992 across 342 Biotechnology names. JBIO ranks #206 (0.0% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	ALNY	Alnylam Pharmaceuticals, Inc.	1,875,937	$564,713,315
2	MRNA	Moderna, Inc.	7,193,530	$503,762,905
3	IONS	Ionis Pharmaceuticals Inc	6,252,342	$495,748,197
4	REGN	Regeneron Pharmaceuticals, Inc.	656,124	$409,119,558
5	BBIO	BridgeBio Pharma, Inc.	4,722,185	$351,708,338
6	EXEL	Exelixis, Inc.	4,209,861	$229,058,537
7	INCY	Incyte Corp	2,003,559	$227,123,448
8	ARGX	Argenx SE	185,638	$172,229,367

14 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-06-30	$1,007,921	45,361	+148.5%	Shares	Sole	2026-08-14
2026-03-31	$256,426	18,251	+10.6%	Shares	Sole	2026-05-15
2025-12-31	$254,533	16,496	-33.0%	Shares	Sole	2026-02-17
2025-09-30	$212,384	24,610	—	Shares	Sole	2025-11-14
2025-03-31 AVTE	—	204,791	-9.4%	Shares	Sole	2025-05-15
2024-12-31 AVTE	—	226,121	-27.8%	Shares	Sole	2025-02-14
2024-09-30 AVTE	—	313,114	+12.3%	Shares	Sole	2024-11-14
2024-06-30 AVTE	—	278,816	+1116.8%	Shares	Sole	2024-08-14
2024-03-31 AVTE	—	22,913	+134.8%	Shares	Sole	2024-05-15
2023-12-31 AVTE	—	9,760	-17.3%	Shares	Sole	2024-02-14
2023-09-30 AVTE	—	11,804	-60.7%	Shares	Sole	2023-11-14
2023-06-30 AVTE	—	30,011	+160.8%	Shares	Sole	2023-08-14
2023-03-31 AVTE	—	11,509	-45.6%	Shares	Sole	2023-05-15
2022-12-31 AVTE	—	21,137	—	Shares	Sole	2023-02-14
No filing history on record for this holder in this stock.