TWO SIGMA INVESTMENTS, LP
Position in MDGL — Madrigal Pharmaceuticals, Inc.
CIK 1179392
NEW YORK, NY
Position in MDGL
as of Jun 30, 2026
· filed Aug 14, 2026
Position Value
$303,913
+$303,913 QoQ
Shares Held
566
Ownership
0.002%
of shares outstanding
% of Portfolio
0.00%
of 13F equity value
Holder Rank
#282
of 411 holders
Holding Since
Mar 2020
10 quarters on record
Voting authority
Sole 100%
Shared 0%
None 0%
Common Shares in MDGL Over Time
Shares Held
Position Value (USD)
Derivatives in MDGL
reported options exposure · as of Jun 30, 2026CallValue
$1,718,240
CallShares
3,200
PutValue
$3,597,565
PutShares
6,700
Notional value of option positions as reported on Form 13F. Calls and puts are disclosed separately and do not net against the common-share stake above.
Position in Biotechnology
Healthcare · as of Jun 30, 2026TWO SIGMA INVESTMENTS, LP holds $7,273,664,878 across 342 Biotechnology names. MDGL ranks #269 (0.0% of the industry book) .
| # | Ticker | Company | Shares | Value (USD) | Open |
|---|---|---|---|---|---|
| 1 | ALNY |
Alnylam Pharmaceuticals, Inc.
|
1,875,937 | $564,713,315 | |
| 2 | MRNA |
Moderna, Inc.
|
7,193,530 | $503,762,905 | |
| 3 | IONS |
Ionis Pharmaceuticals Inc
|
6,252,342 | $495,748,197 | |
| 4 | REGN |
Regeneron Pharmaceuticals, Inc.
|
656,124 | $409,119,558 | |
| 5 | BBIO |
BridgeBio Pharma, Inc.
|
4,722,185 | $351,708,338 | |
| 6 | EXEL |
Exelixis, Inc.
|
4,209,861 | $229,058,537 | |
| 7 | INCY |
Incyte Corp
|
2,003,559 | $227,123,448 | |
| 8 | ARGX |
Argenx SE
|
185,638 | $172,229,367 |
All Filings in MDGL
Export CSV
12 filing rows on record
| Report Date | Value (USD) | Shares | Type | Discretion | Filed | |
|---|---|---|---|---|---|---|
| 2026-06-30 | $3,597,565 | 6,700 | Put | Sole | 2026-08-14 | |
| 2026-06-30 | $303,913 | 566 | Shares | Sole | 2026-08-14 | |
| 2026-06-30 | $1,718,240 | 3,200 | Call | Sole | 2026-08-14 | |
| 2026-03-31 | $418,776 | 800 | Put | Sole | 2026-05-15 | |
| 2023-03-31 | $5,884,979 | 24,292 | Shares | Sole | 2023-05-15 | |
| 2022-12-31 | $2,739,960 | 9,440 | Shares | Sole | 2023-02-14 | |
| 2021-06-30 | $6,646,771 | 68,235 | Shares | Sole | 2021-08-16 | |
| 2021-03-31 | $21,079,748 | 180,215 | Shares | Sole | 2021-05-17 | |
| 2020-12-31 | $8,461,259 | 76,111 | Shares | Sole | 2021-02-16 | |
| 2020-09-30 | $7,910,030 | 66,622 | Shares | Sole | 2020-11-16 | |
| 2020-06-30 | $8,758,981 | 77,342 | Shares | Sole | 2020-08-14 | |
| 2020-03-31 | $1,199,476 | 17,967 | Shares | Sole | 2020-05-15 | |
| No filing history on record for this holder in this stock. | ||||||