TWO SIGMA INVESTMENTS, LP

Position in MIST — Milestone Pharmaceuticals Inc.

CIK 1179392 NEW YORK, NY

Position in MIST

as of Jun 30, 2026 · filed Aug 14, 2026 Compact

Position Value

$2,733,620

-$23,819 QoQ

Shares Held

2,040,015

-12.0% QoQ

Ownership

1.64%

of shares outstanding

% of Portfolio

0.00%

of 13F equity value

Holder Rank

of 78 holders

Holding Since

Sep 2020

11 quarters on record

Voting authority Sole 98% Shared 0% None 2%

Healthcare · as of Jun 30, 2026

TWO SIGMA INVESTMENTS, LP holds $7,273,664,878 across 342 Biotechnology names. MIST ranks #143 (0.0% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	ALNY	Alnylam Pharmaceuticals, Inc.	1,875,937	$564,713,315
2	MRNA	Moderna, Inc.	7,193,530	$503,762,905
3	IONS	Ionis Pharmaceuticals Inc	6,252,342	$495,748,197
4	REGN	Regeneron Pharmaceuticals, Inc.	656,124	$409,119,558
5	BBIO	BridgeBio Pharma, Inc.	4,722,185	$351,708,338
6	EXEL	Exelixis, Inc.	4,209,861	$229,058,537
7	INCY	Incyte Corp	2,003,559	$227,123,448
8	ARGX	Argenx SE	185,638	$172,229,367

11 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-06-30	$2,733,620	2,040,015	-12.0%	Shares	Sole	2026-08-14
2026-03-31	$2,757,439	2,317,176	+53.0%	Shares	Sole	2026-05-15
2025-12-31	$3,059,211	1,514,461	+127.2%	Shares	Sole	2026-02-17
2025-09-30	$1,333,102	666,551	+1177.3%	Shares	Sole	2025-11-14
2023-06-30	$148,730	52,186	+47.8%	Shares	Sole	2023-08-14
2023-03-31	$139,109	35,307	-81.8%	Shares	Sole	2023-05-15
2022-12-31	$769,598	194,343	+1097.1%	Shares	Sole	2023-02-14
2021-06-30	$89,292	16,235	-70.4%	Shares	Sole	2021-08-16
2021-03-31	$317,367	54,813	-4.5%	Shares	Sole	2021-05-17
2020-12-31	$384,653	57,411	+188.5%	Shares	Sole	2021-02-16
2020-09-30	$145,682	19,902	—	Shares	Sole	2020-11-16
No filing history on record for this holder in this stock.