TWO SIGMA INVESTMENTS, LP

Position in MREO — Mereo BioPharma Group plc

CIK 1179392 NEW YORK, NY

Position in MREO

as of Jun 30, 2026 · filed Aug 14, 2026 Compact

Position Value

$419,518

+$357,532 QoQ

Shares Held

1,319,241

+602.3% QoQ

Ownership

0.826%

of shares outstanding

% of Portfolio

0.00%

of 13F equity value

Holder Rank

of 58 holders

Holding Since

Jun 2023

13 quarters on record

Voting authority Sole 97% Shared 0% None 3%

Healthcare · as of Jun 30, 2026

TWO SIGMA INVESTMENTS, LP holds $7,273,657,992 across 342 Biotechnology names. MREO ranks #255 (0.0% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	ALNY	Alnylam Pharmaceuticals, Inc.	1,875,937	$564,713,315
2	MRNA	Moderna, Inc.	7,193,530	$503,762,905
3	IONS	Ionis Pharmaceuticals Inc	6,252,342	$495,748,197
4	REGN	Regeneron Pharmaceuticals, Inc.	656,124	$409,119,558
5	BBIO	BridgeBio Pharma, Inc.	4,722,185	$351,708,338
6	EXEL	Exelixis, Inc.	4,209,861	$229,058,537
7	INCY	Incyte Corp	2,003,559	$227,123,448
8	ARGX	Argenx SE	185,638	$172,229,367

13 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-06-30	$419,518	1,319,241	+602.3%	Shares	Sole	2026-08-14
2026-03-31	$61,986	187,839	-64.2%	Shares	Sole	2026-05-15
2025-12-31	$218,977	525,125	-51.7%	Shares	Sole	2026-02-17
2025-09-30	$2,241,477	1,088,096	+65.1%	Shares	Sole	2025-11-14
2025-06-30	$1,786,318	659,158	+168.8%	Shares	Sole	2025-08-14
2025-03-31	$551,713	245,206	+256.7%	Shares	Sole	2025-05-15
2024-12-31	$240,572	68,735	-48.8%	Shares	Sole	2025-02-14
2024-09-30	$552,026	134,313	-33.4%	Shares	Sole	2024-11-14
2024-06-30	$726,393	201,776	-42.6%	Shares	Sole	2024-08-14
2024-03-31	$1,160,705	351,729	+13.1%	Shares	Sole	2024-05-15
2023-12-31	$718,548	311,060	+118.1%	Shares	Sole	2024-02-14
2023-09-30	$183,956	142,602	-27.9%	Shares	Sole	2023-11-14
2023-06-30	$261,041	197,759	—	Shares	Sole	2023-08-14
No filing history on record for this holder in this stock.