TWO SIGMA INVESTMENTS, LP

Position in NKTR — Nektar Therapeutics

CIK 1179392 NEW YORK, NY

Position in NKTR

as of Jun 30, 2026 · filed Aug 14, 2026 Compact

Position Value

$83,911,899

+$16,945,085 QoQ

Shares Held

1,202,004

+29.1% QoQ

Ownership

3.52%

of shares outstanding

% of Portfolio

0.07%

of 13F equity value

Holder Rank

of 239 holders

Holding Since

Jun 2020

25 quarters on record

Voting authority Sole 99% Shared 0% None 1%

Healthcare · as of Jun 30, 2026

TWO SIGMA INVESTMENTS, LP holds $7,273,657,992 across 342 Biotechnology names. NKTR ranks #25 (1.2% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	ALNY	Alnylam Pharmaceuticals, Inc.	1,875,937	$564,713,315
2	MRNA	Moderna, Inc.	7,193,530	$503,762,905
3	IONS	Ionis Pharmaceuticals Inc	6,252,342	$495,748,197
4	REGN	Regeneron Pharmaceuticals, Inc.	656,124	$409,119,558
5	BBIO	BridgeBio Pharma, Inc.	4,722,185	$351,708,338
6	EXEL	Exelixis, Inc.	4,209,861	$229,058,537
7	INCY	Incyte Corp	2,003,559	$227,123,448
8	ARGX	Argenx SE	185,638	$172,229,367

25 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-06-30	$83,911,899	1,202,004	+29.1%	Shares	Sole	2026-08-14
2026-03-31	$66,966,814	930,741	+96.8%	Shares	Sole	2026-05-15
2025-12-31	$19,999,031	473,014	+8.9%	Shares	Sole	2026-02-17
2025-09-30	$24,708,085	434,237	+446.9%	Shares	Sole	2025-11-14
2025-06-30	$2,051,566	79,395	-94.5%	Shares	Sole	2025-08-14
2025-03-31	$975,865	1,435,096	-6.7%	Shares	Sole	2025-05-15
2024-12-31	$1,429,740	1,537,355	+12.8%	Shares	Sole	2025-02-14
2024-09-30	$1,772,121	1,363,170	-24.7%	Shares	Sole	2024-11-14
2024-06-30	$2,243,383	1,809,180	-13.1%	Shares	Sole	2024-08-14
2024-03-31	$1,936,204	2,081,940	-4.4%	Shares	Sole	2024-05-15
2023-12-31	$1,219,109	2,176,981	-22.1%	Shares	Sole	2024-02-14
2023-09-30	$1,677,029	2,795,049	-12.7%	Shares	Sole	2023-11-14
2023-06-30	$1,857,064	3,201,835	+58.0%	Shares	Sole	2023-08-14
2023-03-31	$1,418,515	2,026,450	+409.5%	Shares	Sole	2023-05-15
2022-12-31	$898,901	397,744	-52.7%	Shares	Sole	2023-02-14
2022-09-30	$2,693,680	841,775	+98.8%	Shares	Sole	2022-11-14
2022-06-30	$1,608,996	423,420	-10.4%	Shares	Sole	2022-08-15
2022-03-31	$2,546,187	472,391	-40.4%	Shares	Sole	2022-05-16
2021-12-31	$10,708,174	792,611	+92.0%	Shares	Sole	2022-02-14
2021-09-30	$7,413,061	412,754	+5.0%	Shares	Sole	2021-11-15
2021-06-30	$6,744,926	393,061	+331.5%	Shares	Sole	2021-08-16
2021-03-31	$1,821,840	91,092	+158.2%	Shares	Sole	2021-05-17
2020-12-31	$599,794	35,282	-84.3%	Shares	Sole	2021-02-16
2020-09-30	$3,719,925	224,227	-20.1%	Shares	Sole	2020-11-16
2020-06-30	$6,502,911	280,782	—	Shares	Sole	2020-08-14
No filing history on record for this holder in this stock.