TWO SIGMA INVESTMENTS, LP

Position in PLX — Protalix BioTherapeutics, Inc.

CIK 1179392 NEW YORK, NY

Position in PLX

as of Jun 30, 2026 · filed Aug 14, 2026 Compact

Position Value

$99,059

+$59,720 QoQ

Shares Held

42,515

+134.5% QoQ

Ownership

0.053%

of shares outstanding

% of Portfolio

0.00%

of 13F equity value

Holder Rank

#35

of 101 holders

Holding Since

Jun 2022

11 quarters on record

Voting authority Sole 100% Shared 0% None 0%

Healthcare · as of Jun 30, 2026

TWO SIGMA INVESTMENTS, LP holds $7,273,664,878 across 342 Biotechnology names. PLX ranks #314 (0.0% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	ALNY	Alnylam Pharmaceuticals, Inc.	1,875,937	$564,713,315
2	MRNA	Moderna, Inc.	7,193,530	$503,762,905
3	IONS	Ionis Pharmaceuticals Inc	6,252,342	$495,748,197
4	REGN	Regeneron Pharmaceuticals, Inc.	656,124	$409,119,558
5	BBIO	BridgeBio Pharma, Inc.	4,722,185	$351,708,338
6	EXEL	Exelixis, Inc.	4,209,861	$229,058,537
7	INCY	Incyte Corp	2,003,559	$227,123,448
8	ARGX	Argenx SE	185,638	$172,229,367

11 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-06-30	$99,059	42,515	+134.5%	Shares	Sole	2026-08-14
2026-03-31	$39,339	18,129	-74.7%	Shares	Sole	2026-05-15
2025-06-30	$105,874	71,537	-17.2%	Shares	Sole	2025-08-14
2025-03-31	$221,066	86,354	+340.6%	Shares	Sole	2025-05-15
2023-12-31	$34,888	19,600	-58.6%	Shares	Sole	2024-02-14
2023-09-30	$78,518	47,300	-14.2%	Shares	Sole	2023-11-14
2023-06-30	$110,250	55,125	-71.6%	Shares	Sole	2023-08-14
2023-03-31	$407,597	194,094	+1816.8%	Shares	Sole	2023-05-15
2022-12-31	$13,872	10,126	-2.2%	Shares	Sole	2023-02-14
2022-09-30	$10,765	10,351	-59.4%	Shares	Sole	2022-11-14
2022-06-30	$27,805	25,510	—	Shares	Sole	2022-08-15
No filing history on record for this holder in this stock.