Position in REPL
as of Mar 31, 2026
· filed May 15, 2026
Position Value
$2,637,345
-$1,679,054 QoQ
Shares Held
344,751
-22.4% QoQ
Ownership
0.411%
of shares outstanding
% of Portfolio
0.00%
of 13F equity value
Holder Rank
—
not a current holder
Holding Since
Jun 2020
22 quarters on record
Voting authority
Sole 100%
Shared 0%
None 0%
Common Shares in REPL Over Time
Shares Held
Position Value (USD)
Position in Biotechnology
Healthcare · as of Mar 31, 2026TWO SIGMA INVESTMENTS, LP holds $5,506,832,621 across 316 Biotechnology names. REPL ranks #143 (0.0% of the industry book) .
| # | Ticker | Company | Shares | Value (USD) | Open |
|---|---|---|---|---|---|
| 1 | ALNY |
Alnylam Pharmaceuticals, Inc.
|
1,992,577 | $659,283,951 | |
| 2 | REGN |
Regeneron Pharmaceuticals, Inc.
|
812,236 | $627,566,023 | |
| 3 | MRNA |
Moderna, Inc.
|
9,086,404 | $461,589,323 | |
| 4 | IONS |
Ionis Pharmaceuticals Inc
|
5,857,629 | $439,849,361 | |
| 5 | BBIO |
BridgeBio Pharma, Inc.
|
3,120,631 | $231,738,058 | |
| 6 | VRTX |
Vertex Pharmaceuticals Inc / Ma
|
378,146 | $168,857,314 | |
| 7 | RVMD |
Revolution Medicines, Inc.
|
1,558,807 | $151,593,980 | |
| 8 | VKTX |
Viking Therapeutics, Inc.
|
4,432,142 | $144,221,900 |
All Filings in REPL
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22 filing rows on record
| Report Date | Value (USD) | Shares | Type | Discretion | Filed | |
|---|---|---|---|---|---|---|
| 2026-03-31 | $2,637,345 | 344,751 | Shares | Sole | 2026-05-15 | |
| 2025-12-31 | $4,316,399 | 444,074 | Shares | Sole | 2026-02-17 | |
| 2025-09-30 | $659,920 | 157,499 | Shares | Sole | 2025-11-14 | |
| 2025-06-30 | $208,291 | 22,421 | Shares | Sole | 2025-08-14 | |
| 2025-03-31 | $432,929 | 44,403 | Shares | Sole | 2025-05-15 | |
| 2024-12-31 | $2,574,416 | 212,586 | Shares | Sole | 2025-02-14 | |
| 2024-09-30 | $1,964,470 | 179,240 | Shares | Sole | 2024-11-14 | |
| 2024-06-30 | $1,863,180 | 207,020 | Shares | Sole | 2024-08-14 | |
| 2024-03-31 | $2,523,230 | 308,841 | Shares | Sole | 2024-05-15 | |
| 2023-12-31 | $962,554 | 114,182 | Shares | Sole | 2024-02-14 | |
| 2023-06-30 | $4,228,617 | 182,111 | Shares | Sole | 2023-08-14 | |
| 2023-03-31 | $4,501,957 | 254,924 | Shares | Sole | 2023-05-15 | |
| 2022-09-30 | $1,461,629 | 84,634 | Shares | Sole | 2022-11-14 | |
| 2022-06-30 | $1,052,418 | 60,207 | Shares | Sole | 2022-08-15 | |
| 2022-03-31 | $3,715,088 | 218,792 | Shares | Sole | 2022-05-16 | |
| 2021-12-31 | $2,620,786 | 96,708 | Shares | Sole | 2022-02-14 | |
| 2021-09-30 | $3,146,463 | 106,156 | Shares | Sole | 2021-11-15 | |
| 2021-06-30 | $6,027,636 | 156,888 | Shares | Sole | 2021-08-16 | |
| 2021-03-31 | $11,248,884 | 368,695 | Shares | Sole | 2021-05-17 | |
| 2020-12-31 | $12,548,755 | 328,932 | Shares | Sole | 2021-02-16 | |
| 2020-09-30 | $1,469,481 | 63,835 | Shares | Sole | 2020-11-16 | |
| 2020-06-30 | $318,750 | 12,827 | Shares | Sole | 2020-08-14 | |
| No filing history on record for this holder in this stock. | ||||||