TWO SIGMA INVESTMENTS, LP

Position in RLAY — Relay Therapeutics, Inc.

CIK 1179392 NEW YORK, NY

Position in RLAY

as of Jun 30, 2026 · filed Aug 14, 2026 Compact

Position Value

$13,114,231

-$508,801 QoQ

Shares Held

700,921

-48.8% QoQ

Ownership

0.320%

of shares outstanding

% of Portfolio

0.01%

of 13F equity value

Holder Rank

#51

of 256 holders

Holding Since

Sep 2021

14 quarters on record

Voting authority Sole 97% Shared 0% None 3%

Healthcare · as of Jun 30, 2026

TWO SIGMA INVESTMENTS, LP holds $7,273,657,992 across 342 Biotechnology names. RLAY ranks #74 (0.2% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	ALNY	Alnylam Pharmaceuticals, Inc.	1,875,937	$564,713,315
2	MRNA	Moderna, Inc.	7,193,530	$503,762,905
3	IONS	Ionis Pharmaceuticals Inc	6,252,342	$495,748,197
4	REGN	Regeneron Pharmaceuticals, Inc.	656,124	$409,119,558
5	BBIO	BridgeBio Pharma, Inc.	4,722,185	$351,708,338
6	EXEL	Exelixis, Inc.	4,209,861	$229,058,537
7	INCY	Incyte Corp	2,003,559	$227,123,448
8	ARGX	Argenx SE	185,638	$172,229,367

14 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-06-30	$13,114,231	700,921	-48.8%	Shares	Sole	2026-08-14
2026-03-31	$13,623,032	1,369,149	-12.2%	Shares	Sole	2026-05-15
2025-12-31	$13,199,841	1,560,265	+42.4%	Shares	Sole	2026-02-17
2025-09-30	$5,719,214	1,095,635	+7.1%	Shares	Sole	2025-11-14
2025-06-30	$3,540,908	1,023,384	+21.3%	Shares	Sole	2025-08-14
2025-03-31	$2,210,902	843,856	+3.4%	Shares	Sole	2025-05-15
2024-12-31	$3,362,270	816,085	-19.6%	Shares	Sole	2025-02-14
2024-09-30	$7,190,214	1,015,567	+39.1%	Shares	Sole	2024-11-14
2024-06-30	$4,759,743	730,022	+24.2%	Shares	Sole	2024-08-14
2024-03-31	$4,877,827	587,690	+45.1%	Shares	Sole	2024-05-15
2023-12-31	$4,458,125	404,916	+1.1%	Shares	Sole	2024-02-14
2023-09-30	$3,369,659	400,673	+1575.8%	Shares	Sole	2023-11-14
2022-06-30	$400,475	23,909	-87.5%	Shares	Sole	2022-08-15
2021-09-30	$6,050,323	191,891	—	Shares	Sole	2021-11-15
No filing history on record for this holder in this stock.