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Equibles

TWO SIGMA INVESTMENTS, LP

Position in SPRO — Spero Therapeutics, Inc.

CIK 1179392 NEW YORK, NY
Back to SPRO Full portfolio

Position in SPRO

as of Jun 30, 2026 · filed Aug 14, 2026
Position Value
$846,018
-$1,226,358 QoQ
Shares Held
382,814
-56.8% QoQ
Ownership
0.657%
of shares outstanding
% of Portfolio
0.00%
of 13F equity value
Holder Rank
#10
of 59 holders
Holding Since
Jun 2020
12 quarters on record
Voting authority Sole 98% Shared 0% None 2%

Common Shares in SPRO Over Time

Shares Held

Position Value (USD)

Position in Biotechnology

Healthcare · as of Jun 30, 2026

TWO SIGMA INVESTMENTS, LP holds $7,283,390,440 across 343 Biotechnology names. SPRO ranks #213 (0.0% of the industry book) .

# Ticker Company Shares Value (USD) Open
1 ALNY
Alnylam Pharmaceuticals, Inc.
 1,875,937 $564,713,315
2 MRNA
Moderna, Inc.
 7,193,530 $503,762,905
3 IONS
Ionis Pharmaceuticals Inc
 6,252,342 $495,748,197
4 REGN
Regeneron Pharmaceuticals, Inc.
 656,124 $409,119,558
5 BBIO
BridgeBio Pharma, Inc.
 4,722,185 $351,708,338
6 EXEL
Exelixis, Inc.
 4,209,861 $229,058,537
7 INCY
Incyte Corp
 2,003,559 $227,123,448
8 ARGX
Argenx SE
 185,638 $172,229,367

All Filings in SPRO

Export CSV
12 filing rows on record
Report Date Value (USD) Shares
2026-06-30 $846,018 382,814
2026-03-31 $2,072,376 885,631
2025-12-31 $868,088 372,570
2025-09-30 $92,870 49,399
2023-09-30 $20,597 17,023
2023-06-30 $122,575 84,535
2023-03-31 $46,545 32,100
2022-12-31 $68,845 39,795
2022-06-30 $324,024 437,280
2022-03-31 $686,499 78,908
2020-12-31 $841,002 43,373
2020-06-30 $380,869 28,150