TWO SIGMA INVESTMENTS, LP

Position in TYRA — Tyra Biosciences, Inc.

CIK 1179392 NEW YORK, NY

Position in TYRA

as of Jun 30, 2026 · filed Aug 14, 2026 Compact

Position Value

$14,366,867

+$10,474,898 QoQ

Shares Held

449,808

+342.6% QoQ

Ownership

0.754%

of shares outstanding

% of Portfolio

0.01%

of 13F equity value

Holder Rank

#26

of 169 holders

Holding Since

Mar 2024

10 quarters on record

Voting authority Sole 100% Shared 0% None 0%

Healthcare · as of Jun 30, 2026

TWO SIGMA INVESTMENTS, LP holds $7,273,657,992 across 342 Biotechnology names. TYRA ranks #70 (0.2% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	ALNY	Alnylam Pharmaceuticals, Inc.	1,875,937	$564,713,315
2	MRNA	Moderna, Inc.	7,193,530	$503,762,905
3	IONS	Ionis Pharmaceuticals Inc	6,252,342	$495,748,197
4	REGN	Regeneron Pharmaceuticals, Inc.	656,124	$409,119,558
5	BBIO	BridgeBio Pharma, Inc.	4,722,185	$351,708,338
6	EXEL	Exelixis, Inc.	4,209,861	$229,058,537
7	INCY	Incyte Corp	2,003,559	$227,123,448
8	ARGX	Argenx SE	185,638	$172,229,367

10 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-06-30	$14,366,867	449,808	+342.6%	Shares	Sole	2026-08-14
2026-03-31	$3,891,969	101,618	-5.1%	Shares	Sole	2026-05-15
2025-12-31	$2,813,634	107,023	-46.3%	Shares	Sole	2026-02-17
2025-09-30	$2,790,137	199,438	+88.5%	Shares	Sole	2025-11-14
2025-06-30	$1,012,745	105,825	+63.3%	Shares	Sole	2025-08-14
2025-03-31	$602,807	64,818	+40.1%	Shares	Sole	2025-05-15
2024-12-31	$643,139	46,269	+18.1%	Shares	Sole	2025-02-14
2024-09-30	$921,027	39,176	+11.1%	Shares	Sole	2024-11-14
2024-06-30	$563,999	35,272	-15.5%	Shares	Sole	2024-08-14
2024-03-31	$684,568	41,742	—	Shares	Sole	2024-05-15
No filing history on record for this holder in this stock.