TYRA · Tyra Biosciences, Inc.

$28.65 +3.79 (+15.25%) At close · Sep 4

Russell 2000 member Rebalance outlook locked

Market Cap

$1.48B

59.68M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP →

Quarter:

Holders: 171

Total Value: $2,230,119,227

Total Shares: 69,822,162

Showing 1–100 of 174 holdings by value · page 1 of 2

Institutional Ownership Trend

20 quarters

Holder Concentration

Across 171 13F filers · Δ vs Mar 31, 2026

Top Holder

17.5%

−0.9 pts

Top 5

47.0%

−0.8 pts

Top 10

65.8%

−2.5 pts

HHI

672

Broadly held−31

Quarterly Activity

vs Mar 31, 2026

New

Increased

Decreased

Sold Out

Unchanged

Holder count: +7

Institutional value: -12.2%

Shares held: +5.1%

Top Buyers

vs Mar 31, 2026

Institution	Added	Now Holds
Mega PRICE T ROWE ASSOCIATES INC /MD/	+1,796,506	2,782,567
Mega FMR LLC	+1,172,865	8,920,513
Mega STATE STREET CORP	+924,290	2,140,368
Mega BlackRock, Inc.	+814,043	3,031,972
Mid DEERFIELD MANAGEMENT COMPANY, L.P.	+468,000	1,017,000

Top Sellers

vs Mar 31, 2026

Institution	Sold	Now Holds
Mega BARCLAYS PLC	−699,424	133,975
Mid Commodore Capital LP	−600,000	1,875,000
Mid Nextech Invest, Ltd.	−502,276	3,553,585
Mid BVF INC/IL	−500,000	1,476,196
Mid Caligan Partners LP	−469,982	806,986

Top New Positions

vs Mar 31, 2026

Institution	Acquired	Value (USD)
Mega Jupiter Topco LLC	4,352,448	$139,017,188
Large Hood River Capital Management LLC	1,016,775	$32,475,793
Mid Siren, L.L.C.	725,000	$23,156,500
Small Defilade Capital Management, L.P.	376,870	$12,037,227
Mega Qube Research & Technologies Ltd	266,934	$8,525,871

Top Sold-Out Positions

vs Mar 31, 2026

Institution	Previously Held	Last Value (USD)
Mega JANUS HENDERSON GROUP PLC	3,890,589	$149,009,558
Large FARALLON CAPITAL MANAGEMENT LLC	3,580,818	$137,145,329
Mid Logos Global Management LP	850,000	$32,555,000
Large Balyasny Asset Management L.P.	351,479	$13,461,645
Large Point72 Asset Management, L.P.	218,950	$8,385,785

Filter: New 33 Increased 74 Reduced 45 Sold out 26 Unchanged 19

Showing 100 of 174

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

RA CAPITAL MANAGEMENT, L.P.

$389,624,082

17.47%

12,198,625

FMR LLC

$284,921,183

12.78%

8,920,513

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	8,123,527	$259,465,452	91.1%	Defined
FIDELITY MANAGEMENT TRUST CO	556,600	$17,777,804	6.2%	Defined
STRATEGIC ADVISERS LLC	19	$606	0.0%	Defined
Fidelity Institutional Asset Management Trust Co	79,979	$2,554,529	0.9%	Defined
FIAM LLC	160,388	$5,122,792	1.8%	Defined

Jupiter Topco LLC

$139,017,188

6.23%

4,352,448

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JANUS HENDERSON INVESTORS UK Ltd	74,677	$2,385,183	1.7%	Defined
JANUS HENDERSON INVESTORS US LLC	4,271,891	$136,444,198	98.1%	Defined
Held directly	5,880	$187,807	0.1%	Defined

Alta Partners Management Company, L.P.

$122,120,194

5.48%

3,823,425

Nextech Invest, Ltd.

$113,501,504

5.09%

3,553,585

TCG Crossover Management, LLC

$103,772,421

4.65%

3,248,980

BlackRock, Inc.

$96,841,181

4.34%

3,031,972

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	26,338	$841,235	0.9%	Sole
BlackRock Asset Management Canada Ltd	244	$7,793	0.0%	Sole
BlackRock Investment Management, LLC	100,590	$3,212,844	3.3%	Sole
BLACKROCK ADVISORS LLC	82,044	$2,620,485	2.7%	Sole
BlackRock Fund Advisors	1,681,538	$53,708,323	55.5%	Sole
BlackRock Institutional Trust Company, N.A.	1,015,589	$32,437,912	33.5%	Sole
BlackRock Fund Managers Ltd.	5,715	$182,537	0.2%	Sole
BlackRock Asset Management Ireland Ltd	65,739	$2,099,703	2.2%	Sole
BlackRock Asset Management Schweiz AG	2,965	$94,702	0.1%	Sole
Aperio Group, LLC	51,029	$1,629,866	1.7%	Sole
SpiderRock Advisors, LLC	181	$5,781	0.0%	Sole

PRICE T ROWE ASSOCIATES INC /MD/

$88,875,189

3.99%

2,782,567

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	51,187	$1,634,912	1.8%	Defined
Held directly	2,731,380	$87,240,277	98.2%	Sole

STATE STREET CORP

$68,363,353

3.07%

2,140,368

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	2,140,368	$68,363,353	100.0%	Defined

Commodore Capital LP

$59,887,500

2.69%

1,875,000

Paradigm Biocapital Advisors LP

$58,405,707

2.62%

1,828,607

VANGUARD CAPITAL MANAGEMENT LLC

$48,179,797

2.16%

1,508,447

BVF INC/IL

$47,149,700

2.11%

1,476,196

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BVF PARTNERS L P/IL	1,476,196	$47,149,700	100.0%	Defined

5AM Venture Management, LLC

$32,875,778

1.47%

1,029,298

DEERFIELD MANAGEMENT COMPANY, L.P.

$32,482,980

1.46%

1,017,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Deerfield UGP, LLC	1,017,000	$32,482,980	100.0%	Defined

Hood River Capital Management LLC

$32,475,793

1.46%

1,016,775

GEODE CAPITAL MANAGEMENT, LLC

$31,005,243

1.39%

970,734

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	120,626	$3,852,794	12.4%	Defined
Held directly	850,108	$27,152,449	87.6%	Defined

Caligan Partners LP

$25,775,132

1.16%

806,986

Canaan Partners XI LLC

$23,955,000

1.07%

750,000

Siren, L.L.C.

$23,156,500

1.04%

725,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invus Group, LLC	725,000	$23,156,500	100.0%	Defined

Sio Capital Management, LLC

$22,208,361

1.00%

695,315

STEMPOINT CAPITAL LP

$20,210,162

0.91%

632,754

MARSHALL WACE, LLP

$18,625,268

0.84%

583,133

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	583,133	$18,625,268	100.0%	Other

GOLDMAN SACHS GROUP INC

$14,803,455

0.66%

463,477

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	419,380	$13,394,997	90.5%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	44,097	$1,408,458	9.5%	Defined

JENNISON ASSOCIATES LLC

$14,403,790

0.65%

450,964

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Prudential Financial Inc	450,964	$14,403,790	100.0%	Defined

TWO SIGMA INVESTMENTS, LP

$14,366,867

0.64%

449,808

VANGUARD PORTFOLIO MANAGEMENT LLC

$12,872,426

0.58%

403,019

Defilade Capital Management, L.P.

$12,037,227

0.54%

376,870

BANK OF AMERICA CORP /DE/

$11,170,439

0.50%

349,732

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	280,386	$8,955,528	80.2%	Defined
MERRILL LYNCH, PIERCE, FENNER & SMITH INC.	28,383	$906,553	8.1%	Defined
BOFA SECURITIES, INC.	40,963	$1,308,358	11.7%	Defined

Walleye Capital LLC

$11,111,862

0.50%

347,898

Woodline Partners LP

$10,222,077

0.46%

320,040

NORTHERN TRUST CORP

$9,904,079

0.44%

310,084

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	290,221	$9,269,657	93.6%	Defined
NORTHERN TRUST GLOBAL INVESTMENTS LTD	14,246	$455,016	4.6%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	5,617	$179,406	1.8%	Other

MORGAN STANLEY

$9,592,284

0.43%

300,322

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	149	$4,759	0.0%	Defined
MORGAN STANLEY & CO. LLC	177,660	$5,674,460	59.2%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	109,998	$3,513,336	36.6%	Defined
MORGAN STANLEY SMITH BARNEY LLC	1,150	$36,731	0.4%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	11,365	$362,998	3.8%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$9,086,930

0.41%

284,500

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	284,500	$9,086,930	100.0%	Other

CITADEL ADVISORS LLC

$8,889,124

0.40%

278,307

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	103,572	$3,308,089	37.2%	Defined
Held directly	174,735	$5,581,035	62.8%	Defined

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$8,550,306

0.38%

267,699

Qube Research & Technologies Ltd

$8,525,871

0.38%

266,934

BNP PARIBAS ARBITRAGE, SA

$7,672,850

0.34%

240,227

ALGERT GLOBAL LLC

$7,637,492

0.34%

239,120

VANGUARD FIDUCIARY TRUST CO

$7,180,271

0.32%

224,805

DIMENSIONAL FUND ADVISORS LP

$6,933,469

0.31%

217,078

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Dimensional Fund Advisors Ltd.	817	$26,094	0.4%	Defined
Dimensional Ireland Ltd	6,753	$215,690	3.1%	Defined
Held directly	209,508	$6,691,685	96.5%	Sole

Affinity Asset Advisors, LLC

$6,388,383

0.29%

200,012

FRANKLIN RESOURCES INC

$6,143,339

0.28%

192,340

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FRANKLIN ADVISERS INC	192,340	$6,143,339	100.0%	Defined

HighVista Strategies LLC

$5,901,681

0.26%

184,774

RAYMOND JAMES FINANCIAL INC

$5,777,338

0.26%

180,881

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RAYMOND JAMES & ASSOCIATES	68,162	$2,177,094	37.7%	Defined
Raymond James Financial Services Advisors, Inc.	112,719	$3,600,244	62.3%	Defined

JPMORGAN CHASE & CO

$5,693,719

0.26%

178,263

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JPMorgan Chase Bank, N.A.	27,070	$864,615	15.2%	Defined
J.P. Morgan Investment Management Inc.	147,366	$4,706,870	82.7%	Defined
J.P. Morgan Securities plc	3,827	$122,234	2.1%	Defined

MILLENNIUM MANAGEMENT LLC

$5,674,843

0.25%

177,672

BOOTHBAY FUND MANAGEMENT, LLC

$5,543,474

0.25%

173,559

ADAGE CAPITAL PARTNERS GP, L.L.C.

$5,174,280

0.23%

162,000

Jump Financial, LLC

$5,014,580

0.22%

157,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Leap GP LLC joint	157,000	$5,014,580	100.0%	Defined

VICTORY CAPITAL MANAGEMENT INC

$4,873,564

0.22%

152,585

Ensign Peak Advisors, Inc

$4,680,391

0.21%

146,537

Trexquant Investment LP

$4,239,715

0.19%

132,740

UBS Group AG

$4,150,443

0.19%

129,945

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	6,499	$207,578	5.0%	Defined
UBS AG	122,466	$3,911,564	94.2%	Defined
UBS Securities LLC	980	$31,301	0.8%	Defined

BNP PARIBAS ASSET MANAGEMENT Holding S.A.

$3,942,034

0.18%

123,420

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BNP PARIBAS ASSET MANAGEMENT Europe	330	$10,540	0.3%	Defined
AXA INVESTMENT MANAGERS UK LIMITED	123,090	$3,931,494	99.7%	Defined

LORD, ABBETT & CO. LLC

$3,891,346

0.17%

121,833

BARCLAYS PLC

$3,631,578

0.16%

113,700

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS CAPITAL INC.	113,700	$3,631,578	100.0%	Defined

Bank of New York Mellon Corp

$3,312,815

0.15%

103,720

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Investments Corporation	38,341	$1,224,611	37.0%	Defined
The Bank of New York Mellon	65,378	$2,088,173	63.0%	Defined
Held directly	1	$31	0.0%	Defined

Russell Investments Group, Ltd.

$3,280,328

0.15%

102,703

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC joint	50,114	$1,600,639	48.8%	Defined
Russell Investments Capital, LLC joint	32,324	$1,032,427	31.5%	Other
Russell Investments France SAS	5,760	$183,974	5.6%	Defined
Russell Investments Trust Company joint	14,505	$463,288	14.1%	Defined

ORBIMED ADVISORS LLC

$3,257,880

0.15%

102,000

JACOBS LEVY EQUITY MANAGEMENT, INC

$2,849,207

0.13%

89,205

OPPENHEIMER & CO INC

$2,676,029

0.12%

83,783

XTX Topco Ltd

$2,597,360

0.12%

81,320

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
XTX EXECUTION SERVICES LLC joint	81,320	$2,597,360	100.0%	Defined

Nuveen, LLC

$2,517,798

0.11%

78,829

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	3,231	$103,198	4.1%	Defined
TEACHERS ADVISORS, LLC joint	75,598	$2,414,600	95.9%	Defined

Kalehua Capital Management LLC

$2,378,412

0.11%

74,465

SEI INVESTMENTS CO

$2,127,427

0.10%

66,607

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SEI TRUST CO	66,607	$2,127,427	100.0%	Sole

Squarepoint Ops LLC

$2,037,931

0.09%

63,805

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Squarepoint Capital LLP	63,805	$2,037,931	100.0%	Defined

CITIGROUP INC

$1,989,190

0.09%

62,279

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	62,279	$1,989,190	100.0%	Defined

Fisher Asset Management, LLC

$1,923,746

0.09%

60,230

ALPS ADVISORS INC

$1,921,478

0.09%

60,159

WELLINGTON MANAGEMENT GROUP LLP

$1,903,655

0.09%

59,601

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	18,612	$594,467	31.2%	Defined
Wellington Trust Company, NA joint	37,529	$1,198,676	63.0%	Defined
Wellington Management Australia Pty Ltd	3,460	$110,512	5.8%	Defined

RHUMBLINE ADVISERS

$1,662,125

0.07%

52,039

TD Asset Management Inc

$1,597,000

0.07%

50,000

Arkadios Wealth Advisors

$1,575,791

0.07%

49,336

ALLIANCEBERNSTEIN L.P.

$1,546,534

0.07%

48,420

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	48,420	$1,546,534	100.0%	Defined

STATE OF WISCONSIN INVESTMENT BOARD

$1,491,502

0.07%

46,697

JANE STREET GROUP, LLC

$1,437,300

0.06%

45,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	45,000	$1,437,300	100.0%	Defined

Susquehanna Portfolio Strategies, LLC

$1,433,403

0.06%

44,878

Swiss National Bank

$1,427,718

0.06%

44,700

MANUFACTURERS LIFE INSURANCE COMPANY, THE

$1,415,804

0.06%

44,327

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MANULIFE FINANCIAL CORP joint	44,327	$1,415,804	100.0%	Defined

ExodusPoint Capital Management, LP

$1,310,370

0.06%

41,026

Rafferty Asset Management, LLC

$1,236,141

0.06%

38,702

DEUTSCHE BANK AG\

$1,179,703

0.05%

36,935

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS INVESTMENT MANAGEMENT AMERICAS, INC	697	$22,262	1.9%	Defined
DWS Investments UK Ltd	36,238	$1,157,441	98.1%	Defined

Verdad Advisers, LP

$1,149,935

0.05%

36,003

WELLS FARGO & COMPANY/MN

$1,071,938

0.05%

33,561

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	33,561	$1,071,938	100.0%	Defined

Sofinnova Investments, Inc.

$1,030,607

0.05%

32,267

Engineers Gate Manager LP

$1,020,738

0.05%

31,958

AQR CAPITAL MANAGEMENT LLC

$953,502

0.04%

29,853

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RF&L WEALTH MANAGEMENT, LLC	15	$479	0.1%	Other
Compound Planning, Inc.	5	$159	0.0%	Other
Arax Advisory Partners	65	$2,076	0.2%	Other
HALBERT HARGROVE GLOBAL ADVISORS, LLC	501	$16,001	1.7%	Other
Stokes Family Office, LLC	118	$3,768	0.4%	Other
Held directly	29,149	$931,019	97.6%	Defined

Tidal Investments LLC

$942,836

0.04%

29,519

Tema ETFs LLC

$942,836

0.04%

29,519

SG Americas Securities, LLC

$940,441

0.04%

29,444

PDT Partners, LLC

$820,346

0.04%

25,684

MILLENNIUM MANAGEMENT LLC

$798,500

0.04%

25,000

Invesco Ltd.

$795,080

0.04%

24,893

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	5,551	$177,298	22.3%	Defined
Invesco Trust Co joint	14,524	$463,896	58.3%	Defined
Invesco Capital Management LLC	4,818	$153,886	19.4%	Defined

CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM

$783,935

0.04%

24,544

STRS OHIO

$705,874

0.03%

22,100

Creative Planning

$696,387

0.03%

21,803

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CREATIVE PLANNING TRUST Co LLC	277	$8,847	1.3%	Defined
Held directly	21,526	$687,540	98.7%	Sole

MetLife Investment Management, LLC

$693,832

0.03%

21,723

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
METLIFE INC	21,723	$693,832	100.0%	Defined

MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.

$682,365

0.03%

21,364

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Global X Management CO LLC joint	16,868	$538,763	79.0%	Defined
Global X Management (AUS) Ltd joint	4,496	$143,602	21.0%	Defined

LMR Partners LLP

$675,562

0.03%

21,151

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wabon Partners, L.P.	21,151	$675,562	100.0%	Sole

Key facts CIK 1863127 CUSIP 90240B106 13F (30d) 140 filings 140 filers Visit website Investor relations