FRAZIER MANAGEMENT LLC

CIK

1032165

Location

SEATTLE, WA

Portfolio Value

Small $849,294,212

Diversification

Diversified

Filing Date

Global Rank

#1,534 / 6,777 ▼ 52 · as of Dec 2021

Top Industry

Biotechnology 100.0%

3Y Alpha vs SPY

+7.8%

Period ended 4 years ago

Filed Feb 8, 2022 · 4y

8 quarters · since Mar 2020

Clone Performance

Jul 2023–Jul 2026 · vs SPY

Hypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.

Cloned portfolio

+124.4%

SPY

+76.5%

Annualised alpha

+10.1%

Max drawdown

−39.0%

Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.

Portfolio Concentration

23 positions · as of Dec 31, 2021 · Δ vs Sep 30, 2021

Top Position

20.6%

−3.2 pts

Top 5

54.4%

−14.6 pts

Top 10

77.1%

−8.6 pts

HHI

901

Diversified−416

Portfolio Trend

8 quarters · across all stocks

Sector Breakdown

As of Dec 31, 2021

Sector	% Portfolio	Value	Positions
Healthcare	100.0%	$849,294,212	23

Last Quarter's Activity

Export CSV

Dec 31, 2021 vs Sep 30, 2021

Added To

Positions the filer increased

6 positions

Ticker	Company	Δ Shares	Shares	Value
SNDX	Syndax Pharmaceuticals Inc	+1,583,927	2,772,062	$60,680,437
KALV	KalVista Pharmaceuticals, Inc.	+1,148,280	1,305,087	$17,266,301
CRNX	Crinetics Pharmaceuticals, Inc.	+532,987	1,384,293	$39,327,764
AUTL	Autolus Therapeutics plc	+216,200	3,746,857	$19,446,187
REPL	Replimune Group, Inc.	+158,864	650,862	$17,638,360
BCYC	Bicycle Therapeutics PLC	+112,360	555,240	$33,797,458
No positions match the current search.

Trimmed

Positions the filer reduced

1 positions

Ticker	Company	Δ Shares	Shares	Value	Open
IOVA	Iovance Biotherapeutics, Inc.	−926,677	1,747,622	$33,362,103
No positions match the current search.

New Positions

Positions the filer opened this quarter

3 positions

Ticker	Company	Shares	Value
SLN	Silence Therapeutics plc	886,173	$21,170,672
COGT	Cogent Biosciences, Inc.	1,774,891	$15,228,564
ARVN	Arvinas, Inc.	163,763	$13,451,492
No positions match the current search.

Sold Out

Positions the filer fully exited

1 positions

Ticker	Company	Shares	Value	Open
GRTX	Galera Therapeutics, Inc.	241,000	$1,952,100
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

23 positions · $849,294,212 total · as of Dec 31, 2021

All sectors Healthcare

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
ARQT	Arcutis Biotherapeutics, Inc. Healthcare	Held	8,434,232	0	$174,925,971	−13.2%	20.60%
PHAT	Phathom Pharmaceuticals, Inc. Healthcare	Held	5,827,415	0	$114,625,253	−38.7%	13.50%
SNDX	Syndax Pharmaceuticals Inc Healthcare	Added	2,772,062	+1,583,927	$60,680,437	+167.3%	7.14%
MIRM	Mirum Pharmaceuticals, Inc. Healthcare	Held	3,566,912	0	$56,892,246	−19.9%	6.70%
PCVX	Vaxcyte, Inc. Healthcare	Held	2,309,554	0	$54,944,289	−6.2%	6.47%
KRYS	Krystal Biotech, Inc. Healthcare	Held	771,250	0	$53,948,937	+34.0%	6.35%
CRNX	Crinetics Pharmaceuticals, Inc. Healthcare	Added	1,384,293	+532,987	$39,327,764	+119.5%	4.63%
BCYC	Bicycle Therapeutics PLC Healthcare	Added	555,240	+112,360	$33,797,458	+83.5%	3.98%
IOVA	Iovance Biotherapeutics, Inc. Healthcare	Reduced	1,747,622	-926,677	$33,362,103	−49.4%	3.93%
TARS	Tarsus Pharmaceuticals, Inc. Healthcare	Held	1,417,157	0	$31,886,032	+4.4%	3.75%
VRDN	Viridian Therapeutics, Inc.\DE Healthcare	Held	1,505,200	0	$29,757,804	+20.2%	3.50%
SLN	Silence Therapeutics plc Healthcare	NEW	886,173	NEW	$21,170,672	NEW	2.49%
ANAB	Anaptysbio, Inc Healthcare	Held	899,700	0	$20,843,079	+28.1%	2.45%
AUTL	Autolus Therapeutics plc Healthcare	Added	3,746,857	+216,200	$19,446,187	−15.9%	2.29%
REPL	Replimune Group, Inc. Healthcare	Added	650,862	+158,864	$17,638,360	+21.0%	2.08%
TYRA	Tyra Biosciences, Inc. Healthcare	Held	1,250,000	0	$17,587,500	−20.0%	2.07%
KALV	KalVista Pharmaceuticals, Inc. Healthcare	Added	1,305,087	+1,148,280	$17,266,301	+531.0%	2.03%
COGT	Cogent Biosciences, Inc. Healthcare	NEW	1,774,891	NEW	$15,228,564	NEW	1.79%
ARVN	Arvinas, Inc. Healthcare	NEW	163,763	NEW	$13,451,492	NEW	1.58%
RGNX	REGENXBIO Inc. Healthcare	Held	235,809	0	$7,710,954	−22.0%	0.91%
ACRS	Aclaris Therapeutics, Inc. Healthcare	Held	408,329	0	$5,937,103	−19.2%	0.70%
IMVT	Immunovant, Inc. Healthcare	Held	585,759	0	$4,990,666	−2.0%	0.59%
SRRK	Scholar Rock Holding Corp Healthcare	Held	156,000	0	$3,875,040	−24.8%	0.46%