ALKS · Alkermes plc.

This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 11/19/2025.

This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 3/14/2025.

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $46.8269 to $47.3197. Full information regarding the number of shares sold at each separate price can be provided to the issuer, any security holder of the issuer or the SEC staff upon request.

This option exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 3/14/2025.

This option exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 3/14/2025.

These options are fully vested in accordance with their terms.

This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 5/15/2026.

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $49.61 to $49.79. Full information regarding the number of shares sold at each separate price can be provided to the issuer, any security holder of the issuer or the SEC staff upon request.

This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 5/15/2026.

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $48.6092 to $49.49. Full information regarding the number of shares sold at each separate price can be provided to the issuer, any security holder of the issuer or the SEC staff upon request.

This award was granted in connection with the reporting person's appointment as President and Chief Executive Officer.

Shares underlying the stock option shall vest and become exercisable, if at all, in two tranches based upon the closing price of an ordinary share of Alkermes plc, as reported by the Nasdaq Global Select Market or another national securities exchange on which Alkermes plc's ordinary shares are listed, trading at certain pre-specified levels for 30 consecutive trading days, subject in each case to the reporting person's completion of two years of continuous service (or less, in the event of a change in control) in the role of President and Chief Executive Officer. This award expires ten years from the date of grant.

This award was granted in connection with the reporting person's appointment as President and Chief Executive Officer.

Shares underlying the stock option vest and become exercisable in four equal annual installments, commencing on 8/5/2027.

This option exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 3/14/2025.

These options are fully vested in accordance with their terms.

This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 3/14/2025.

These options are fully vested in accordance with their terms.

This option exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 3/14/2025.

These options are fully vested in accordance with their terms.

This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 11/19/2025.

This option exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 3/14/2025.

This option exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 3/14/2025.

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $50.07 to $50.70. Full information regarding the number of shares sold at each separate price can be provided to the issuer, any security holder of the issuer or the SEC staff upon request.

These options are fully vested in accordance with their terms.

This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 11/19/2025.

This option exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 3/14/2025.

These options are fully vested in accordance with their terms.

This option exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 3/14/2025.

This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 3/14/2025.

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $52.10 to $52.17. Full information regarding the number of shares sold at each separate price can be provided to the issuer, any security holder of the issuer or the SEC staff upon request.

This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 3/14/2025.

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $51.06 to $52.04. Full information regarding the number of shares sold at each separate price can be provided to the issuer, any security holder of the issuer or the SEC staff upon request.

This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 3/11/2026.

This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 11/19/2025.

This option exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 3/14/2025.

These options are fully vested in accordance with their terms.

This option exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 3/14/2025.

This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 3/14/2025.

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $41.37 to $42.19. Full information regarding the number of shares sold at each separate price can be provided to the issuer, any security holder of the issuer or the SEC staff upon request.

These options are fully vested in accordance with their terms.

These options are fully vested in accordance with their terms.

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $42.245 to $42.50. Full information regarding the number of shares sold at each separate price can be provided to the issuer, any security holder of the issuer or the SEC staff upon request.

Each restricted stock unit represents a contingent right to receive one ordinary share.

Each restricted stock unit represents a contingent right to receive one ordinary share.

This award is fully vested in accordance with its terms.

Each restricted stock unit represents a contingent right to receive one ordinary share.

This award is fully vested in accordance with its terms.

Each restricted stock unit represents a contingent right to receive one ordinary share.

This award is fully vested in accordance with its terms.

Each restricted stock unit represents a contingent right to receive one ordinary share.

Each restricted stock unit represents a contingent right to receive one ordinary share.

Each restricted stock unit represents a contingent right to receive one ordinary share.

This award is fully vested in accordance with its terms.

Each restricted stock unit represents a contingent right to receive one ordinary share.

Each restricted stock unit represents a contingent right to receive one ordinary share.

This award is fully vested in accordance with its terms.

Each restricted stock unit represents a contingent right to receive one ordinary share.