ALKS

This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 11/19/2025.

This option exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 3/14/2025.

These options are fully vested in accordance with their terms.

This option exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 3/14/2025.

This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 3/14/2025.

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $52.10 to $52.17. Full information regarding the number of shares sold at each separate price can be provided to the issuer, any security holder of the issuer or the SEC staff upon request.

This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 3/14/2025.

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $51.06 to $52.04. Full information regarding the number of shares sold at each separate price can be provided to the issuer, any security holder of the issuer or the SEC staff upon request.

This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 3/11/2026.

This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 11/19/2025.

This option exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 3/14/2025.

These options are fully vested in accordance with their terms.

This option exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 3/14/2025.

This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 3/14/2025.

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $41.37 to $42.19. Full information regarding the number of shares sold at each separate price can be provided to the issuer, any security holder of the issuer or the SEC staff upon request.

These options are fully vested in accordance with their terms.

These options are fully vested in accordance with their terms.

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $42.245 to $42.50. Full information regarding the number of shares sold at each separate price can be provided to the issuer, any security holder of the issuer or the SEC staff upon request.

Each restricted stock unit represents a contingent right to receive one ordinary share.

Each restricted stock unit represents a contingent right to receive one ordinary share.

This award is fully vested in accordance with its terms.

Each restricted stock unit represents a contingent right to receive one ordinary share.

This award is fully vested in accordance with its terms.

Each restricted stock unit represents a contingent right to receive one ordinary share.

This award is fully vested in accordance with its terms.

Each restricted stock unit represents a contingent right to receive one ordinary share.

Each restricted stock unit represents a contingent right to receive one ordinary share.

Each restricted stock unit represents a contingent right to receive one ordinary share.

This award is fully vested in accordance with its terms.

Each restricted stock unit represents a contingent right to receive one ordinary share.

Each restricted stock unit represents a contingent right to receive one ordinary share.

This award is fully vested in accordance with its terms.

Each restricted stock unit represents a contingent right to receive one ordinary share.

Each restricted stock unit represents a contingent right to receive one ordinary share.

Each restricted stock unit represents a contingent right to receive one ordinary share.

This award is fully vested in accordance with its terms.

Shares subject to the award vest (and if applicable, become exercisable) in full on the earlier of the one-year anniversary of the date of grant or the date of the issuer's next annual general meeting of shareholders that occurs at least 50 weeks after the date of grant.

Shares subject to the award vest (and if applicable, become exercisable) in full on the earlier of the one-year anniversary of the date of grant or the date of the issuer's next annual general meeting of shareholders that occurs at least 50 weeks after the date of grant.

This amendment is being filed to reflect the vesting terms applicable to this award, which were reported incorrectly on the original Form 4. The correct vesting schedule is set forth in Footnote 1 above.

Shares subject to the award vest (and if applicable, become exercisable) in full on the earlier of the one-year anniversary of the date of grant or the date of the issuer's next annual general meeting of shareholders that occurs at least 50 weeks after the date of grant.

This amendment is being filed to reflect the vesting terms applicable to this award, which were reported incorrectly on the original Form 4. The correct vesting schedule is set forth in Footnote 1 above.

Each restricted stock unit represents a contingent right to receive one ordinary share.

Shares subject to the award vest (and if applicable, become exercisable) in full on the earlier of the one-year anniversary of the date of grant or the date of the issuer's next annual general meeting of shareholders that occurs at least 50 weeks after the date of grant.

Shares subject to the award vest (and if applicable, become exercisable) in full on the earlier of the one-year anniversary of the date of grant or the date of the issuer's next annual general meeting of shareholders that occurs at least 50 weeks after the date of grant.

Each restricted stock unit represents a contingent right to receive one ordinary share.

Shares subject to the award vest (and if applicable, become exercisable) in full on the earlier of the one-year anniversary of the date of grant or the date of the issuer's next annual general meeting of shareholders that occurs at least 50 weeks after the date of grant.

Shares subject to the award vest (and if applicable, become exercisable) in full on the earlier of the one-year anniversary of the date of grant or the date of the issuer's next annual general meeting of shareholders that occurs at least 50 weeks after the date of grant.

Each restricted stock unit represents a contingent right to receive one ordinary share.

Shares subject to the award vest (and if applicable, become exercisable) in full on the earlier of the one-year anniversary of the date of grant or the date of the issuer's next annual general meeting of shareholders that occurs at least 50 weeks after the date of grant.

Shares subject to the award vest (and if applicable, become exercisable) in full on the earlier of the one-year anniversary of the date of grant or the date of the issuer's next annual general meeting of shareholders that occurs at least 50 weeks after the date of grant.

Shares subject to the award vest (and if applicable, become exercisable) in full on the earlier of the one-year anniversary of the date of grant or the date of the issuer's next annual general meeting of shareholders that occurs at least 50 weeks after the date of grant.

Each restricted stock unit represents a contingent right to receive one ordinary share.

Shares subject to the award vest (and if applicable, become exercisable) in full on the earlier of the one-year anniversary of the date of grant or the date of the issuer's next annual general meeting of shareholders that occurs at least 50 weeks after the date of grant.

Each restricted stock unit represents a contingent right to receive one ordinary share.

Shares subject to the award vest (and if applicable, become exercisable) in full on the earlier of the one-year anniversary of the date of grant or the date of the issuer's next annual general meeting of shareholders that occurs at least 50 weeks after the date of grant.

Shares subject to the award vest (and if applicable, become exercisable) in full on the earlier of the one-year anniversary of the date of grant or the date of the issuer's next annual general meeting of shareholders that occurs at least 50 weeks after the date of grant.

Each restricted stock unit represents a contingent right to receive one ordinary share.

Shares subject to the award vest (and if applicable, become exercisable) in full on the earlier of the one-year anniversary of the date of grant or the date of the issuer's next annual general meeting of shareholders that occurs at least 50 weeks after the date of grant.

This amendment is being filed to reflect the vesting terms applicable to this award, which were reported incorrectly on the original Form 4. The correct vesting schedule is set forth in Footnote 1 above.

Each restricted stock unit represents a contingent right to receive one ordinary share.

Shares subject to the award vest (and if applicable, become exercisable) in full on the earlier of the one-year anniversary of the date of grant or the date of the issuer's next annual general meeting of shareholders that occurs at least 50 weeks after the date of grant.

This amendment is being filed to reflect the vesting terms applicable to this award, which were reported incorrectly on the original Form 4. The correct vesting schedule is set forth in Footnote 1 above.

Each restricted stock unit represents a contingent right to receive one ordinary share.

Shares subject to the award vest (and if applicable, become exercisable) in full on the earlier of the one-year anniversary of the date of grant or the date of the issuer's next annual general meeting of shareholders that occurs at least 50 weeks after the date of grant.

This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 11/19/2025.