TWO SIGMA INVESTMENTS, LP

CIK

1179392

City

NEW YORK

State / Country

NY

Stock

AXSM — Axsome Therapeutics, Inc.

Top Portfolio Positions

3,298 positions · $111,953,798,342 total · as of Mar 31, 2026

Ticker	Company	Shares	Value (USD)	% of Portfolio	Open
NVDA	Nvidia Corp Technology	12,053,545	$2,102,138,248	1.88%
AAPL	Apple Inc. Technology	6,085,143	$1,544,348,441	1.38%
GOOGL	Alphabet Inc. Communication Services	4,810,528	$1,383,315,431	1.24%
AMZN	Amazon Com Inc Consumer Cyclical	6,454,567	$1,344,292,669	1.20%
TSLA	Tesla, Inc. Consumer Cyclical	3,116,099	$1,158,409,803	1.03%
JPM	Jpmorgan Chase & Co Financial Services	3,523,588	$1,036,498,646	0.93%
PLTR	Palantir Technologies Inc. Technology	6,809,802	$996,137,836	0.89%
COST	Costco Wholesale Corp /New Consumer Defensive	891,093	$887,911,797	0.79%
TJX	Tjx Companies Inc /De/ Consumer Cyclical	5,277,968	$842,891,489	0.75%
MA	Mastercard Inc Financial Services	1,682,998	$840,926,780	0.75%

Portfolio Trend

25 quarters · across all stocks

Holdings in AXSM

Compact Export CSV

Shares Held

Position Value (USD)

11 quarters on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-03-31	$54,555,937	322,778	+8623.7%	Shares	Sole	2026-05-15
2026-03-31	$625,374	3,700	-97.5%	Put	Sole	2026-05-15
2025-12-31	$26,591,836	145,597	+1674.1%	Shares	Sole	2026-02-17
2025-09-30	$996,740	8,207	-82.5%	Shares	Sole	2025-11-14
2025-03-31	$5,482,193	47,005	-66.7%	Shares	Sole	2025-05-15
2022-09-30	$6,305,341	141,312	+167.3%	Shares	Sole	2022-11-14
2022-03-31	$2,188,454	52,874	-42.9%	Shares	Sole	2022-05-16
2021-12-31	$3,497,294	92,570	+336.7%	Shares	Sole	2022-02-14
2021-09-30	$698,752	21,200	-86.9%	Shares	Sole	2021-11-15
2021-03-31	$9,161,172	161,801	+917.6%	Shares	Sole	2021-05-17
2020-12-31	$1,295,373	15,900	—	Shares	Sole	2021-02-16
No 13F history on record for this holder in this stock.