GYRE · Gyre Therapeutics, Inc. · Holdings

$7.09 +0.56 (+8.58%) At close · Oct 28

Russell 2000 member Rebalance outlook locked

Market Cap

$728.16M

111.51M

Volume · Oct 28 125.15K Avg daily vol (3M) 120.21K

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP → See every holder of GYRE: 13F, 13D and 13G, insiders and funds →

The Sep 30, 2026 filing window is still open — showing the latest known positions. Funds that have not filed yet carry their prior-quarter positions; a fund that filed without this stock counts as sold out. Each fund's Change is measured against its own previous reported quarter, shown in the Reported column. Pick a completed quarter in the Quarter selector below to put every fund on one quarter and see the stock-wide activity breakdown.

Quarter:

Holders: 57

Total Value: $57,219,669

Total Shares: 8,663,588

Institutional Ownership Trend

12 quarters

Holder Concentration

Across 60 13F filers

Top Holder

43.3%

of institutional value

Top 5

82.0%

of institutional value

Top 10

92.6%

of institutional value

HHI

2,294

Moderately concentrated

Who Holds GYRE

Last 8 quarters through Sep 30, 2026 (filing window open)

Each kind of 13F filer's share of the common shares 13F filers report. Holder type comes from regulatory records, never the filer's name; style, turnover and horizon are measured from each filer's own 13F book. The quarter selector does not change this card.

Jun 30, 2026, the newest closed quarter: 59 filers, like-for-like change +154.3%; actively managed books +807.8%; index-like books +14.6%.

Holder type	Share	Filers	Change	New	Exited
Registered adviser	32.1%	24	+61.7%	8	2
Bank	6.4%	10	+26.0%	0	1
Benefit plan	0.3%	2	+19.4%	0	0
Non-US	2.2%	3	+2.3%	0	0
Holding company	13.1%	5	+32.3%	0	0
Exempt adviser	0.0%	0	-100.0%	0	1
Adviser	0.0%	0	—	0	0
Insurer	0.0%	0	—	0	0
Broker-dealer	0.0%	0	—	0	0
Unknown	45.8%	15	+2335.8%	3	3

Style	Share	Filers	Change	New	Exited
Index-like	37.1%	16	+14.6%	1	0
Systematic-like	0.3%	2	new	2	0
Concentrated	54.3%	8	+292895.2%	4	2
Diversified active	8.2%	33	+19.2%	4	5
Not measured	0.0%	0	—	0	0
Unknown	0.0%	0	—	0	0

Turnover	Share	Filers	Change	New	Exited
Low turnover	74.8%	41	+200.3%	7	5
Medium turnover	11.4%	9	+3608.9%	2	0
High turnover	0.4%	5	+61.0%	2	2
Unknown	13.4%	4	-3.3%	0	0
Not measured	0.0%	0	—	0	0

Holding horizon	Share	Filers	Change	New	Exited
Short horizon	13.5%	6	-2.3%	1	0
Medium horizon	24.9%	13	+126.6%	4	2
Long horizon	61.6%	40	+325.5%	6	5
Not measured	0.0%	0	—	0	0
Unknown	0.0%	0	—	0	0

13F book size	Share	Filers	Change	New	Exited
Under $1B	0.1%	8	+1984.1%	3	0
$1B to $10B	56.3%	11	+2437.8%	3	4
$10B to $100B	0.6%	9	+36.7%	2	3
$100B or more	43.0%	31	+17.3%	3	0
Not measured	0.0%	0	—	0	0

Client base	Share	Filers	Change	New	Exited
Individuals and high net worth	0.0%	9	+71.7%	5	1
Pooled investment vehicles	11.3%	3	+9745.6%	2	0
Registered funds and BDCs	20.3%	6	+4.9%	1	0
Insurance companies	0.0%	1	0.0%	0	0
Governments and sovereign funds	0.2%	1	+28.6%	0	0
Other investment advisers	0.0%	2	+72.7%	0	0
Diversified	0.3%	2	+13.1%	0	0
Pension and profit sharing plans	0.0%	0	-100.0%	0	1
Unknown	67.9%	35	+249.0%	3	5

Private funds	Share	Filers	Change	New	Exited
Hedge funds	0.2%	1	+32.9%	1	2
Private equity funds	11.0%	1	new	1	0
Venture capital funds	0.0%	1	new	1	0
Real estate funds	0.0%	2	+3700.0%	1	1
Other private funds	0.7%	3	+48.9%	1	0
Mixed private funds	0.3%	2	+12.6%	0	0
No private funds	20.0%	14	+4.1%	3	0
Private funds, type not stated	0.0%	0	—	0	0
Unknown	67.9%	35	+251.9%	3	4

Location	Share	Filers	Change	New	Exited
United States	54.1%	48	+47.5%	10	6
Outside the US	45.9%	11	+1621.5%	1	1

The Sep 30, 2026 filing window is still open, so its bar carries the Jun 30, 2026 positions of filers that have not filed yet.

How the mix is measured

Shares are 13F common shares restated to today's split basis; options and principal amounts are left out. The change compares only filers with a 13F in both quarters and keeps each filer in its bucket of the later quarter on both sides; a filer that continues under a new CIK is compared through its successor. Holder type comes from each filer's current regulatory profile; client base and private funds come from the Form ADV roster current at each quarter end (rosters from December 2019, so an earlier quarter reads Unknown). Style, turnover, horizon and book size are measured from each filer's 13F book in the newest measured quarter, and Not measured means none was. Actively managed books are those measured systematic-like, concentrated or diversified active.

Excluded 1 holder with no observed 2026-06-30 13F.

Conviction and Crowding

59 13F filers, quarter ended Jun 30, 2026

Measured across every 13F filer's common-share book once the quarter's filing window closed. Crowding counts filers with high turnover or that advise private funds on Form ADV.

Conviction holders

1.69% of filers hold it in their top 10

Mar 31, 2026: 0

Holders above 5%

median weight 0.000%

Mar 31, 2026: 0

Crowding

1.10%

of shares outstanding, 5th percentile

Mar 31, 2026: 0.083%

Private-fund advisers

1.09%

of shares outstanding

Institutional ownership

8.93%

9.53% of the estimated free float

Top 10 holders

92.6%

of 13F shares, Herfindahl 0.229

Active holders

+807.8%

like-for-like share change of active filers

5% stakes on record

3 13D, 0 13G

How long holders have held it value-weighted 3.6 quarters

Under 1 year 68.8% 1 to 3 years 31.2% 3 years or more 0.000% Since coverage start 0.000%

Managers in the top fifth by current three-year FundScore alpha were net buyers of $0 (0 buying, 0 selling).

Estimated Holder Cost Basis

Quarter ended Jun 30, 2026, on that quarter's share basis

Estimated, never filed: each 13F buy is costed at its quarter's average traded price and each sale keeps the average cost, so this is what holders paid on average if they traded evenly through each quarter.

Estimated avg cost

$7.05

estimated per share

Mar 31, 2026: $9.59

Quarter-end price

$6.59

implied by 13F values

Estimated gain or loss

-6.6%

price against the estimated cost

Estimated at a loss

100.0%

of costed 13F value

Estimated cost covers 61.8% of the 13F shares; positions already held when a filer's 13F history starts, or bought in a quarter without a trusted average price, have no estimate.

Shareholder Targets

13F filers that own its peers but not GYRE, quarter ended Jun 30, 2026

GYRE has no holder-overlap peers, so these filers hold the largest Healthcare stocks: LLY, JNJ, ABBV, UNH, MRK, TMO, AMGN, AZN, GILD, ABT, ISRG, VRTX, CVS, DHR, SYK, BMY, PFE, MDT, MCK, ELV. 6,240 filers in all.

#	Filer	In peers	Of book	Largest peers
1	LILLY ENDOWMENT INC Unknown, Unknown	$108,400,867,760 1 held	100.0%	LLY
2	Capital World Investors Adviser, Diversified active	$89,827,396,720 14 held	10.7%	LLY, VRTX, UNH
3	NORGES BANK Non-US, Index-like	$70,478,623,091 20 held	7.02%	LLY, JNJ, ABBV
4	PNC FINANCIAL SERVICES GROUP, INC. Bank, Concentrated	$67,493,367,200 20 held	33.5%	LLY, JNJ, ABBV
5	Capital Research Global Investors Adviser, Diversified active	$66,678,636,531 16 held	9.32%	LLY, VRTX, ABBV
6	WELLINGTON MANAGEMENT GROUP LLP Holding company, Diversified active	$62,277,671,744 20 held	10.8%	LLY, MRK, JNJ
7	Invesco Ltd. Adviser, Diversified active	$47,788,334,225 20 held	3.78%	AMGN, GILD, ISRG
8	FRANKLIN RESOURCES INC Adviser, Diversified active	$38,407,690,244 20 held	8.42%	LLY, ABBV, TMO
9	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC Registered adviser, Index-like	$37,386,289,243 20 held	6.81%	LLY, JNJ, ABBV
10	Capital International Investors Adviser, Diversified active	$36,212,541,834 15 held	7.50%	LLY, AZN, ABBV

Fund Ownership of GYRE by Fund Type

Registered funds' Form N-PORT reports for the quarter ended Jun 30, 2026

Index funds and index ETFs hold 1.96% of shares outstanding.

Fund type	Of shares outstanding	Change	Shares	Funds
Index funds	0.50%	+0.04 pp	559,404	40
Index ETFs	1.46%	+0.06 pp	1,626,246	17
Active ETFs	0.00%	0.00 pp	320	1
Active funds	0.10%	+0.06 pp	116,839	16
Unclassified	0.00%	0.00 pp	1,907	1
All registered funds	2.07%	+0.16 pp	2,304,716	75

How fund types are measured

Each fund series counts once, with its latest Form N-PORT report dated inside the quarter; only long share positions count, restated to today's split basis. The fund type is the series' latest Form N-CEN answer on or before the quarter end (the index-fund box and the exchange-traded flag), never its name. Unclassified funds have no usable N-CEN; unit investment trusts are among them, so index ownership is a floor. Funds sit inside their advisers' 13F reports, so these shares overlap the 13F figures and are never added to them.

Holder type: Registered adviser 23 Bank 10 Benefit plan 2 Non-US 3 Holding company 5 Unknown 14

Showing 57 of 57

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

HSG Holding Ltd

$24,714,470

43.19%

3,750,299

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SNP China Enterprises Ltd	3,750,299	$24,714,470	100.0%	Defined

BlackRock, Inc.

$6,550,081

11.45%

993,943

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	4,363	$28,752	0.4%	Sole
BlackRock Investment Management, LLC	47,198	$311,034	4.7%	Sole
BLACKROCK ADVISORS LLC	46,262	$304,866	4.7%	Sole
BlackRock Fund Advisors	558,305	$3,679,229	56.2%	Sole
BlackRock Institutional Trust Company, N.A.	335,257	$2,209,343	33.7%	Sole
Aperio Group, LLC	2,558	$16,857	0.3%	Sole

Octagon Capital Advisors LP

$6,289,601

10.99%

954,416

VANGUARD CAPITAL MANAGEMENT LLC

$5,778,948

10.10%

876,927

GEODE CAPITAL MANAGEMENT, LLC

$3,512,140

6.14%

532,950

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	76,824	$506,270	14.4%	Defined
Held directly	456,126	$3,005,870	85.6%	Defined

STATE STREET CORP

$1,617,199

2.83%

245,402

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	245,402	$1,617,199	100.0%	Defined

SBI Securities Co., Ltd.

$1,244,025

2.17%

169,717

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$1,214,444

2.12%

184,286

NORTHERN TRUST CORP

$1,117,247

1.95%

169,537

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	166,671	$1,098,361	98.3%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	2,866	$18,886	1.7%	Other

VANGUARD FIDUCIARY TRUST CO

$995,571

1.74%

151,073

VANGUARD PORTFOLIO MANAGEMENT LLC

$816,850

1.43%

123,953

GOLDMAN SACHS GROUP INC

$568,288

0.99%

86,235

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	86,235	$568,288	100.0%	Defined

Bank of New York Mellon Corp

$413,521

0.72%

62,750

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Investments Corporation	34,588	$227,934	55.1%	Defined
The Bank of New York Mellon	28,162	$185,587	44.9%	Defined

MORGAN STANLEY

$274,741

0.48%

41,691

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	36	$237	0.1%	Defined
MORGAN STANLEY & CO. LLC	4,887	$32,205	11.7%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	32,451	$213,852	77.8%	Defined
MORGAN STANLEY SMITH BARNEY LLC	292	$1,924	0.7%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	4,025	$26,523	9.7%	Defined

STRS OHIO

$170,022

0.30%

25,800

DIMENSIONAL FUND ADVISORS LP

$166,515

0.29%

25,268

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Dimensional Ireland Ltd	758	$4,995	3.0%	Defined
Held directly	24,510	$161,520	97.0%	Sole

ALLIANCEBERNSTEIN L.P.

$162,048

0.28%

24,590

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	24,590	$162,048	100.0%	Defined

Nuveen, LLC

$161,487

0.28%

24,505

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
TEACHERS ADVISORS, LLC joint	24,505	$161,487	100.0%	Defined

UBS Group AG

$123,646

0.22%

18,763

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	25	$164	0.1%	Defined
UBS AG	17,879	$117,822	95.3%	Defined
UBS Securities LLC	859	$5,660	4.6%	Defined

MILLENNIUM MANAGEMENT LLC

$121,835

0.21%

18,488

DEUTSCHE BANK AG\

$118,217

0.21%

17,939

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS INVESTMENT MANAGEMENT AMERICAS, INC	37	$243	0.2%	Defined
DWS Investments UK Ltd	17,902	$117,974	99.8%	Defined

RHUMBLINE ADVISERS

$111,140

0.19%

16,865

WELLS FARGO & COMPANY/MN

$107,396

0.19%

16,297

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	16,231	$106,962	99.6%	Defined
Wells Fargo Securities, LLC	66	$434	0.4%	Defined

PRICE T ROWE ASSOCIATES INC /MD/

$99,054

0.17%

15,031

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	15,031	$99,054	100.0%	Defined

FMR LLC

$98,678

0.17%

14,974

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	14,974	$98,678	100.0%	Defined

ROYAL BANK OF CANADA

$86,953

0.15%

13,195

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RBC CMA LTD.	537	$3,538	4.1%	Defined
RBC Capital Markets, LLC	2,128	$14,023	16.1%	Defined
Held directly	10,530	$69,392	79.8%	Sole

BANK OF AMERICA CORP /DE/

$82,539

0.14%

12,525

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	12,525	$82,539	100.0%	Defined

Polymer Capital Management (US) LLC

$77,630

0.14%

11,780

Vanguard Global Advisers, LLC

$65,787

0.11%

9,983

Police & Firemen's Retirement System of New Jersey

$59,382

0.10%

9,011

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Capital	9,011	$59,382	100.0%	Defined

CITIGROUP INC

$56,580

0.10%

8,586

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	8,586	$56,580	100.0%	Defined

MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.

$55,659

0.10%

8,446

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Global X Management CO LLC joint	8,446	$55,659	100.0%	Defined

JPMORGAN CHASE & CO

$51,605

0.09%

7,831

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JPMorgan Chase Bank, N.A.	7,604	$50,110	97.1%	Defined
J.P. Morgan Investment Management Inc.	56	$369	0.7%	Defined
J.P. Morgan Securities plc	171	$1,126	2.2%	Defined

Russell Investments Group, Ltd.

$24,929

0.04%

3,783

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC	3,783	$24,929	100.0%	Defined

BNP PARIBAS ARBITRAGE, SA

$22,972

0.04%

3,486

BARCLAYS PLC

$21,272

0.04%

3,228

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	2,816	$18,557	87.2%	Defined
BARCLAYS CAPITAL INC.	412	$2,715	12.8%	Defined

NEW YORK STATE COMMON RETIREMENT FUND

$17,793

0.03%

2,700

Tower Research Capital LLC (TRC)

$16,270

0.03%

2,469

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Latour Trading LLC (Latour)	2,469	$16,270	100.0%	Defined

Legal & General Group Plc

$13,535

0.02%

2,054

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Legal & General Investment Management America Inc	2,054	$13,535	100.0%	Defined

Ameritas Investment Partners, Inc.

$4,500

0.01%

683

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
EATON VANCE MANAGEMENT	683	$4,500	100.0%	Other

Activest Wealth Management

$3,906

0.01%

533

Sterling Capital Management LLC

$3,723

0.01%

508

Farther Finance Advisors, LLC

$2,646

0.00%

361

Arax Advisory Partners

$1,621

0.00%

246

CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM

$1,093

0.00%

166

Bare Financial Services, Inc

$520

0.00%

GoalVest Advisory LLC

$366

0.00%

Covestor Ltd

$316

0.00%

OSAIC HOLDINGS, INC.

$289

0.00%

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
OSAIC WEALTH, INC.	33	$217	75.1%	Defined
Osaic Advisory Services, LLC	11	$72	24.9%	Defined

Allworth Financial LP

$250

0.00%

EverSource Wealth Advisors, LLC

$129

0.00%

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BMSS Wesson Wealth Solutions, LLC	5	$32	24.8%	Sole
Held directly	15	$97	75.2%	Sole

Caitong International Asset Management Co., Ltd

$98

0.00%

Root Financial Partners, LLC

$51

0.00%

Optiver Holding B.V.

$39

0.00%

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Optiver VOF	6	$39	100.0%	Defined

Smartleaf Asset Management LLC

$39

0.00%

IFP Advisors, Inc

0.00%

ROTHSCHILD INVESTMENT LLC

0.00%

Key facts CIK 1124105 CUSIP 403783103 13F (30d) 7 filings 7 filers Visit website Investor relations