TWO SIGMA INVESTMENTS, LP

Position in PYXS — Pyxis Oncology, Inc.

CIK 1179392 NEW YORK, NY

Position in PYXS

as of Jun 30, 2026 · filed Aug 14, 2026 Compact

Position Value

$252,722

+$145,704 QoQ

Shares Held

83,961

+14.5% QoQ

Ownership

0.101%

of shares outstanding

% of Portfolio

0.00%

of 13F equity value

Holder Rank

#26

of 76 holders

Holding Since

Jun 2022

13 quarters on record

Voting authority Sole 100% Shared 0% None 0%

Healthcare · as of Jun 30, 2026

TWO SIGMA INVESTMENTS, LP holds $7,273,657,992 across 342 Biotechnology names. PYXS ranks #283 (0.0% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	ALNY	Alnylam Pharmaceuticals, Inc.	1,875,937	$564,713,315
2	MRNA	Moderna, Inc.	7,193,530	$503,762,905
3	IONS	Ionis Pharmaceuticals Inc	6,252,342	$495,748,197
4	REGN	Regeneron Pharmaceuticals, Inc.	656,124	$409,119,558
5	BBIO	BridgeBio Pharma, Inc.	4,722,185	$351,708,338
6	EXEL	Exelixis, Inc.	4,209,861	$229,058,537
7	INCY	Incyte Corp	2,003,559	$227,123,448
8	ARGX	Argenx SE	185,638	$172,229,367

13 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-06-30	$252,722	83,961	+14.5%	Shares	Sole	2026-08-14
2026-03-31	$107,018	73,300	-30.5%	Shares	Sole	2026-05-15
2025-12-31	$121,357	105,528	+126.9%	Shares	Sole	2026-02-17
2025-09-30	$103,232	46,501	+172.5%	Shares	Sole	2025-11-14
2024-12-31	$26,624	17,067	-30.6%	Shares	Sole	2025-02-14
2024-09-30	$90,215	24,582	-74.3%	Shares	Sole	2024-11-14
2024-06-30	$316,776	95,703	+4.5%	Shares	Sole	2024-08-14
2023-12-31	$164,813	91,563	-23.6%	Shares	Sole	2024-02-14
2023-09-30	$238,427	119,813	+10.5%	Shares	Sole	2023-11-14
2023-06-30	$277,521	108,407	+205.6%	Shares	Sole	2023-08-14
2022-12-31	$47,539	35,477	-5.8%	Shares	Sole	2023-02-14
2022-09-30	$74,223	37,677	-10.9%	Shares	Sole	2022-11-14
2022-06-30	$100,664	42,296	—	Shares	Sole	2022-08-15
No filing history on record for this holder in this stock.