6-K

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON D.C. 20549

FORM 6-K

Report ofForeign Private Issuer

Pursuant to Rule 13a-16 or15d-16

of the Securities Exchange Act of 1934

March 21, 2022

CHINASOUTHERN AIRLINES COMPANY LIMITED

68 Qi Xin Road

Guangzhou, 510403

People’s Republic of China

(Address of principal executive offices)

Indicate by check mark whether the registrant files or will file annual reports under cover Form 20-F or Form 40-F.

Form 20-F  ☒             Form 40-F  ☐

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1):  ☐

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7):  ☐

Indicate by check mark whether the registrant by furnishing the information contained in this Form is also thereby furnishing the information to the Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.

Yes  ☐    No  ☒

If “Yes” is marked, indicate below the file number assigned to the registrant in connection with Rule 12g3-2(b): N/A

China Southern Airlines Company Limited (the “Company”) published the following announcement on March 18, 2022 on the Hong Kong Stock Exchange’s website at:

https://www1.hkexnews.hk/listedco/listconews/sehk/2022/0318/2022031800997.pdf, in relation to the approval by the China Securities Regulatory Commission of the application for the non-public issuance of overseas listed foreign shares (H shares) of the Company.

The announcement in English is included as an exhibit to this Form 6-K.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

EX-99.1

Exhibit 99.1

Hong Kong Exchanges and Clearing Limited and The Stock Exchange of Hong Kong Limited take no responsibility for the contents of this announcement, make norepresentation as to its accuracy or completeness and expressly disclaim any liability whatsoever for any loss howsoever arising from or in reliance upon the whole or any part of the contents of this announcement.

This announcement appears for information purposes only and does not constitute an invitation or offer to acquire, purchase or subscribe for securities ofChina Southern Airlines Company Limited.

(a joint stock limited company incorporated in the People’s Republic of China with limited liability)

(Stock Code: 1055)

ANNOUNCEMENT IN RELATION TO APPROVAL BY THE CSRC OF THE APPLICATION FOR THE NON-PUBLIC ISSUANCE OFOVERSEAS LISTED FOREIGN SHARES (H SHARES) OF THE COMPANY

References are made to the announcements of China Southern Airlines Company Limited (the “Company”) dated 29 October 2021 and 11 January 2022, and the circular of the Company dated 11 November 2021 (the “Circular”), in relation to, among other things, (i) the proposed issue of 803,571,428 new A Shares to CSAH; and (ii) the proposed issue of not more than 855,028,969 new H Shares (including 855,028,969 H Shares) to Nan Lung. Unless otherwise defined, capitalized terms used herein shall have the same meaning as defined in the Circular.

The Company recently received the Approval on Issuance of Overseas Listed Foreign Shares by China Southern Airlines Company Limited (Zheng Jian Xu Ke 2022 No. 497) (《關於核准中國南方航空股份有限公司發行境外上市外資股的批復》（證監許可 [2022] 497 號）) (the “Approval”) issued by the CSRC. Pursuant to the Approval, the CSRC has approved the issue of not more than 855,028,969 overseas listed foreign shares by the Company, all of which are ordinary shares with the nominal value of RMB1 per share. The Approval shall be effective for a term of 12 months from the date of the Approval.

The Company will continue to deal with subsequent matters in respect of the issuance in accordance with relevant laws and regulations and the requirements set out in the Approval and disclose the relevant information in a timely manner according to the progress of relevant matters. Investors are advised to pay attention to the investment risks.

Shareholders and potential investors are advised to exercise caution when dealing in the Shares, and are recommended to seekprofessional advice if they are in any doubt about their position and as to actions that they should take.

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Guangzhou, the People’s Republic of China

18 March 2022

As at the date of this announcement, theDirectors include Ma Xu Lun and Han Wen Sheng as executive Directors; and Liu Chang Le, Gu Hui Zhong, Guo Wei and Yan Andrew Y as independent non-executive Directors.

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