6-K

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON D.C. 20549

FORM 6-K

Report ofForeign Private Issuer

Pursuant to Rule 13a-16 or15d-16 of

the Securities Exchange Act of 1934

July 18, 2022

CHINASOUTHERN AIRLINES COMPANY LIMITED

68 Qi Xin Road

Guangzhou, 510403

People’s Republic of China

(Address of principal executive offices)

Indicate by check mark whether the registrant files or will file annual reports under cover Form 20-F or Form 40-F.

Form 20-F  ☒            Form 40-F  ☐

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1):  ☐

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7):  ☐

Indicate by check mark whether the registrant by furnishing the information contained in this Form is also thereby furnishing the information to the Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.

Yes  ☐            No  ☒

If “Yes” is marked, indicate below the file number assigned to the registrant in connection with Rule 12g3-2(b): N/A

China Southern Airlines Company Limited (the “Company”) published the following announcement on July 15, 2022 on the Hong Kong Stock Exchange’s website at:

https://www1.hkexnews.hk/listedco/listconews/sehk/2022/0715/2022071501180.pdf, in relation to the estimated loss in the results for the first half of 2022.

The announcement in English is included as an exhibit to this Form 6-K.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

Date: July 18, 2022

EX-99.1

Exhibit 99.1

Hong Kong Exchanges and Clearing Limited and The Stock Exchange of Hong Kong Limited take no responsibility for the contents of this announcement, make norepresentation as to its accuracy or completeness and expressly disclaim any liability whatsoever for any loss howsoever arising from or in reliance upon the whole or any part of the contents of this announcement.

(a joint stock limited company incorporated in the People’s Republic of China with limitedliability)

(Stock Code: 1055)

ANNOUNCEMENT ON ESTIMATED LOSS IN THE RESULTS FOR THE FIRST HALF OF 2022

This announcement is made by China Southern Airlines Company Limited (the “Company”) pursuant to Rule 13.09 of the Rules Governing the Listing of Securities on The Stock Exchange of Hong Kong Limited (the “Listing Rules”) and the Inside Information Provisions (as defined in the Listing Rules) under Part XIVA of the Securities and Futures Ordinance (Chapter 571 of the Laws of Hong Kong).

1 January 2022 to 30 June 2022 (the “Reporting Period”)

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During the Reporting Period, the domestic civil aviation industry was affected by multiple shocks such as repeated impact of pandemic, high oil prices, and the depreciation of the Renminbi. In the first half of 2022, the Company’s passenger capacity and revenue passenger kilometers decreased by 34.3% and 42.6%, respectively, as compared with the corresponding period in last year, and decreased by 54.8% and 64.8%, respectively, as compared with the first half of 2019.

In the face of the complex and severe external situation, the Company adhered to the general principle of seeking progress while maintaining stability, and made every effort to respond to various challenges, and has done a good job in epidemic prevention and control and safe production and operation, and strived to minimize adverse effects. However, affected by multiple factors such as the epidemic, the operating performance of the Company in the first half of 2022 continued to loss.

There is no other substantial uncertainty which may affect the accuracy of the estimated results of the Company.

The data set out in this announcement is only preliminary accounting data. The specific and accurate financial data should be those to be officially disclosed in the 2022 interim report of the Company. Investors are advised to pay attention to such investment risks involved.

Guangzhou, the People’s Republic of China

15 July 2022

As at the date of this announcement, theDirectors include Ma Xu Lun and Han Wen Sheng as executive Directors; and Liu Chang Le, Gu Hui Zhong, Guo Wei and Yan Andrew Y as independent non-executive Directors.

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