6-K

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON D.C. 20549

FORM 6-K

Report ofForeign Private Issuer

Pursuant to Rule 13a-16 or15d-16 of

the Securities Exchange Act of 1934

November 17, 2021

CHINASOUTHERN AIRLINES COMPANY LIMITED

68 Qi Xin Road

Guangzhou, 510403

People’s Republic of China

(Address of principal executive offices)

Indicate by check mark whether the registrant files or will file annual reports under cover Form 20-F or Form 40-F.

Form 20-F  ☒            Form 40-F  ☐

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1):  ☐

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7):  ☐

Indicate by check mark whether the registrant by furnishing the information contained in this Form is also thereby furnishing the information to the Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.

Yes  ☐            No  ☒

If “Yes” is marked, indicate below the file number assigned to the registrant in connection with Rule 12g3-2(b): N/A

China Southern Airlines Company Limited (the “Company”) published the following announcement on November 16, 2021 on the Hong Kong Stock Exchange’s website at:

https://www1.hkexnews.hk/listedco/listconews/sehk/2021/1116/2021111600330.pdf, in relation to the key operating data of the Company and its subsidiaries for October 2021.

The announcement in English is included as an exhibit to this Form 6-K.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

CHINA SOUTHERN AIRLINES COMPANY LIMITED

Date: November 17, 2021

EX-99.1

Exhibit 99.1

Hong Kong Exchanges and Clearing Limited and The Stock Exchange of Hong Kong Limited take no responsibility for the contents of this announcement, make norepresentation as to its accuracy or completeness and expressly disclaim any liability whatsoever for any loss howsoever arising from or in reliance upon the whole or any part of the contents of this announcement.

(a joint stock limited company incorporated in the People’s Republic of China with limited liability)

(Stock Code: 1055)

ANNOUNCEMENT ON KEY OPERATING DATA

This announcement is made based on the operating data for October 2021 of the Group to be published on the Shanghai Stock Exchange and pursuant to Part XIVA of the Securities and Futures Ordinance.

The relevant key operating data was calculated based on the internal statistics of the Group, which may differ from the data disclosed in the relevant periodic reports. Investors are hereby reminded of the risks which may result from inappropriate reliance upon or utilization of the relevant information.

This announcement is made based on the operating data for October 2021 of China Southern Airlines Company Limited (the “Company”) and its subsidiaries (collectively, the “Group”) to be published on the Shanghai Stock Exchange and pursuant to Part XIVA of the Securities and Futures Ordinance.

In October 2021, passenger capacity (measured by available seat kilometres (“ASK”)) of the Group decreased by 20.57% as compared with the same period last year (a year-on-year (“YoY”) basis), of which, passenger capacity for domestic, regional and international routes decreased by 20.08%, 48.96% and 32.39%, respectively, as compared with the same period last year. Compared with the same period last year, passenger traffic (measured by revenue passenger kilometres (“RPK”)) decreased by 27.72%, of which, passenger traffic for domestic, regional and international routes decreased by 27.36%, 66.43% and 40.25%, respectively, as compared with the same period last year. The passenger load factor was 69.57%, representing a decrease of 6.88 percentage points as compared with the same period last year, of which, the passenger load factor for domestic, regional and international routes decreased by 7.04, 10.29 and 6.45 percentage points, respectively, as compared with the same period last year.

In terms of cargo operations, in October 2021, cargo capacity (measured by available tonne kilometers (“ATK”) - Cargo and Mail) decreased by 13.38% as compared with the same period last year. Cargo and mail traffic (measured by revenue tonne kilometres (“RTK”) - Cargo and Mail) decreased by 5.01% as compared with the same period last year. The cargo and mail load factor was 51.44%, representing an increase of 4.53 percentage points as compared with the same period last year.

1

In October 2021, the Group has newly launched the following major routes: Changchun – Changsha – Xishuangbanna – Changsha – Changchun, Zhuhai – Nanning – Chengdu – Nanning – Zhuhai, Zhuhai – Chongqing – Urumqi – Chongqing – Zhuhai, Zhuhai – Wuhan – Lanzhou – Wuhan – Zhuhai, Kashgar – Urumqi – Jinan – Urumqi – Kashgar (each being seven flights a week).

In October 2021, the Group introduced one ARJ21 aircraft. As of the end of October 2021, the Group operated a fleet of 875 aircraft as set out below:

2

3

Notes:

The key operating data above was calculated based on the internal preliminary statistics of the Group, which may be subsequently adjusted or differ from the data disclosed in the relevant periodic reports. Investors are hereby reminded of the risks which may result from inappropriate reliance upon or utilization of the information given above.

4

Guangzhou, the People’s Republic of China

16 November 2021

As at the date of this announcement,the Directors include Ma Xu Lun and Han Wen Sheng as executive Directors; and Liu Chang Le, Gu Hui Zhong, Guo Wei and Yan Andrew Y as independent non-executive Directors.

5