MEDP · Medpace Holdings, Inc.

The transactions reported on this Form 4 were effected pursuant to a limit order placed by the Reporting Person during an open window period.

The reported price is a weighted average price. These shares were sold in multiple transactions ranging from $600.00 to $600.45. The Reporting Person undertakes to provide full pricing information to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission upon request.

The transactions reported on this Form 4 were effected pursuant to a limit order placed by the Reporting Person during an open window period.

The transactions reported on this Form 4 were effected pursuant to a limit order placed by the Reporting Person during an open window period.

The reported price is a weighted average price. These shares were sold in multiple transactions ranging from $600.00 to $603.495. The Reporting Person undertakes to provide full pricing information to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission upon request.

Each restricted stock unit represents a contingent right to receive one share of MEDP common stock.

On November 28, 2025, the Reporting Person was granted 143 restricted stock units vesting in four approximately equal installments on March 31, 2026, June 30, 2026, September 30, 2026 and December 31, 2026.

Each restricted stock unit represents a contingent right to receive one share of MEDP common stock.

Each restricted stock unit represents a contingent right to receive one share of MEDP common stock.

On November 28, 2025, the Reporting Person was granted 113 restricted stock units vesting in four approximately equal installments on March 31, 2026, June 30, 2026, September 30, 2026 and December 31, 2026.

Each restricted stock unit represents a contingent right to receive one share of MEDP common stock.

On November 28, 2025, the Reporting Person was granted 130 restricted stock units vesting in four approximately equal installments on March 31, 2026, June 30, 2026, September 30, 2026 and December 31, 2026.

Each restricted stock unit represents a contingent right to receive one share of MEDP common stock.

Each restricted stock unit represents a contingent right to receive one share of MEDP common stock.

The transactions reported on this Form 4 were effected pursuant to a limit order placed by the Reporting Person during an open window period.

The option vested in full on February 15, 2026.

The option vests on the earlier of (i) the day immediately preceding the date of the first annual meeting of the Issuer following the date of grant, and (ii) the first anniversary of the date of grant, subject to continued service on the board of directors of the Issuer through the vesting date.

The option vests on the earlier of (i) the day immediately preceding the date of the first annual meeting of the Issuer following the date of grant, and (ii) the first anniversary of the date of grant, subject to continued service on the board of directors of the Issuer through the vesting date.

The option vests on the earlier of (i) the day immediately preceding the date of the first annual meeting of the Issuer following the date of grant, and (ii) the first anniversary of the date of grant, subject to continued service on the board of directors of the Issuer through the vesting date.

The option vests on the earlier of (i) the day immediately preceding the date of the first annual meeting of the Issuer following the date of grant, and (ii) the first anniversary of the date of grant, subject to continued service on the board of directors of the Issuer through the vesting date.

The option vests on the earlier of (i) the day immediately preceding the date of the first annual meeting of the Issuer following the date of grant, and (ii) the first anniversary of the date of grant, subject to continued service on the board of directors of the Issuer through the vesting date.

The option vests on the earlier of (i) the day immediately preceding the date of the first annual meeting of the Issuer following the date of grant, and (ii) the first anniversary of the date of grant, subject to continued service on the board of directors of the Issuer through the vesting date.

Each restricted stock unit represents a contingent right to receive one share of MEDP common stock.

The restricted stock units vest in full on the fifth anniversary of the grant date, subject to the Reporting Person's continued employment with the Issuer or one of its subsidiaries.

Each restricted stock unit represents a contingent right to receive one share of MEDP common stock.

The restricted stock units vest in full on the second anniversary of the grant date, subject to the Reporting Person's continued employment with the Issuer or one of its subsidiaries.

The option vests on the fifth anniversary of the grant date, subject to the Reporting Person's continued employment with the Issuer or one of its subsidiaries.

The option vests on the second anniversary of the grant date, subject to the Reporting Person's continued employment with the Issuer or one of its subsidiaries.

The option vests on the second anniversary of the grant date, subject to the Reporting Person's continued employment with the Issuer or one of its subsidiaries.

Each restricted stock unit represents a contingent right to receive one share of MEDP common stock.

The restricted stock units vest in full on the fifth anniversary of the grant date, subject to the Reporting Person's continued employment with the Issuer or one of its subsidiaries.

The option vested in full on February 15, 2026.

The option vested in full on February 15, 2026.

Each restricted stock unit represents a contingent right to receive one share of MEDP common stock.

The restricted stock units vest in full on the second anniversary of the grant date, subject to the Reporting Person's continued employment with the Issuer or one of its subsidiaries.

The option vests on the fifth anniversary of the grant date, subject to the Reporting Person's continued employment with the Issuer or one of its subsidiaries.

Each restricted stock unit represents a contingent right to receive one share of MEDP common stock.

On November 28, 2025, the Reporting Person was granted 143 restricted stock units vesting in four approximately equal installments on March 31, 2026, June 30, 2026, September 30, 2026 and December 31, 2026.

Each restricted stock unit represents a contingent right to receive one share of MEDP common stock.

Each restricted stock unit represents a contingent right to receive one share of MEDP common stock.

Each restricted stock unit represents a contingent right to receive one share of MEDP common stock.

Each restricted stock unit represents a contingent right to receive one share of MEDP common stock.

On November 28, 2025, the Reporting Person was granted 113 restricted stock units vesting in four approximately equal installments on March 31, 2026, June 30, 2026, September 30, 2026 and December 31, 2026.

Each restricted stock unit represents a contingent right to receive one share of MEDP common stock.

On November 28, 2025, the Reporting Person was granted 130 restricted stock units vesting in four approximately equal installments on March 31, 2026, June 30, 2026, September 30, 2026 and December 31, 2026.

The option vested in full on October 27, 2025.

The option vested in full on February 15, 2026.

The reported price is a weighted average price. These shares were sold in multiple transactions ranging from $451.36 to $460.288. The Reporting Person undertakes to provide full pricing information to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission upon request.

The option vested in full on February 15, 2026.

The option vested in full on February 28, 2020.

The option vested in full on May 14, 2020.

Each restricted stock unit represents a contingent right to receive one share of MEDP common stock.

Each restricted stock unit represents a contingent right to receive one share of MEDP common stock.

On November 29, 2024, the Reporting Person was granted 227 restricted stock units, which vested in multiple tranches and was fully vested on December 31, 2025.

Each restricted stock unit represents a contingent right to receive one share of MEDP common stock.

On November 29, 2024, the Reporting Person was granted 198 restricted stock units, which vested in multiple tranches and was fully vested on December 31, 2025.