Good day, everyone, and welcome to the First Quarter 2024 Maravai LifeSciences Earnings Conference Call. This call is being recorded. I would now like to hand it over to Debbie Hart, Head of Investor Relations. You may begin.

Good afternoon, everyone. Thanks for joining us on our first quarter 2024 earnings call. Our press release and the slides that accompany today's call are posted on our website and available at investors.maravai.com. As you can see on our agenda for today on Slide 2, Trey will first provide you with a business update, and Kevin will review our financial results and guidance. Drew Burch, President of Nucleic Acid Production; and Becky Buzzeo, our Chief Commercial Officer, will join the call for the question-and-answer session following the prepared remarks. During today's call, management will make forward-looking statements and refer to GAAP and non-GAAP financial measures. It is possible that actual results could differ from management's expectations. We refer you to Slide 3 for more detail on forward-looking statements and our use of non-GAAP financial measures. Our just-issued press release provides reconciliations to the most directly comparable GAAP measures. Please also refer to Maravai's SEC filings for additional information on the risks and uncertainties that may impact our operating results, performance, and financial conditions. Now I'll turn the call over to Trey.

Thank you, Deb, and good afternoon, everyone. We appreciate having you join us for our call today. Let me briefly recap the quarter, highlight some innovative new products we are introducing, and provide a few business updates before turning the call over to Kevin. Let's start with our first-quarter results on Slide 5. Today, we reported $64 million in revenue for Q1, $8 million in total adjusted EBITDA and a loss of $0.02 in adjusted fully diluted EPS for the quarter. Q1 revenue results exceeded the range of expectations that we shared with you during our fourth-quarter conference call. Our Nucleic Acid Production segment had revenue of $46 million in Q1. The Biologics Safety Testing revenue was $18 million in the first quarter, and this was our first quarter of growth for BST since Q1 of 2023. Kevin will go into more detail on these results later in the call. Slide 6 shows that our adjusted free cash flow in the quarter was $4 million. Cash on hand at the end of the quarter was $562 million, down $13 million from year-end as we continue to progress with the build-out and equipment installation for our 2 new Flanders GMP facilities. Debt is $532 million gross. Thus, we maintain a $30 million net cash position. This puts us in a great position to fund our long-term growth strategy through organic investments while simultaneously pursuing external partnerships and/or M&A. We continue to see multiple potential strategic opportunities in our space where we will endeavor to responsibly deploy our capital. As we sit here today, we remain focused on our return to growth strategy. To enable long-term sustainable growth for our business, we expect to continue to expand our product portfolio, advance our market leadership in the mRNA space, and accelerate the introduction of scientific innovations in ways that support our customers' rapidly evolving needs. To the first point on product portfolio expansion and our focus on innovation, let's turn to Slide 7 and some updates in our Nucleic Acid Production segment. In our enzyme product portfolio, I'm happy to announce that our toolkit now consists of the majority of enzymes used in the mRNA IVT process. Incorporating Alphazyme enzymes into the TriLink mRNA workflow, which we trademark as CleanScript, provides our customers with industry-leading high-purity mRNAs with increased activity and reduced toxicity. We recently launched over 20 new catalog mRNA products from our TriLink Discovery Group. This project leverages our decades of RNA experience through the incorporation of our industry-leading capabilities in capping, base modifications, and mRNA manufacturing workflows in addition to the enzymes manufactured at Alphazyme. As many of our discovery customers look to advance their programs from mRNA design to LNP or other delivery system optimization, they need catalog mRNAs to rapidly advance their projects. With that in mind, we've launched these new catalog mRNA offerings with CleanCap M6 and N1-methyl-pseudouridine. This enables customers to use the best chemistry from the outset of their programs. In addition, we've refreshed the entire catalog using the latest version of our CleanScript IVT production process. CleanScript allows us to deliver the highest purity products that have reduced double-stranded RNA levels and can enhance in vivo protein expression. The innovation doesn't stop with these newly announced catalog discovery products. We intend to launch many additional mRNA products as we move forward, and we are engaging more deeply with customers as we support their research programs with custom constructs. Turning to Slide 8. We continue to bolster our market leadership in the mRNA space through strategic partnerships. TriLink entered into a nonexclusive license and supply agreement with Lonza for CleanCap analogs for use in Lonza's global mRNA development and manufacturing services from preclinical through Phase III programs. Lonza is one of the world leaders for producing biologic drugs. They've elected to bring CleanCap into their portfolio to enable many more customers to benefit from the advantages of CleanCap, and we see this as an important partnership for us to seed the market with our technologies. We believe Lonza's decision to incorporate our solutions in their highly regarded development and manufacturing services is a strong endorsement that CleanCap is the optimal way to produce mRNA. And we are excited for this partnership to unfold. Alphazyme announced a collaboration with Applied DNA for scale-up manufacturing, enabling the Linea RNA Polymerase. Under the terms of the agreement, Alphazyme will perform manufacturing process development, enabling the scaling of their RNA polymerase manufacturing from its current research scale to the commercial scale necessary to empower the growing demand for the company's Linea IVT platform. We developed a full enzyme production process and have made breakthroughs in the manufacturing workflow for Applied DNA. We're fully able to support their forecasted demand and help enable their growth. We also continue to foster key academic partnerships to enhance innovation and accelerate market adoption of the latest technology. We currently have active research collaborations with 5 top-tier academic institutions to address a wide range of disease indications and custom nucleic acid applications, demonstrating our desire to be a technology partner to scientists developing the next generation of medicines. We believe that investing in new product innovation and partnering with leading academic and industry partners is a key driver for creating long-term value. We are in an exceptional position to win customers early for product and technology adoption. Turning to Slide 9 and tying innovation to our commercial strategy, which is a critical part of our return to growth. Again, we're in a unique position producing the process inputs used in the IVT reaction as well as the full clinical scale production of mRNA. As we work to improve mRNA production, we see several opportunities to drive new product and process innovations to improve the overall manufacturing workflow. This is a luxury in that it helps us move the mRNA field forward in a unique way. By winning early in the discovery process with our CleanCap and our CleanScript technologies, our commercial team can cross-sell NTPs, enzymes, and other raw materials at earlier stages of the clinical pipeline, putting us in a position to grow with our customers to support them with their later-stage development. This can include providing either RUO or GMP materials depending on their needs. This year has started with exciting positive momentum, thanks to the efforts from our commercial operations and business teams. We have made great progress in evolving and building our commercial team and building the flywheel between our products and services activities. As we continue to expand our customer funnel for RUO and GMP offerings, it is important that we offer an unmatched customer experience from day 1 and for as long as the customer is with us. Our enhanced commercial team has the talent, tools, and processes to help build Maravai 3.0 in support of our return to growth strategy. Let's turn to Slide 10 in our Biologics Safety Testing segment updates under the Cygnus Technologies brand. As with the nucleic acid segment, we continue to innovate to bring improved products to market to support our customers. Cell and gene therapy development has experienced tremendous growth as the FDA and other regulatory agencies worldwide continue their efforts to enable innovators in this new class of medicines. The FDA and other global regulatory agencies have approved several cell and gene therapy products. And we are very proud that Cygnus kits now support all 21 of the 21 FDA-approved CAR-T cell and gene therapies. We are also pleased that Maravai was recognized as among FastCompany's Most Innovative Companies in Biotech in 2024 for our Cygnus MockV RVLP kit, which detects retrovirus-like particles that can be produced during the manufacturing of biologic drug products. The kit, which uses a surrogate noninfectious virus-like particle, can be run without extra safety and containment measures. This enables faster, easier, and more cost-effective optimization of viral clearance to assure biopharmaceutical safety prior to human clinical trials, regulatory approval and commercialization. This award adds to the many recognitions the MockV RVLP kit has received since its introduction in 2022. We remain very optimistic about the MockV product line and our ability to disrupt the viral clearance market. As in the NAP segment, we plan to continuously improve our offerings in BST to ensure superior technical support, the highest quality services and offerings, and the most comprehensive catalog of products to meet our customers' needs. Cygnus consistently supports and advances the technology to improve biotherapeutic safety and accelerate the movement of new therapeutic monoclonal antibodies, biosimilars, and cell and gene therapies through the development and regulatory approval process. Now moving to Slide 11 and our facilities update. As many of you are aware, Flanders 1 is our new GMP manufacturing site for small molecules. I'm pleased to report that we have produced our first engineering batch of GMP small molecule products in the new facility and are quickly migrating our CleanCap M6 to GMP quality. As we approach the 1-year anniversary of the M6 launch, customers have lined up for M6 GMP batches and are eager to move CleanCap M6 into the clinic. Flanders 1 adds scale and mitigates operational risk as we now have redundant capacity to manufacture small molecules. This includes the CleanCap analogs as well as other NTPs such as N1-methyl-pseudouridine, which are needed as GMP-grade inputs for mRNA production. This will not only bolster our supply chain resilience. Flanders 1 is a designated facility to aid the U.S. government in future pandemic preparedness. We hosted our Flanders 2 grand opening in April and are now officially in the market for late-phase cGMP mRNA production. Flanders 2 was designed to meet the manufacturing requirements of mRNA-based medicines through all drug development phases. We have enabled mRNA clinical programs for over 10 years from discovery through investigational new drug or IND filings. Our new cGMP facility will serve our partners with late-phase clinical and commercial mRNA drug substance manufacturing. The 32,000-foot facility includes 3 Grade C manufacturing clean rooms, a dedicated fill suite, and an independent buffer prep and staging area. We have on-site quality control, EM monitoring, and release testing supporting 1-gram to 100-gram batch sizes. We couldn't be more excited to open our doors and help enable the life-saving medicines our customers are developing. Many of our customers have been asking to stay with our talented team as their clinical programs advance into Phase II, Phase III, and beyond. And I'm so pleased that we can now support them. In fact, we have already signed statements of work to support a Phase II clinical trial and our first Phase III batches. We believe this is a capability extension that will make it easier for drug developers to select us for Phase I or even preclinical batches at the beginning stages of their development as they know they will have a partner who can support them through commercialization. We have a long history of innovation in mRNA. Our significant investment in these 2 facilities underlines our commitment to innovate the process for producing the next generation of genomic medicines and the raw materials that enable their production. This expands our capabilities to help our customers unlock the potential of mRNA and develop life-changing vaccines and therapies. The Wateridge facility will continue to support the important work underway in TriLink Discovery and act as a key partner, providing development expertise to our customers. Moving to Slide 12. I'll now ask Kevin to provide more details on our first quarter performance and our expectation for the balance of the year. Kevin?

Thanks for the handoff, Trey. Echoing Trey's remarks, we are pleased with the top line performance in the quarter and excited about the business accomplishments that are laying a solid foundation for our future. Today, I will summarize our financial results for Q1 and then discuss our reaffirmed financial expectations for the full year. Let's start with the Q1 financial results on Slide 13. As Trey mentioned, our revenue for the quarter was $64 million. Our GAAP net loss before noncontrolling interests was $23 million for the first quarter of 2024. This compares to a net loss of $1 million for the comparable first quarter of 2023. Adjusted EBITDA, a non-GAAP measure, was $8 million for Q1 2024 compared to $24 million for Q1 2023. Our adjusted EBITDA margin was 12% in Q1 2024. This adjusted EBITDA margin was slightly lower than our internal forecast for the quarter by about $1 million, partially tied to the timing of some operational readiness period costs for our new Flanders facility, which we are incredibly excited about. For the trailing 12 months or last 4 quarters combined, our adjusted EBITDA margin was 18% on revenues of $274 million. Overall, our adjusted EBITDA margin in any given quarter will vary primarily based on revenues, given the high proportion of labor and facility-related costs and the relatively low revenue-based variable costs. As it relates to labor and our previously discussed cost reduction actions, you'll see on Slide 14 we ended the quarter with 575 full-time employees compared to 673 employees we had at the end of September 2023 prior to our restructuring initiatives. And we completed all of the related actions over the course of Q4 2023 and Q1 2024. As we look forward, we continue to evolve our organization with an eye to the future. This includes continued investment in innovation, commercial infrastructure, and GMP operations that are at least partially funded by the targeted reductions in our G&A structure and balancing our NAP operations team to the current demand profile. We continue to be focused on funding future growth opportunities while maintaining a cost-effective structure. With 575 employees, our revenue per employee metric for 2024 is just under $0.5 million in revenue per employee, which is amongst the best in life science tools. This, coupled with a broad and expanding capabilities of Maravai, positions us well for operating efficiency moving forward. I will discuss EBITDA by segment in a few slides. Moving to Slide 15 and EPS. Basic and diluted EPS for the first quarter was a loss of $0.09 per share compared to breakeven EPS in the first quarter of 2023. Adjusted EPS was a loss of $0.02 per share for Q1. Moving forward to the year-end balance sheet, cash flow, and other financial metrics on Slide 16. We ended the quarter with $562 million in cash and $532 million in long-term debt, resulting in a $30 million net cash position. Adjusted free cash flow was $4 million for the quarter. That calculation of adjusted free cash flow, a non-GAAP measure, is based on our adjusted EBITDA less capital expenditures, which were $8 million and $4 million in the quarter, respectively. For Q1 2024, cash used in operations was $8 million primarily associated with the $20 million in planned retention payments associated with the 2-year anniversary of the MyChem acquisition. Capital expenditures, net of BARDA reimbursements, were $4 million in the quarter. We anticipate our quarterly 2024 capital expenditures to peak in Q2 of this year, corresponding with the final outfitting stage of our Flanders buildings. Depreciation and amortization was $12 million in the quarter, which is in line with our expectations and previous guidance. Interest expense net of interest income was $4 million in the quarter, slightly better than our expectations as our interest rate cap contract maintained higher values, and excess cash yields stayed high based on the evolving expectation that rates will not shift downward in 2024 as quickly as previously expected. Stock-based compensation, a noncash charge, was $12 million for the quarter, also in line with our expectations. We ended Q1 with 133 million Class A shares outstanding and 119 million Class B shares outstanding for a total of 252 million shares outstanding at the end of March on an as-if fully converted basis, in line with our expectations for Q1 and flat versus the same time a year ago. Next to Slide 17 and the discussion of segment performance in the quarter. Our Nucleic Acid Production segment, which includes both our discovery and GMP products and services marketed under our TriLink, Glen Research, and Alphazyme brands, had revenues in the first quarter of $46 million and adjusted EBITDA of $10 million, a margin of 22%, a lower margin than previous quarters as anticipated based on the lower revenue level over our cost base. Our Biologics Safety Testing segment, which includes products from our Cygnus brand, had revenues of $18 million in the first quarter and adjusted EBITDA of $14 million, a strong and consistent adjusted EBITDA margin of 77%. As detailed in these segment results, the combined adjusted EBITDA of our operating segments prior to the corporate shared service expenses was $24 million for Q1 2024, a combined margin of 37%. Corporate shared service expenses, including the impact adjusted EBITDA, which includes centralized functions such as human resources, finance and accounting, legal, IT and the incremental expenses associated with being a public company, totaled $60 million in the first quarter, down almost $2 million from the comparable first quarter of 2023. Let's move on to our current thinking around the full year of 2024 on Slide 18. Based on the solid start to the year and our assessment of the likely range of revenue outcomes, we are comfortable with existing 2024 total revenue guidance range of $265 million to $285 million in revenues. Looking at the segments, our Biologics Safety Testing business printed a strong $18 million first quarter, which we see as the high quarterly mark this year, consistent with previous years and achieving an overall load of mid-single-digit growth over 2023 for this segment. After taking this estimated range for the BST business of around $65 million to $70 million for the year, we expect the NAP segment will be roughly $200 million to $215 million for the year 2024. As for the cadence of estimated revenue, we estimate the first half of the year now carrying close to 50% of the year, up from our previous expectation of 47%, which, based on the midpoint of our full year range and the Q1 results, would result in a second quarter revenue estimate at about $73 million or so. So we see the top line firming up after a solid start and balancing the first and second half of the year. We anticipate that margin will expand from Q1 with the sequential increase in revenues as we have seen in the past. We see the range of our profitability metrics within the same range as our initial guidance, adjusted EBITDA margin expectations of 23% to 25% and our full-year adjusted EPS in the range of $0.00 per share to a $0.06 per share loss. Our guidance also holds the following expectations in 2024: interest expense net of interest income to be between $25 million and $30 million; depreciation and amortization between $40 million and $50 million; equity-based compensation, which we saw as the reconciling item from GAAP to non-GAAP EBITDA, to be between $45 million and $50 million; as-if fully converted share count of 254 million shares; and an adjusted effective tax rate of 24%. Finally, net capital expenditures of $30 million to $35 million in 2024. Overall, a solid start to the year.

I'll now turn the call back over to Trey. Thanks, Kevin. So to wrap up on Slide 20, we had a solid start to the year and are tracking against the revenue guidance range that we've communicated to you in March. We are executing on our return to growth strategy and year-to-date have introduced significant new innovations to the market that further extend our leadership across the entire mRNA production workflow as well as increasing our manufacturing capacity at our TriLink Flanders 1 and Flanders 2 facilities in these high-value areas. We have also strengthened our commercial team and continue to bolster our market leadership in the mRNA space through key industry and academic partnerships. Our TriLink, Glen Research, Alphazyme, and Cygnus brands all continue to lead their fields while pushing the boundaries of innovation to offer unique and even better solutions to solve customer problems and advance discoveries. Our balance sheet remains strong, and we are well positioned to execute on opportunities for inorganic investments to bolster our market position and provide our customers with additional solutions. We remain confident in the fundamental strength of our end markets and the value we provide our customers for the life-changing development of drug therapies, diagnostics, and novel vaccines. We remain committed to building a strong foundation for the long-term sustainable growth of our businesses. I would now like to turn the call back over to the operator to open the line for your questions. Thank you.

Your first question comes from Matt Hewitt with Craig-Hallum.

Congratulations on the strong start to the year. Maybe first up, congratulations on the Lonza contract. How should we be thinking about the ramp of that relationship? Is it something that will kind of build over time? Or is there an initial kind of an order flow that you would expect and then kind of stabilizing from there? Just help us walk through that relationship a little bit.

Sure. Thanks for the question. The arrangement with Lonza is similar to others we've announced where we just want to make sure that we open all avenues for customers' development programs to CleanCap and our other technologies. As you might guess, it's not an instant moment where things start up. It's an enablement that will take time to build, particularly you see in GMP services and particularly at the high level Lonza operates that these are contracts that are negotiated several quarters ahead of time typically. So we would expect a ramp in the consumption. But again, the idea is to make sure that there are many avenues toward incorporating our technologies, whether we are producing or others are.

That's great. And then maybe a separate follow-up question. I've been getting a lot of questions from investors asking about the Biosecure Act and the impact that this may or may not have on respective businesses. I'm just curious as it sounds like there's a markup meeting next week with the House. How would that impact your business if, in fact, that becomes law?

Well, there's definitely a lot of conversation about this. And like you say, it's not law yet. As we've looked at things, we have a significant proportion of our business in the U.S. and Europe. From the perspective of CDMO services, if something like that were to go into effect, we think it would essentially lead to a new equilibrium across geographies. As we are a majority U.S. and Europe, we would be able to participate in that.

Your next question comes from the line of Tejas Savant with Morgan Stanley.

I just want to follow up on that Lonza question from earlier, Trey. Can you just give us some color on how the deal came about? Was this an unsolicited inbound? Did Lonza consider alternatives as they chose Maravai? And has this contract win sparked further discussions with either pharma customers or other CDMOs? And does it come with any minimum volume commitments at all?

Great questions, Tejas. Let me hand that over to Becky, who is actually directly involved in those discussions. Becky, are you with us?

Yes. So look, I think this is really a broader strategy that we have. We see CDMOs as a very good channel for our GMP biomanufacturing materials. And to enable the adoption of CleanCap, we realized that there are customers that have many choices, and there are many choices to connect to us. Certainly, capacity, expertise, and desire, and different partnership structures that we can have with different CDMOs are all part of the driver of selection. So what we're looking to do is build enablement structures to partner with Tier 1 CDMOs that have a desire to partner with us. Yes, we have a contract with them, and there's typically a mutual agreement around wanting to bring CleanCap in as a platform technology and then have a glide path for customers to have ease of use with that CDMO and really streamline activities between the 2 companies and make it easier.

Got it. That's super helpful color. And then, Trey, one for you on the opening of the San Diego facility here. Is there a backlog of work that's already in place there or is building up the book of business still ahead of you? Just help us think through the capacity utilization ramp at the site. And what's the max sort of potential revenue that we can expect to see there over time?

Sure. There is definitely a buildup to be had because, in no small part, we did not have the late-phase clinical capabilities from an infrastructure point of view until the opening of the facility. But I will hand it to Drew, who has been living this life to give you some more color there.

We have received our first committed orders for that facility. As expected, it's a pipeline that we anticipate will continue to expand over time. Additionally, we have already secured contracts for late-phase mRNA builds at the facility.

Your next question comes from the line of Dan Leonard with UBS.

So I know it's gotten harder to unscramble the egg between what's COVID and what's non-COVID nowadays. But as best you can tell, did the base business, the non-COVID business with the Nucleic Acid Production, did that grow sequentially versus the fourth quarter?

Versus the fourth quarter?

Yes.

Well, and you're saying base non-COVID Q1 versus Q4?

Yes, best efforts because I know it's hard to unscramble that.

It is.

I mean, Dan, obviously, we're not breaking that out now, so I can't directly answer the question. What I would say to that, generally speaking, certainly, the Nucleic Acid Production business was down versus the fourth quarter sequentially as expected. One component of that were these GMP orders for CleanCap, which we had scheduled coming into this year. And that took a step down from the run rate we had been seeing throughout the course of 2023. That was the largest contributor to that sequential decline. I think that's the best way for me to answer that question.

I understand. I appreciate that. For my follow-up, I need some clarity on the gross margin line. You mentioned that margins were in line with your expectations, but it seems our model may not have been accurate. Additionally, costs of goods were higher than we anticipated and increased year-over-year, even with lower revenue. How should we approach understanding the progression of gross margins from this point onward?

Yes, certainly, Dan. Certainly, gross margin as well as our EBITDA margin will fluctuate predominantly based on revenues. When you really take that down to the next layer, it's within the Nucleic Acid Production segment, and even a layer lower tied to our manufacturing facilities here in San Diego, where we have the most substantial amount of fixed costs and overall labor. I think another component of that, that we saw here in the first quarter, which was relatively as anticipated, was just the mix. I mean we did have a lower overall CleanCap quarter versus some of the previous quarters we had seen. That's certainly a higher-margin product, particularly when we're doing it at higher volumes and in bulk to some of our larger pharma customers for their needs. So you'll see that margin ebb and flow a little bit with the overall volume of CleanCap. When you look back at the fourth quarter of '23 or the first quarter of '23, we had those larger CleanCap quarters; you see those gross margins higher. As we go into the second quarter, we do see a substantial increase in CleanCap based upon those contracted shipments that we have visibility to today. So lower revenue margin predominantly. I mentioned a little bit start-up costs related to Flanders. We do have some period costs to go through and revalidating new equipment and putting in disposable things, kits, and gloves and chemicals and other things needed. That was another part of it. You'll see the margin bounce around a little bit, and that really flows down overall to the EBITDA margin as well. But as we look forward, particularly here in the second quarter, we see that bouncing back and likely to be very consistent with some of what we saw in the fourth quarter of '23.

Your next question comes from the line of Catherine Schulte with Baird.

This is Tom Peterson on for Catherine. Just to start, I guess, we've heard from peers that there's perhaps a slower-than-normal budget release from pharma this year. I guess did you see any of these dynamics in the quarter, particularly just any atypical phasing that you saw in the first quarter?

Sure. With our two different segments, there are varying dynamics. Typically, in BST, we reach our peak in the first quarter. This is primarily due to calendar budgets, pharmaceutical program planning, and consequently, CDMO program planning. In NAP, we did observe some of that. I'll pass it over to Drew for more details.

Yes. I would say we saw a couple of different dynamics. It's a little tough to disentangle. I think we're seeing some rationalization, both among big pharma and small pharma. That said, we also saw some situations where people are continuing to push pipelines ahead. We saw a stronger funding environment in the public and the venture capital markets. So a little bit of cross currents. I don't think in our business, we see any discernible trends from that. We assume it's probably going to take a bit of time before those funding dynamics, the strengthening in funding shows up in orders. But that's how I would characterize the environment.

Okay. That's helpful. And then maybe just one for Kevin on some of the cost actions and restructuring. How rightsized do you feel that the incorporating cost structure is today, given some of the comments around some of the commercial focus on today's call? Should we be thinking about any kind of incremental actions in '24 in either direction? And should we still be thinking about kind of $26 million of net benefit from the cost action here in '24?

Yes, I think definitely. We are targeting around $30 million in cost actions, with about two-thirds of that related to labor, and those have all been implemented. Given the adjustments in headcount and the metrics I mentioned, we will continue to invest strategically in commercial areas. I believe we will see that reflected in our R&D investments as we make incremental contributions throughout the year. To clarify, instead of reducing our costs from 200 units to 170 units, we aimed to prevent our costs from rising to what they could have been, around 240 or closer to 210. We aimed to lower our run rate while still ensuring we invested in R&D for innovation purposes. We have made notable progress in commercial areas, including Alphazyme and Cygnus, which are both performing well and growing. Our primary focus was on reducing costs in G&A and right-sizing operations at our San Diego facility, while also reallocating some labor to meet the increasing demand expected from Flanders 2. It has been a concentrated effort, and we are pleased with our execution and on track to achieve the savings we discussed.

Your next question comes from the line of Matthew Sykes with Goldman Sachs.

This is Evie on for Matt. Could you walk through the current GMP to RUO split and how you see that trending throughout this year with the new facilities coming online?

Yes, I can address that. It’s not something we typically break out, but when we analyze our business, especially in Nucleic Acid Production, we view it from various angles. We have our business units which include our Alphazyme segment, which is showing consistent growth and strong performance. Our Glen Research unit, which mainly focuses on diagnostic sequencing and related applications, is also performing exceptionally well. Within our TriLink products, we distinguish between the discovery and the research-use-only segments, as well as our GMP offerings. Throughout the year, discovery has remained fairly constant and will be somewhat stable, whereas GMP tends to have more variability. The GMP side involves larger orders and bulk purchases, and is driven by recurring customers. This is why we manage those segments differently. In GMP, we may experience fluctuations due to large bulk orders for CleanCap or specific GMP mRNA projects. Moving forward, particularly with our Flanders capabilities, we see opportunities for growth. Currently, the distribution within TriLink this quarter is quite balanced, but we anticipate changes next quarter due to upcoming GMP projects and an increase in CleanCap orders already booked for the second quarter.

I agree with that assessment. We anticipate that the discovery business will become more extensive and diversified, and as Kevin mentioned, it will involve lower ticket items, which likely means less volatility. GMP will continue to experience the typical fluctuations associated with late-phase pharmaceuticals. Therefore, we don’t necessarily view the business through that lens. As Kevin indicated, we manage TriLink Discovery and TriLink GMP independently. Given the nature of GMP, it is significantly influenced by large order variations, so the proportion can change significantly over time. This is something that needs to be monitored over longer durations.

Okay. Definitely, that makes sense. And then second, on the EBITDA margin, could you talk about what an exit rate might look like compared to last year? I know there's a lot of puts and takes with less COVID volume but also taking into consideration some of the cost savings. So I guess just thinking about the cadence, especially as we get into like Q4 and then into 2025?

Yes, with revenue being low in the first quarter compared to previous periods, we see this reflected in a lower EBITDA margin, the lowest in the last five quarters. However, we anticipate growth. To simplify, if we refer to the midpoints of our guidance, we're expecting average revenue of around $71 million for the next few quarters and an average EBITDA of about $19 million. This would result in average EBITDA margins of approximately 27 percent over the next three quarters, although there will be some fluctuations related to quarterly movements in CleanCap and our higher-margin products. Looking ahead, we expect the second quarter revenue to be in the low 70s with a significantly higher margin, and we will reassess the remainder of the year as we progress. Currently, we aim to return to the margins we saw at the end of Q4, targeting a range of 25 to 30 percent, closely tied to our revenue profile, particularly in the NAP segment.

Your next question comes from the line of Matt Larew with William Blair.

First question, Trey, you talked about a litany of new product and service offerings, which has been the theme over the last year. But obviously, the top line impact maybe hasn't been apparent just because of the broader headwinds your business is facing. Could you maybe help us point to one or multiple of those products you see as the most potentially needle-moving in terms of helping to inflect the top line, be it from traction you're seeing with customers, most promising funnel building, maybe where you have the most apparent right to win just because there's so much new that's going on? Help us focus in on what you see as most meaningful.

Yes, absolutely. That's a good way to look at it actually, and it sort of dovetails into the previous question about the business dynamics that are different between the discovery business, which is where those mRNA catalog products we announced here. They sit in discovery/RUO versus, of course, GMP services, where we do contract mRNA production for people, but also where GMP CleanCap and other process inputs sit. I would say probably the most needle-moving and most exciting over the past year, we are, I guess, about to hit the 1-year anniversary of the launch of CleanCap M6, which was an RUO product. I would say that that product exceeded our initial expectations pretty significantly. As we just announced taking that to GMP where we've already run an engineering batch, we will hit GMP M6 within a year of the launch of the RUO product, and that's pretty exceptional. Of course, the historical participation of this company in pandemic vaccines and other things comes from the GMP reagents space. So those are definitely needle movers. I would say that probably the most exciting and needle-moving of the NPIs is a great example because it was an RUO from almost exactly a year ago and now will be GMP going forward shortly here.

Okay. I have a question for Kevin regarding the trend of general and administrative expenses. In the last call, you mentioned G&A expenses being down about 5% for the full year, and we've certainly projected a decrease on a sequential basis. While you mentioned some one-time factors, it seems that to reach the upper 20s EBITDA margin range, especially considering the gross margins you discussed, there would need to be a significant reduction in G&A in the second quarter and continuing thereafter. Is that still accurate? Also, could you remind us of the changes from Q4 to Q1 and from Q1 to Q2?

Yes. I think that one of the things you have to obviously carve out of there are the non-EBITDA impacting items. That's certainly part of that view. When you look at the adjusted G&A expense for the first quarter here versus where we were a year ago, that is down just under 20% year-over-year on the expenses to hit the EBITDA line. So I think we're very happy with the progress we're making there and have made and see that as a steady run rate to achieve that full-year savings.

Your next question comes from the line of Michael Ryskin with Bank of America Securities.

This is Bob Chen on for Mike. I wanted to touch back on the biotech funding line of questioning. Understandably, an uptick in biotech funding isn't going to immediately become revenues for Maravai, but I'm interested in your thinking around are you seeing this reflected in your conversations? Or how should we think about the lag between an improvement in the end market and then that translating into your order book and eventually revenues?

Yes. We mentioned that the improvement in that environment will be beneficial in the future, although it won't happen immediately. Drew, do you have any insights or anonymized examples to share?

Yes, sure. Look, I think every customer has their own journey, translating through their new funding where they have achieved such into new clinical plans, putting those to work, purchasing raw material inputs or purchasing mRNA. It's going to be a variety of time. I think we landed where we expected to land for Q1 or maybe a little bit stronger. We haven’t seen any dramatic change as a result of the funding in aggregate, but every customer journey is maybe a little bit exposed.

Thank you for the insights. I'd like to shift gears a bit. I noticed you mentioned your willingness to consider mergers and acquisitions several times during the presentation. Are there specific areas within your portfolio that you believe are particularly ripe for such additions? Also, what are you observing regarding seller expectations for valuations now that the overall sector has begun to recover?

Very insightful question. We have definitely been active. One of the tricks with all of this is that we can't really talk about it until it's official. One of the things I would say is we have seen a tremendous number of things that are strategically aligned. That's what we look for first. The challenge to date has been finding strategically aligned opportunities that are also financially aligned. Our specialty at Maravai has been scientific founder-driven category-leading companies. We think that's a very good niche that we fill, and there are certainly plenty of opportunities to do that. Your comment is correct about expectations. This has been such a dynamic environment with the pandemic, with the pandemic falloff, with interest rates, with funding. It has been head-spinning, to be sure. The challenge, I would say, for us has not been a challenge of finding strategically aligned opportunities but more so financially aligned. We continue to look for that right fit, and we're definitely still very active in that area.

Your next question comes from the line of Conor McNamara with RBC Capital Markets.

This is David Carter on for Conor. I just wanted to touch on what the step-up in volume and revenue is for customers as they move up in clinical trials? For your Flanders 2 as it comes up.

Okay.

For your Flanders 2 as it comes up.

Yes. I mean this comes back a little bit to the prior theme. In RUO, you have PO sizes in the 5 to 6 figures, sometimes in the 7 figures. In GMP, you typically start in the 6 figures and go into the 7 or even 8 figures, but it's completely program-dependent. When you sell a GMP reagent, for example, it's simply a function of scale. But when you do a contract mRNA service under GMP, each and every program is unique, bespoke. It completely depends on yield, purity, analytical services, and all sorts of other elements. They're all custom quoted. Unfortunately, if I understand your question correctly, there's not necessarily a standard expectation there. Those are big line items, and they're big projects, but they're all very different.

Could you also provide some color on the impact of the Thermo CleanCap partnership that you announced in relation to the message?

What was the last part of that, sorry? Thermo partnership?

The Thermo including your MCAP in their in vitro transcription kits?

Yes. Okay. So that's another example, I would say, of our wanting to make sure that we are seeding the market with our technology, whether the discovery market or the GMP market. That's another public license where Thermo is licensed to incorporate chemistries in their in vitro transcription kits. This is one of the many ways that developers will get mRNA in their own hands. In that case, they might have to template themselves and run the IVT process on the bench. That's an RUO-only application. But that's, I think, just another of the broad examples of our trying to make sure that we have broad accessibility for all our technical solutions in the market.

That concludes our Q&A session. I will now turn the conference over to Debbie Hart.

Great. Well, thank you, everyone, for joining us today. We'll be attending several conferences in the coming months. So I encourage you to look at our Events section of our website. And hopefully, we can catch up with you in person at one of those events. Feel free to connect with us with any further questions, and we hope you have a great evening. Good night.

Ladies and gentlemen, that concludes today's call. Thank you all for joining. You may now disconnect.