PRF Technologies Ltd 6-K, filed Dec 2, 2025
PRF Technologies Ltd. (PRFX)
6-K
2025-12-02
For: 2025-12-02
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Added on
April 10, 2026
About this 6-K
PRF Technologies Ltd filed this 6-K on December 2, 2025.
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Form 6-K
Report of Foreign Private Issuer
Pursuant to Rule 13a-16 or 15d-16
of the Securities Exchange Act of 1934
For the month of December 2025
Commission File Number: 001-39481
PainReform Ltd.
(Translation of registrant’s name into English)
65 Yigal Alon St., Tel Aviv 6744316
Israel
(Address of principal executive offices)
Indicate by check mark whether the registrant files or will file annual reports under cover Form 20-F or Form 40-F.
Form 20-F ☒ Form 40-F ☐
On December 2, 2025, PainReform Ltd. issued a press release entitled “PainReform Commences Development for OcuRing™-K Phase II Trial,
LayerBio’s Drop-Less Sustained-Release Ocular Therapy”. A copy of the press release is attached hereto as Exhibit 99.1 and incorporated herein by reference.
Exhibit Index
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Exhibit No.
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Description
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SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf
by the undersigned, thereunto duly authorized.
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Date: December 2, 2025
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PAINREFORM LTD.
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By:
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/s/ Ehud Geller
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Ehud Geller
Executive Chairman of the Board and Interim Chief Executive Officer
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Exhibit 99.1
PainReform Commences Development for OcuRing™-K Phase II Trial,
LayerBio’s Drop-Less Sustained-Release Ocular Therapy
Development plan positions OcuRing™-K for advancement in the fast-growing, multi-
billion-dollar global cataract surgery market
Tel Aviv – December 2, 2025 — PainReform Ltd. (Nasdaq: PRFX) today announced, through its pharmaceutical division, the commencement of its
development plan for OcuRing™-K, LayerBio’s patented, drop-less, intraoperatively administered sustained-release ocular therapy designed to deliver controlled, site-specific release of ketorolac following cataract surgery. Following the closing of
PainReform’s majority investment in LayerBio and the integration of OcuRing-K into PainReform’s development portfolio, the Company conducted a methodical internal assessment with LayerBio’s management team to define development priorities and
establish a clear path for advancing the program. Work is now progressing toward the Phase II clinical trial.
OcuRing-K is an erodible, intraoperatively administered sustained-release device designed to provide extended and consistent intraocular therapeutic levels of
an NSAID (non-steroidal, non-opiate, anti-inflammatory analgesic). LayerBio’s technology is designed to address major limitations of traditional postoperative eye-drop regimens, which typically require multiple daily steroid and NSAID drops for
several weeks and deliver only a small fraction—often less than 5%—of the drug inside the eye. OcuRing-K is designed to eliminate this drop-dependent approach through a single, intraoperative, sustained-release therapy.
This inefficient delivery of eye drops produces sharp fluctuations in drug levels, increasing the potential for inconsistent efficacy and side effects. In
contrast, OcuRing-K’s in-situ depot formulation provides direct, localized delivery to target tissues with markedly lower systemic exposure, offering controlled and stable therapeutic coverage compared to conventional eye drops. By removing the need
for patient-administered drops, OcuRing-K also reduces contamination risks, such as inadvertent contact between dropper bottles and ocular tissues.
Preclinical studies and a Phase I clinical evaluation demonstrated reductions in post-surgical pain and inflammation while using significantly lower total
drug exposure than standard eye-drop regimens. The sustained-release kinetics of OcuRing-K maintained therapeutic levels over time, supporting the potential for improved ocular safety, reduced systemic side effects associated with high-volume topical
dosing, and enhanced patient compliance, particularly among elderly populations.
Cataract surgery is one of the most common procedures worldwide, with approximately 4.5 million surgeries performed annually in the United States and more
than $9 billion in global annual surgical procedure volume. Current postoperative management depends heavily on multi-week corticosteroid and NSAID eye-drop regimens—treatments that are burdensome for elderly patients and often delivered
inconsistently to ocular tissues. These limitations have contributed to growing clinical interest in drop-less approaches designed to simplify recovery and improve treatment consistency.
LayerBio’s sustained-release platform also supports delivery of a wide range of other ocular therapeutics—including NSAIDs, antibiotics, steroids, and
anti-VEGF agents—aligning with PainReform’s plans to explore additional ophthalmic indications following the development of OcuRing-K.
“Our plan identifies post-cataract pain and inflammation as the initial target indication for OcuRing-K. Commencing the development plan for OcuRing-K and advancing work toward
the next clinical trial marks a key milestone in our strategy to deliver meaningful, drop-less solutions to one of the most common and impactful surgical procedures worldwide,” said Ehud Geller, Chairman of PainReform. “LayerBio’s data demonstrate
the potential of this sustained-release depot technology to provide consistent pain and inflammation control with significantly lower drug exposure than traditional drops. With this plan in place, PainReform is well positioned to advance OcuRing-K
into its next phase of development.”
As previously announced, PainReform and LayerBio plan to advance OcuRing-K through its next stage of clinical development in the United States, where approval
could unlock a high-volume reimbursable market and enable expansion across additional ophthalmic indications.
OcuRing-K continues to be led by Dr. Ken Mandell, LayerBio’s founder and Chief Executive Officer, a Harvard-trained ophthalmologist and biotechnology
innovator with more than a dozen INDs and multiple Phase 1–3 ophthalmic trials to his credit.
PainReform will provide further updates as the OcuRing-K program advances.
About PainReform
PainReform Ltd. (Nasdaq: PRFX) is a company focused on the reformulation of established therapeutics, and a developer of AI-driven energy optimization technologies through its DeepSolar platform. The
Company’s pharmaceutical programs leverage a proprietary extended-release drug-delivery system intended to provide prolonged post-surgical pain relief while minimizing the need for repeated dosing and reducing reliance on opioids. Through DeepSolar,
PainReform also delivers advanced software solutions that enable both consumers and enterprises to monitor, forecast, and optimize energy consumption—particularly in solar-integrated environments. This dual business model reflects PainReform’s
strategic commitment to applying precision technology across high-impact sectors including healthcare and sustainable energy. For more information, please visit www.painreform.com.
Notice Regarding Forward-Looking Statements
This press release contains forward-looking statements about PainReform’s expectations, beliefs and intentions including with respect to the development plan for OcuRing-K and its plans for the
commencement of clinical trials. Forward-looking statements can be identified by the use of forward-looking words such as “believe”, “expect”, “intend”, “plan”, “may”, “should”, “could”, “might”, “seek”, “target”, “will”, “project”, “forecast”,
“continue” or “anticipate” or their negatives or variations of these words or other comparable words or by the fact that these statements do not relate strictly to historical matters. These forward-looking statements are based on assumptions and
assessments made in light of management’s experience and perception of historical trends, current conditions, expected future developments and other factors believed to be appropriate. Forward-looking statements in this press release are made as of
the date of this press release, and we undertake no duty to update or revise any such statements, whether as a result of new information, future events or otherwise. Forward-looking statements are not guarantees of future performance and are
subject to risks and uncertainties, many of which are outside of our control. Many factors could cause our actual activities or results to differ materially from the activities and results anticipated in forward- looking statements, including, but
not limited to, the following: our ability to continue as a going concern, our history of significant losses, our need to raise additional capital and our ability to obtain additional capital on acceptable terms, or at all; our dependence on the
success of our initial product candidate, PRF-110 OcuRing™-K, LayerBio Inc.’s lead product candidate, and the commercialization of the DeepSolar solution; the outcomes of preclinical studies, clinical trials and other research regarding PRF-110,
OcuRing™-K and future product candidates; our limited experience managing clinical trials; our ability to retain key personnel and recruit additional employees; our reliance on third parties for the conduct of clinical trials, product manufacturing
and development; the impact of competition and new technologies; our ability to comply with regulatory requirements relating to the development and marketing of our product candidates; our ability to establish and maintain strategic partnerships
and other corporate collaborations; the implementation of our business model and strategic plans for our business and product candidates; the scope of protection we are able to establish and maintain for intellectual property rights and our ability
to operate our business without infringing the intellectual property rights of others; the overall global economic environment; our ability to develop an active trading market for our ordinary shares and whether the market price of our ordinary
shares is volatile; our ability to maintain our listing on the Nasdaq Capital Market; and statements as to the impact of the political and security situation in Israel on our business. More detailed information about the risks and uncertainties
affecting us is contained under the heading “Risk Factors” included in the Company’s most recent Annual Report on Form 20-F and in other filings that we have made and may make with the Securities and Exchange Commission in the future.
Contact:
Crescendo Communications, LLC
Tel: 212-671-1021
Email: prfx@crescendo-ir.com
Dr. Ehud Geller
Chairman and interim Chief Executive Officer
PainReform Ltd.
Tel: +972-54-4236711
Email: egeller@medicavp.com