GREAT POINT PARTNERS LLC

CIK

1281446

Location

Greenwich, CT

Portfolio Value

Small $237,565,982

Diversification

Diversified

Filing Date

Global Rank

#3,827 / 7,976 ▲ 854

Top Industry

Biotechnology 90.3%

3Y Alpha vs SPY

-4.3%

Period ended 9 months ago

Filed Nov 14, 2025 · 7mo

23 quarters · since Mar 2020

Clone Performance

Jun 2023–Jun 2026 · vs SPY

Hypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.

Cloned portfolio

+60.2%

SPY

+76.5%

Annualised alpha

-3.8%

Max drawdown

−61.9%

Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.

Portfolio Concentration

29 positions · as of Sep 30, 2025 · Δ vs Jun 30, 2025

Top Position

9.7%

−3.7 pts

Top 5

40.0%

−6.7 pts

Top 10

64.6%

−5.2 pts

HHI

537

Diversified−107

Portfolio Trend

23 quarters · across all stocks

Sector Breakdown

As of Sep 30, 2025

Sector	% Portfolio	Value	Positions
Healthcare	100.0%	$237,565,982	29

Last Quarter's Activity

Export CSV

Sep 30, 2025 vs Jun 30, 2025

Added To

Positions the filer increased

4 positions

Ticker	Company	Δ Shares	Shares	Value
ZURA	Zura Bio Ltd	+645,736	3,815,930	$16,522,976
IMVT	Immunovant, Inc.	+237,824	500,000	$8,060,000
JBIO	Jade Biosciences, Inc.	+134,545	632,599	$5,459,329
DBVT	DBV Technologies S.A.	+3,915	378,594	$3,785,940
No positions match the current search.

Trimmed

Positions the filer reduced

6 positions

Ticker	Company	Δ Shares	Shares	Value
ABVX	Abivax S.A.	−1,141,617	150,000	$12,735,000
RZLT	Rezolute, Inc.	−581,653	2,451,809	$23,047,004
IONS	Ionis Pharmaceuticals Inc	−420,000	80,000	$5,233,600
AMLX	Amylyx Pharmaceuticals, Inc.	−300,000	1,700,000	$23,103,000
LEGN	Legend Biotech Corp	−236,540	113,460	$3,699,930
NGNE	Neurogene Inc.	−39,045	446,814	$7,743,286
No positions match the current search.

New Positions

Positions the filer opened this quarter

12 positions

Ticker	Company	Shares	Value
NKTR	Nektar Therapeutics	300,000	$17,070,000
SLNO	Soleno Therapeutics Inc	225,000	$15,210,000
ASND	Ascendis Pharma A/S	75,000	$14,910,750
APGE	Apogee Therapeutics, Inc.	304,000	$12,077,920
DNTH	Dianthus Therapeutics, Inc. /DE/	265,803	$10,459,348
EPRX	Eupraxia Pharmaceuticals Inc.	1,200,000	$7,080,000
PHVS	Pharvaris N.V.	155,105	$3,869,869
ORKA	Oruka Therapeutics, Inc.	183,330	$3,525,435
SANA	Sana Biotechnology, Inc.	700,000	$2,485,000
ABSI	Absci Corp	796,438	$2,421,171
HRMY	Harmony Biosciences Holdings, Inc.	85,000	$2,342,600
CAPR	Capricor Therapeutics, Inc.	87,700	$632,317
No positions match the current search.

Sold Out

Positions the filer fully exited

6 positions

Ticker	Company	Shares	Value
AKBA	Akebia Therapeutics, Inc.	1,985,915	$7,228,730
EOLS	Evolus, Inc.	720,118	$6,632,286
ACLX	Arcellx, Inc.	100,000	$6,585,000
KALV	KalVista Pharmaceuticals, Inc.	323,170	$3,653,436
CNTA	Centessa Pharmaceuticals plc	225,000	$2,956,500
SRRK	Scholar Rock Holding Corp	61,607	$2,182,119
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

29 positions · $237,565,982 total · as of Sep 30, 2025

All sectors Healthcare

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
AMLX	Amylyx Pharmaceuticals, Inc. Healthcare	Reduced	1,700,000	-300,000	$23,103,000	+80.2%	9.72%
RZLT	Rezolute, Inc. Healthcare	Reduced	2,451,809	-581,653	$23,047,004	+70.3%	9.70%
NKTR	Nektar Therapeutics Healthcare	NEW	300,000	NEW	$17,070,000	NEW	7.19%
ZURA	Zura Bio Ltd Healthcare	Added	3,815,930	+645,736	$16,522,976	+396.4%	6.96%
SLNO	Soleno Therapeutics Inc Healthcare	NEW	225,000	NEW	$15,210,000	NEW	6.40%
ASND	Ascendis Pharma A/S Healthcare	NEW	75,000	NEW	$14,910,750	NEW	6.28%
ABVX	Abivax S.A. Healthcare	Reduced	150,000	-1,141,617	$12,735,000	+28.9%	5.36%
APGE	Apogee Therapeutics, Inc. Healthcare	NEW	304,000	NEW	$12,077,920	NEW	5.08%
DNTH	Dianthus Therapeutics, Inc. /DE/ Healthcare	NEW	265,803	NEW	$10,459,348	NEW	4.40%
CYTK	Cytokinetics Inc Healthcare	Held	150,000	0	$8,244,000	+66.3%	3.47%
IMVT	Immunovant, Inc. Healthcare	Added	500,000	+237,824	$8,060,000	+92.1%	3.39%
XENE	Xenon Pharmaceuticals Inc. Healthcare	Held	200,000	0	$8,030,000	+28.3%	3.38%
NGNE	Neurogene Inc. Healthcare	Reduced	446,814	-39,045	$7,743,286	+6.6%	3.26%
EPRX	Eupraxia Pharmaceuticals Inc. Healthcare	NEW	1,200,000	NEW	$7,080,000	NEW	2.98%
UPB	Upstream Bio, Inc. Healthcare	Held	300,000	0	$5,643,000	+71.3%	2.38%
JBIO	Jade Biosciences, Inc. Healthcare	Added	632,599	+134,545	$5,459,329	+9.7%	2.30%
IONS	Ionis Pharmaceuticals Inc Healthcare	Reduced	80,000	-420,000	$5,233,600	−73.5%	2.20%
TSHA	Taysha Gene Therapies, Inc. Healthcare	Held	1,500,000	0	$4,905,000	+41.6%	2.06%
CNTX	Context Therapeutics Inc. Healthcare	Held	4,683,711	0	$4,538,515	+47.9%	1.91%
PHVS	Pharvaris N.V. Healthcare	NEW	155,105	NEW	$3,869,869	NEW	1.63%
DBVT	DBV Technologies S.A. Healthcare	Added	378,594	+3,915	$3,785,940	+10.3%	1.59%
LEGN	Legend Biotech Corp Healthcare	Reduced	113,460	-236,540	$3,699,930	−70.2%	1.56%
ORKA	Oruka Therapeutics, Inc. Healthcare	NEW	183,330	NEW	$3,525,435	NEW	1.48%
UNCY	Unicycive Therapeutics, Inc. Healthcare	Reduced	796,558	-796,558	$3,472,992	−54.3%	1.46%
SANA	Sana Biotechnology, Inc. Healthcare	NEW	700,000	NEW	$2,485,000	NEW	1.05%
ABSI	Absci Corp Healthcare	NEW	796,438	NEW	$2,421,171	NEW	1.02%
HRMY	Harmony Biosciences Holdings, Inc. Healthcare	NEW	85,000	NEW	$2,342,600	NEW	0.99%
PLRX	Pliant Therapeutics, Inc. Healthcare	Held	850,000	0	$1,258,000	+27.6%	0.53%
CAPR	Capricor Therapeutics, Inc. Healthcare	NEW	87,700	NEW	$632,317	NEW	0.27%