CTNM · Contineum Therapeutics, Inc.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

Options granted under the Issuer's 2012 Equity Incentive Plan (the "Plan"). The option is fully vested.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.00 to $16.06, inclusive. The reporting person undertakes to provide to Issuer, any security holder of Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote to this Form 4.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

The stock options are fully vested and exercisable.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

The stock options are fully vested and exercisable.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

Options granted under the Issuer's 2012 Equity Incentive Plan (the "Plan"). The option is fully vested.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $15.15 to $16.14, inclusive. The reporting person undertakes to provide to Issuer, any security holder of Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote to this Form 4.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.16 to $16.40, inclusive. The reporting person undertakes to provide to Issuer, any security holder of Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote to this Form 4.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

The stock options are fully vested and exercisable.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

Options granted under the Issuer's 2012 Equity Incentive Plan (the "Plan"). The option is fully vested.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.00 to $16.35, inclusive. The reporting person undertakes to provide to Issuer, any security holder of Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote to this Form 4.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

The stock options are fully vested and exercisable.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

Options granted under the Issuer's 2012 Equity Incentive Plan (the "Plan"). The option is fully vested.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

One-half of the option shares vested on October 28, 2025, and the remainder vests in 36 equal monthly installments thereafter, subject to the Reporting Person's continuous service.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.00 to $16.12, inclusive. The reporting person undertakes to provide to Issuer, any security holder of Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote to this Form 4.

Includes 5,605 shares of the Issuer's Class A Common Stock acquired by the Reporting Person in one or more transactions with the Issuer pursuant to its Employee Stock Purchase Plan, which transactions are exempt pursuant to Rules 16a3(f)(1)(i)(B) and 16b3(c).

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.00 to $16.15, inclusive. The reporting person undertakes to provide to Issuer, any security holder of Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote to this Form 4.

Includes 8,961 shares of the Issuer's Class A Common Stock acquired by the Reporting Person in one or more transactions with the Issuer pursuant to its Employee Stock Purchase Plan, which transactions are exempt pursuant to Rules 16a3(f)(1)(i)(B) and 16b3(c).

Options granted under the Issuer's 2024 Equity Incentive Plan (the "Plan"), pursuant to the Issuer's Non-Employee Director Compensation Program, as amended, which states that upon the conclusion of each regular annual meeting of the Company's stockholders, each non-employee director who continues to serve as a member of the Company's Board of Directors thereafter will automatically be granted a stock option under the Plan for 19,000 shares of the Company's Class A Common Stock. Option will vest in full on the earlier of (i) June 26, 2027, the one-year anniversary of the date of grant, or (ii) the next regular annual meeting of stockholders, subject to the Reporting Person's continuous service.

Options granted under the Issuer's 2024 Equity Incentive Plan (the "Plan"), pursuant to the Issuer's Non-Employee Director Compensation Program, as amended, which states that upon the conclusion of each regular annual meeting of the Company's stockholders, each non-employee director who continues to serve as a member of the Company's Board of Directors thereafter will automatically be granted a stock option under the Plan for 19,000 shares of the Company's Class A Common Stock. Option will vest in full on the earlier of (i) June 26, 2027, the one-year anniversary of the date of grant, or (ii) the next regular annual meeting of stockholders, subject to the Reporting Person's continuous service.

Options granted under the Issuer's 2024 Equity Incentive Plan (the "Plan"), pursuant to the Issuer's Non-Employee Director Compensation Program, as amended, which states that upon the conclusion of each regular annual meeting of the Company's stockholders, each non-employee director who continues to serve as a member of the Company's Board of Directors thereafter will automatically be granted a stock option under the Plan for 19,000 shares of the Company's Class A Common Stock. Option will vest in full on the earlier of (i) June 26, 2027, the one-year anniversary of the date of grant, or (ii) the next regular annual meeting of stockholders, subject to the Reporting Person's continuous service.

Options granted under the Issuer's 2024 Equity Incentive Plan (the "Plan"), pursuant to the Issuer's Non-Employee Director Compensation Program, as amended, which states that upon the conclusion of each regular annual meeting of the Company's stockholders, each non-employee director who continues to serve as a member of the Company's Board of Directors thereafter will automatically be granted a stock option under the Plan for 19,000 shares of the Company's Class A Common Stock. Option will vest in full on the earlier of (i) June 26, 2027, the one-year anniversary of the date of grant, or (ii) the next regular annual meeting of stockholders, subject to the Reporting Person's continuous service.

Options granted under the Issuer's 2024 Equity Incentive Plan (the "Plan"), pursuant to the Issuer's Non-Employee Director Compensation Program, as amended, which states that upon the conclusion of each regular annual meeting of the Company's stockholders, each non-employee director who continues to serve as a member of the Company's Board of Directors thereafter will automatically be granted a stock option under the Plan for 19,000 shares of the Company's Class A Common Stock. Option will vest in full on the earlier of (i) June 26, 2027, the one-year anniversary of the date of grant, or (ii) the next regular annual meeting of stockholders, subject to the Reporting Person's continuous service.

Options granted under the Issuer's 2024 Equity Incentive Plan (the "Plan"), pursuant to the Issuer's Non-Employee Director Compensation Program, as amended, which states that upon the conclusion of each regular annual meeting of the Company's stockholders, each non-employee director who continues to serve as a member of the Company's Board of Directors thereafter will automatically be granted a stock option under the Plan for 19,000 shares of the Company's Class A Common Stock. Option will vest in full on the earlier of (i) June 26, 2027, the one-year anniversary of the date of grant, or (ii) the next regular annual meeting of stockholders, subject to the Reporting Person's continuous service.

Options granted under the Issuer's 2024 Equity Incentive Plan (the "Plan"), pursuant to the Issuer's Non-Employee Director Compensation Program, as amended, which states that upon the conclusion of each regular annual meeting of the Company's stockholders, each non-employee director who continues to serve as a member of the Company's Board of Directors thereafter will automatically be granted a stock option under the Plan for 19,000 shares of the Company's Class A Common Stock. Option will vest in full on the earlier of (i) June 26, 2027, the one-year anniversary of the date of grant, or (ii) the next regular annual meeting of stockholders, subject to the Reporting Person's continuous service.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $12.995 to $13.360, inclusive. The reporting person undertakes to provide to Issuer, any security holder of Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote to this Form 4.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $12.69 to $13.57, inclusive. The reporting person undertakes to provide to Issuer, any security holder of Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote to this Form 4.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $13.79 to $13.86, inclusive. The reporting person undertakes to provide to Issuer, any security holder of Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote to this Form 4.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $13.08 to $13.60, inclusive. The reporting person undertakes to provide to Issuer, any security holder of Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote to this Form 4.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

One-half of the option shares vested on October 28, 2025, and the remainder vests in 36 equal monthly installments thereafter, subject to the Reporting Person's continuous service.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $14.60 to $15.41, inclusive. The reporting person undertakes to provide to Issuer, any security holder of Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote to this Form 4.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $14.60 to $15.41, inclusive. The reporting person undertakes to provide to Issuer, any security holder of Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote to this Form 4.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

The stock options are fully vested and exercisable.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.00 to $16.05, inclusive. The reporting person undertakes to provide to Issuer, any security holder of Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote to this Form 4.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

The stock options are fully vested and exercisable.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.00 to $16.05, inclusive. The reporting person undertakes to provide to Issuer, any security holder of Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote to this Form 4.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

The stock options are fully vested and exercisable.

These transactions were effected pursuant to a 10b5-1 trading plan adopted by the reporting person on September 23, 2025.

The stock options are fully vested and exercisable.