GRAL · GRAIL, Inc. · Insider Trading

Represents automatic 'sell-to-cover' transactions by an executing broker to cover withholding taxes upon award vesting and share delivery. The price reported in Column 4 is a weighted average price calculated by the broker executing these transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

Represents automatic 'sell-to-cover' transactions by an executing broker to cover withholding taxes upon award vesting and share delivery. The price reported in Column 4 is a weighted average price calculated by the broker executing these transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $93.89 to $94.33 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote

The sale transactions reported in this Form 4 are made pursuant to a Rule 10b5-1 trading plan adopted on December 11, 2025

Represents an option originally granted on March 6, 2020 for which the performance condition was determined to be met on November 1, 2024. The option vests and becomes exercisable in thirty-six substantially equal monthly installments beginning December 1, 2024. As of September 21, 2026, approximately 61% of the shares subject to the option had vested, and the remaining approximately 39% of the shares vests over the remaining period afterwards.

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $100.68 to $100.69 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote

The sale transactions reported in this Form 4 are made pursuant to a Rule 10b5-1 trading plan adopted on December 2, 2025

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $93.04 to $93.90 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote

The sale transactions reported in this Form 4 are made pursuant to a Rule 10b5-1 trading plan adopted on December 2, 2025

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $92.19 to $93.00 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote

The sale transactions reported in this Form 4 are made pursuant to a Rule 10b5-1 trading plan adopted on December 11, 2025

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $92.04 to $92.93 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote

The sale transactions reported in this Form 4 are made pursuant to a Rule 10b5-1 trading plan adopted on December 2, 2025

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $96.00 to $96.71 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote

The sale transactions reported in this Form 4 are made pursuant to a Rule 10b5-1 trading plan adopted on December 2, 2025

The sale transactions reported in this Form 4 are made pursuant to a Rule 10b5-1 trading plan adopted on December 2, 2025

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $94.5 to $95.00 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote

The sale transactions reported in this Form 4 are made pursuant to a Rule 10b5-1 trading plan adopted on December 2, 2025

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $99.42 to $100.28 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote

The sale transactions reported in this Form 4 are made pursuant to a Rule 10b5-1 trading plan adopted on December 2, 2025

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $97.74 to $98.00 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote

The sale transactions reported in this Form 4 are made pursuant to a Rule 10b5-1 trading plan adopted on December 2, 2025

The sale transactions reported in this Form 4 are made pursuant to a Rule 10b5-1 trading plan adopted on December 11, 2025

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $85.00 to $85.11 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $85.00 to $85.11 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote.

Includes 314 shares acquired under the Company's ESPP purchased on May 14, 2026.

Represents 268 deferred stock units granted to Mr. Mizell under our deferred stock program and 2024 Equity Incentive Plan in lieu of $19,945.21 of cash fees payable to Mr. Mizell for his service as a director, based on a price per share of $74.36, which was the closing price per share of the Company's common stock on July 15, 2026. The awards will vest immediately upon grant date.

Represents 276 deferred stock units granted to Mr. Chase under our deferred stock program and 2024 Equity Incentive Plan in lieu of $20,568.49 of cash fees payable to Mr. Chase for his service as a director, based on a price per share of $74.36, which was the closing price per share of the Company's common stock on July 15, 2026. The awards will vest immediately upon grant date.

Represents 427 deferred stock units granted to Mr. Summe under our deferred stock program and 2024 Equity Incentive Plan in lieu of $31,787.67 of cash fees payable to Mr. Summe for his service as a director, based on a price per share of $74.36, which was the closing price per share of the Company's common stock on July 15, 2026. The awards will vest immediately upon grant date.

Represents an award of 5,491 deferred stock units ("DSUs") granted to Mr. Chase under our 2024 Equity Incentive Plan in lieu of 5,491 restricted stock units. The DSUs will vest in full on the earlier to occur of (i) June 18, 2027 and (ii) the date of the next annual meeting of the Company's stockholders, in each case subject to continued service through the applicable vesting date. Each DSU represents the right to receive, at settlement, one share of common stock.

Represents an award of 5,491 deferred stock units ("DSUs") granted to Ms. Krevans under our 2024 Equity Incentive Plan in lieu of 5,491 restricted stock units. The DSUs will vest in full on the earlier to occur of (i) June 18, 2027 and (ii) the date of the next annual meeting of the Company's stockholders, in each case subject to continued service through the applicable vesting date. Each DSU represents the right to receive, at settlement, one share of common stock.

Represents an award of 5,491 deferred stock units ("DSUs") granted to Mr. Summe under our 2024 Equity Incentive Plan in lieu of 5,491 restricted stock units. The DSUs will vest in full on the earlier to occur of (i) June 18, 2027 and (ii) the date of the next annual meeting of the Company's stockholders, in each case subject to continued service through the applicable vesting date. Each DSU represents the right to receive, at settlement, one share of common stock.

Represents an award of 5,491 deferred stock units ("DSUs") granted to Mr. Mizell under our 2024 Equity Incentive Plan in lieu of 5,491 restricted stock units. The DSUs will vest in full on the earlier to occur of (i) June 18, 2027 and (ii) the date of the next annual meeting of the Company's stockholders, in each case subject to continued service through the applicable vesting date. Each DSU represents the right to receive, at settlement, one share of common stock.

Represents automatic 'sell-to-cover' transactions by an executing broker to cover withholding taxes upon award vesting and share delivery. The price reported in Column 4 is a weighted average price calculated by the broker executing these transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

Represents an award of restricted stock units ("RSUs") which will vest in four substantially equal annual installments, beginning on May 31, 2027, subject to the awardee continuing to be a service provider on such date. Each RSU represents the right to receive, at settlement, one share of common stock. The RSUs will be settled in common stock upon vesting.

Represents an award of restricted stock units ("RSUs") which will vest in four substantially equal annual installments, beginning on May 31, 2027, subject to the awardee continuing to be a service provider on such date. Each RSU represents the right to receive, at settlement, one share of common stock. The RSUs will be settled in common stock upon vesting.

Represents 631 deferred stock units granted to Mr. Summe under our deferred stock program and 2024 Incentive Award Plan in lieu of $31,438.36 of cash fees payable to Mr. Summe for his service as a director, based on a price per share of $49.79, which was the closing price per share of the Company's common stock on April 15, 2026. The awards will vest immediately upon grant date.

Represents 396 deferred stock units granted to Mr. Mizell under our deferred stock program and 2024 Incentive Award Plan in lieu of $19,726.03 of cash fees payable to Mr. Mizell for his service as a director, based on a price per share of $49.79, which was the closing price per share of the Company's common stock on April 15, 2026. The awards will vest immediately upon grant date.

Represents 408 deferred stock units granted to Mr. Chase under our deferred stock program and 2024 Incentive Award Plan in lieu of $20,342.47 of cash fees payable to Mr. Chase for his service as a director, based on a price per share of $49.79, which was the closing price per share of the Company's common stock on April 15, 2026. The awards will vest immediately upon grant date.

Represents automatic 'sell-to-cover' transactions by an executing broker to cover withholding taxes upon award vesting and share delivery. The price reported in Column 4 is a weighted average price calculated by the broker executing these transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

Represents automatic 'sell-to-cover' transactions by an executing broker to cover withholding taxes upon award vesting and share delivery. The price reported in Column 4 is a weighted average price calculated by the broker executing these transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

Represents automatic 'sell-to-cover' transactions by an executing broker to cover withholding taxes upon award vesting and share delivery. The price reported in Column 4 is a weighted average price calculated by the broker executing these transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

Represents automatic 'sell-to-cover' transactions by an executing broker to cover withholding taxes upon award vesting and share delivery. The price reported in Column 4 is a weighted average price calculated by the broker executing these transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

Represents automatic 'sell-to-cover' transactions by an executing broker to cover withholding taxes upon award vesting and share delivery. The price reported in Column 4 is a weighted average price calculated by the broker executing these transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

Represents automatic 'sell-to-cover' transactions by an executing broker to cover withholding taxes upon award vesting and share delivery. The price reported in Column 4 is a weighted average price calculated by the broker executing these transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

Represents automatic 'sell-to-cover' transactions by an executing broker to cover withholding taxes upon award vesting and share delivery. The price reported in Column 4 is a weighted average price calculated by the broker executing these transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

Represents automatic 'sell-to-cover' transactions by an executing broker to cover withholding taxes upon award vesting and share delivery. The price reported in Column 4 is a weighted average price calculated by the broker executing these transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

Represents automatic 'sell-to-cover' transactions by an executing broker to cover withholding taxes upon award vesting and share delivery. The price reported in Column 4 is a weighted average price calculated by the broker executing these transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

Represents automatic 'sell-to-cover' transactions by an executing broker to cover withholding taxes upon award vesting and share delivery. The price reported in Column 4 is a weighted average price calculated by the broker executing these transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

Represents automatic 'sell-to-cover' transactions by an executing broker to cover withholding taxes upon award vesting and share delivery. The price reported in Column 4 is a weighted average price calculated by the broker executing these transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

Represents automatic 'sell-to-cover' transactions by an executing broker to cover withholding taxes upon award vesting and share delivery. The price reported in Column 4 is a weighted average price calculated by the broker executing these transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

Represents automatic sell-to-cover transactions by an executing broker to cover withholding taxes upon award vesting and share delivery. The price reported in Column 4 is a weighted average price calculated by the broker executing these transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

Represents automatic sell-to-cover transactions by an executing broker to cover withholding taxes upon award vesting and share delivery. The price reported in Column 4 is a weighted average price calculated by the broker executing these transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

Represents automatic 'sell-to-cover' transactions by an executing broker to cover withholding taxes upon award vesting and share delivery. The price reported in Column 4 is a weighted average price calculated by the broker executing these transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

Represents automatic 'sell-to-cover' transactions by an executing broker to cover withholding taxes upon award vesting and share delivery. The price reported in Column 4 is a weighted average price calculated by the broker executing these transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

Represents automatic sell-to-cover transactions by an executing broker to cover withholding taxes upon award vesting and share delivery. The price reported in Column 4 is a weighted average price calculated by the broker executing these transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

Represents automatic sell-to-cover transactions by an executing broker to cover withholding taxes upon award vesting and share delivery. The price reported in Column 4 is a weighted average price calculated by the broker executing these transactions. These shares were sold as part of a block trade in multiple transactions, and the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price.

Represents an award of 84,540 restricted stock units ("RSUs") which will vest in four substantially equal annual installments, beginning on February 28, 2027, subject to the awardee's continuing to be a service provider on such date. Each RSU represents the right to receive, at settlement, one share of common stock. The RSUs will be settled in common stock upon vesting.

Adjusted the reported holdings to include an additional 152 shares of Common Stock, representing dividend shares received in connection with the GRAIL, Inc. spin-off from Illumina, Inc. on June 24. 2024, with respect to shares of Illumina, Inc. held in a separate brokerage account by the Reporting Person and inadvertently omitted.

Represents an award of 60,118 restricted stock units ("RSUs") which will vest in four substantially equal annual installments, beginning on February 28, 2027, subject to the awardee's continuing to be a service provider on such date. Each RSU represents the right to receive, at settlement, one share of common stock. The RSUs will be settled in common stock upon vesting.