Good morning and welcome to the IDEXX Laboratories Second Quarter 2021 Earnings Conference Call. As a reminder, today’s conference is being recorded. Participating in the call this morning are Jay Mazelsky, President and Chief Executive Officer; Brian McKeon, Chief Financial Officer; and John Ravis, Senior Director, Investor Relations. IDEXX would like to preface the discussion today with a caution regarding forward-looking statements. Listeners are reminded that our discussion during the call will include forward-looking statements that are subject to risks and uncertainties that could cause actual results to differ materially from those discussed today. Additional information regarding these risks and uncertainties is available under the forward-looking statements notice in our press release issued this morning, as well as in our periodic filings with the Securities and Exchange Commission, which can be obtained from the SEC or by visiting the Investor Relations section of our website, idexx.com. During this call, we will be discussing certain financial measures not prepared in accordance with Generally Accepted Accounting Principles, or GAAP. A reconciliation of these non-GAAP financial measures to the most directly comparable GAAP measures is provided in our earnings release, which may also be found by visiting the Investor Relations section of our website. In reviewing our second quarter 2021 results, please note all references to growth, organic growth, and comparable growth refer to growth compared to the equivalent period in 2020, unless otherwise noted. To allow broad participation in the Q&A, we ask that each participant limit their questions to one, with one follow-up as necessary. We appreciate you may have additional questions, so please feel free to get back into the queue and if time permits, we will take your additional questions. I would now like to turn the call over to Brian McKeon.

Good morning, everyone. I'm pleased to take you through our second quarter results and to provide an update on our full year financial outlook for 2021. In terms of highlights, IDEXX delivered another quarter of outstanding financial results supported by continued strong global momentum in our companion animal business. Revenue increased 30% as reported and 25% organically supported by 26% organic growth in CAG Diagnostic recurring revenues, reflecting continued high gains across U.S. and international regions. As we work through comparisons to prior year COVID impacts, we'll be highlighting select two-year average annual revenue growth metrics to calibrate our business trends. In the second quarter, average annual two-year organic growth for CAG Diagnostic recurring revenues was 16%, in line with the strong two-year growth trends in Q4 and Q1. Operating profit increased 30% on a comparable basis in the second quarter, reflecting benefits from high revenue growth and moderate operating margin gains, as we begin to lap the tight cost controls introduced during the initial stages of the pandemic in 2020. High operating profit gains enabled delivery of $2.34 in earnings per share, an increase of 33% on a comparable basis. Continued strong momentum in our CAG business has us on track to deliver high revenue and profit gains in 2021. We're raising our full year revenue growth outlook range by $55 million at midpoint to $3,170 million to $3,205 million. This reflects an outlook for reported revenue growth of 17% to 18.5%, including favorable impacts from FX changes and benefits from our recent acquisitions. Our updated full year outlook is for 14.5% to 16% overall organic revenue growth and 16% to 17.5% growth in CAG Diagnostic recurring revenues. These organic growth ranges are 1% to 1.5% higher than our last outlook, reflecting expectations for sustained strong performance in our CAG business globally. Our full year financial outlook reflects a targeted 175 to 225 basis point improvement in operating margins on a comparable basis, up 25 basis points from our last outlook as we advance increased investments in our CAG innovation and commercial capability. We're increasing our EPS outlook to $8.20 to $8.36 per share, up $0.25 per share at midpoint reflecting 25% to 27% full year comparable EPS growth. We'll discuss our updated 2021 financial outlook later in my comments. Let's begin with a review of our second quarter results and recent sector trends. Second quarter organic revenue growth of 25% was driven by 27% CAG revenue gains and 27% growth in our water business, benefitting from the lapping of prior year pandemic impacts. As noted, CAG Diagnostic recurring revenues increased 26% organically reflecting 24% growth in the U.S. and 30% growth in international regions. On a two-year basis, average annual CAG Diagnostic recurring revenue growth was 16% overall, reflecting 16% gains in the U.S. and 18% growth in international. Strong CAG results were also supported by 78% organic growth in CAG Diagnostic instrument revenues compared to constrained prior year levels. Q2 growth in U.S. CAG Diagnostic recurring revenues was aided by high year-on-year gains in U.S. clinical visits, benefiting in part from comparisons to lower visit levels in April and May of 2020. U.S. clinical visit growth was 13% overall in Q2 with strong gains across non-wellness and wellness visit categories. On an average two-year basis, same-store clinical visit growth increased at a 4.8% annual rate, down modestly from strong Q1 results. The IDEXX U.S. CAG Diagnostic recurring revenue growth premium to U.S. clinical visits was approximately 1,100 basis points in the second quarter, up moderately and on track with our full year outlook. Expanding pet healthcare services, including continued solid increases in the utilization of diagnostics, supported a 16% same-store increase in overall veterinary clinic revenues in Q2. Diagnostic revenue per practice increased 15% on a one-year basis and 12% on an average two-year basis in Q2. Looking ahead to the second half of 2021, as noted in our last call, we expect to see lower levels of one-year growth in U.S. clinical visits and CAG Diagnostic revenue gains, as we lap the significant step up in demand we saw in the second half of 2020. These dynamics are factored into our revenue guidance which projects sustained strong tier growth in CAG Diagnostic recurring revenues in H2. IDEXX innovation and commercial initiatives continue to build on positive healthcare demand trends driving high Q2 organic revenue gains across our major testing modalities globally. IDEXX global reference lab revenues increased 25% organically in Q2, reflecting over 20% organic gains in the U.S. and approximately 30% growth in international regions. Our international reference lab gains continue to benefit from strong growth in Europe, supported by our new German core lab capability, our expanded commercial presence and growth in IDEXX 360 program agreements. Global reference lab gains continue to be driven by high same-store volume growth, with strong gains across testing categories. IDEXX VetLab consumable revenues increased 26% on an organic basis in the second quarter, also reflecting continued over 20% growth in the U.S. and approximately 30% organic gains in international. Gains continue to be supported by increases in testing utilization across regions, high customer retention levels, and expansion of our global premium instrument install base. CAG instrument placements increased significantly in Q2 compared to constrained prior year levels. Total premium placements reached 3,756 units, up over 400 units from strong Q1 results and doubled the placement levels seen last year. The quality of CAG instrument placements remains excellent, reflected in 308 catalyst placements at new and competitive accounts in North America, up 87% year-on-year and 938 new and competitive placements in international regions, up 75%. We also benefited from 571 second catalyst placements, driven by continued strong demand from high volume customers. These new placements and high customer retention levels supported a 14% year-on-year growth in our global catalyst install base. We achieved 1,119 premium hematology placements, including hundreds of ProCyte One installs as we advance our global rollout schedule. This supported 11% growth in our global premium hematology install base compared to Q2 2020. We also placed 662 SediVue, including strong placement levels in international regions under IDEXX 360 agreements, which supported a year-on-year global increase in our premium urine sediment install base by 24%. We're looking forward to building on this momentum as we gain increased direct access at veterinary clinics globally and support strong demand for diagnostic testing. Rapid assay revenues also expanded at a strong 28% organic growth rate in Q2, reflecting over 20% gains in the U.S., supported by high demand for wellness testing and accelerated over 30% growth in international geographies. Of note, core vector borne disease retention rates for U.S. rapid assay reached 97% in the quarter, aligned with sustained high IDEXX retention rates across our major modalities. High CAG Diagnostic revenue growth remains primarily volume-driven across our modalities with consistent overall net price gains of 2% to 3%. In other areas of our CAG business, our veterinary software and diagnostic imaging revenues increased 26% organically and 33% as reported, including initial benefits from our recent ezyVet acquisition. We saw high growth in diagnostic imaging system placements, driven by favorable customer response to our entry level ImageVue DR30 platform with approximately 80% of placements at competitive accounts. We also continue to see over 20% growth in recurring digital service revenues, including expansion of Web PACS subscriptions aligned with our expanding cloud-based capability. In our veterinary software services business, we posted double-digit organic revenue gains driven by growth in Cornerstone and Neo placements, and strong growth in recurring services. As Jay will discuss, we expanded our cloud-based software capability to our recently announced acquisition of ezyVet, which closed in June. We estimate ezyVet will contribute approximately $15 million to full year 2021 revenues, which is factored into our updated outlook. Turning to our other business segments, water business revenues increased 27% organically in Q2 compared to 16% declines in last year’s second quarter driven by early pandemic-related impacts. We continue to see a solid recovery in demand for water testing as economies reopen including recovery in non-compliance related testing volumes that have been more constrained during the pandemic. Livestock, poultry, and dairy revenue decreased 2% organically in Q2. Those results were constrained by the lapping of high prior year demand in key areas such as African swine fever testing. Revenue growth was also impacted by relatively lower herd health screening levels reflecting reduced exports, including effects from restrictions on live animal imports into China. We're planning on reduced LPE revenues year-on-year in the second half of 2021, as we continue to lap the benefits from high prior year demand for our ASF programs, and manage through expected pressure on our China LPD business from rebuilding swine herds, low pork prices, and changing government requirements related to livestock infectious disease programs. Turning to the P&L, we had another quarter of strong profit gains in Q2, driven primarily by benefits from high year-on-year CAG Diagnostic recurring revenue gains. We're now starting to work through comparisons to control costs levels in the prior year that were implemented as part of our pandemic contingency management efforts. Despite these dynamics, our strong revenue growth supported the solid 110 basis point expansion of our operating margins on a comparable basis, helping to drive an increase in operating profits of 34% as reported and 30% on a comparable basis. Gross profit increased 29% in Q2, driven by high revenue gains. Gross margins decreased modestly on a comparable basis, reflecting mixed impacts from higher instrument revenue and moderated lab gross margins gains as we lapped tightly controlled prior year cost levels in key areas such as lab operations. Gross margin gains continue to benefit from strong CAG Diagnostic recurring revenue growth, including positive impacts from moderate price gains. We're planning for constrained gross margin gains over the balance of this year as we continue to lap tightly controlled prior year spending levels and see impacts from increases in reference lab staffing and capacity, aligned with supporting high revenue growth. Operating expenses in Q2 increased 24% as reported and 20% on a comparable basis. In Q2 of 2020, we advanced approximately $25 million of cost reductions related to planned levels, including temporary reductions in salary and benefits, and also saw significant cost reductions in other areas such as employee healthcare accruals. The higher operating expense cost growth in Q2 reflects lapping these dynamics as well as the advancement of investments in our global commercial and innovation capability, aligned with our accelerated revenue growth profile. We anticipate operating expense growth will be higher than revenue growth in the second half of 2021, as these investments and the integration of the ezyVet acquisition advance. We also expect to see relative increases in costs such as employee healthcare claims and travel, as pandemic-related restrictions are eased. Q2 EPS was $2.34 per share, including benefits of $6 million or $0.07 per share related to share-based compensation activity. On a comparable basis, Q2 EPS increased 33%. Foreign exchange added $8 million to operating profits and $0.07 to EPS in Q2 net of $3 million in hedge losses. Free cash flow was $211 million in the quarter and $316 million for the first half of 2021. On a trailing 12-month basis, our net income to free cash flow conversion rate was 95%, including benefits from delayed capital spending and extension of tax payments last year. We're increasing our outlook for full year 2021 capital spending to $150 million to $160 million to reflect additional investments to support manufacturing and distribution growth capacity, including approximately $20 million in real estate purchases. With this higher level of projected spending, we're updating our free cash flow conversion outlook for the full year to approximately 80% of net income. Our balance sheet remains in a very strong position. We ended the quarter with debt to EBITDA leverage ratios of 0.9x gross and 0.7x net of cash with $232 million in cash and no borrowings on our $1 billion revolving credit facility. We allocated $188 million in capital to repurchase 341,000 shares in the quarter. Turning to our 2021 full year outlook, we're increasing our projected revenue range for overall revenue to $3,170 million to $3,205 million. At midpoint, this reflects approximately $30 million in organic operational improvement, approximately $10 million benefits from updated FX assumptions and approximately $15 million in increased full year revenue benefit from acquisitions. Our updated revenue outlook is 17% to 18.5% as reported, including approximately 2% for full year growth benefit from FX at approximately 0.5% benefit from acquisitions. Our updated overall organic revenue growth outlook of 14.5% to 16% reflects an estimated organic growth range of 16% to 17.5% for CAG Diagnostic recurring revenue. The high end of our CAG Diagnostic recurring revenue growth outlook range reflects two-year average annual growth rates in line with strong H1 performance levels. As noted on a one-year growth basis, we expect to see moderation in H2 from very high year-on-year growth rate seen in the first half of this year as you work through the comparison to the acceleration in growth that we saw in the second half of 2020, including fulfillment of pent-up demand in last year's third quarter. Other elements of our revenue growth outlook include expectations for lower year-on-year LPD revenues in the second half, and for a reduction in human COVID testing revenues year-on-year as we lapped the benefits over prior initiatives and plan for lower human PCR testing levels. In terms of key financial metrics, we're increasing our reported operating margin outlook for 2021 to 28.6% to 29.1%, reflecting increased expectations for 175 to 225 basis points of full year comparable operating margin improvement. Our EPS outlook incorporates updated projections for foreign exchange, which we now estimate will provide $0.17 of positive full year EPS benefit net of established hedge positions. Our full year outlook also includes an updated estimate of $0.25 per share of tax benefit related to share-based compensation activity, $0.06 per share higher than our prior projections. We provided details on our updated estimates in the tables in our press release in earnings snapshot. That concludes our financial review. I'll now turn the call over to Jay for his comments.

Thanks, Brian, and good morning. Today, we're pleased to report another quarter of strong results supported by continued favorable trends in our core CAG business and excellent execution by the IDEXX team. As noted, we delivered 25% organic revenue growth in the second quarter, supported by high organic CAG Diagnostics recurring revenue growth. There were strong gains across all CAG business segments and testing modalities, representing a continuation of the accelerated growth trends we've seen since the second half of 2020. Strong sector growth and outstanding execution by the IDEXX team gives us confidence to raise our 2021 financial outlook, as we continue to invest towards our significant long-term growth opportunity. Today, I'll provide a brief update on the trends we're seeing in key regions in our companion animal sector and discuss the status of our initiatives to strengthen our international commercial capabilities. I’ll also share an update on our ProCyte One launch and growing software portfolio, including the ezyVet acquisition which will better position us to capitalize on favorable tailwinds, further enhance practice productivity and raise the standard of patient care. Let me start with an update on sector trends. Global sector trends remained favorable in the second quarter reflected, for example, in sustained high U.S. clinical visit levels that support continued strong increases in veterinary service revenues, including diagnostics. As Brian noted, U.S. clinical visits increased 13% in the quarter and 4.8% on a two-year average annual basis, with continued strong gains across wellness and non-wellness categories. This growth was supported by growing pet population and veterinarians focus on medical services, which has sustained even as pandemic restrictions have eased. The solid trends we're seeing across all global regions in Q2, our strong commercial execution is building on this momentum, reflected in IDEXX CAG Diagnostics organic recurring revenue growth of 26% on a one-year basis and 16% on a two-year average annual basis. Within the clinic, veterinarians and the teams continued to rise to the challenge of increased demand, working hard to keep up with industry growth, while also delivering excellent patient care to ever more engaged pet parents. IDEXX is well positioned to provide them the tools and services necessary to meet these demands, supporting 15% diagnostics revenue growth per practice, and even faster growth for IDEXX revenues. Overall, we feel very positive about the strong sector backdrop, our strategy to bring testing and information management innovation to the practice and our team's level of execution, which is reflected in our raised full year revenue outlook. In terms of execution, our commercial team continues to deliver exceptional results despite continued constraint clinic access. Instrument placements showed increased momentum in the second quarter, with over 3,750 total premium placements, up solidly from a strong Q1, helping to drive 14% growth in our premium worldwide install base for the quarter. This included double-digit growth in premium chemistry, hematology and urine analysis and cell basis, as well as continued excellent growth in new and competitive accounts. Veterinary customers are extremely busy due to high visit volumes, and they're investing in IDEXX instruments, diagnostics and tools to support practice growth, patient care and staff productivity. Our digital cytology solution is an excellent example of this point and innovative service that extends the capability and reach of the practice. By providing cytology testing results in the U.S. with a report authored by expert pathologists in under two hours at any time during the day or week, 365 days a year, veterinarians are able to provide a higher standard of care to their patients, improve staff and clinical productivity, and drive appropriate testing and practice revenues. Validating this medical value proposition, we saw strong customer interest in orders for a digital cytology solution Q2. We also continue to advance key programs, like IDEXX preventive care that helped clinics raise the standard of care aligned with higher levels of pet owner engagement. In Q2, we executed 150 new preventive care enrollments as we continue to advance towards our goal of 10,000 engaged customers in the U.S. by 2024. In terms of customer access, we continue to operate in a hybrid model, with access to a limited but improving in both the U.S. and international regions. In the U.S., approximately 60% of customer visits were in-person in Q2, whereas it was approximately 50% in Europe. This hasn’t impacted our ability to deliver outstanding results as both new innovations and our excellent relationships we have with customers have driven significant growth across all regions. The deep customer relationships with our sales professionals have only been reinforced and strengthened by the best-in-class support we provided to customers throughout the pandemic. Of note, we're particularly pleased with our high levels of execution in regions like Europe, where we are expanding the successful go-to-market approaches we've applied in the U.S. This was reflected in 400 catalysts placements in new and competitive accounts outside of North America, with half of these placements under IDEXX 360 agreements. The expansion to the IDEXX 360 program is also supporting sustained strong gains and lab revenues in Europe, accelerating new account acquisition and helping to inspire faster customer growth at IDEXX 360 customers. A key focus of our strategy in this context is on developing the long-term international revenue opportunity through an expansion of our direct commercial presence. We've completed the commercial expansions first announced in Q3 of last year, which were focused on three countries; Germany, France and South Korea. By almost doubling our commercial footprint in these countries, we have appreciably increased the frequency and intensity of our calling activities with existing customers and competitive accounts. Our experience is that when we do this, our customers grow faster as they adopt our innovations, and so do we. Three additional countries have been targeted as the next stage for expansion over the remainder of 2021 and into 2022. We're excited to share with you our broader commercial approach at the upcoming Investor Day. Our expanding global commercial capability will support the adoption of key innovations, like ProCyte One. Following our first U.S. shipments in late March, ProCyte One’s international launch began in June with inflations and presale customers in France, Germany, UK, and in Southern Europe. Many of our international geographies are hematology-focused, meaning customers prioritize CBC for patient health assessment. Not surprisingly, we've seen an extremely positive reaction to the ProCyte One introduction in international regions. Customers applauded simplicity and small footprint, while still delivering the excellent accuracy, usability and reliability profile veterinarians and their staff pride so highly. Additionally, we expect a multiplier impact from ProCyte One as chemistry and hematology testing go hand in hand with the additional potential to inspire reference lab and rapid assay business and placed as part of the IDEXX 360 program. Speaking of rapid assay, we're very pleased with the strong momentum we continue to drive in this business globally. We achieved over 20% organic growth in the U.S. in Q2, while raising customer retention levels to 97% supported by innovations like SNAP Pro. We now have over 80% of SNAP 4Dx customer volume engaged on this platform, which enhances insight and supports practice workflow. SNAP Pro is also helping to achieve accelerated growth in international regions. In Europe, after installing a clinic’s first SNAP Pro, we see a significant expansion in testing volumes. We look forward to building on the strong momentum supported by continued IDEXX innovation. We're also excited with the progress we're advancing on our cloud-based software capability. We had another excellent quarter of new software installations with Cornerstone and Neo placements growing 21%, while cloud-based offerings continue to represent the majority of PIMS placement. As we continue to expand our install base, we also continue to drive expansion to profitable recurring services, such as credit card processing, which grew at strong double-digit rates organically. Software solutions have taken on significant importance to the effective management of the veterinary practice. Practices have never been busier and IDEXX integrated easy-to-use software solutions to support patient care and workflow, productivity and communications amongst the care team and with the client. Moreover, IDEXX diagnostic solutions are seamlessly integrated into both our and third-party solutions, enabling practices to capture and invoice the full range of activities that veterinarian deliver. We know that IDEXX customers who use all of our solutions have a higher customer experience and tend to test more and grow faster. Relating to the growing importance of practice software solutions, cloud-based technologies have the potential to make important contributions to the overall software experience of the veterinary clinic. For example, practice owners are free from the challenges of supporting on-premise IP solutions that include frequent hardware updates. Moreover, providers of cloud-based solutions like IDEXX to provide frequent, seamless updates in an environment that offers security advantages. Our software capabilities were augmented in Q2 with the acquisition of ezyVet, a fast-growing innovative practice information management system that is native cloud-based, used by advanced general practices as well as specialty, emergency and large corporate groups worldwide. This acquisition complements our PIMS portfolio by providing additional options to practices with more complex needs and enterprise functionality. Customers appreciate ezyVet software for its easy use and rich features. In fact, ezyVet is the number one rated full-featured practice management solution with 94% customer satisfaction according to Capterra, an industry standard business software customer review site. Bringing ezyVet into the IDEXX family also grows our cloud development talent, enabling us to capitalize on the evolving nature of the veterinary clinic software product. With that, I'd like to welcome the ezyVet team to IDEXX. We look forward to working together with you to continue to develop best-in-class software products. We're also excited about the progress we're driving in our diagnostic imaging business. We saw very strong growth in digital imaging placements in Q2 and strong growth in our backlog, reflecting a continued appreciation of our focus on providing a full range of premier low-dose imaging solutions. Growth of these placements also supports the expansion of recurring services, including cloud-based services like Web PACS. Our Web PACS subscriptions grew at high-teens rates with much faster growth in premium and unlimited subscription tiers, reflecting the high value and diagnostic insight clinicians derived from IDEXX software solutions. Overall, we're very pleased with our business momentum and optimistic as we continue to respond to the reopening of economies globally. In terms of IDEXX’s specific plans, we're excited to advance plans to bring more IDEXXs back to the office safely and in ways that ensure business continuity. We anticipate maintaining a more hybrid working environment and appreciate our employees’ flexibility in adapting to new ways of working while continuing to deliver high growth, provide top-notch customer service, and support our world-class product portfolio. Before I wrap up my remarks, I’d like to publicly welcome a new leader to IDEXX. Dr. Martin Smith will be joining my leadership team in August as Executive Vice President and Chief Technology Officer. Martin brings 30-plus years of experience in the life sciences industry, most recently as Chief Technology Officer at Cytiva and Pall Corporation, both subsidiaries of Danaher. He has a strong track record of driving R&D strategy in concert with enterprise strategic initiatives, commercial efforts, and we look forward to Martin leading our world-class R&D organization. Welcome, Martin. With that, I'd like to add that I'm extremely proud of the way the entire IDEXX team is executing as we are on track for another strong year in 2021 with financial performance aligned with our long-term goals. Our growth and performance reflect a consistent business strategy focused on opportunity development within our core businesses, and our employees continue to execute against this strategy daily. I look forward to sharing more on our strategy and long-term potential at our upcoming Investor Day on Thursday, August 12. The event remains virtual due to the evolving nature of COVID-19, and we invite you to register on the Investor Relations section of our website. Participating will be members of my senior management team, including Brian McKeon, Executive Vice President and CFO; Dr. Tina Hunt, Executive Vice President and General Manager for Point of Care Diagnostics and Worldwide Operations; Mike Lane, Executive Vice President and GM for Reference Laboratories and Information Management; Jim Polewaczyk, Executive Vice President and Chief Commercial Officer; Kerry Bennett, Senior Vice President of Corporate Strategy and Advanced Analytics; and Michael Schreck, Senior Vice President of Veterinary Software and Services. The event will last approximately three hours. It will conclude with a Q&A session. That concludes my opening remarks. We now have time for questions.

Thank you. We will now begin the question-and-answer session. And our first question is from Michael Ryskin from Bank of America.

Hi, guys. Thanks for taking the questions and congrats on the quarter. I guess the first question would be on sort of the updated guide and the outlook for the second half of the year. And mostly I want to focus on the P&L. I just want to make sure we have all the moving pieces. It seems like you're expecting some incremental spend, some T&E coming back, some healthcare costs going higher. Could you walk us through the cadence of that and how we expect that to come back? And is that really just tied to sort of going back to prior ways of doing business pre-COVID? Is that some incremental spin on top of that? So what are the investment areas? How that should roll in, in the second half? And sort of what's the plan there going forward as far as effects?

Sure. Thanks, Mike, for your question. On OpEx, we're transitioning into a period now where we're comparing to more controlled cost levels from the prior year. I think you saw that in the second quarter where the comparable OpEx was up 20%. And we are starting to see some costs come back, things like healthcare accruals were up in the second quarter, we expect that to continue. And as the pandemic conditions hopefully continue to get eased, we expect to see some T&E come back. As well, we're advancing investments. We've talked about the commercial investments, particularly in areas like international and our R&D organization. We're leaning into the positive growth. And overall, we think that will create an environment where we've got sustained higher OpEx growth year-on-year and it will be above the revenue growth, which is now up against tougher compares. So that's really the dynamic that we're working through. I think it's all very healthy. We think we're on track for very good full year performance in terms of margin improvement, and look forward to building off that going forward. But second half, we'll be working through those dynamics.

And are you seeing any incremental issues of freight costs, transportation cost, any other inflation factors, whether it's sort of on the raw material side or on the human capital side in the market?

Selectively, I wouldn't say it's been a big impact on our business. I think more just managing through keeping up with the high demand has been the bigger challenge for the business. And I think we've been able to manage those dynamics well. So it hasn't been as big a factor for us to date.

Okay. And as far as some of the new products you called out, things like ProCyte, can you give us an update on sort of how vets are interacting with the sales force and how some of the nuances are going on? I realize it's been a very different environment launching something during COVID than traditionally. I'm just wondering if you could speak to willingness to uptake and sort of expand the menu offering versus sort of relying on the traditional tools.

Good morning, Mike. Yes, as we indicated in the remarks, the practices are incredibly busy at this point, maybe never busier. And so they certainly welcome I think new menu, new tools, ProCyte One specifically, that helps with productivity. So the reception has been outstanding. We see in the case of the U.S., about 60% of our visits are now in person. Internationally, it's about 50% or so. So they really welcome the opportunity to reengage what they consider to be trusted advisors and partners in the field. And more and more they're looking to IDEXX to be able to provide the analyzers and software solutions that really help them from the standpoint of not just increasing patient care, which has always been the case, but also really driving staff productivity and communications within the practice and with their clients. So overall very, very positive. And we think that there's really an exceptional long-term opportunity, not just in hematology with the ProCyte One, but the entire in-clinic lab suite, because as you know, hematology and chemistry are also very often in vast majority of cases used together.

Thanks. I will get back in the queue.

And our next question is from Erin Wright from Credit Suisse.

Great. Thanks. I'm curious what you're seeing or assuming in your guidance in terms of the sustainability of growth in clinical visits and just overall veterinary demand trends, what are you seeing on a monthly basis and also quarter-to-date? I'm just curious if the recurring CAG momentum here is holding up on a two-year stack basis, and if there's any sort of seasonal dynamics as well to consider here? Thanks.

Yes, why don't I start and I think Jay can help with color on what we're seeing at the clinic level. The trends in the sector and in our growth held up very well in the second quarter. The CAG Dx recurring, as you note, on a two-year stack basis, that's the way we like to track it as we're working through some of these compares was a little above 16% is pretty much in line with what we saw in Q1 and Q4. And so that's very encouraging. I think we're benefiting from continued solid market trends at the clinic level. The visit number was down a bit Q4 to Q1, but the diagnostic revenue growth on a one-year and a two-year stack basis sustained at very good rates. So all indications are demand is holding up very well and that's informing our full year outlook, the higher end of our outlook ranges for the two-year trends to continue in the second half for CAG Dx recurring. And we obviously have a range because there may be some other dynamics that we don't anticipate that go on, and we're going to learn more as we're working through. Hopefully the economies continue to open, but I think we're very encouraged by the strong trends.

Just to build on that. Definitely the demand trends remain intact. And I think the execution and our ability to be able to build on that has also been very strong. We saw, as Brian indicated, 60% global two-year CAG Diagnostics recurring revenue. And if you break it down by region, it was 15.5% in the U.S. and international and really across all modalities. So the in-clinic, rapid assay, and the reference lab business. I think the really positive thing on top of that was just the instrument placement, really strong growth coming off of a strong Q1 and the compare to a depressed level last year. Practices report, as I had indicated earlier, being extremely busy. It's not surprising given a lot of the factors we've talked about in the past, and they're looking more and more to be able to really partner with IDEXX and helping them increase the productivity of care workflow as well as the business itself.

Okay, great. And then just given some of the stepped-up investments internationally, are you seeing any changes in the competitive landscape there? And this goes back also to my bigger question, I guess, that people have is what's the right size for the commercial effort overall? It sounds like you're seeing the growth to justify it. But how are you thinking about in terms of your optimal goal there? Thanks.

Sure. We'll discuss this further at Investor Day regarding our perspective on the international market and what the final landscape should look like. I want to emphasize that our international investments are being executed continuously. Currently, three countries are behind us and three are in line for attention. The international markets appear to be very strong, and veterinary practices are busy. However, in terms of optimizing our operations, we're not as far along as we are in the U.S. as a benchmark. We manage around 120 accounts per manager domestically, while the international figure is significantly lower. We believe that our international investments will yield a solid return, and there is substantial market development ahead of us. We will share more detailed information in a couple of weeks.

Okay, great. Thank you.

Our next question is from Jon Block from Stifel.

Thanks, guys. Good morning. First question is centered on capacity. In the snapshot in the wellness clinical growth decelerated in a two-year stack basis to roughly 85%. It had been 12% to 13% stacked, again, the wellness the prior three quarters. And I feel sometimes Wall Street takes for granted by sort of the ability of an industry to absorb all the additional demand. We've actually anecdotally heard of some practices turning away new customers. So as market leaders, I’d love to get your thoughts, what are you guys hearing? Are there any capacity constraints going on in the industry that's pushing off wellness tests? And this might be a slight headwind for the industry, as we think about the next handful of quarters.

Yes, Jon, I'll take that. The veterinarians will tell you that they're extremely busy, and that's a good thing. So they at times may find themselves fatigued or not being able to take on new clients, and that's to be expected. Having said that, I think they're very creative at being able to increase the capacity within the practice, if you're doing things like adding staff and that sometimes takes time, increasing the number of exam rooms. I think they're investing in software and diagnostics and other tools that help them be more productive. So there's lots of things that they can do short term as well as intermediate term to be able to increase capacity, extending hours, using reference lab services, which takes some of the pressure off veterinary technicians. So, I think it's largely a good thing. And we're seeing some of the markets work in terms of dynamically being able to react to the increased demand.

Okay. And maybe just part B to that one, a follow up. Are you seeing that translate from the veterinarians’ perspective on raising prices to the pet parent? In other words, the demand’s there. They're actually pushing through price. And does that give you guys an opportunity when we think about 2% to 3% annual price increases to maybe bump that up? And then I'll just ask my second question, if that's okay.

Yes. So I mean that's situational. We don't have end market visibility in terms of how they're pricing to their clients. We obviously sell them diagnostic solutions that they markup on that insofar as they may be paying their staff more. I think what is true is their end markets are very robust, in that they do have room to increase prices without necessarily negatively impacting patient demand. But I think that's case by case. I think most practices are taking a long-term view and really they're very loyal, have very good relationships with pet owners, and they want to obviously maintain those. And where they have to raise prices I guess, bottom line is they do. But in most cases, what we're seeing is it is pretty moderate.

Yes, exactly, Jon. And then my second question, Brian, for you. I think I've got these numbers right, but you raised EPS from 1Q to 2Q and midpoint by $0.25. I think stock comp, tax and FX was $0.12 on the button. And I'm guessing ezy might have been another nickel. But can you talk about the flow through on that remaining $30 million of core revenue increase? It just seems like the incremental is on that $30 million if I run through the math. Is it too dissimilar from corporate averages? Is that true? And maybe is that reflective of what you're alluding to of some of the reinvestments in the business in the back part of the year? Thanks. Yes, I believe you're connecting the numbers. We did see a slight contribution from foreign exchange. The stock compensation was $0.06 from our previous position, which accounts for about $0.08 of the $0.25. The stock compensation also reflects the tax effect. I'm not sure about ezy, but it does present some challenges for us as we integrate that acquisition. Overall, the flow-through is quite positive. Regarding the full-year increase, it aligns closely with our previous outlook. We are pleased to raise both the revenue and EPS numbers operationally, building on the strong trends in our business. This also enables us to continue investing in future growth opportunities. We are very optimistic about the robust growth in our international business, which reinforces our decision to invest there and positions us well for sustained growth moving forward.

Perfect. Thanks, guys.

Our next question is from Nathan Rich from Goldman Sachs.

Good morning. Thanks for the questions. Brian, maybe going back to your comments on margins. There's obviously been a lot of variability last year and in the first part of this year, just given the different pandemic effects that you guys have felt. So I guess like when we think about operating margins for kind of 2022 and beyond, how should we kind of frame the right jumping-off point, kind of assuming that these pandemic effects normalize? I guess what’s sort of the right baseline type margin as we think about the business going forward?

We'll provide more details on that at Investor Day. I anticipate it will resemble discussions we've had previously. We believe we can build on the improvements we've achieved and aim for an annual comparable improvement of 50 to 100 basis points over time. The strong growth in CAG Diagnostic recurring revenue allows us to enhance our lab productivity, which is beneficial for us. We still see opportunities to improve our gross margins, which enables us to reinvest in expanding the annuity of our business long-term, yielding a high return on investment. We strive to align that effort with our execution capabilities to ensure we deliver strong financial performance each year. We're eager to continue this progress. We do have some specific dynamics to navigate related to comparisons with the pandemic and the cost controls we implemented. However, we are confident in our ability to manage these near-term challenges.

Great. And then just a couple of quick follow-ups. Brian, I think if I caught the number right, you said that in the second quarter, you were lapping I think $25 million of cost reductions. Did I catch that right? And do you have a comparable number for 3Q and 4Q as we think about cycling the temporary cost reductions from last year?

We implemented at the height of the kind of early phase of the pandemic spread, salary and benefit freezes and a number of other actions, and that was a $25 million reduction to our plan levels. And so it gets a little noisy. As we work through the year, we started reinstating aspects of that. But we basically kept headcount controls in place and benefited from pretty significant year-on-year reductions in things like T&E and in healthcare costs. So, we'll continue to see dynamics from that. I think it was meaningful in Q2 relatively more than the balance of the year, but still something that will play out over the next couple of quarters. And we'll try to help you understand that dynamic as we report our results.

Great. And if I could just sneak one more in. You've continued to see the premium or the spread between clinical visits and the CAG Dx growth above that 9% to 10% range that I think had been assumed in guidance at the beginning of the year. Is that still roughly the right range to use for the full year overall? Or just given what you’ve seen develop in the first half, do you think that you could continue to see that slightly higher spread than what you've seen historically?

That's a good question. I think we're very pleased with that. It was about 1,100 basis points in Q2 and it was 900 in Q1. Normalized, it was about 1,000 to 1,100. And if I recall, we had some days effects in there. So we feel quite good about that. I think we've factored that thinking into our guidance range. And as we noted earlier, the high end is really sustaining those kind of trends, the strong two-year growth trends for the back half. So that's clearly a factor that helps to drive our confidence in that number.

Yes, Nate, the way we tend to think about that is it's also I think directly related to our execution, which has been excellent, both from an innovation standpoint and we have lots of new stuff, like ProCyte One and digital cytology and software solutions like ezyVet, and also our commercial expansion. So the market’s doing one thing, and it's a very strong market backdrop. And then our execution and ability to develop these markets is the other factor. And I think we've demonstrated a very strong execution in being able to do that. So we're optimistic.

Great. I really appreciate the comments.

Our next question is from Chris Schott from JPMorgan.

Hi, this is Ekaterina on for Chris. Thank you so much for taking our questions. So the first question is on innovation. And we've obviously seen through very healthy pet ownership and standard of care trends over these past several quarters. Is this making you think any differently about R&D and the type of tests that you're developing, something that perhaps didn't make economic sense for the vet or pet owner previously but makes sense just given the higher willingness to pay? And then the second question is, outside of the U.S., talk a bit about the regional differences you're seeing in both visits and testing utilization as countries are exiting the pandemic? Are there countries where you're seeing better or worst trends? And how do you see that evolving through the year? Thank you.

I'll first address the innovation aspect. Our commitment to innovation remains strong, as we believe it brings differentiation and addresses significant challenges for our customers in both clinical and business contexts. Last year, in 2020, we launched seven major products and services, all of which were well received and adopted by our customers. Therefore, we will continue to invest in innovation. At our Investor Day, we will discuss our strategy and framework, which encompasses platforms, instruments, assays, and software, as well as innovations in business models and our reference lab network. This area is active and remains a key focus for us. Regarding regional differences and testing utilization, we are experiencing strong growth overall. The U.S. and North America demonstrate much higher diagnostic usage, and we believe there is potential for increased international market adoption, with the total addressable market being approximately twice that of the U.S. This goes beyond just commercial expansion and includes establishing a reference lab network, similar to what we've achieved in Kornwestheim, as well as creating centers of excellence and a wider range of valued solutions for customers. There are some moderate differences across countries in response to the pandemic; for example, in-person visits in the U.S. are around 60%, while in Europe they are about 50%. However, our ability to support our customers and facilitate business transactions has not been adversely affected. Customers have adapted well to the evolving environment and are experiencing significant traffic, similar to the trends we see in the U.S.

Thank you.

And our next question is from Ryan Daniels from William Blair.

Hi, guys. Nick in for Ryan. Thanks for taking the questions and congrats on the solid quarter again. Earlier in your comments, you mentioned that about 60% of your visits in the U.S. at least right now are in-person. I'm assuming you're talking about your sales visits? And then if so, how has that kind of been tracking over the last quarter? Has it been kind of steadily going up?

Right. The 60% does refer to customer-facing sales visits. That has gone up from what's plateaued about 50% thereabouts at sort of the height of last year is a little bit below 50%. But we adapted very quickly to the changed environment. And obviously, it's a function of how things play out going forward, whether that continues to increase in terms of the Delta variant and some of the procedures local governments have put in place in addition to CDC. But we expect as the pandemic recedes that it will continue to increase our in-person visits, but to be determined.

Is that a number that, say, like in a post-COVID era ever returns to 100%, or are you kind of realizing some of the benefits from kind of a virtual sales process such that you'll kind of keep that going on at least for a little bit going forward?

Yes. I think there's been some great takeaways in terms of what visits really should be done in person versus where you can support the customer virtually. I think from the standpoint of getting those benefits from a productivity standpoint. I don't think we'd go back to 100%. Having said that, I think what our customers would like to say, given how busy they are is more efficient visits. So at one point, maybe they have time for 45 minutes or an hour, and now they'd like to be able to get them the same amount of work and conversation in 20 minutes or 25 minutes. So we think there's great opportunity there to help them and to increase productivity on both sides of the partnership.

Great. Thank you. That's definitely helpful. And then I guess on the visit and practice revenue front, it looks like there is a little kind of variability in what would be revenue per visit quarter-over-quarter. I was wondering if there's any dynamics to kind of call out on that front.

It held up well. I think there's always a bit of quarter-to-quarter variability. Nothing really specifically. We're trying to highlight our trends were quite good. I think vets are very busy. I think that's one thing that we hear gives us a way so that could be a dynamic. But overall, I think the bigger theme is continued strong growth, and we're feeling good about our outlook.

Okay. I want to thank everybody for calling in. I also want to express my gratitude to the IDEXX team for their continued exceptional performance. We have an amazing purpose as a company and our employees represent our values every day. I couldn't be more appreciative of their efforts and what we accomplished this past quarter. With that, we'll conclude the call. Thank you.

Thank you. Ladies and gentlemen, this concludes today's call. Thank you for participating. You may now disconnect.