Good morning, and welcome to the IDEXX Laboratories' Fourth Quarter 2024 Earnings Conference Call. As a reminder, today's conference is being recorded. Participating in the call this morning are Jay Mazelsky, President and Chief Executive Officer; Brian McKeon, Chief Financial Officer; Andrew Emerson, Senior Vice President, Corporate and Companion Animal Group Finance; and John Ravis, Vice President, Investor Relations. IDEXX would like to preface the discussion today with a caution regarding forward-looking statements. Listeners are reminded that our discussion during the call will include forward-looking statements that are subject to risks and uncertainties that could cause actual results to differ materially from those discussed today. Additional information regarding these risks and uncertainties is available under the forward-looking statements notice in our press release issued this morning, as well as in our periodic filings with the Securities and Exchange Commission, which can be obtained from the SEC or by visiting the Investor Relations section of our website, idexx.com. During this call, we will be discussing certain financial measures not prepared in accordance with Generally Accepted Accounting Principles, or GAAP. A reconciliation of these non-GAAP financial measures to the most directly comparable GAAP measures is provided in our earnings release, which may also be found by visiting the Investor Relations section of our website. In reviewing our fourth quarter 2024 results and initial 2025 guidance, please note all references to growth, organic growth and comparable growth refer to growth compared to the equivalent prior-year period, unless otherwise noted. To allow broad participation in the Q&A, we ask that each participant limit their questions to one with one follow-up as necessary. We appreciate you may have additional questions, so please feel free to get back into the queue, and if time permits, we'll take your additional questions. Today's prepared remarks will be posted to the Investor Relations section of our website after the earnings conference call concludes. I would now like to turn the call over to Brian McKeon.

Good morning, everyone, and welcome to our fourth quarter earnings call. Today, I'm pleased to review our Q4 and full year 2024 financial results. Andrew Emerson, who will be assuming responsibility as IDEXX's CFO on March 1st, will take you through the details of the company's outlook for 2025. IDEXX had a solid finish to 2024, reflected in fourth quarter performance ahead of our expectations. Revenue increased 6% organically, supported by 7% organic gains in CAG Diagnostics recurring revenues. Operating profits increased 7% as reported and 8% on a comparable basis, benefiting from solid gross margin gains, which supported operating margin performance at the high end of our guidance range. We also saw positive impacts from increased stock-based compensation activity, which benefited our effective tax rate. These factors supported delivery of $2.62 in EPS in Q4, up 10% on a comparable basis. IDEXX execution drove solid expansion of our business for the full year 2024. This is reflected in 7% full year organic growth in CAG Diagnostics recurring revenues, 9% growth in our global premium instrument installed base, 11% organic gains in recurring software and digital imaging revenues, and 11% organic growth in our Water business. We delivered excellent full year financial performance in 2024, supported by comparable operating margin gains at the high-end of our long-term annual improvement goals. Full year EPS of $10.67 per share, which includes $0.56 per share of negative impact related to a discrete litigation expense accrual, increased 12% on a comparable basis, including 2% of negative growth impact from the lapping of a 2023 customer contract resolution payment. These results were achieved as we successfully advanced our innovation-driven growth strategy and worked through greater-than-expected sector and macro headwinds. As Andrew will discuss, this performance sets a solid foundation for our business to build upon as we enter 2025. Let's begin with a review of our 2024 results. Fourth quarter organic revenue growth of 6% reflected solid gains across IDEXX's major business segments, including: 6% organic growth in CAG; 7% organic gains in LPD; and 9% organic growth in Water. Worldwide CAG Diagnostic recurring revenue increased 7% organically in Q4, including benefits from improved volume growth trends. Results were supported by average global net price improvement of 4% to 4.5%, with US net price realization of approximately 3.5%. As noted in our last earnings call, US net price realization includes impacts from the successful extension and expansion of three major customer agreements in 2024, which will provide long-term incremental volume growth benefits for IDEXX. US CAG Diagnostics recurring revenue increased 4% organically in Q4, net of a 1% negative growth impact from fewer equivalent selling days. IDEXX execution drove approximately 2% US volume growth in the quarter, normalized for equivalent days. These results were supported by sustained solid new business gains, high customer retention levels, and relatively higher gains in diagnostic frequency and volume utilization per clinical visit. IDEXX achieved a solid 800 basis point normalized growth premium compared to US clinical visit growth levels in the fourth quarter. We continue to work through pressure on US same-store clinical visit levels, which declined nearly 3% in Q4 and 2% for the full year in 2024. This has been the primary constraint on IDEXX's recent growth, reflecting transitional sector macro impacts following the accelerated expansion of pet healthcare during the pandemic. International CAG Diagnostic recurring revenue growth was 12% in Q4, including a 1% benefit from equivalent days effects. Strong Q4 international results benefited from net price gains and improved volume growth, supported by new business expansion, reflected in double-digit year-on-year growth in our international premium instrument installed base. IDEXX fourth quarter performance was supported by strong global growth in consumable revenues. IDEXX VetLab consumable revenues increased 12% organically, reflecting double-digit gains in US and international regions, normalized for equivalent days effects. Consumable gains were supported by a 9% increase in our global premium instrument installed base in 2024, reflecting solid gains across our Catalyst, Premium Hematology and SediVue platforms. For the full year 2024, we achieved approximately 18,500 premium instrument placements with excellent quality, reflected in sustained, high, new and competitive Catalyst placements. In the fourth quarter, we placed 4,625 premium instruments, down 12% from high prior-year levels. Overall CAG instrument revenues also declined 12% organically in Q4. Quarterly placement results were supported by strong gains in SediVue and continued expansion of ProCyte One. We also initiated shipments of IDEXX inVue Dx in the quarter, supporting strong comparable EVI gains, including the projected value of inVue preorders. Rapid assay revenue was flat on an organic basis in Q4. Rapid assay results were constrained by pressure on US wellness visits as well as by the addition of the pancreatic lipase slide to our Catalyst menu, which we estimated to be a 4% headwind to Q4 revenue growth. Global lab revenues expanded 4% organically in Q4. Reference lab results in the quarter were supported by solid normalized volume growth in US and international regions, and net price gains. Reference lab net price gains were moderated in Q4 by near-term impacts from major new customer agreements, which will benefit long-term reference lab growth. CAG veterinary software services and diagnostic imaging revenues increased 7% organically in Q4 compared to strong prior-year levels. Results continue to be supported by solid growth in recurring revenues and ongoing momentum in cloud-based software placements. In other business segments, Water revenues increased 9% organically in Q4 compared to strong prior year levels, driven by continued solid gains in the US and Europe. Livestock, Poultry and Dairy revenues increased 7% organically in Q4, supported by solid gains in our US, Europe and Latin American regions. Turning to the P&L, Q4 operating profits increased 7% as reported and 8% on a comparable basis, supported by gross margin gains. Gross profit increased 8% as reported and 9% on a comparable basis. Gross margins were 59.8%, up 130 basis points on a comparable basis, adjusting for approximately 10 basis points of positive FX impact. Gross margin gains reflected favorable business mix supported by strong consumable growth, benefits from net price improvement, and higher Water gross margins. Operating expenses were up 10% as reported, and 9% on a comparable basis in the quarter, reflecting increases in R&D spending, aligned with advancing our innovation initiatives, including our new instrument platforms. For the full year 2024, operating margins were 29%, an increase of 60 basis points on a comparable basis, including an approximately 40 basis point negative impact from lapping a customer contract resolution payment in 2023. Full year operating margins included 160 basis points of negative impact related to a discrete litigation expense accrual recorded in the second quarter. Q4 EPS was $2.62 per share, up 10% on a comparable basis. In Q4, EPS benefited from a lower effective tax rate, including $0.13 per share in tax benefits from share-based compensation activity and $0.06 per share benefit from a non-recurring tax reserve release related to the lapping of an applicable statute of limitations. Foreign exchange drove a $0.03 per share EPS headwind in the quarter, net of approximately $3 million in hedge gains. Full year EPS was $10.67 per share, an increase of 6% on a reported basis and 12% on a comparable basis, including a 2% negative EPS growth impact related to lapping a customer contract resolution payment. 2024 full year EPS results include $0.56 of negative impact from a discrete expense accrual related to an ongoing litigation matter, $0.05 of negative impact from currency changes, and $0.24 in tax benefits from share-based compensation activity. Foreign exchange had limited impact on Q4 and full year revenue growth. For the full year, foreign exchange reduced operating profits by $5 million and EPS by $0.05 per share, net of $6 million in hedge gains. Free cash flow was $808 million for 2024 or 91% of net income, aligned with our guidance and long-term goals. Capital spending was $121 million for the full year or approximately 3% of revenue. We allocated $249 million to repurchase 564,000 shares in the fourth quarter. For the full year, we allocated $859 million to repurchase 1,760,000 shares. Our balance sheet is in a strong position. We ended 2024 with leverage ratios of 0.7 times gross and 0.4 times net of cash. That concludes our financial review. Andrew will now walk you through our initial 2025 financial outlook.

Thank you, Brian. Turning to our 2025 full year outlook, IDEXX is planning to deliver solid organic revenue growth and profit gains, led by strong execution and benefits from new innovation. We're providing initial guidance for revenue of $4.055 billion to $4.170 billion, an increase of 4% to 7% on a reported basis. On an organic basis, this reflects a growth range of 6% to 9% overall, supported by 5% to 8% organic growth in CAG Diagnostic recurring revenues. At current exchange rates, we expect foreign exchange to have a 2% negative impact on full year revenue growth. In terms of key drivers for our 2025 organic growth outlook, the midpoint of our CAG Diagnostic recurring revenue growth range incorporates expectations for global net price realization of 4% to 4.5% and volume gains of approximately 2%. The outlook includes assumptions for declines in US same-store clinical visit growth levels with the midpoint reflecting a similar rate of a decline seen in 2024. These targets incorporate continued solid global growth benefits from IDEXX execution drivers, including new customer gains and increases in testing utilization, supported by IDEXX innovations. The higher end of our CAG Diagnostic recurring revenue growth outlook captures the potential for improved sector visit and same-store growth trends, while the lower end of the range calibrates for further potential effects of macroeconomic conditions. Our revenue growth outlook includes approximately $50 million of projected IDEXX inVue Dx instrument revenue aligned with 4,500 placements. Jay will discuss progress against our inVue Dx launch in his comments. Our reported operating margin outlook for the full year 2025 is 31% to 31.5%. On a comparable basis, this reflects an outlook of 30 basis points to 80 basis points of improvement year-over-year, net of a 160 basis point operating margin benefit related to the lapping of the discrete litigation expense recorded in the second quarter of 2024. We're planning for solid gross margin gains on a comparable basis in 2025, supported by growth in CAG Diagnostics recurring revenues, benefits from lab productivity initiatives, and expansion of our high-margin cloud-based software business. This is partially offset by unfavorable business mix planned from higher levels of CAG Diagnostics instrument revenue gains and preliminary estimates for tariff risk on internationally-sourced materials. Our 2025 EPS outlook is $11.74 per share to $12.24 per share. This reflects an increase of 8% to 12% on a comparable basis, net of a 6% EPS growth benefit from the lapping of the Q2 2024 discrete litigation expense, and includes a $0.06 per share headwind from higher taxes related to a non-recurring tax reserve release during the fourth quarter of 2024. Our EPS outlook also includes $42 million of net interest expense at prevailing rates. Foreign exchange is expected to have a negative impact of $0.21 year-over-year at the rates disclosed in our press release, net of established hedge positions. In terms of sensitivities to changes in foreign exchange rates, we project a 1% change in the value of the US dollar would impact the full year reported revenue by $15 million and operating income by $5 million, net of hedge positions. Our 2025 free cash flow outlook is for net income to free cash flow conversion ratio of 85% to 90%, aligned with our long-term goals. This reflects estimated capital spending of approximately $160 million or about 4% of revenues. The outlook incorporates increased capital deployment, aligned with $1.5 billion towards share repurchases or approximately 4% of our current equity market capitalization. This reflects our high confidence in IDEXX growth potential, including continued strong execution and advancement of our innovation agenda. Regarding our Q1 outlook, we're planning for overall organic revenue growth of 4% to 6%, with similar gains in CAG Diagnostics recurring revenue net of a 1% to 1.5% days headwind. This factors in US clinic visit trends more aligned with Q4 2024 and pricing benefits at the low-end of our full year price realization range as we work through the major customer agreements noted by Brian. Reported revenue growth of 2% to 4% includes approximately 2% negative impact from foreign exchange at current rates. Our Q1 reported operating margins are planned for 30.2% to 30.6%. This reflects moderate compression in comparable margins in the quarter compared to high prior-year levels and reflects investments to support recent and upcoming product launches. Overall, we're well-positioned to build on our solid 2024 financial performance with continued strong execution and a robust set of new product launches during 2025. This concludes our guidance update, and I will now turn the call over to Jay for his comments.

Good morning, and thank you, Andrew. IDEXX delivered another strong quarter to close out 2024, capped with the initial placements of IDEXX inVue Dx. Our results this quarter exemplified the resilience of our business model, built on the foundation of customer-centric innovation, high-touch commercial execution, and a steadfast commitment to growth, by advancing the standard of care in veterinary medicine. This year, we celebrated significant milestones, including the highly-anticipated launch of IDEXX inVue Dx, a groundbreaking cellular analyzer redefining slide-free Point-of-Care testing. We recently announced the launch of IDEXX Cancer Dx with canine lymphoma, a transformative oncology screening and aid-in-diagnosis panel that will expand over time to address the most common canine cancer. We're also concurrently commercializing three new products and services as part of our Catalyst technology-for-life platform in test menu and enabling software. Introductions include: Pancreatic Lipase Testing, a single-slide solution already embraced by thousands of clinics; SmartQC, which enables very easy monthly calibration on our chemistry platform; and an updated IDEXX VetLab Station with a more modern, intuitive interface supporting workflow efficiencies. IDEXX commercial teams continue to operate at a high level this year, supporting new business gains, solid net price realization, high-90%s customer retention levels across major testing modalities, and sustained adoption levels of diagnostic testing utilization near post-pandemic highs. High placement levels across our core premium instrument platforms drove a 9% growth in our premium instrument installed base. The team also delivered very strong year-on-year EVI gains when incorporating benefits from nearly 1,600 global pre-orders for IDEXX inVue Dx, which will benefit our business over the coming year. 2024 also saw the extension and expansion of three major customer agreements, which will provide solid volume gains for our reference lab business. These important contractual renewals highlight the value IDEXX solutions bring to our customers, supporting their practice revenue growth through highly important diagnostic testing categories. 2024 was also a pivotal year for our software business. With double-digit growth in our cloud-native PIMS placements, and the launch of our pet owner engagement solution Vello, we are helping clinics bridge the gap between patient care and operational efficiency. Vello, now adopted by nearly 600 practices, has enhanced pet-owner engagement by streamlining communication and driving increased clinical visits and diagnostic frequency. These advancements highlight the expanding role of software in unlocking the full potential of diagnostics while delivering a seamless experience for veterinarians and pet owners alike. This strong execution was delivered in a dynamic macro-economic and sector environment, which saw continued pressure on clinical visits. For pets visiting US clinics, pet owners continue to demonstrate interest in a higher standard of care, reflecting the strength of the pet-owner bond and the prioritization of pet health. Diagnostics play a key central role in enabling better medical outcomes, as nearly half of clinical visits include some form of diagnostic testing. The growth in the use of blood work in preventive screening highlights the value pet parents place on proactive care, driven by advancements in technology and awareness of health benefits. Our commercial strategy is to support this positive trend through the use of preventive care marketing programs like Simple Start, and testing innovations such as IDEXX Cancer Dx, which will be included at attractive prices to inspire pull-through. IDEXX's commercial execution continues to be a cornerstone of our success, reflecting the deep expertise, commitment, and customer-focus of our teams around the globe. Our partnership approach has yielded exceptional customer retention rates of over 97%, ensuring that practices continue to see IDEXX as an indispensable partner in their growth and efficiency goals. Customers trust IDEXX to help them navigate challenges of staffing and visit trends. Our nearly double-digit premium instrument installed base growth is driven by robust new placements across chemistry, hematology, and SediVue platforms, as well as the first placements of IDEXX inVue Dx. We also continue to make strong progress in placing our IDEXX VetLab suites in competitive and greenfield accounts, a focus area since we get the full growth benefit of consumables usage. Customers are hungry for Point-of-Care technology that supports their medical mission with fast, real-time results, while minimizing workflow bottlenecks with innovations such as load-and-go capability, a common easy-to-use interface, and instrument uptime measured in years. An additional benefit is that our large, rapidly growing installed base of over 74,000 chemistry analyzers allows for rapid global adoption of new testing innovations such as Pancreatic Lipase, the tenth such menu extension in a bit over 12 years. Menu extensions such as Pancreatic Lipase help support a healthy volume premium to the clinic visit baseline. Our international regions showcased strong performance in 2024, contributing significantly to our growth story. Double-digit expansion of our premium instrument installed base outside the US underscored the benefits of our targeted global commercial investments over the past three years. Our maturing international sales organization has not only secured high-quality placements but also driven consistent diagnostic utilization gains, particularly in the Europe and Asia-Pacific regions, where we continue to see untapped potential. Spotlighting our European region's very strong performance, we saw the seventh consecutive quarter of double-digit CAG Diagnostics recurring revenue growth, with IDEXX VetLab consumables growth in the high-teens. Customer satisfaction remains at the heart of our commercial strategy, supported by sustained sector-leading levels of engagement and trust. IDEXX's investment in areas such as VetConnect PLUS feature expansion now gives the customer the ability to access reference lab sample turnaround time and order status information. This is part of our strategy to not only provide subject matter expertise and complementary testing support through our medical consulting organization but also workflow optimization that helps clinics navigate the complexities of modern veterinary care. This focus on customer success not only drives loyalty but also ensures that IDEXX remains the go-to partner for diagnostic solutions. The launch of IDEXX inVue Dx has been one of the most exciting developments in 2024, marking a new era in Point-of-Care diagnostics. Designed as a technology-for-life platform, inVue Dx combines advanced optics, artificial intelligence, and a slide-free workflow to deliver transformative diagnostic insights with unparalleled ease of use. The initial menu focuses on ear cytology and blood morphology, tapping into two clinically well-understood, high-volume use cases that benefit from automation and a step up in testing consistency and performance. Customer interest for IDEXX inVue Dx continues to be exceptionally strong, with nearly 1,600 preorders globally by the end of Q4, reflecting the high demand for this next-generation platform. International interest has been similarly robust as we began taking orders in select geographies in Q4; though like the US, we have placed some limits on the number of preorders our account managers take. This level of enthusiasm underscores the transformative potential of inVue Dx in clinics worldwide. As I mentioned previously, we initiated a controlled launch of IDEXX inVue Dx in Q4, and to ensure a best-in-class customer experience, we will gradually ramp up placements through 2025. Early feedback from customers, both in the customer experience trials and for the initial placements, has been exceptionally positive. Customers are simply amazed at how easy the analyzer is to use, eliminating the need for complex slide preparation or interpretation, with results in minutes. Underpinning the financial guidance Andrew shared is a placement target for 4,500-plus inVue placements over the course of the year, as we march towards our 20,000 placement goal over five years. IDEXX operations and supply chain teams have made outstanding progress ramping manufacturing to support this level of placements while our field service representative team has been expanded and trained to provide critical installation capacity to support both the inVue ramp and continued growth of our core instrument platforms. The moment is upon us to bring this transformative analyzer to our global customer base. Looking ahead, we remain on track to expand IDEXX inVue Dx's capabilities further with the addition of Fine Needle Aspirate, or FNA, testing for lumps and bumps later in 2025, unlocking significant opportunity in oncology diagnostics. We are excited to have announced at VMX the March launch of IDEXX Cancer Dx panel with Lymphoma, a pioneering advancement in veterinary oncology. This innovative screening solution represents a significant step forward in companion animal healthcare, addressing a critical need for early cancer detection and as an aid-in-diagnosis in canine patients. The IDEXX Cancer Dx panel has breakthrough cost, performance, and turnaround-time attributes for early-stage cancer diagnostic screening and as an aid-in-diagnosis test, priced for as little as $15 per test when included as part of select diagnostic panels. This will change how and when canine cancer is detected, and its early diagnosis will likely change how cancer care is managed, with positive patient implications for the support of longer, healthier lives. Given the performance, cost and turnaround-time attributes of the Cancer Dx panel, the opportunity is to inspire a much broader inclusion of cancer screening as an essential part of preventive care blood work. The Cancer Dx panel will initially launch with lymphoma detection, one of the most common and treatable cancers in dogs. Over the next three years, the panel will expand to include the six most prevalent canine cancers, which collectively account for over 50% of cancer cases in dogs. This expanded menu will tap into an estimated $1.1 billion addressable opportunity, underscoring the potential of this diagnostic innovation. Our software ecosystem plays a pivotal role in supporting veterinarians by enhancing clinic efficiency, optimizing workflows, and fostering deeper connections with practices and pet owners. With double-digit growth in cloud-native placements, software remains a critical enabler of diagnostic adoption and practice success, reinforcing our position as a leader in vertical SaaS offerings tailored to veterinary needs. One of the year's standout achievements was the expansion of Vello, our pet-owner engagement application. Designed to address the growing demand for seamless communication and improved visit outcomes, Vello has been embraced by nearly 600 practices at year-end, doubling its user base since Q3. Early results from the app's deployment have been highly encouraging, with participating clinics reporting increased clinical visits, higher diagnostic usage, and improved revenue. This underscores Vello's ability to address critical workflow pain points while fostering stronger relationships between veterinarians and pet owners. We have meaningfully increased development resources and investment in Vello throughout 2024 and now in 2025. Looking ahead, Vello's development roadmap promises even greater value with upcoming enhancements focused on streamlining communications, expanding engagement tools, including the ability to personalize messaging, and integrating advanced analytics. Customers appreciate our commitment to an integrated diagnostics and software suite and the way it unlocks new opportunity for growth. Beyond Vello, we continued to expand our broader software portfolio. We placed a record number of cloud-native PIMS, expanding that installed base by 20% year-over-year, as our offerings remain a top choice for clinics seeking modern, scalable solutions. We finished the year with 60% of our PIMS installed base in the cloud, ahead of our estimate shared at Investor Day in August. IDEXX Web PACS, our cloud-native imaging workflow engine, also experienced double-digit subscriber growth, demonstrating its relevance in addressing key pain points such as dental imaging workflows. These advancements not only simplify complex processes but also allow clinicians to spend more time focusing on patient care. The integration of diagnostics and software remains a cornerstone of IDEXX's value proposition. By providing intuitive, efficient, and comprehensive tools, we empower clinics to unlock new levels of performance while delivering superior care to their patients. As we move into 2025, our focus on software innovation will continue to drive recurring revenue growth and deepen our partnerships with veterinary practices worldwide. As we turn the page on 2024, IDEXX remains steadfast in its purpose: to create exceptional long-term value for our customers, employees, and shareholders by enhancing the health and well-being of pets, people, and livestock. I extend my deepest gratitude to our nearly 11,000 employees whose dedication and hard work have made these accomplishments possible. Together, we have delivered robust financial results while setting the stage for a promising 2025 and beyond, supported by a new wave of IDEXX innovations. I'd like to thank Brian McKeon for the exceptional contributions he has made over a 20-year IDEXX career, spanning both as a member of our Board and over the last 11 years as IDEXX's CFO. As previously announced, Brian will be stepping down from the role as CFO as of March 1st. One of Brian's many contributions has been to build a world-class finance team and develop future leadership talent. It's my great pleasure to welcome Andrew Emerson, who will become our new CFO as of March 1st. Andrew brings more than 20 years of finance experience in the healthcare industry in roles of increasing responsibility, including over nine years at IDEXX working side-by-side with Brian throughout this time. He is well-versed in our business, our sector, and our strategy, and he is set to contribute on day one. Brian will remain with IDEXX in a senior advisory capacity until his retirement date of June 1st in order to help ensure a smooth and seamless transition for Andrew. With that, I will turn it back over for Q&A. Thank you.

Thank you. The first question is from Erin Wright with Morgan Stanley.

Great, thanks. And Brian, it's been great working with you over the years, and congrats on your retirement. And looking forward to working with you, too, Andrew, as we kind of move forward. But, in terms of my questions, I'll start with innovation. So, I guess, can you speak to what guidance assumes now in terms of the innovation contribution in 2025? Is that adding about 1 point to CAG recurring growth assumptions for you? And I just wanted to get an update on inVue on that front. I guess, why are you limiting preorders in the US and the replacements, I guess, of 10, but preorders of 1,600, so I guess why is there such a backlog there? Is there more AI training needed? Is there necessary adjustments to the offering or timing of the rollout or anything like that, or practitioners just waiting for FNA? I guess, when do you expect FNA to launch as well, and what is guidance assumed on that front? Thanks.

Good morning, Erin. This is Andrew. Happy to kick us off with what's included in the guidance and then I'll hand it over to Jay to talk a bit about inVue. Just in terms of what we've provided, we initially get the benefits from the instrument revenues as we launch a platform like inVue. What we noted in the prepared remarks is approximately $50 million and 4,500 placements on the innovation launch of the inVue Dx platform. So, we feel good about that. That's captured in our overall guidance. We haven't necessarily broken out the other innovation areas, but we do expect benefits from Pancreatic Lipase and Cancer, as Jay highlighted in his remarks. They're going to allow us to continue to build momentum, both domestically and internationally, but we haven't broken those out. We just have included that, and we feel good about the guidance that we've provided at this point.

Good morning, Erin. As disclosed, we commenced shipping in the fourth quarter. Customer interest has been very high, as shown by nearly 1,600 preorders. Customers are responding positively to key attributes of the system, which include the menu, ear cytology, and blood morphology, with FNA expected later in 2025. They see these clinical use cases as high volume, well understood, and well-integrated into their workflows. Additionally, they appreciate the slide-free operation, since preparing slides can be a significant bottleneck, sometimes taking 15 to 20 minutes. Ultimately, what customers desire are consistent and highly accurate results, and they believe inVue can deliver on that. Regarding the launch strategy, we adhere to a controlled launch process for all our analyzers. This is my fourth premium instrument launch at IDEXX, aimed at providing an exceptional customer experience aligned with their expectations. Our world-class product development organization is making excellent progress. We plan to deliver over 4,500 units in 2025, with a ramp throughout the year. Our manufacturing and installation capacity are ahead of schedule, putting us in a strong position to meet our plans, and to directly address your question, customers are not waiting for FNA to commence delivery.

That's helpful. Does your guidance take into account any significant changes from a customer account perspective at Point-of-Care or reference labs? I assume you are still working through some of the repricing effects from 2024. Could you remind us when you will fully cycle through that? Also, could you clarify how that impact will continue into 2025? Will it still be a headwind, or will it lessen in 2025? Thank you.

Thanks, Erin. So, just on pricing, what we noted was 4% to 4.5% for the full year. In Q1 specifically, we did a remark that we would expect to be on the lower end of that range, just given the three large customer lapping that Brian had captured in his commentary on our Q4 results. So, we will continue to lap that throughout the year, but I think we've captured that in our guidance. And again, we feel good that we have strong momentum in terms of our ability to continue to work with our customers and expand our installed base, both internationally where we saw double-digit growth as well as globally where we had a 9% installed base expansion for 2024.

Okay, great. Thank you.

The next question is from Chris Schott with JPMorgan.

Great. Thanks so much for the questions. Just two on the 2025 guidance. First, can you just elaborate on the vet visit trajectory you expect from here? It sounds like, I think from the prepared remarks, down 3% or so in 1Q, but can you just talk about the recovery and confidence in recovery from there? And the second question was just on US versus ex-US growth this year. Any notable kind of differences or trends that you're expecting as we think about the regions? Thank you.

Good morning, Chris. So, just to talk about the vet visits, in terms of what we've included in the guide for the US, we signaled it was similar to the decline that we intended for 2024. So that would represent approximately 2%, as Brian highlighted. When we think about Q1, we are anticipating that we saw similar trends as we exited the year. Q4 was about a 3% decline on clinical visits overall. And just as we saw in Q4, we saw some modest differences by quarter, but ultimately, again, we're anticipating about a 2% decline in clinical visits for 2025. So, not really an improvement as we head into the year and that could bounce around a little bit by quarter, and we'll provide more information as the year goes on.

Good morning, Chris. I want to emphasize our performance in international markets. We have invested significantly in expanding our global commercial presence over the past three years, resulting in impressive growth in the overall number of our premium instruments and the related consumable sales. In Europe, we have experienced seven consecutive quarters of double-digit growth, with consumable sales increasing by high-teens percentages. This is indicative of our strong execution, longer customer relationships, and the positive response to innovations like ProCyte One and other solutions that enhance medical practices.

Great. Thanks so much.

The next question is from Michael Ryskin with Bank of America.

Thank you for taking my question. I have a couple of quick ones. First, regarding the visit dynamics, I want to focus on the fourth quarter. I know we shouldn't read too much into quarter-to-quarter trends since they can be volatile, but I've noticed a significant difference between wellness and non-wellness visits. It seems like this gap accelerated through 2024, reaching its widest point in the fourth quarter. Wellness visits dropped sharply compared to total clinical and non-wellness visits. I'm curious about what you're observing on the ground and the feedback you're receiving. There's concern that this may be linked to demand, price elasticity, a weak consumer environment, and people pulling back from more discretionary visits. You've mentioned in previous quarters that visit trends might be impacted by some therapeutic options, including injectable drugs. Could you provide any insight into the wellness aspect specifically and why it has declined throughout 2024?

Sure. Let me provide some insight on that, Mike. We do think at the margin, there was probably the impacts from the consumer and the overall macro environment, but the interesting thing about wellness is the inclusion of diagnostics actually went up. So, we saw a really nice premium growth. Our belief is that the quality of these visits went up. The pet owner in veterinarian really used that higher intensity of diagnostics. So, though there's probably some marginal pet owners dropping off potentially deferring or delaying some of those visits, the ones that came in, very high quality, and we benefited from that, and we think with our IDEXX Cancer Diagnostics panel included in wellness visits, we'll continue to inspire potentially pull-through on that end, too.

For my follow-up question, I noticed that in the guidance for 2025, there seems to be an assumption of a higher share buyback, indicating a 2% to 3% reduction in shares compared to the typical 1% reduction observed in previous years. Can you provide any additional insight regarding the reasoning behind this change? Thank you.

Yeah, Mike. So, just in terms of kind of a rationale, we have high confidence in the company's potential growth model here. We've executed exceptionally well, and I think we're really on the cusp of that new wave of innovation, which Jay has highlighted several times. This really reflects strong free cash flow generation. We have a really healthy balance sheet with high liquidity. Brian mentioned on the call in terms of Q4, our gross leverage was about 0.7 times, and this largely sustains those levels at a higher deployment rate. So, it does achieve that 2% to 3% reduction in average shares. And again, we look at this as a positive momentum for the long-term.

All right. Thanks.

The next question is from Jon Block with Stifel.

Thanks, guys. Good morning. It looks like the IDEXX premium for the quarter, so in other words, 4Q '24 was the strongest of the year and that was before the rollout of Cancer Dx, I mean, essentially before inVue for the most part. So, can you just talk about what led to the uptick for the premium in the quarter, allowed you to arguably offset the down whatever was 2.9% in clinical and still put up some pretty good CAG Dx recurring? That's specific to the fourth quarter '24 question. Then, I'll ask a follow-up.

Hey, Jon, it's Brian. As you pointed out, it was a very good quarter, our best volume growth quarter of the year when you normalize for days. We saw very strong consumable growth. I think that that's reflective of the progress that we've made on instrument placements, growing the installed base during the year. Some benefit from innovation, the pancreatic lipase slide is helpful on that front, and globally, just really good international momentum. So, I think it's reflective of the strong execution that we've seen throughout the year that's enabled us to grow at a faster rate than the sector. And as the team has pointed out, I think the company is really well positioned to build on that heading into 2025 with the new innovations that will be coming.

I understand. That's helpful. For my second question on pricing, I believe you mentioned it’s around 3.5% in the US, which suggests it might be over 5% internationally. Jay, could you share your thoughts on how comfortable you are with these pricing levels and whether the consumer can handle the expected increases? I anticipate your response will be that you don't set prices for consumers, but in a way, you do since veterinarians won't absorb the full cost on their margins. In relation to Mike's earlier question, do you believe that this higher pricing environment, while providing a temporary solution, is acting as a barrier as we see a decline in wellness visits and pet owners hesitate due to the costs associated with wellness services? Additionally, regarding the $42 million in interest expense, could you clarify that? It appears quite high compared to where we stood in '24. Thank you.

Yeah, let me talk about pricing and I'll turn it to Andrew to talk about the interest expense. Of course, I'm going to caveat it and say our customers determine sector pricing. Keep in mind, wellness versus non-wellness pricing are different things. Typically for a wellness visit, the veterinarian doesn't spend more than five, seven, or ten minutes with the pet owner. So, they price it differently, and we offer a number of programs like compliance-based pricing, which I think positions those panels very advantageously. I would say that we are very mindful of the need to be in front of the differentiation that we offer through innovations. A lot of what we offer, for example, is complementary to the customer, whether it's VetConnect PLUS, whether we add in tapes and Cystoisospora for fecal antigen. I think Cancer Dx is a great example of really keeping that price very moderate at $15-plus per select panels. So overall, we're comfortable in terms of where we've priced. We've seen an increase, as I just indicated, in the inclusion of diagnostics and wellness panels, in fact, very strong increase in Q4. So, the quality of the visits and the quality of diagnostics inclusion has been growing fairly strongly.

Yeah, Jon. Just in terms of the $42 million on interest, that does align with the step up in terms of our planned buybacks of $1.5 billion. So, again, we've calibrated that based off of current rates. As Brian noted, we did just about $850 million in 2024. So, there's an increased level there, and we've captured that in our interest expense cost.

All right. Thanks.

The next question is from Daniel Clark with Leerink Partners.

Yes. Thank you. I just had a quick clarification on inVue. Are you still limiting preorders or are you fully allowing those now?

Yeah. So, we generally, we've opened the funnel in terms of what our field organizations can take in North America. I would say internationally, it's more limited and we'll continue to just offer it in select countries. And throughout the year, we'll revisit that.

Okay, got it. Thank you. And then just a separate question, was there any impact from weather that's worth calling out in terms of visit trends for 4Q or how you're thinking about 1Q? Thanks.

Good morning, Dan. So, just in the fourth quarter, I think we had signaled on the last call that we anticipated about 50 basis points of weather associated with what we saw in early October. Yes, as we head into Q1, certainly, we've seen some weather types of impacts, but at the end of the day, we've captured those in our outlook and again feel good about the guide that we presented today.

The next question is from Navann Ty with BNP Paribas Exane.

Hi, good morning. First on the vet visit, if you can discuss further the underlying factors embedded in the 2% decline, expected midpoint in terms of macro impact and time to replenish vet and vet techs graduate? And do you expect potential improvement in 2026? And then, in terms of margin, should we still expect 2025 margin expansion to be still gross margin-led? And can you discuss the SG&A and R&D this year with the inVue and Cancer Diagnostics launches and expansions? Thank you.

I will discuss the trends in clinical visits. We still believe that capacity constraints present a challenge for practices, not just in terms of employment levels but also in relation to the number of hours worked. From conversations with several corporate accounts, there is a clear desire to hire more veterinarians and staff as they become available. In this way, supply can influence demand. A significant factor at play is the macroeconomic environment, particularly the cumulative effects of inflation and some moderation associated with that.

Yeah, Navann, just on the gross margin and breakout of OpEx, we didn't provide any explicit detail here. But overall, what we're planning for is an operating margin improvement of 30 basis points to 80 basis points on a comparable basis year-over-year, the midpoint being about 50 basis points. I think you'll expect most of that to be gross margin-led as we reinvest back into the business. Certainly, again, we feel good about the innovation cycle we have here and the potential for growth over time. We want to make sure we're making investments in the right areas in order to support that ultimately.

Okay. I'd like to thank everybody for their questions this morning. We're now going to conclude our Q&A portion of this morning's call. It's been a pleasure to review another quarter and full year of strong IDEXX results. So, thank you again for your participation this morning, and we'll conclude the call.

Thank you. This concludes today's call. Thank you for your participation. You may now disconnect.