Good morning. My name is Joseph. And I'll be your conference operator today. At this time, I would like to welcome everyone to the Integer Holdings Corporation Q4 2021 Earnings Call. All lines have been placed on mute to prevent any background noise. After the speaker remarks, there will be a question-and-answer session. Thank you. I would like to now turn the conference over to Senior Vice President of Investor Relations, Anthony Borowicz. Please go ahead, sir.

Good morning, everyone. Thank you for joining us, and welcome to Integer's fourth quarter 2021 earnings conference call. With me today are Joe Dziedzic, President and Chief Executive Officer; and Jason Garland, Executive Vice President and Chief Financial Officer. As a reminder, the results and data we discuss today reflect the consolidated results of Integer for the periods indicated. During our call, we will discuss some non-GAAP measures. For a reconciliation of these non-GAAP measures, please refer to the appendix of today's presentation, today's earnings press release and the trending schedules, which are available on our website at integer.net. Please note that today's presentation includes forward-looking statements. Please refer to the Company's SEC filings for a discussion of the risk factors that could cause our actual results to differ materially. On today's call, Joe will provide his opening comments and a timely update to Integer's portfolio and product line strategies, along with our progress towards achieving above-market sales growth. Jason will then review our adjusted financial results for the fourth quarter, total year 2021, provide additional insight on our product line performance and share our full year 2022 guidance. Joe will come back to provide his closing remarks. And then we'll open up the call for your questions. With that, I'll turn the call over to Joe.

Thank you, Tony. And thanks to everyone for joining the call today, especially the Integer associates who have continued to develop and manufacture products for our customers, so they can provide life-saving and life-enhancing products for patients around the globe during these challenging times. Integer delivered strong fourth quarter and full year results. Sales grew 16% in the quarter and 14% for the full year. Earnings per share grew 39% in the quarter and 47% for the full year. Even with these strong results, we experienced about 200 basis points of unfavorable gross margin impact from the labor and supply chain environment, most of which we believe are temporary. We closed the acquisition of Oscor in December and are well underway with integrating our businesses to deliver a broader and deeper product offering to our customers. We have continued to execute our structured and disciplined process to accelerate top line growth and drive bottom line outperformance. Today, I will share a detailed review of our portfolio and product line strategies and provide an update on the great progress we are making. In 2022, we expect to deliver double-digit sales and profit growth at the midpoint of our guidance, despite the continuation of a challenging labor and supply chain environment. The Integer investment thesis summarizes why we believe Integer is executing a clear and compelling strategy to sustainably outperform. Our portfolio strategy and product line strategies define how we win in the markets we serve. Our operational strategy defines how we achieve excellence in everything we do, and our values define how we engage with each other. The bottom of this slide articulates the industry and Integer fundamentals that create a resilient business model. The elements of our strategy to generate sales growth and the structured approach we've taken to develop a performance culture. Our financial objectives are clear and measurable. Everything we do in the company is anchored to this strategy, which is why we share it every quarter. So let's look at some of the important milestones we have achieved on our strategy journey. We started in March of 2017 by performing our portfolio review and developing the overall Integer strategy. We launched the portfolio strategy in January of 2018 and within six months, executed the divestiture of our AS&O business for $600 million. As a further evolution of our portfolio strategy, we just initiated in the fourth quarter of last year, the partial exit of the Portable Medical business, which I'll discuss in more detail on the next slide. As highlighted in the middle section, we formally launched our operational strategy in the second half of 2018, starting with Manufacturing Excellence, then followed by the other five strategic imperatives. We saw immediate impact from Manufacturing Excellence as margins expanded during 2018 and 2019. Not surprisingly, the pandemic and the current labor and supply chain constraints have created margin rate headwinds. We're confident our strategy and operational excellence will overcome these headwinds over time. The bottom row highlights the progression we have made in our product line strategies, which define how we will win in the markets we serve. These strategies were defined by what we call growth teams. The growth teams own the product line strategies in all respects. These teams were launched in the fourth quarter of 2018 and began developing and executing their specific strategies during 2019. The investments we've made, both organically and inorganically, have been driven by the product line strategies. The growth teams are executing a structured and disciplined process to deliver accelerated sales growth. Let's cover an update on our portfolio strategy. Our Portable Medical product line sales have been flat for the past four years. We've highlighted a few of the many markets we serve with rechargeable battery packs, power supplies and chargers. The market and product dynamics are generally unfavorable as there is a limited amount of technology differentiation in what is primarily an assembly business with high sourced material content. Given these dynamics, we communicated to certain customers during the fourth quarter of last year that we were exiting all but two of the markets we serve in this product line. We are working closely with these customers to support the transition of these products to other suppliers, and it will take three to four years to complete this transition due to the quality and regulatory requirements. So even though we're exiting $40 million of sales, we do not expect to see a decline in these sales until around 2026. We are retaining approximately $30 million of sales in the Heart Failure & Cochlear application markets where technology differentiation and higher growth rates make these products and markets more attractive. They closely align with the battery expertise and active implantable device technologies of our CRM&N product line. We expect this exit to be margin accretive from reducing overhead and raising prices as we consolidate these products into the CRM&N product line. Another important benefit is that we will be able to reallocate the manufacturing capacity in this Tijuana facility to more profitable growth going forward. To summarize, we are exiting $40 million in sales over the next four years while improving margins and reallocating low-cost manufacturing space to higher-margin growth. This is a great example of how we will continue to evaluate our portfolio for opportunities to create more value. We have talked a lot over the past several years about our operational strategic imperatives with a focus on how we've been implementing manufacturing excellence to drive margin expansion. We have not spent as much time discussing our growth teams and our product line strategies. There are two reasons for this. First, as we just highlighted on the timeline, we launched Manufacturing Excellence much earlier than our product line strategies. And second, the Manufacturing Excellence strategy was able to positively impact the financial results much faster than the product line strategy decisions and actions. Our Manufacturing Excellence planning started in early 2018, launched in the middle of 2018, and began to have an immediate impact on margin expansion, contrasting that with our growth teams, which were formed in late 2018 and began developing and executing the strategies during 2019. Another important variable impacting the timing of developing and executing our strategy is getting the right leaders in place. The leaders who have joined Integer since 2018 have very intentionally aligned to do specific elements of our strategy. Let's cover what the growth teams do. They are organized around the end markets we serve, and they follow a very structured and disciplined process. Many organizations call this process product management. We like to term growth teams as it starts with a goal in mind, which is growth. The middle of the slide summarizes the process they follow, which I think you'll find very logical and clear. They own understanding our markets, products, customers, and competitors, and they are developing and executing the strategies that will deliver above-market profitable growth, including identifying what capabilities and investments are needed to win. These teams ultimately enable us to maintain and capitalize on the broadest and deepest product offering in the Medical Device outsourcing industry to deliver sustained growth. This slide summarizes the work of our Cardio & Vascular focused growth teams, and we have the same slide for Cardiac Rhythm Management and one for Neuromodulation. This takes a picture of where the end markets are in their growth curve and how they compare in size on a relative basis. The curve represents the growth rate of the end market, which is slower during the emerging and mature phases of the technology maturity timeline. The size of the bubbles represents the current estimated end market size. The horizontal axis represents the technology maturity of the products in the end market, which range from emerging to growth to mature. Integer is uniquely positioned to serve our customers in each phase of the technology maturity timeline. During the emerging phase, we have the expertise, proprietary technology, and design and development capability to de-risk emerging products from concept all the way to commercialization. During the growth phase, we can accelerate the speed to market through collaborative product design and development, leveraging our quick turn capability and manufacturing capacity to deliver seamless transitions to scale production. And during the mature phase, we bring vertical integration that simplifies our customers' supply chains, reduces the number of suppliers they must work with, and lowers their costs. Because of our deep technology, breadth of capability of products, global manufacturing footprint, and strategic focus, we can serve our customers across all phases of the technology maturity timeline, a truly unique customer value proposition that differentiates Integer. The blue box in the middle of the slide that encompasses full-scale ablation, structural heart, neurovascular, electrophysiology, and parts of peripheral vascular shows the markets that are receiving a disproportionate share of our customers' investments to address significant unmet patient needs. We have aligned our strategy with our customers to focus our investments on additional capabilities and capacity in these faster-growing end markets. We are excited to be able to enable our customers to bring life-saving and life-financing products to market faster than our competitors. Let's drill down into the three fastest-growing markets from the Cardio & Vascular growth curve, structural heart, electrophysiology, and neurovascular, and cover the actions we've taken to expand our ability to serve our customers and thereby accelerate our growth. All three of these markets are growing high single digits or low double digits. They are multibillion-dollar end markets for our customers with significant opportunity for us to serve as an outsourced partner for both components and finished devices for these medical procedures. Our growth teams understand the technology and the devices and how that technology is evolving. They've identified where Integer has leading technology and where we have gaps, which led directly to the actions highlighted in the middle column. We have invested in critical capabilities such as laser cutting, coatings, and complex braiding that enable us to vertically integrate and accelerate the speed of development for our customers. We have developed these through both organic and inorganic investments, which offer different benefits, but ultimately give us access to a greater portion of the devices for design, development, and manufacturing. Our success in building a pipeline of development programs for our customers has generated the need to increase capacity to support our growth in these fast-growing markets. This slide summarizes the cardiac rhythm management growth curve, and I don't think it will surprise anyone to see the largest segment of this market concentrated in the conventional CRM bubble on the far right. But they are emerging in growth products in CRM, as highlighted in the light blue box on this slide. Integer's ability to support our customers across the technology maturity curve applies to CRM as well, but is more focused on the higher technology components and sub-assemblies of these devices as the finished devices are primarily assembled by our OEM customers. Our historically deep and differentiated component and sub-assembly technology. The neuromodulation growth curve is comprised of emerging and growth markets. Even the traditional spinal cord stimulation market is estimated to grow at high single digits from the continued innovation in this space. These markets have significantly more early-stage companies than the C&V or CRM market because of the significant number of companies that are investing to develop treatments for currently unmet or underserved patient conditions. Integer is uniquely positioned to be able to bring the full design, development, and high volume manufacturing to these customers, while also vertically integrating the most technologically advanced components with our own intellectual property from decades of innovation. Very few of the companies have the breadth of design and development capability and even fewer offer the depth of component technology that Integer offers to our customers. Integer is uniquely positioned to enable emerging companies to bring innovative therapies to market. The CRM&N growth markets play to the strengths of Integer's technologies as they benefit from our extensive intellectual property portfolio in component technology and our strong design and development capability for finished devices. We continue to strengthen our position by developing novel batteries, miniaturizing the technologies we possess, and developing platforms and designs that enable the emerging and growth products to come to market. We have been investing in our battery facility to add capacity to support the increased demand for neuromodulation and cochlear applications. Our Tijuana facility was the first Class III active implantable medical device manufacturing site in Mexico to receive FDA approval. This augments the significant Implantable Pulse Generator or IPG manufacturing capacity already available in two other facilities. We already manufacture several components for IPGs in our Tijuana facility, and this furthers our vertical integration capability for IPGs. The recently completed acquisition of Oscor expands our implantable lead design and development capabilities while adding additional low-cost manufacturing of leads in the Dominican Republic. The expansion of our end-to-end capabilities, platform technologies, and capacity positions us well to accelerate our growth in these faster-growing end markets. Earlier in the presentation, I highlighted our strategy journey that we developed our portfolio strategy in 2017 and launched our operational and product line strategies in 2018 and 2019. At the end of 2019, less than two years into our strategy execution, we have achieved two of the three financial objectives of our strategy. Our debt leverage was 2.9 times EBITDA and our profit was growing twice as fast as sales. The third financial objective is accelerating sales to grow 200 basis points above the market. The strategy to deliver this third objective resides with our growth teams. I highlighted earlier that our growth teams who own the development and oversight of the execution of our product line strategies were formed in late 2018 and began developing and implementing them in 2019. So we have been developing and implementing these strategies for less than three years. This is an important point because of how long it takes to convert new business into revenue in the income statement. To help investors understand the time it takes to convert new business into sales and the income statement, we developed this slide to summarize the approximate cycle times required for products to go through the product development phase through the clinical or regulatory phase and we introduce these products into the market. It is important to highlight this process doesn't start until after Integer has already won the business with customers, which has a cycle time that happens prior to what is highlighted on this slide. We brought the new revenue down into three types of products. The first one is existing product transfers. These are products that are already being manufactured by either our customer or a competitor. These products generally require Integer to develop manufacturing processes to produce the components or finished device. This generally takes somewhere between one to two years. Then the regulatory phase when required could take up to six months, after which the manufacturing ramp starts. The entire cycle time for existing product transfers generally averages somewhere between one and 2.5 years. The second type of product is a new 510(k) product developed with a customer. This includes product development, potentially clinical and regulatory, market introduction, and then manufacturing ramp. It is common for this entire process to take somewhere between three years and more than five years. The third category is new PMA product developed with customers. This is the same process as a 510(k), but the product development, clinical, and regulatory generally takes much longer. The total cycle time is generally somewhere between five and more than nine years. But some products can take significantly longer as the product development in the clinical phases can be extended or iterative to develop a device that delivers the desired therapeutic benefits, which may ultimately not achieve market acceptance. The chart on the top right of this slide demonstrates that Integer generates revenue throughout the entire cycle. The revenue from process or product development is for the engineering work and is generally the lowest amount of revenue in the cycle. The clinical or regulatory phase includes components or devices needed to perform the SSA trials to gain approval of the product and usually generates more revenue than the process or product development phase. Once market introduction starts and we move into manufacturing ramp, we experienced significant growth in revenues until we reach market penetration, at which point we grow with the market and market share changes of our customer. The importance of this slide is to demonstrate the time it takes to convert new business into revenues and manufacturing ramp. It also illustrates the resiliency of our business model because the combination of Integer's proprietary technologies, a long development cycle, and a substantial regulatory approval process leads to high switching costs for our customers. I suspect you might be thinking, well, that's interesting enough, but when will sales grow at 200 basis points above the market. The short answer is, we're getting closer, but we're not ready to provide a specific date. But there are several leading indicators that we are tracking to measure the success of our product line strategies and understand when sales will accelerate. Let's start by looking at the new PMA products we are developing with customers, which have the longest cycle time. This is an update from a slide that we shared on our third quarter 2020 earnings call and demonstrates that we have a strong pipeline of customers moving through the product development to launch process. This slide only covers emerging customers and does not include the components or devices we are working on with larger, more established OEMs. These customers are primarily in the neuromodulation markets and have generally followed the new business timelines shared on the prior slide. We have highlighted the changes on the left-hand side of this slide as more customers have moved into product introduction and into the launch phase. On the right-hand side, we achieved the estimated sales of approximately $20 million during 2020, and our 2022 estimate of $40 million of sales is still on track. We are adding a new estimate for 2024 that projects these customers growing to somewhere between $60 million and $80 million with possibly more depending upon the success of their product launches. This slide demonstrates that we've been working this strong pipeline for many years, and we are entering a phase where we will see revenue acceleration from the manufacturing ramp phase for these customers. Accelerating growth starts with product development. So we have a rigorous process to target the opportunities that have the strongest market potential. Let's look at some additional in-process metrics that we believe demonstrate our significant progress towards accelerating our revenue growth. We have grown our development revenue by 150% over the last four years. This is measuring actual revenue in 2021 compared to actual revenue in 2017. We have also added 54% more R&D resources to support this revenue growth. We believe this is an important measure of the volume we're adding to the pipeline to drive accelerated growth. Another important measure is the quality of the revenue we're developing. Our product line strategies had very clearly targeted faster growth markets, the ones we define as emerging or growing on the growth curve. We have shifted the mix to significantly more emerging and growing markets in 2021 compared to 2017. So not only have we increased the volume of development revenue, but we've also shifted the mix too. This gives us confidence in our ability to deliver on our third financial objective of growing sales 200 basis points faster than the market. As we prepare for accelerated growth from the development opportunities highlighted in our leading indicators, we have been investing to both fuel and fulfill this growth. We have increased our growth CapEx by 60% over the last four years, totaling approximately $100 million. We have also added 32% more capacity, primarily through acquisitions and some targeted expansions of existing facilities. We also have plans to reallocate space in our Tijuana facility related to the partial exit of our Portable Medical product line discussed earlier. We're also building a greenfield facility in Galway to support growth in the fast-growing structural art and neurovascular markets based on the development projects underway. In summary, we have been executing product line strategy since 2019 to maximize our unique position to serve customers across the entire product life cycle. We have been focusing our investments on faster growing end markets in a very structured and disciplined manner. The execution of our strategy and the in-process metrics we are tracking give us confidence in our ability to deliver on our financial objective of accelerating revenue growth to 200 basis points above the markets we serve. I'll now hand the call over to Jason.

Thank you, Joe. Good morning, everyone. And thank you again for joining our call. I'll provide more details on our fourth quarter and full year 2021 adjusted financial results, summarize our product line sales trends and conclude with our expectations for 2022. Starting with our fourth quarter results. At $313 million, our sales delivered strong growth over last year, up $44 million or 16%, and that included $5 million of sales from one month of Oscor. Organic sales growth, which excludes the impact of the acquisition and currency differences, is 15% higher than last year. Our adjusted EBITDA was $58 million, up $9 million compared to last year, an increase of 19%, and adjusted operating income was up 16% versus the prior year. With adjusted net income of $33 million, we delivered $0.99 of adjusted diluted earnings per share, up $0.28 or 39% from the fourth quarter of 2020. Our fourth quarter results represent another quarter of strong financial performance versus last year. Again, our 2021 reported financial results include one month of Oscor. Our full year sales were $1.221 billion, an increase of $148 million compared to the prior year, which is a strong increase of 14% or 13% organically. Adjusted EBITDA was $243 million, up 28% versus last year, and adjusted operating income was $187 million, up $43 million compared to the prior year, an increase of 30%. Our adjusted net income was $136 million, and we delivered $4.08 of adjusted diluted earnings per share of $1.31 from the prior year. These strong year-over-year results were achieved while overcoming an extremely difficult labor and supply chain environment. As Joe mentioned, we have been committed to delivering the products needed by our customers and ultimately the patients they serve. This has required the team to work a great deal of overtime to cover labor gaps, incentivizing associates and new hires, incurring significant training costs, managing the inefficiencies of redirecting production to match material availability and incurring inflation costs in our supply chain. We estimate these additional costs contributed to approximately 200 basis points of erosion in our gross margin for the full year. The constraints were more significant in the third and fourth quarters. And as a result, the gross margin impact was more pronounced in the second half of 2021. The good news is that we believe the majority of these incremental costs are temporary in nature and will subside. That said, we do expect these incremental costs to remain through at least the first half of 2022. We are proud of Integer's dedicated associates for continuing to deliver product during these dynamic times. To provide more color on our full year 2021 adjusted net income, we increased $44 million compared to 2020. We delivered $38 million of operational improvement as compared to last year driven by our sales volume returning to pre-pandemic levels and by our manufacturing and supply chain team doing an excellent job of accelerating production to meet demand from industry recovery and new product introductions, while of course managing through the labor and supply chain headwinds that began primarily in the second half of the year. In addition, FX was favorable, contributing $1 million in improvement versus 2020. Lower adjusted interest expense delivered a $9 million improvement in adjusted net income compared to last year, driven by our continued focus on debt repayment and the savings cash with our debt refinancing in the third quarter. Our adjusted effective tax rate was 15% for the full year 2021. While this is a very favorable rate, we saw a year-over-year headwind of $4 million due to the adjusted effective tax rate in 2020 being 12.2%. You may recall that 2020 benefited from the rate impact of lower pandemic-driven pretax income, as well as from several significant discrete items recorded in 2020 related to the favorable impact of final tax reform regulations and our tax plan strategy. Discrete items in 2021 were also favorable, but not as significant as the prior year. For 2022, we expect our adjusted effective tax rate to be between 16% to 17.5% as we expect lower benefits from tax return closures and deductions from stock-based compensation. We continued a strong conversion of income to cash in the fourth quarter, generating $39 million in cash flow from operating activity. We generated $60 million of free cash flow, inclusive of $23 million of capital expenditures in the fourth quarter, in line with our total year guidance of $50 million to $60 million. As Joe shared with you earlier, we continue to ensure we are making focused investments to fuel and fulfill growth, consistent with our product line strategy. Net total debt increased $206 million to $818 million, which includes the impact of $220 million in new borrowings to fund the acquisition of Oscor. Excluding the new borrowings, our net total debt reduction was $14 million in the fourth quarter. Our debt leverage at the end of the fourth quarter was 3.4 times adjusted EBITDA. This leverage ratio includes the impact of the new borrowings to fund the Oscor acquisition, while remaining within our target ratio range. We'll now transition to a discussion of our product line sales. Please note that these product line sales are consistent with the product classifications we have used historically and do not yet include the product line reporting changes associated with the Portable Medical update Joe shared earlier. I will close with a summary of the impact of this portfolio update on our product line reporting and some additional improvements we are making at the end of the session. Slide 29 reflects trailing four quarter reported sales year-over-year changes. Through the first quarter of 2021, our sales were significantly impacted by the COVID pandemic. The trend reversed in the second quarter of 2021 and continued to improve in the third and fourth quarters as reflected in the significant increase in our trailing four quarter sales growth rate. I'll also note that we added an indication of the percentage of sales that each product line contributes to total Integer. This should provide additional insight on the impact each has on our total growth rate. Beginning with our first product line. Cardio & Vascular sales were up 19% in the fourth quarter compared to the fourth quarter of 2020. The fourth quarter growth was driven by double-digit sales increases across all cardio and vascular markets with the neurovascular market delivering particularly strong year-over-year growth despite supply chain constraints. Trailing fourth quarter sales grew 10% year-over-year in the fourth quarter. Moving to Cardiac Rhythm Management & Neuromodulation. Sales grew 90% in the fourth quarter with both Cardiac Rhythm Management & Neuromodulation market increasing double digits, again, overcoming end market demand fluctuations and supply chain challenges. Trailing four quarter sales continued with strong year-over-year growth, up 29%. As a reminder, the Advanced Surgical, Orthopedics & Portable Medical product line includes sales under supply agreements to the acquirer of our divested AS&O product line in addition to our Portable Medical sales as reported historically. Fourth quarter sales declined 10% versus the prior year, mostly due to the decreased demand for ventilator and patient monitoring components that peaked last year during the pandemic. Trailing four quarter sales declined 10% year-over-year due to the decline in Advanced Surgical and Orthopedics and as previously noted, a decline in Portable Medical driven by the lower demand for COVID-related ventilators and patient monitoring components. Finally, wrapping up with Electrochem, our Non-Medical segment. Fourth quarter sales increased 34% as we continued to see improvement in the energy market that began a recovery in the first half of 2021. Trailing four quarter sales grew 8% year-over-year. As I just mentioned a few moments ago, I wanted to share changes we are making in our product line sales classifications as we move into 2022. There are two changes. First, consistent with our discussion on Portable Medical, we will move active implantable medical device components into CRM&N from their current alignment in the AS&O and Portable Medical product line. Second, we are moving access and delivery products associated with CRM & Neuromodulation procedures in the CRM&N product line from their current alignment with Cardio & Vascular. We're making these changes because we believe these new product line classifications are better aligned to our end markets and our product line strategies. Again, the preseason slides just review do not reflect these changes, and we will begin using this alignment in the first quarter of 2022. However, in the appendix of this presentation, we have provided a version of these product line slides using the new realigning product line classifications. We're hopeful this provides a clear and smooth transition. We now like to talk about our expectations for 2022. As summarized earlier, we expect 2022 sales, including $66 million of Oscor to be in the range of $1.340 billion to $1.365 billion, an increase of 10% to 12% compared to 2021. On an organic basis, we expect sales to grow 5% to 7% compared to 2021. We see strengthening demand as evidenced by our firm backlog orders, which have grown meaningfully since the end of 2020. However, the difficult labor and supply chain environment continue to impact our sales, and we expect the first quarter of 2022 to be similar to the fourth quarter of 2021. We expect the second quarter of 2022 to be sequentially better than the first quarter as we believe the impacts from both the COVID surge in January and supply chain volatility will improve. We expect sales growth in the second half of the year to steadily improve as we believe labor and supply chain challenges will subside and we will realize the impact of growth from new product introductions. Following the sales range we just discussed, we expect 2022 adjusted EBITDA to be between $270 million to $282 million, which is 11% to 16% year-over-year growth. This includes an estimated $12 million of EBITDA for Oscor. We expect 2022 adjusted operating income to be between $201 million to $213 million, reflecting growth of 7% to 14%. These growth rates incorporate the continuation of cost pressures associated with labor and supply chain challenges through the first half of the year. Adjusted EPS is expected to be between $4.35 to $4.65, reflecting growth of 7% to 14%. This assumes an adjusted effective tax rate between 16% to 17.5% as mentioned earlier, and assumes our adjusted interest expense to be between $24 million to $28 million. As I close, we anticipate another strong year of cash flow, generating between $160 million to $175 million in cash flow from operations and between $90 million to $105 million of free cash flow. Consistent with our strategy, we are increasing and concentrating our investments in the business to drive growth, and we expect to spend between $65 million to $75 million on capital expenditures, which is an increase in the run rate of our prior year spending. We expect to reduce net total debt by $85 million to $100 million and expect to be at the end of the year within our target leverage ratio of 2.5 to 3.5 times adjusted EBITDA. With that, I'll turn the call back to Joe. Thank you.

Thank you, Jason. We delivered a strong 2021 coming off the depths of the pandemic. We expect to grow our 2022 revenues and profit, low double digits at the midpoint of our guidance as we manage through both labor and supply chain constraints. Integer is uniquely positioned to serve our customers across all phases of their product life cycles. Through the execution of our product line strategies, we have demonstrated progress by increasing customer development program revenue by 150% and shifting the mix of these programs to 80% higher growth markets. We have a strong pipeline of emerging customers with PMA products that is expected to go from $20 million in 2020 to $40 million this year and to between $60 million and $80 million in 2024. I remain confident in our strategy and our associates and our ability to earn a valuation premium for our shareholders. Thank you for joining our call this morning. I will now turn the call back to our moderator for the Q&A portion of our call.

Your first question comes from the line of Matt Mishan. Your line is now open.

Hey, guys. This is Brett Fishbin on today for Matt. Just wanted to start off on the supply chain issues. Can you provide some more color from a revenue perspective on how the current situation is impacting trends just given lower than ideal inventory levels at some of your customers? And then as a follow-up, does this dynamic add to a potential backlog into 2H22 and '23? Thank you.

Thanks, Brett. Thanks for the question. So what we're seeing in supply chain is really our Tier 2, 3, and 4 suppliers who are seeing the ripple effect of whether it's force majeures or labor shortages or tools they break or them just trying to deal with the volumes and then having struggles. And I think our supply teams have done a phenomenal job of managing that and working to be as far advance of that as we can. We're doing things to help our suppliers be able to supply us and ultimately enable us to continue to meet the needs of our customers so that they can serve patients. And the feedback we're getting from our customers is we're meeting patient needs. But we do believe that there is some inventory that's been depleted at our customers that's in the supply chain. So we do think there's an order of magnitude, it's hard to estimate, but maybe it's in the $10 million to $15 million range worth of sales that maybe have been inventory depletion. And so we would expect to see some increase in future sales as that inventory gets replenished. Whether that gets replenished in the second quarter or second half is hard to tell. It will likely be dependent upon the labor environment and the supply chain environment. But we have already incorporated that order of magnitude for inventory replenishment in our future guidance. So that's been factored into the outlook that you see, and we provided a qualitative assessment of the quarterly profile for the year where, look, we expect first quarter 2022 to look a lot like the fourth quarter of 2021, and that's really a function of the COVID surge. We saw pretty significant absenteeism, particularly in Europe, in our Ireland facilities in the fourth quarter. But we saw a much, much more dramatic impact from absenteeism in January from the Covid surge. I think we've heard that and seeing that across all of our customers, as well as our suppliers. That was a pretty significant impact in January, which is why we think there's at least this $10 million to $15 million worth of inventory depletion that's occurred in the system. So that's really our outlook. We would expect the second quarter to get progressively or on a sequential basis, better than the first quarter. And in the second half, we really expect the volume to begin to accelerate because there's very strong demand, very strong demand. And as you can imagine, with that level of absenteeism and the supply chain challenges, we made that point indicating, but that's also driving cost. And you see that reflected in the margins, both, particularly in the fourth quarter. But also, I would expect to see that similar impact in the first quarter. And that will get progressively better as we get into the second quarter and second half of the year.

All right. Thanks for that color. And then I just wanted to move on to some of the longer-term elements. Given the starting point for guidance of 5% to 7% was a little bit above your traditional starting points for a year. Is it fair to think of that as kind of the sustainable go-forward organic growth rate for Integer and would that kind of imply that you're about halfway to your goal of market growth plus two?

It's a great question, Brett. And the short answer is yes to both of those. But I would add to it and say, we set our goal, which we think at the time four years ago was ambitious to say 200 basis points above the markets we serve, the growth rate. But we think that's at least what the goal, right. That we want to get it leased. We want to be sustainable - we want to grow sustainably faster than our markets. We picked 200 basis points because we do that, when we do that consistently sustainably, we believe we'll be viewed as an outperformer in a consistent, sustainable basis that ultimately should lead to a valuation premium. The reason we took the time today to go through our product line strategies, give you an overview of our strategy journey is we wanted to frame for investors what our journey has been. In 2017, we built the portfolio - we did a portfolio analysis. 2018, we started recruiting the leaders and developing the elements and the specific actions of the strategy. It was really the end of '18, beginning of '19 that we - I would say we got into full execution mode. And so if we're in full execution mode for '19, '20, '21, we're really three years into our strategy, and we thought it was important to share with investors how to think about the revenue generation cycle times. We shared that on one of the slides because it gives you some perspective on the business that we're seeing show up in sales in 2022, the new business, new product introduction that's driving the slightly faster growth, the 100 basis points faster than where we've been historically. That was business that we targeted and won back in '18 and '19, and then it took us '19, 2021 to go through the process or product development cycle, marketed regulatory, market introduction, and ramp. And so we're starting to see some of those strategies begin to deliver and show in our sales acceleration. And so we thought it was important to see kind of the journey to understand where we are in that journey. And yes, seeing the 5% to 7% growth is a step up from 4% to 6%, and it's because we have in-process metrics that we're monitoring to track our progress, and we think it's demonstrating that our sales are growing employees to continue growing at a faster rate.

Excellent. And then lastly from me, can you just provide an update on how you're seeing the M&A pipeline at this point where you might be seeing some more opportunities? And then just your overall level of optimism around the ability to deploy $200 million to $250 million this year just based on the current landscape? Thank you very much...

Certainly, thank you. We've had a robust pipeline from a number of years. Throughout the pandemic, we were - the team was vigilant and diligent in continuing to assess opportunities. We love the Oscor acquisition. The integration process is going incredibly well. We're more excited today than we've ever been now that we've gotten a chance to work more closely with our new associates and colleagues, and we see tremendous growth potential and synergies from working together. We believe we are stronger together. When we look at the pipeline of opportunities, it's robust. Unfortunately, deals have a life of their own and the timing of their own that the sellers are more in control of than the buyer, but we like the opportunities we have in the pipeline. And I'll just reiterate, what we're looking for is very specific capabilities that fill out our portfolio that complete our ability to vertically integrate. We are very focused and targeted on the faster growing end markets. You've heard us say this. We went through it on the growth curves, whether it's structural heart, electrophysiology or neurovascular or neuromodulation. Those are the faster-growing end markets where there's unmet patient need where our customers are disproportionately investing. And so those are the types of companies and capabilities we're looking to acquire. We feel like there's a very strong pipeline of those, and we're confident we can deploy that capital in a prudent, cost-effective way that helps to accelerate our growth and generate returns. So we're confident that we can execute on our capital deployment strategy. Thanks for the questions, Brett.

Thank you.

Our next question comes from the line of Jim Sidoti. Your line is open.

Hi, good morning. And thanks for taking the questions.

Good morning, Jim.

Good morning. So you talked about the decision to exit some of the Portable Medical business, and it seems to make a lot of sense from a margin and growth point of view. But can you just give us a little more color on why it will take four years to exit that business?

Jim, it's a great question. And I would simply say it's the stickiness of highly regulated medical device products. I'd also emphasize, it's a partial exit. So of the 70%, we're exiting 40%, retaining 30%. And so summary is, it's $40 million of products that are largely undifferentiated from a technology standpoint. We went to our customers and said, this business isn't profitable enough. We would rather redeploy all of the resources supporting this business, including freeing up manufacturing space for more profitable growth in a low-cost country. And those customers came back to us and said, it's going to take a while to move that business, you know, two, three, in some cases, four years. And so we would look at - we look at this and say, this is how all of our products are with the distinction being this is undifferentiated from a technology standpoint. And now when you think about most of our business that has Integer proprietary technologies or manufacturing processes, the stickiness is even higher. And so we look at this and say this is indicative or representative of the industry. We're going to support these customers. We absolutely are, we've accepted the timelines that they've given us. We're getting paid for it because we're raising the prices to make sure that it's profitable and worth spending the resources on doing, but it's going to take four years. And so when you look at that $40 million, it's going to be there for another four years. It will be 2025 or 2026 before you begin to see any decline in those sales. And quite frankly, it will also be dependent upon the ability and the effectiveness of the transfers to those suppliers. So it's out there, but the good news - in the short term, we're going to support them, serve them and ensure that they can meet patient needs. But we're also going to make this more profitable for us through the price increases and the overhead reductions. And that gives us the ability to now start planning to move business into that low-cost manufacturing location and take advantage of the growth we see elsewhere, more profitable growth in that location without any meaningful capital investment in the facility.

All right. And then the other thing we spent a lot of time today talking about was the product development cycle. And you pointed out how some of these cycles can be up to five years long. So when you're in the early part of that process, how do you measure your progress? How are you sure you're on time, when it's such a long development process?

Yes, great question, Jim. We tried to highlight a few of those in terms of the amount of product development revenue we're generating. So what we're getting paid to do development. And then we showed how we've shifted the mix to be 80% the faster growing end markets. So we've been very targeted at which - what business we're winning. We've been very targeted at what business we're going after. And in fact oftentimes, it's saying no, it's a business that's in the maybe more mature, less differentiated, less attractive markets in order to shift that mix. So we've been able to grow the volume of development work by 150%, while shifting the mix to faster growth, the 80% is in the faster growing end markets that we've been targeting. Those are our in-process metrics. We monitor the development and the timeline of these development programs. The good news is, particularly on the PMA customers, our PMA products with the longest cycle. We've been at this a long time, particularly in the emerging customer space, and we've got a robust pipeline. We updated the slide we shared in the third quarter of 2020, and you see we've seen progression of more customers moving into product introduction and launched. You see the progression of the sales, the $10 million in '18 to $20 million in 2020, $40 million in 2022, we added a new 2024 going to 60% to 80% or even higher depending upon introduction. So these are the in-process metrics that we're monitoring. It also - the new product introductions that are happening in 2022 from business that we won in '18, '19, and we spent the last three years doing the development and transfer to production. That's what's giving us the confidence. These are organic growth of 5% to 7%. But it's what gives us confidence in our ability to hit our third financial objective of at least 200 basis points above the markets.

Great, thank you.

Thanks for the question, Jim.

There are no further questions at this time. Mr. Borowicz, I turn the call back over to you.

Great. I know we presented a lot of content today for everyone to absorb. So I remind you that you can find the audio replay in today's slides on our website at integer.net. So thank you for your interest in Integer. And that concludes the call for today.