Good day, and thank you for standing by. Welcome to the Myriad Genetics Fourth Quarter 2024 Financial Earnings Conference Call. At this time, all participants are in a listen-only mode. After the speakers' presentation, there will be a question-and-answer session. Please be advised that today's conference is being recorded. I would now like to hand the conference over to our speaker today, Matt Scalo. Please go ahead. Thanks, Latania, and good afternoon, and welcome to the Myriad Genetics fourth quarter and full year 2024 earnings call. During the call, we will review financial results we released today. And afterwards, we will host a question-and-answer session. Our quarterly earnings release was issued this afternoon on Form 8-K and can be found on our website at investor.myriad.com. I'm Matt Scalo, Senior Vice President of Investor Relations. And on the call with me today are Paul Diaz, our President and Chief Executive Officer; Scott Leffler, our Chief Financial Officer; Sam Raha, our Chief Operating Officer; and Mark Verratti, our Chief Commercial Officer. This call can be heard live via webcast at investor.myriad.com, and a recording will be archived in the Investors section of our website, along with the slide presentation. Please note that some of the information presented today contains projections or other forward-looking statements regarding future events or the future financial performance of the company. These statements are based on management's current expectations, and the actual events or results may differ materially and adversely from those expectations for a variety of reasons. We refer you to the documents the company files from time-to-time with the SEC, specifically the company's annual report on Form 10-K, its quarterly reports on Form 10-Q and its current reports on Form 8-K. These documents identify important risk factors that could cause the actual results to differ materially from those contained in our projections or forward-looking statements. And now, I turn the call over to our CEO, Paul Diaz.

Thanks, Matt. Good afternoon, everyone, and thank you for joining us. On today's call, we will discuss our fourth quarter and full year performance and provide an update on the progress we continue to make to accelerate profitable revenue growth and innovation in advanced diagnostics. First, I want to thank my Myriad teammates and our provider partners for their continued support and commitment to advancing our mission and vision to make genetic testing and precision medicine more accessible to help people take more control of their health. Delivering on our mission would not be possible without our Myriad teammates, who continue to recognize our company as a great place to work, with approximately 84% of our teammates rating us as such. Additionally, Forbes recently named Myriad in its list of best employers for 2025. Most everyone you meet at Myriad loves what they do, and we see it played out daily as our teammates go above and beyond to serve our provider partners and their patients. This is reinforced by our strong 72 Net Promoter Score, which captures how different external groups from providers to payers score their interactions with Myriad. Our active pipeline of innovative and clinically-relevant products is supported by the clinical studies and data that we continue to produce at an accelerated rate. As we continue to invest to bring new science to the marketplace, we continue to maintain industry-leading margins, achieve profitability and are seeing growth across the enterprise. I want to now highlight the progress that Myriad Genetics has made over the past five years. We're a very different company than when we started this journey in 2020, and our proven ability to innovate, grow organically and reap profitability has set us apart from many of our respected peers in the industry. Top tier science and innovation are at the foundation of Myriad Genetics as we deliver clinically-differentiated products supported by technology to deliver value in real-world clinical settings, and enable early detection and better treatment decisions for providers and their patients. Combining our mission and vision with expertise in our lab operations and our technical capabilities, together with our in-depth regulatory compliance of revenue cycle management, we find ourselves in a position to serve our customers at scale and profitably. We continue to deliver our commitment to shareholders, as we achieve 11% revenue growth in 2024 as compared to 2023, reflecting both volume and revenue per test improvements across the portfolio. Our focus on profitable growth continues, as we generated approximately $589 million in adjusted gross profits, $40 million of adjusted EBITDA, positive adjusted EPS of $0.14, and maintained approximately $158 million in liquidity in 2024. Continued execution of our strategic priorities and commercial growth strategy support our long-term financial targets, which together with our recent and new pending product launches give us the confidence we can accelerate growth in 2026 and beyond. Today, we announced an exclusive partnership with PATHOMIQ to apply their advanced AI technology platform to our suite of oncology products, enabling Myriad to provide urologists and radiation oncologists with molecular and AI-powered testing solutions to inform decisions both before treatment, at the time of biopsy for active surveillance and following surgery or radiation treatment. This complements Myriad's existing offerings of combining germline and comprehensive tumor profiling as recommended by NCCN guidelines for prostate cancer care. With that, I'll now turn the call over to Sam.

Thank you, Paul. I want to take a moment to recognize the hard work that you and our Myriad team have put in over the past 4.5 years to deliberately focus in on areas of strategic importance, divesting non-strategic assets, restructuring to get our cost basis under control, and shifting to invest and prioritize for growth. Thank you, Paul, for your leadership. As we move forward into 2025 and beyond, we will continue to be guided by our mission to advance health and well-being for all, along with our commitment to delivering predictable, sustained, profitable growth. Four elements of our strategy in oncology, women's health and pharmacogenomics remain intact, as does our focus on providing an easy-to-use customer experience across our product portfolio from learning about our offerings to test ordering, to results delivery, along with patient and provider education and support. We will continue to increase our focus on innovation and providing relevant compelling product offerings for sizable, attractive market opportunities, where we can leverage Myriad's differentiated capabilities and right to win. We will also have a stepped-up focus on execution excellence across the company to support the achievement of our strategic intent and ongoing business and financial objectives. MyRisk remains the gold standard in the market for hereditary cancer testing. Building on this cornerstone, our strategy in oncology remains to serve the continuum of patient care from screening and prognostics products including MyRisk and Prolaris to therapy selection with products including MyChoice Precise Tumor to monitoring and therapy adjustment, including Precise MRD for the most prevalent cancer indications including breast, prostate and ovarian. We will drive growth by focusing on products that are most needed by community oncologists and healthcare providers, leveraging our broad commercial reach and established reputation for quality and delivering diagnostic insights with clear clinical utility. As we develop and update products, we will be deliberate about having a clear path to guideline inclusion and reimbursement. Our biopharma service business will help to drive evidence generation for key applications, while also supporting our pipeline of new cancer diagnostic tests and providing profitable revenue. Our strategy for women's health remains centered on providing relevant, trusted testing solutions throughout a woman's reproductive journey and beyond. We're excited about the potential for our women's health business, including the sizable MyRisk cancer screening opportunity related to an estimated 50 million unaffected women in the United States that meet guidelines for hereditary cancer testing. We will continue establishing and strengthening partnerships with hospital systems and provider networks to identify and serve these unaffected patients. We will also continue to bring differentiated, clinically-relevant, prenatal health products to market for carrier screening and NITS such as Prequel, which delivers critical insights at 8 weeks gestational age, as compared to 10 to 12 weeks for other available tests. Looking ahead, let me share some of the key elements that will enable Myriad's sustained growth. First, as Paul and I have already touched on, an important part of the growth will come from a stream of organically-developed, innovative products. This includes recently launched Prequel for early gestational age, the upcoming launches of FirstGene and Precise MRD. Our growth will also come from the increased focus on executing corporate programs that have the potential to drive material testing volume increases, including the breast cancer risk assessment program and EMR integration value realization. Finally, in a dynamic, fast-paced market where technology is advancing quickly, there will be times where partnering is a faster, more efficient path to capture an opportunity, by complementing our own areas of expertise. We will supplement our organic efforts with purposeful partnerships that enable us to serve high growth, attractive market opportunities with a focus of bringing compelling solutions to our targeted customers with speed with the potential of drawing high return on invested capital. The PATHOMIQ collaboration that we announced earlier today illustrates how we will leverage strategic partnerships. PATHOMIQ's validated AI technology platform extracts hidden insights from complex cancer morphological structures to quickly and efficiently deploy new use cases to predict patient outcomes, treatment responses and genotype mutations. This image-based AI technology can deliver results in one or two days after receiving the digital images from a patient sample. PATHOMIQ was founded around prostate cancer and has a deep clinical expertise and extensive relationships with KOLs in this area. While the current PATHOMIQ model is specific for use in patients with prostate cancer, the underlying foundational model provides opportunities for applications in virtually all solid tumor cancers that are diagnosed through a biopsy with H&E staining. Also, the partnership with PATHOMIQ will help accelerate the timeline for gaining Simon Level 1 evidence for Prolaris.

Thanks Sam for the kind words, trust and leadership. I also want to echo Sam's comments and thank Paul for his leadership, guidance and partnership over the last 4.5 years. Turning to the full year 2024 revenue grew 11% year-over-year and our ASP remained stable with 3% growth over the year. For the fourth quarter, hereditary cancer testing revenue increased 6% compared to last year, while prenatal revenue grew 12% over the same period. GeneSight continued to show strong demand as well, with revenues up 14% in the quarter. I do want to address our slower-than-expected volume growth in Q4. Our prenatal, GeneSight and affected hereditary business remained on-track, while our unaffected business slowed due to attention placed on the launch of Prequel at eight weeks gestational age and EMR workflow conversions taking longer-than-expected. EMR solutions continue to be a key area of investment across our enterprise, as we seek to improve the customer and patient experience. Our efforts with EMR systems are making a difference in the way we engage with our customers and will be an important driver of future volume growth. As Sam has mentioned on previous calls over the past two years, we have doubled our investment in EMR through engineering, integration and commercial pull-through, resulting in more than 4,500 new clinic locations in 2024. We have system integration across 15 plus different vendors, including strategic partnerships with key EMRs like Athena, EPIC, Flatiron for Oncology and Lumia for Urology. This has been an incredible effort by all our teams, although we have seen workflow disruptions at certain health systems take longer to fully integrate and often take several quarters to stabilize and yield increased volumes.

Thanks, Mark. I'll start on the next slide. We are pleased with our continued progress this year, having generated 11% total revenue growth, including domestic revenue growth of 15%. This growth was driven across a number of areas, hereditary cancer testing revenues grew 11%, while prenatal and pharmacogenomics grew 17% and 23%, respectively. 2024 revenue growth also reflects the positive sustainable pricing environment, which we have highlighted on past calls. Regarding fourth quarter results, total revenue grew 7% year-over-year. Domestic revenue grew 11% in the quarter partly offset by the Q3 of '24 divestiture of our EndoPredict business in Europe, which removes approximately $11 million of annual run rate revenue. Mark addressed the commercial dynamics affecting Q4 volume growth, and I reiterate our belief that test volume growth in hereditary cancer and prenatal will reaccelerate as the year progresses. We did benefit modestly from a favorable change of estimates from prior periods in Q4, but the amount was less than either Q3 of '24 or Q4 of '23. We have been highlighting key drivers for sustainable progress and average revenue per test, including various investments and initiatives by both our revenue cycle and payer markets teams. These include, among other things, working with health plans to encourage their implementation of medical policies that can form the state biomarker legislation. There is a growing list of states that have passed biomarker legislation that lends itself to ensuring access to precision medicine and advanced diagnostics. Generally, no one of these wins is likely to have a material impact on revenue but we certainly expect the accumulation of many small and medium-sized wins over time to contribute to the rate environment for our products. In Q4, we again saw stability in underlying rates across our portfolio, which represents another proof point for the great work being done by our revenue cycle on payer market teams, along with others throughout the company. Our 7% revenue growth in Q4 also translated to 12% year-over-year growth in gross profit dollars and a 72% gross margin. That improved 300 basis points over last year. This year-over-year improvement in gross margin partially reflects improvements in average revenue per test as well as overall lab efficiencies. Adjusted operating expenses increased year-over-year and were driven primarily by greater investment in R&D and the timing of incremental marketing spend. We continue to focus on striking the right balance between investment for future growth and profitability as we generated a third consecutive quarter of positive adjusted EPS reporting $0.03 in the fourth quarter. It's a testament to the health of the underlying business that we were able to deliver a strong bottom line performance while still absorbing the incremental investment in R&D. The profit and cash generating potential of the business are also highlighted by our improving positive adjusted EBITDA profile with $11 million of adjusted EBITDA for the fourth quarter and $40 million for the full year. We also finished Q4 in a strong liquidity position with $158 million of total liquidity from a combination of cash and cash equivalents and availability under our revolver. We saw sequential increases in cash and cash equivalent balances from Q3 to Q4 and delivered adjusted free cash flow of approximately $10 million in Q4 as well. During the fourth quarter, we also determined that the previously recorded $21 million contingent payment to Ravgen, which was to be paid out beginning in 2026, was no longer probable. We therefore, reverse the accrual and importantly, no longer feel that this contingent payment will impact our liquidity needs in the future. For the full year 2025, we reaffirm our financial guidance as previously issued in January with a revenue range of $840 million to $860 million, a gross margin range of 69.5% to 70.5% and adjusted OpEx of between $575 million and $595 million. This results in positive adjusted EPS of between $0.07 and $0.11 for the full year 2025. We are also targeting adjusted operating cash flow of between $20 million and $30 million. While we don't guide on a quarterly basis, we wanted to set appropriate expectations for the first quarter of this year, we anticipate generating first quarter revenue of between $196 million and $204 million. As a reminder, we had a total of $7 million benefits in Q1 of 2024 from a combination of change of estimates and an unusual payer market win from a payer retroactively granting coverage of one of our products. Those make for a more difficult growth comp in Q1 of this year. We also anticipate a first quarter adjusted EPS loss of between $0.04 and $0.08.

Thanks, Scott. I'd like to close by saying thank you to our Board of Directors for the opportunity to serve here at Myriad Genetics for the past 4.5 years. To my colleagues in the industry, and to everyone in the investment community on the line today, your help in learning advanced diagnostics and your advice over the years has been invaluable. Most importantly, thank you to my Myriad teammates for their commitment and friendship as we work together to reset Myriad's Genetics culture, which is our foundation for continued growth, innovation and value creation for all of our stakeholders. I'll now pass it back to Matt for Q&A.

Thanks, Paul. And as a reminder, during today's call, we use certain non-GAAP financial measures. A reconciliation of the GAAP to non-GAAP financial results and a reconciliation of GAAP to non-GAAP financial guidance can be found in our earnings release and under the Investor Relations section of our website. Now we are ready to begin our Q&A session. To ensure broad participation, we're asking participants to please ask only one question and one follow-up. Latania, we are now ready to address the Q&A portion of this call.

This is Madeline Mollman on for Doug. Just wanted to touch on the operating expense. On the 25% increase in R&D spend, should we assume this is primarily allocated towards clinical evidence generation for Precise MRD? And given this increase, is it reasonable to assume that SG&A would decline year-over-year to align with the overall OpEx guidance for 2025? And then are you still targeting 1,000 basis point SG&A reduction by 2026 versus 2023?

So yes, the quarter definitely reflected our acceleration of our investments in clinical studies in advance of the launch of FirstGene and Precise MRD, where we're continuing to be excited about the studies that should come out this summer. As referenced earlier in the call and in the earnings release, we've made certain changes in our operating cost model that reflect the UnitedHealthcare payment changes. So across commercial, SG&A and R&D. But I think what you will see is a 25% increase in R&D to support future growth, about an 8% increase in our technology spend and belt tightening elsewhere in the organization for an overall pretty modest 3% increase, Scott, I think we're forecasting year-over-year. So I think that just reflects our ongoing discipline about operating expense management dealing with the UnitedHealthcare change in a pragmatic way, while reallocating our investment dollars for future growth.

This is Will Ortmayer on for Matt. Just wanted to shift over to hereditary cancer. With the unaffected market still around 10% penetrated, you mentioned some good traction in your breast cancer risk assessment program recently. Can you talk a little bit more about the progress you're making in that affected market and the runway you're seeing for sustained growth there?

Yes. As we said in the call, we think that is a real sweet spot for Myriad. We think we have a competitive advantage with our breast cancer risk assessment program and we are gaining traction in a large part, a lot of that EMR integration that we talked about will help fuel that. But as we also mentioned, as you can imagine, switching workflows, especially in the unaffected market where it requires a lot of patient education, it requires gathering family history. There's a lot of ancillary parts other than just ordering the test, but we see a lot of future growth. And as you mentioned, it's only 10% penetrated. And so that is definitely an area that we're excited about moving forward into 2025, not to mention, as Sam mentioned, the 50 million women who really can benefit by getting hereditary cancer testing.

And then just a follow-up. You mentioned some opportunity from the recent market dislocation in that space. Has that been playing out for you to start the year? And how big of a tailwind could those share gains be throughout the year?

So as we said last quarter, the integration with Labcorp really just sort of happened here in January. In terms of potential impact for customers, Labcorp does a fine job, but that certainly presents an opportunity for people that are looking for a different experience. The Ambry acquisition by Tempus just occurred a couple of weeks ago. And so typically, these kinds of changes in the marketplace take several quarters to sort of play out. But they do provide an opportunity for us, given our value proposition about reliability, consistency, accuracy, and fast turnaround times to gain share in these markets, particularly in hereditary cancer.

This is Madison on for Tejas. Just want to start off. As we look out to the next year, how should we be thinking about revenue phasing? And is there any seasonality we should be keeping in mind and just giving us maybe a little bit of a sense of weighting between first half and second half?

Yes. I mean, generally, I would say we made some comments on the call about expecting an acceleration in the volume growth trajectory in the second half of the year based on some of these initiatives, including accelerating ramp from EMR. So that, I think, will weigh a little bit more heavily towards the second half of the year. Other than that, I would say, bear in mind some of the typical seasonality that we see as a business. We have talked in the past about, for example, Q3 being a relatively lighter quarter and Q4 being a relatively stronger quarter.

Yes. Q2 and Q4 are typically where we see a little bit more bounce. Yes. I would say that most of that change is behind us. And so we expect to see stable to modest growth for MyChoice going forward. The thing that we're the most excited about MyChoice is expansion to other indications where we're making progress to expand beyond ovarian to breast and prostate much bigger TAMs. And so that's very, very little in terms of growth in 2025 is based on MyChoice. But the expansion of indications really sets us up well for greater growth in '26 and '27.

This is Thomas on for Subbu. Just one on Prolaris. So thinking about NCCN guideline updates and the confusion in recent months. Just curious where your focus is with Prolaris today and where can you add the most value this year for growth in that test?

Yes. I think there's a couple of things. Number one, we continue to work with our KOLs as we mentioned on the call, as well as those that are in charge of writing the guidelines to potentially get that confusion removed. So I think that's sort of step one. I think step two, as we said, we are increasing our investments across marketing, medical affairs, KOL engagement, across the board because we're excited not only about where our product sits today, but as well as the announcement that we made with PATHOMIQ and our ability to bring the pairing together of AI as well as Prolaris. And then as we also mentioned, also within those guidelines was our ability to bring MyRisk and precise tumor also to the table. So we see this as an area that we're going to strongly invest in, and we expect growth in the future.

And then my second one is on GeneSight. So over the last couple of months, Myriad has made it a point to get out in front of investors and customers, following some '24 decisions that didn't go your way. Curious if you can share what that time has been spent in terms of where you're spending your attention on your sales force? Or is it being more customer-facing? Or is that time spent in front of commercial payers? And then where have you seen the most benefit given the situation and where will you continue to aim your focus this year?

Yes. Let me clarify. So the sales force hasn't changed its focus at all, right? So the sales force remains completely focused on those providers that are treating mental health patients, and they've been continuing to do that which is why the GeneSight demand continues to remain strong, why they're the market leader, but also unfortunately, because of the mental health crisis that is happening today. Internally, as an executive team, we've been working with United. We've had our different medical affairs teams working on data evidence generation as well as our government affairs team working with advocacy support and so on. Two very completely separate things. And we think that's the way it needs to be so that we can remain focused and we can make sure that the patients who need GeneSight continue to get GeneSight while we continue to work through this.

Yes. To elaborate on the answer, as Mark mentioned and implied in your question, we continue to see strong demand for GeneSight. Our market approach remains unchanged, and we view the opportunity to address the UHC policy change positively. Apart from our ongoing efforts with UHC to modify or reverse that policy, we are also focusing on biomarker legislation and our advocacy efforts in that area, investing more time and resources. I want to emphasize two key points. As of today, February 24, we have not observed any impact on GeneSight volumes, nor have we seen any effect on Prolaris volumes due to confusion regarding NCCN guidelines. Furthermore, as Mark indicated, the fundamental strategy that Sam highlighted regarding our ability to provide a comprehensive range of prostate cancer offerings represents the future opportunity for our company that we are most excited about.

I would like to revisit Prolaris for a moment. Can you explain the specific steps you believe are necessary to achieve Level 1b in the guidelines? Do you think this is feasible, and is there a timeline for it? Additionally, while I know you don't provide guidance for Prolaris, could you give us an indication of what you have incorporated into your projections, considering all the variables involved?

Maybe I'll take the first part, Mark, you can take the second part. As it relates to getting Simon Level 1 evidence, I think we've been pretty open about it. One of our challenges has been access to the samples that are needed to get that designation. The partnership now with PATHOMIQ who has this deep-set relationships, they started with prostate cancer. We are excited, and we're seeing receptivity to the working with us when you have a combination of clinical collaboration, which includes not just molecular, which is our base of Prolaris, that combined with the AI element that PATHOMIQ brings. So we haven't quantified yet, give us just a little bit of time. We announced the collaboration formulary this morning, but we are confident that the timelines, which we have been working under are going to be accelerated. We look forward to sharing more of that with you in the upcoming months.

And as you said, Tycho, we don't guide at the individual product level. But what I can tell you is that we are expecting growth revenue and volume growth from Prolaris in 2025.

I'll just ask my questions together. Just we're hearing more and more about these kind of AI-enabled testing technologies, capabilities, etc. So just kind of curious, with this exclusive partnership with PATHOMIQ, why is PATHOMIQ the right partner? Is the multimodal testing approach pretty unique to what you guys are trying to do? And then what do you think differentiates the different AI technology platforms out there? Is it just the access to the amount of data, patient data that you have? Or is it just some sort of differentiated technology, AI technology platform that provides a competitive advantage?

Thank you for the insightful question. I want to emphasize that we've been utilizing AI in various operational areas for an extended period, including our pipelines for variant calling. Regarding your question about why we chose PATHOMIQ, what excites us is their strong foundation in prostate cancer, where they have considerable expertise. The PATHOMIQ team consists of individuals who have dedicated their careers to this field. Additionally, they maintain established relationships with leading institutes focused solely on prostate cancer, which not only allows us access to valuable samples but also expands our network focused exclusively on this area. This partnership, combined with their IT capabilities, which we believe are robust, provides us with the freedom to operate and innovate together. We're also impressed that their product will be launched starting from H&E staining, which is the fundamental method in pathology. This will allow us to use digital images of those slides to apply our proprietary AI algorithm for analysis and interpretation, all within the partnership where Myriad will manage the commercial aspect and customer service. We believe this synergy with our channel is key to our confidence in this partnership. Furthermore, we've spent considerable time exploring and conducting pilot projects with PATHOMIQ to ensure they are the right partner for us. We are excited about Rajat, the CEO, and his team, and we look forward to sharing more about this partnership in the upcoming months.

I guess just a question on the CEO transition, which isn't necessarily surprising given the timing of when you brought Sam and Scott on and you've been asked about it a lot. But maybe you could give us some sense of why is now the right time? Or maybe if I ask it a little bit differently, why is it not the wrong time right now?

Well, it certainly would have felt a lot better before the United decision but, the truth is that Sam has done an exceptional job here as has Mark. And there's always more work to be done. There's always more opportunity. But this is a personal decision for me and my family. I have the opportunity to join Cressey & Company as a managing partner, which is not typically when an operator like me gets to go do for his last chapter. So that's really what drove the timing my confidence in our strategy, and this team and the platform that we have built, the opportunities that we have are significant. And so never a perfect time, but it was the right time given the opportunity that was presented to me personally and the significant runway that Sam and Mark and the rest of the teams have here.

That's helpful to understand that it was sort of driven by the timing of your opportunity as well. I guess just go ahead.

Well, just to clarify, I'm sorry if I misunderstood your question, but we had made previously commented about the full year. We had not previously made any comments about Q1 expectations.

That's what I said. You could have, but you didn't.

Yes, I think it would have been premature for us to do that. If you reflect on my earlier comments, I pointed out that we experienced a significant favorable outcome in the first quarter of last year. There is always a chance we could see something similar that might provide a tailwind. However, given our current situation, we believe this will create a more challenging comparison for the quarter. Additionally, we are still ramping up in some other areas that Mark mentioned during the call.

Nothing has changed from when we gave initial guidance in our views of the year or, quite frankly, the seasonality that we typically see in the quarter. You have co-pays and deductibles. If you look back over the last couple of years, Bill, as we talked about earlier on the call, typically, you have Q1, Q3 seasonality.

My question is focused on the future. Diagnostics has remained relatively unaffected so far, but I'm curious about the Medicaid exposure. Can you explain the potential risk if the new administration decides to implement Medicaid spending cuts?

Yes. When considering potential Medicaid spending cuts related to block rates and our source of Medicaid reimbursement, it primarily impacts prenatal services. Historically, state legislatures have not targeted this area for cuts, despite my experience with other sectors facing Medicaid reductions. There are many policy questions currently. However, when we analyze our revenue distribution across Medicare, commercial, and Medicaid, particularly where Medicaid revenue fits in our products, we believe our exposure to Medicaid block grants or changes in reimbursement is limited. Yes. Thank you, Puneet. That's a great question. As I mentioned, at this point, I feel privileged that I've been an important part, along with Mark and Paul and Scott and others of developing our strategy and areas of focus. Right? So in the near term, at least, there is no intention of changing our strategy or focus. You're right. When you talk about we are excited. We've already developed our expanded carrier screening, Foresight Universal Plus product. So we're ready to catch the wave, if you will, when ACOG guidelines are updated, that's exciting for us. And oncology remains another probably at the heart of the company, still a great opportunity to build on the cornerstones that we have, and it's not just MyRisk, it's MyChoice. We are the HRD gold standard. And we're looking at other opportunities to take HRD broader into the market. We announced with Illumina. I think a few months ago how it will get integrated into their TSO kits as well. But really, it's serving the continuum of cancer care. I'll go back to that. Right, really filling out those gold standard positions with new offerings, which allow us to look at therapy selection with precise tumor to build on that, to get a liquid solution for therapy selection in the market in 2026 as well. And of course, there continues to be a lot of real engagement and work on MRD. Again, our first indication that we're going to bring a product to market is going to be breast cancer. We have nearly 20 different clinical studies in MRD that are underway and a total of more than 4,000 patients that either are in the process of being enrolled. And since you look at multiple data points in the journey of a patient looking at remission and relapse, we're talking at over 30,000 data points. So the focus there and then the opportunity again is really about the continuum of cancer care. And the partnership like that we announced with PATHOMIQ, which we're very excited about, complements what we have to give us a solution where, honestly, we were not participating already, right? Excuse me, we were not participating today in post-radical prostatectomy. So we're going to have a solution there by the end of 2025 with our partnership, very excited about that. And just kind of a foreshadowing, I think I mentioned in my prepared remarks, we understand that along with the great organic work that we do, there are opportunities to get to market faster with select deep partnerships. So PATHOMIQ is a great example, but there will be more to come. That allows us to accelerate the path that Myriad has been on organically.

This is Ben on for Jason. So I just want to start with the launch of Prequel at 8 weeks there. I was hoping you'd be able to provide some commentary sort of on what you're hearing from the docs there. Just really how that adoption and merger reception has been.

Yes. Let me just frame it by. We launched it in November of last year. So we're still in the early innings. But as I called out on the call, one of the keys within that space is that first OB visit is typically at 8 weeks. And so historically, when you've got a 10-week test or you got a 12-week test, that kind of disrupts workflows, it's not the best for the patient and certainly not the best for the provider. So we've seen a lot of excitement about it. And it is something very unique because of our Amplify technology. So Prequel was always sort of one of the best tests out there. So now that it is at 8 weeks, we're seeing a lot of acceptance. And you will hear more from us in the upcoming quarters. It's just still a little early for us to really comment and get into more details. I don't think we've provided specific volume numbers. Scott has mentioned stable ASPs and hopefully a continued contribution, a couple of percentage points if we keep executing. However, we don't provide guidance on specific volumes for any products.

Yes. Just a question on the LRP. The language here is changing a little bit. You're going from 12% to double-digit revenue growth. Can you maybe comment on that?

We experienced a $45 million reduction in our run rate for United, which has set us back somewhat. However, GeneSight has significantly contributed to our growth with a 23% increase this past year. We maintain a long-term growth objective of 12%, but in the intermediate term, we aim to return to double-digit growth by 2025 and continue expanding from there.

Yes, I was commenting specifically on the 2026 and beyond guidance that you have on the slides.

Yes. Again, we'll be launching new products in '26, but you are correct. We have because of the contribution of GeneSight and because it will be early in the launches of FirstGene and Precise MRD, we have modified that to double-digits, call it 10%, as opposed to 12%, obviously, with our expectation that we can get back there quickly. We were certainly on that path to that and beyond before we sustain the United piece. And I just want to underscore that we continue to work with United on what we think was an error in their policymaking process here. As Mark talked about, we'll continue to submit clinical evidence and engage with them, and hopefully, certainly by the end of the year, when they revisit their policy, we'll have submitted 2 or 3 different studies that underscore the value proposition of GeneSight and quite frankly, get at a couple of the points that people have criticized vis-a-vis the PRIME study and other things.

Okay. Thanks, Latania. This concludes our earnings call. A replay will be available via webcast on our website for one week. Thank you again for joining us and have a good afternoon.

And this concludes today's conference call. Thank you for participating. You may now disconnect.