PACB · Pacific Biosciences Of California, Inc.

Represents the number of shares automatically sold to cover tax withholding obligations in connection with the vesting of restricted stock units.

This sale price represents the weighted average sale price of the shares sold ranging from $1.13 to $1.15 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.

Each share is represented by a Restricted Stock Unit ("RSU"). The RSUs will vest in equal annual installments on August 10 of each of 2027, 2028, and 2029, subject to the Reporting Person's continued status as a service provider through the applicable vesting dates.

The shares subject to the option will vest in 36 equal monthly installments beginning on September 10, 2026, subject to the Reporting Person's continued status as a service provider through the applicable vesting dates.

The shares subject to the option will vest monthly over one (1) year, on the same day of the month as the date of grant or, if earlier, on the date of the next annual meeting of the Company's stockholders occurring after the date of grant, provided such Reporting Person continues to serve as a director through the applicable vesting dates.

The shares subject to the option will vest monthly over one (1) year, on the same day of the month as the date of grant or, if earlier, on the date of the next annual meeting of the Company's stockholders occurring after the date of grant, provided such Reporting Person continues to serve as a director through the applicable vesting dates.

The shares subject to the option will vest monthly over one (1) year, on the same day of the month as the date of grant or, if earlier, on the date of the next annual meeting of the Company's stockholders occurring after the date of grant, provided such Reporting Person continues to serve as a director through the applicable vesting dates.

The shares subject to the option will vest monthly over one (1) year, on the same day of the month as the date of grant or, if earlier, on the date of the next annual meeting of the Company's stockholders occurring after the date of grant, provided such Reporting Person continues to serve as a director through the applicable vesting dates.

The shares subject to the option will vest monthly over one (1) year, on the same day of the month as the date of grant or, if earlier, on the date of the next annual meeting of the Company's stockholders occurring after the date of grant, provided such Reporting Person continues to serve as a director through the applicable vesting dates.

The shares subject to the option will vest monthly over one (1) year, on the same day of the month as the date of grant or, if earlier, on the date of the next annual meeting of the Company's stockholders occurring after the date of grant, provided such Reporting Person continues to serve as a director through the applicable vesting dates.

The shares subject to the option will vest monthly over one (1) year, on the same day of the month as the date of grant or, if earlier, on the date of the next annual meeting of the Company's stockholders occurring after the date of grant, provided such Reporting Person continues to serve as a director through the applicable vesting dates.

The shares subject to the option will vest monthly over one (1) year, on the same day of the month as the date of grant or, if earlier, on the date of the next annual meeting of the Company's stockholders occurring after the date of grant, provided such Reporting Person continues to serve as a director through the applicable vesting dates.

One-third of the shares subject to the option will vest on March 3, 2027, which is the one year anniversary of Mr. Gibson joining the Board, and the remainder will vest in equal monthly installments thereafter for 24 months on the same date of the month as his initial start date, provided he continues to serve as a director through each vesting date.

Mr. Gibson was elected to the Board of Directors on March 3, 2026. Each share is represented by a Restricted Stock Unit ("RSU"). The RSUs will vest in equal annual installments on March 3rd of each of 2027, 2028, and 2029, provided such Reporting Person continues to serve as a director through the applicable vesting dates.

Represents the number of shares mandatorily sold to cover tax withholding obligations in connection with the vesting of restricted stock units.

This sale price represents the weighted average sale price of the shares sold ranging from $1.35 to $1.39 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.

Represents the number of shares mandatorily sold to cover tax withholding obligations in connection with the vesting of restricted stock units.

This sale price represents the weighted average sale price of the shares sold ranging from $1.49 to $1.56 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.

Represents the number of shares mandatorily sold to cover tax withholding obligations in connection with the vesting of restricted stock units.

This sale price represents the weighted average sale price of the shares sold ranging from $1.49 to $1.56 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.

Mr. Gibson was elected to the Board of Directors on March 3, 2026. Each share is represented by a Restricted Stock Unit ("RSU"). The RSUs will vest in equal annual installments on March 3rd of each of 2027, 2028, and 2029, provided such Reporting Person continues to serve as a director through the applicable vesting dates.

Represents the number of shares mandatorily sold to cover tax withholding obligations in connection with the vesting of restricted stock units.

This sale price represents the weighted average sale price of the shares sold ranging from $1.49 to $1.56 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.

Includes 7,500 shares purchased on March 2, 2026 under the Company's 2010 Employee Stock Purchase Plan.

One-third of the shares subject to the option will vest on March 3, 2027, which is the one year anniversary of Mr. Gibson joining the Board, and the remainder will vest in equal monthly installments thereafter for 24 months on the same date of the month as his initial start date, provided he continues to serve as a director through each vesting date.

Each share is represented by a Restricted Stock Unit ("RSU"). The RSUs will vest in equal annual installments on February 15 of each of 2027, 2028, and 2029, subject to the Reporting Person's continued status as a service provider through the applicable vesting dates.

The shares subject to the option will vest in 36 equal monthly installments beginning on March 27, 2026, subject to the Reporting Person's continued status as a service provider through the applicable vesting dates.

Each share is represented by a Restricted Stock Unit ("RSU"). The RSUs will vest in equal annual installments on February 15 of each of 2027, 2028, and 2029, subject to the Reporting Person's continued status as a service provider through the applicable vesting dates.

Each share is represented by a Restricted Stock Unit ("RSU"). The RSUs will vest in equal annual installments on February 15 of each of 2027, 2028, and 2029, subject to the Reporting Person's continued status as a service provider through the applicable vesting dates.

The shares subject to the option will vest in 36 equal monthly installments beginning on March 27, 2026, subject to the Reporting Person's continued status as a service provider through the applicable vesting dates.

Each share is represented by a Restricted Stock Unit ("RSU"). The RSUs will vest in equal annual installments on February 15 of each of 2027, 2028, and 2029, subject to the Reporting Person's continued status as a service provider through the applicable vesting dates.

The shares subject to the option will vest in 36 equal monthly installments beginning on March 27, 2026, subject to the Reporting Person's continued status as a service provider through the applicable vesting dates.

The shares subject to the option will vest in 36 equal monthly installments beginning on March 27, 2026, subject to the Reporting Person's continued status as a service provider through the applicable vesting dates.

Represents the number of shares mandatorily sold to cover tax withholding obligations in connection with the vesting of restricted stock units.

This sale price represents the weighted average sale price of the shares sold ranging from $1.55 to $1.70 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.

Represents the number of shares mandatorily sold to cover tax withholding obligations in connection with the vesting of restricted stock units.

This sale price represents the weighted average sale price of the shares sold ranging from $1.55 to $1.70 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.

Represents the number of shares mandatorily sold to cover tax withholding obligations in connection with the vesting of restricted stock units.

This sale price represents the weighted average sale price of the shares sold ranging from $1.55 to $1.70 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.

Includes 7,500 shares purchased on September 2, 2025 under the Company's 2010 Employee Stock Purchase Plan.

Represents the number of shares mandatorily sold to cover tax withholding obligations in connection with the vesting of restricted stock units.

This sale price represents the weighted average sale price of the shares sold ranging from $1.51 to $1.68 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.

Represents the number of shares mandatorily sold to cover tax withholding obligations in connection with the vesting of restricted stock units.

This sale price represents the weighted average sale price of the shares sold ranging from $1.51 to $1.68 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.

Includes 7,500 shares purchased on September 2, 2025 under the Company's 2010 Employee Stock Purchase Plan.

Represents the number of shares mandatorily sold to cover tax withholding obligations in connection with the vesting of restricted stock units.

This sale price represents the weighted average sale price of the shares sold ranging from $1.51 to $1.68 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.

Represents the number of shares automatically sold to cover tax withholding obligations in connection with the vesting of restricted stock units.

This sale price represents the weighted average sale price of the shares sold ranging from $1.30 to $1.32 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.

The shares subject to the option will vest monthly over one (1) year, on the same day of the month as the date of grant or, if earlier, on the date of the next annual meeting of the Company's stockholders occurring after the date of grant, provided such Reporting Person continues to serve as a director through the applicable vesting dates.

The shares subject to the option will vest monthly over one (1) year, on the same day of the month as the date of grant or, if earlier, on the date of the next annual meeting of the Company's stockholders occurring after the date of grant, provided such Reporting Person continues to serve as a director through the applicable vesting dates.

The shares subject to the option will vest monthly over one (1) year, on the same day of the month as the date of grant or, if earlier, on the date of the next annual meeting of the Company's stockholders occurring after the date of grant, provided such Reporting Person continues to serve as a director through the applicable vesting dates.

The shares subject to the option will vest monthly over one (1) year, on the same day of the month as the date of grant or, if earlier, on the date of the next annual meeting of the Company's stockholders occurring after the date of grant, provided such Reporting Person continues to serve as a director through the applicable vesting dates.

The shares subject to the option will vest monthly over one (1) year, on the same day of the month as the date of grant or, if earlier, on the date of the next annual meeting of the Company's stockholders occurring after the date of grant, provided such Reporting Person continues to serve as a director through the applicable vesting dates.

The shares subject to the option will vest monthly over one (1) year, on the same day of the month as the date of grant or, if earlier, on the date of the next annual meeting of the Company's stockholders occurring after the date of grant, provided such Reporting Person continues to serve as a director through the applicable vesting dates.

The shares subject to the option will vest monthly over one (1) year, on the same day of the month as the date of grant or, if earlier, on the date of the next annual meeting of the Company's stockholders occurring after the date of grant, provided such Reporting Person continues to serve as a director through the applicable vesting dates.

The shares subject to the option will vest monthly over one (1) year, on the same day of the month as the date of grant or, if earlier, on the date of the next annual meeting of the Company's stockholders occurring after the date of grant, provided such Reporting Person continues to serve as a director through the applicable vesting dates.

Represents the number of shares automatically sold to cover tax withholding obligations in connection with the vesting of restricted stock units.

This sale price represents the weighted average sale price of the shares sold ranging from $1.00 to $1.01 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.

1/4th of the shares subject to the option will vest on the one year anniversary of the date of grant, and the balance of shares will vest monthly thereafter over the next three years, provided that the Reporting Person continues to serve through each vesting date.

Each share is represented by a Restricted Stock Unit ("RSU"). The RSUs will vest in equal annual installments on March 31 of each of 2026, 2027, 2028 and 2029, provided that the Reporting Person continues to serve through each vesting date.

The shares subject to the option will vest in 24 equal monthly installments beginning on March 15, 2025, subject to the Reporting Person's continued status as a service provider through the applicable vesting dates.

Each share is represented by a Restricted Stock Unit ("RSU"). The RSUs will vest in equal annual installments on February 15 of each of 2026 and 2027, subject to the Reporting Person's continued status as a service provider through the applicable vesting dates.

Each share is represented by a Restricted Stock Unit ("RSU"). The RSUs will vest in equal annual installments on February 15 of each of 2026 and 2027, subject to the Reporting Person's continued status as a service provider through the applicable vesting dates.

The shares subject to the option will vest in 24 equal monthly installments beginning on March 15, 2025, subject to the Reporting Person's continued status as a service provider through the applicable vesting dates.

Each share is represented by a Restricted Stock Unit ("RSU"). The RSUs will vest in equal annual installments on February 15 of each of 2026 and 2027, subject to the Reporting Person's continued status as a service provider through the applicable vesting dates.